Digital Commons Network^™

Potential Benefits Of Combined Statin And Metformin Therapy On Resistance Training Response In Older Individuals, Douglas E. Long, Kate Kosmac, Cory M. Dungan, Marcas M. Bamman, Charlotte A. Peterson, Phillip A. Kern

Clinical and Translational Science Faculty Publications

Metformin and statins are currently the focus of large clinical trials testing their ability to counter age-associated declines in health, but recent reports suggest that both may negatively affect skeletal muscle response to exercise. However, it has also been suggested that metformin may act as a possible protectant of statin-related muscle symptoms. The potential impact of combined drug use on the hypertrophic response to resistance exercise in healthy older adults has not been described. We present secondary statin analyses of data from the MASTERS trial where metformin blunted the hypertrophy response in healthy participants (>65 years) following 14 weeks …

Evaluating Simulation-Based Tobacco Treatment Scenarios For Providers Delivering Treatment For People Living With Mental Illnesses, Chizimuzo T. C. Okoli, Janet Otachi, Sarret Seng, Bassema Abufarsakh, Lovoria B. Williams

Clinical and Translational Science Faculty Publications

Background: People living with mental illnesses (PMI) experience elevated tobacco use and related morbidity and mortality. Despite the availability of effective and safe tobacco treatments along with evidence that PMI are motivated and able to quit successfully, few Mental and behavioral healthcare providers (MHPs) engage PMI in such treatment. MHPs may lack the confidence or skills to engage their clients in tobacco treatment. Currently, there are limited training modalities to prepare MHPs in delivering tobacco treatment for PMI. However, animated scenario-based simulated encounters can bridge this gap to effectively provide tailored MHP training to enhance treatment delivery. Hence, the purpose …

Forage News [2022-04], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

Targeting Squalene Epoxidase Interrupts Homologous Recombination Via The Er Stress Response And Promotes Radiotherapy Efficacy, Zhipeng Hong, Tao Liu, Lingfeng Wan, Pengyan Fa, Pankaj Kumar, Yanan Cao, Chandra Bhushan Prasad, Zhaojun Qiu, Joseph Liu, Hongbing Wang, Zaibo Li, Qi-En Wang, Peixuan Guo, Deliang Guo, Ayse S. Yilmaz, Lanchun Lu, Ioanna Papandreou, Naduparambil K. Jacob, Chunhong Yan, Qing-Bai She

Pharmacology and Nutritional Sciences Faculty Publications

Over 50% of all patients with cancer are treated with radiotherapy. However, radiotherapy is often insufficient as a monotherapy and requires a nontoxic radiosensitizer. Squalene epoxidase (SQLE) controls cholesterol biosynthesis by converting squalene to 2,3-oxidosqualene. Given that SQLE is frequently overexpressed in human cancer, this study investigated the importance of SQLE in breast cancer and non–small cell lung cancer (NSCLC), two cancers often treated with radiotherapy. SQLE-positive IHC staining was observed in 68% of breast cancer and 56% of NSCLC specimens versus 15% and 25% in normal breast and lung tissue, respectively. Importantly, SQLE expression was an independent predictor of …

Tumor Suppressor Par-4 Regulates Complement Factor C3 And Obesity, Nathália Araujo, James Sledziona, Sunil K. Noothi, Ravshan Burikhanov, Nikhil Hebbar, Saptadwipa Ganguly, Tripti Shrestha-Bhattarai, Beibei Zhu, Wendy S. Katz, Yi Zhang, Barry S. Taylor, Jinze Liu, Li Chen, Heidi L. Weiss, Daheng He, Chi Wang, Andrew J. Morris, Lisa A. Cassis, Mariana N. Nikolova‑Karakashian, Prabhakara R. Nagareddy, Olle Melander, B. Mark Evers, Phillip A. Kern, Vivek M. Rangnekar

Clinical and Translational Science Faculty Publications

Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show that conventional Par-4 knockout (Par-4^-/-) mice and adipocyte-specific Par-4 knockout (AKO) mice, but not hepatocyte-specific Par-4 knockout mice, are obese with standard chow diet. Par-4^-/- and AKO mice exhibit increased absorption and storage of fat in adipocytes. Mechanistically, Par-4 loss is associated with mdm2 downregulation and activation of p53. We identified complement factor c3 as a p53-regulated gene linked to fat storage in adipocytes. Par-4 re-expression in adipocytes or c3 deletion reversed …

