Digital Commons Network^™

When May A State Require Teaching Alternatives To The Theory Of Evolution? Intelligent Design As A Test Case, Stephen L. Marshall

Kentucky Law Journal

No abstract provided.

School Vaccination Requirements: Historical, Social, And Legal Perspectives, James G. Hodge Jr., Lawrence O. Gostin

Kentucky Law Journal

No abstract provided.

The Organ Trail: Express Versus Presumed Consent As Paths To Blaze In Solving A Critical Shortage, Emily Denham Morris

Kentucky Law Journal

No abstract provided.

The Naked Clone, John Charles Kunich

Kentucky Law Journal

No abstract provided.

Justice Scalia's Rhetoric Of Dissent: A Greco-Roman Analysis Of Scalia's Advocacy In The Vmi Case, Michael Frost

Kentucky Law Journal

No abstract provided.

Cognitive And Somatic Item Response Pattern Of Orofacial Pain Patients Compared To Fibromyalgia Patients And A Non-Pain Control Group, Morten Hadsel

University of Kentucky Master's Theses

Previous work has suggested that chronic pain patients report psychological distress through higher endorsement of somatic rather than cognitive signs of anxiety and depression. The present study compared female Non-Pain (11=52), Orofacial Pain (n=3 17) and Fibromyalgia (n=50) groups. on SCL-90-R Somatization, Anxiety and Depression raw scores and cognitive-somatic symptom patterning of the Anxiety and Depression scales. Comparisons were also made amongst orofacial pain diagnostic subgroups and subgroups based on Multidimensional Pain Inventory (MPI) classification groups. The Somatization. Anxiety and Depression scores were higher in the OroFacial Pain and Fibromyalgia than Non-Pain group and higher in the Dysfunctional than Adaptive …

Simulation Study Of Multilane Selectivity Bank In Automotive Industry, Sachin G. Nagane

University of Kentucky Master's Theses

This study deals with a very common problem encountered in many automotive industries. Automotive companies try to level the production of different models over time based on the demands for these models in the