A Hedonic Analysis Of Factors Impacting The Value Of Planters On The Used Machinery Market, John Allison Jr., Tyler B. Mark, Kenneth H. Burdine, Jordan M. Shockley

Agricultural Economics Faculty Publications

A hedonic model was employed to examine factors that influence the resale price of row crop planters on the used machinery market. Planter sale data from 2016 to 2018 were utilized to conduct the analysis. Results suggested that the primary factors impacting planter resale prices were make, age, condition, planter configuration, row number, and row spacing. As a function of age (depreciation), planter values were generally determined to decrease at a decreasing rate. Finally, it was determined that there was a significant interaction between the variables make and age, suggesting that different planter makes depreciate differently.

Building Sustainable Rangeland Management Systems Through A One System Innovative Approach, Benedict C. Irwin, T. A. Ameha, M. Mangano, B. W. Solomon, T. Wood

IGC Proceedings (1977-2023)

Working through a collaborative working partnership between the USAID Feed the Future Resilience in Pastoralist Areas (RiPA)1 program and Land Governance Activity (LGA)2 and selected technical partners, these new rangeland programs aim to build on significant breakthrough successes in rangeland management from their previous lowland programs3. These new lowlands pastoralist development programs have been purposely positioned by USAID to coordinate, collaborate and combine working activities focused on the continued improvement and strengthening of rangeland management systems in the lowlands of Ethiopia. In light of this positioning, it is proposed that the programs work together to build a comprehensive sustainable rangeland …

Sustainable Development And The Transformation Of Female Rural Labor: The Case Of Woman Cattle Ranchers In Uruguay, Virginia Courdin

IGC Proceedings (1977-2023)

Internationally, rural women are considered key to sustainable development. However, in the Uruguayan livestock sector, women’s work is largely unrecognized by public policy makers, causing younger women to migrate, and resulting in the "masculinization" of livestock husbandry. In Uruguay, extensive livestock production (range livestock) analysis has historically ignored the genuinely productive role that women play in rangelands, limiting the visibility of their action to reproductive activities while ignoring their importance in terms of income generation, herd management, networking, strategic planning, etc. Although family production integrates women, their work is often invisible, subsumed within domestic chores or seen as "helping" the …

Ruminant Livestock Production Systems And Imperatives For Sustainable Development, J. W. Smith

IGC Proceedings (1977-2023)

No abstract provided.

Biodiversity Conservation And Sustainable Livelihoods In Rangelands: Trends, Challenges And Opportunities, J. Waithaka

IGC Proceedings (1977-2023)

Rangelands cover about 54% of the earth’s surface and are essential for agricultural and livestock production, environmental protection and the in-situ conservation of genetic resources. Despite providing services that support life on earth, rangelands have been neglected to a large extent when compared to other types of ecosystems. This paper provides an overview of the importance of rangelands in conserving biodiversity and supporting the livelihoods of millions of people globally. Rangelands have lost ecological integrity due to unsustainable anthropogenic land-use changes and impacts. It is estimated that over 80% of Key Biodiversity Areas (KBAs) are either not adequately protected or …

Feasibility Of Organic Certification Of Sheep And Goats Produced In Pastoral Systems In Northern Kenya, F. Von Steimker, H. T. Wario, B. Kaufmann

IGC Proceedings (1977-2023)

In pastoral systems of Kenya, sale of small ruminants is the main regular income source for most households. Although the meat of small ruminants produced in Marsabit county is preferred in the domestic market, no mechanisms are in place that allow for a respective price differentiation. Establishing value chains for labelled sheep and goat meat would be an option to allow pastoralists to profit from their high process and product quality. The aim of the current study is to assess the requirements and feasibility to establish a value chain for labelled products (e.g. origin labelled, organic certified) together with the …

Uses Of Native Plant Species Of A Communal Rangeland Within ‘Sierra De Huautla’ Protected Area, México, E. Cortés-Díaz, T. González-Bonilla, L. López-Aguilar, Pedro A. Martínez-Hernández, A. Hernández-Tapia

IGC Proceedings (1977-2023)

Sustainability of communal rangelands has become a major concern at national and international levels because land use conflicts and associated social conflicts allows for over-utilization of selected species making a high pressure on them and given away their places to species with no use at all becoming lands degraded and unproductive. The objective of the study was to determine floristic composition and native plant uses by local peasants. The range surface is of 4262 ha, belongs to the communal land ‘El Limon’, in Tepalcingo, Morelos, Mexico, and it is within the Natural Reserve Area “Sierra de Huautla”. Native vegetation is …

Sustainable Intensification In Crop-Livestock Systems, P. Rovira, Paulo C. De F. Carvalho, J. Terra, F. Lattanzi, R. Pizzio, W. Ayala

IGC Proceedings (1977-2023)

Extensive livestock production is the main animal source food system in the Pampas and Campos sub-regions in South America. Beef cattle and sheep convert forage biomass that humans cannot eat into nutrient-dense human-edible foods (meat and milk) and valuable co-products (wool). However, diverse global pressures are acting on Pampas systems including increasing demand for protein sources (food security), climate change, environmental footprint, and competition for land. The integration of small areas of pasture-crop rotations is an alternative for increasing efficiency and sustainable intensification of agroecosystems based on natural grasslands. Rotations led by improved pastures increase the carrying capacity and productivity …

The Comparative Effects Of Short Duration, High Density And Conventional, Rotational Grazing On Different Soil, Vegetation And Animal Parameters In Dry And Mesic Grasslands Of South Africa, Jamie Paulse, Paul Malan, Nico Smit

IGC Proceedings (1977-2023)

Short duration, high density grazing is a grazing management strategy that incorporates the rotation of large livestock herds, often at double or triple the normal prescribed stocking densities of the specific area. It is claimed that this type of grazing management can improve rangeland health by improving soil and vegetation condition, and subsequently influencing animal performance. Regardless of the scarcity of scientific evidence validating these claims, the change from conventional rotational grazing systems to short duration, high density grazing systems is on the increase in South Africa. This study aims to assess these claims, through the quantification of various rangeland …

Enhancing Grassland Biodiversity And Its Consequences For Grassland Management And Utilisation, Johannes Isselstein

IGC Proceedings (1977-2023)

Key points

1. Grasslands make an important contribution to the biodiversity of rural landscapes.

2. Biodiversity has the potential to support the production function of grassland. The conditions for this are largely unexplored.

3. The enhancement of biodiversity on agriculturally improved, species-poor grasslands is difficult to achieve due to seed limitation and high residual soil fertility.

4. Measures to overcome constraints are addition of propagules, depletion of soil nutrients, and the use of specific sward treatments.

5. Agri-environmental schemes will play an increasing role in achieving the biodiversity targets in the future, however, the efficiency of such schemes needs improvement.

Methane And Nitrous Oxide Emissions From Grazed Grasslands, Harry Clark, C. Pinares-Patiño, C. De Klein

IGC Proceedings (1977-2023)

Key points

1. Emissions of methane (CH₄) and nitrous oxide (N₂O) from grasslands make a substantial contribution to total agricultural emissions of these two gases.

2. At present practical mitigation options that relate to grazing ruminants and grazed pastures are limited.

3. Research into agricultural greenhouse gas emissions is of low priority in most developed countries.

4. Direct manipulation of the rumen ecosystem provides the best opportunity for large reductions in CH₄ in the long term.

5. Reducing the amount of nitrogen (N) excreted by grazing animals is a priority in N₂O research, …

Phenotypic Evaluation Of Energycane Varieties For Bioenergy, Wyatt Eason, D. M. Hollowell, Anna Hale, Jesse Ira Morrison, Brian Baldwin

IGC Proceedings (1977-2023)

The need for renewable and carbon-neutral energy is growing as fossil fuel supplies decrease and concerns of climate change increase. C₄ grasses are among the most efficient carbon accumulators. Sugarcane (Saccharum officinarum) is a renewable bioenergy crop with low inputs and high yields, but it is limited to tropical and sub-tropical climates. A close relative, Saccharum spontaneum, readily hybridizes with S. officinarum. S. spontaneum lends cold tolerance and higher yields to the hybrid progeny, called energycane. The Sugarcane Breeding Unit (USDA, Houma, Louisiana, USA) selected twenty-six genotypes for testing at Mississippi State University to determine production …

Key Factors For Improving Rigor And Reproducibility: Guidelines, Peer Reviews, And Journal Technical Reviews, Hong S. Lu, Alan Daugherty

Saha Cardiovascular Research Center Faculty Publications

To respond to the NIH's policy for rigor and reproducibility in preclinical research, many journals have implemented guidelines and checklists to guide authors in improving the rigor and reproducibility of their research. Transparency in developing detailed prospective experimental designs and providing raw data are essential premises of rigor and reproducibility. Standard peer reviews and journal-specific technical and statistical reviews are critical factors for enhancing rigor and reproducibility. This brief review also shares some experience from Arteriosclerosis, Thrombosis, and Vascular Biology, an American Heart Association journal, that has implemented several mechanisms to enhance rigor and reproducibility for preclinical research.

Grazing Land Contributions To Carbon Sequestration, Ronald F. Follett, G. E. Schuman

IGC Proceedings (1977-2023)

Key points

1. Grazing management can be used to increase soil organic carbon sequestration.

2. Grazing land soils contain large amounts of carbon with depth, and can store it for centuries.

3. Policies to encourage terrestrial carbon sequestration through conservation and good management of grazing lands are critical for many countries and the world.

Global Atmospheric Change And Its Effect On Managed Grassland Systems, Andreas Lüscher, J. Fuhrer, P. C. D. Newton

IGC Proceedings (1977-2023)

Key points

1. Increasing atmospheric CO2 concentration and a trend to warmer mean temperatures are the most reliable aspects of global atmospheric change. Projections of the extent of climate change and the frequency of extreme weather conditions remain uncertain.

2. Research has considerably reduced the uncertainty about effects of global atmospheric change on physiology of plants, productivity and species composition of plant communities.

3. Other factors (e.g. nutrient availability, soil type) and long-term adaptation of the ecosystem (e.g. nutrient cycling and sequestration) influence the response of plant communities to global atmospheric change. Generalisation is not possible with respect to the …

Grassland Productivity And Water Quality: A 21St Century Issue, David M. Nash, P. M. Haygarth

IGC Proceedings (1977-2023)

Key points

1. Irrigation and other changes to the hydrological cycle can increase soil and water salinity.

2. Primary salinisation is a natural process that affects much of Europe, Asia, Africa, the Americas and Australia. Secondary salinisation is caused by human activities such as irrigation and land clearing that mobilise salt stored in the soil.

3. The critical water contaminants exported from grasslands are nitrogen, phosphorus, potential pathogens and sediment.

4. The mechanisms responsible for diffuse pollution from grasslands and mitigation strategies are most effectively investigated using a ‘source-mobilisation-transport’ framework.

5. There is a lack of coherent interaction across discipline …

Soil Quality Assessment And Management, M. G. Kibblewhite

IGC Proceedings (1977-2023)

Key points

1. Soil quality is related to the capacity of soil to deliver ecosystem services on a sustainable basis.

2. Effective management of soil within grasslands can deliver many benefits to mankind but poor management may cause loss of soil quality from erosion, loss of organic matter, physical deterioration etc.

3. Services are delivered from soil by biological processes. Soil quality depends on the form and condition of the soil habitat. Fixed factors (e.g. texture) are useful for assigning soil to types. Variable factors (e.g. organic carbon) can then be used to assess quality within soil types, by reference …

Water Resources, Agriculture And Pasture: Implications Of Growing Demand And Increasing Scarcity, M. W. Rosegrant, R. A. Valmonte-Santos, S. A. Cline, C. Ringler, W. Li

IGC Proceedings (1977-2023)

Key points

1. Water availability for irrigation is threatened in many regions by rapidly increasing demand for nonagricultural water uses in industry, households, and the environment. The scarcity of irrigation water will not only impact crop production, but also meat production, as much of the pasture used to feed livestock is irrigated.

2. Grassland is caught between two countervailing forces: a requirement for increasing meat demand that boosts the need for additional pasture to support livestock production, and rapidly increasing water scarcity that makes pasture irrigation uneconomical.

3. The most effective means of dealing with water scarcity is likely to …

Soil Microbial Community: Understanding The Belowground Network For Sustainable Grassland Management, Y. G. Zhu, W. D. Kong, B. D. Chen, Z. B. Nan, P. Christie

IGC Proceedings (1977-2023)

Key points

1. In addition to the use of conventional methodologies in soil microbial research, molecular techniques are now being applied to gain insights into the soil microbial community;

2. Plant diversity can exert impacts on soil microbial diversity (through root activities and plant litter etc.), but may in itself be significantly altered by soil properties;

3. Soil microbial diversity largely determines the stability of soil ecosystems under biotic and abiotic perturbations.

4. Management of soil microbial diversity can only be achieved through better understanding their structures and functions.

Gingival Transcriptome Of Innate Antimicrobial Factors And The Oral Microbiome With Aging And Periodontitis, Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Linh Nguyen, Octavio A. Gonzalez

Center for Oral Health Research Faculty Publications

The epithelial barrier at mucosal sites comprises an important mechanical protective feature of innate immunity, and is intimately involved in communicating signals of infection/tissue damage to inflammatory and immune cells in these local environments. A wide array of antimicrobial factors (AMF) exist at mucosal sites and in secretions that contribute to this innate immunity. A non-human primate model of ligature-induced periodontitis was used to explore characteristics of the antimicrobial factor transcriptome (n = 114 genes) of gingival biopsies in health, initiation and progression of periodontal lesions, and in samples with clinical resolution. Age effects and relationship of AMF to …

The Potential Of Grassland And Associated Forages To Produce Fibre, Biomass, Energy Or Other Feedstocks For Non-Food And Other Sectors: New Uses For A Global Resource, M. F. Askew

IGC Proceedings (1977-2023)

Key points

1. In developed countries increased areas of land will become available for non-food production. Recent reforms of the Common Agricultural Policy will further intensify this trend in Europe.

2. There is potential for grassland and associated species to contribute to large tonnage markets of energy and bulk fibres, to the supply of fermentation products and to speciality markets, but processes and approaches to the market are not as yet developed.

3. There is potential for the establishment of Graminaceous species - specifically for nonfood use. For European conditions particular attention is being given to Miscanthus sinensis (Miscanthus), Arundo …

Adoption Of Tropical Legume Technology Around The World: Analysis Of Success, H. M. Shelton, S. Franzel, M. Peters

IGC Proceedings (1977-2023)

Key points

1. Examples of successful adoption of forage legumes are reported from all continents, where they delivered profitability and often provided multipurpose benefits to farmers.

2. Factors vital to successful adoption were: meeting the needs of farmers; building relevant partnerships; understanding the socio-economic context and skills of farmers; participatory involvement with rural communities; and long-term involvement of champions.

3. Organisation of seed supply, achieving scale-up and forming partnerships to implement adoption are key features.

4. Legumes remain an important but under-exploited resource for tropical farming systems. The alternative to legumes will be greater and more costly use of N-fertilisers …

Grasses As Biofactories: Scoping Out The Opportunities, Nick Roberts, K. Richardson, G. Bryan, C. Voisey, W. Mcnabb, T. Conner, M. Christey, R. Johnson

IGC Proceedings (1977-2023)

Key points

1. Plant biopharming is set to dominate commercial recombinant protein expression for specific proteins.

2. The choice of plant species depends on a multitude of factors and is determined on a caseby- case basis.

3. As a leaf based expression system grasses would have to compete predominantly with tobacco and alfalfa.

4. The grass-endophyte symbiosis offers a number of unique possibilities for biopharming.

Evolution Of Integrated Crop-Livestock Production Systems, Martin H. Entz, William D. Bellotti, J. M. Powell, S. V. Angadi, W. Chen, K. H. Ominski, B. Boelt

IGC Proceedings (1977-2023)

Key points

1. Many factors contribute to changes in the crop-livestock systems, but no logical end-point in the evolution process exists.

2. While benefits of integrated crop-livestock systems over specialised crop and livestock systems are well documented, there has been a move to specialised crop and livestock production.

3. Sustainability issues (manure nutrient concentration, soil quality maintenance, salinity, herbicide resistance, economic instability) have created a renewed interest in integrated crop-livestock systems.

4. Farmer adaptability is as an important link in the evolution between ‘states of integration’.

Overcoming Seasonality Of Production: Opportunities Offered By Forage Conservation Technologies, P. O'Kiely, A. G. Kaiser

IGC Proceedings (1977-2023)

Key points

1. Seasonality of forage supply is a key contributor to the seasonality of meat and milk production.

2. Conserving forages as silage or hay can help reduce the seasonality of feed supply.

3. Forage conservation technologies make this contribution mainly through increases in the yield or quality of suitable crops, through an improved efficiency of the conservation process or by allowing a reduction in costs.

4. Future research needs differ considerably among regions of the world.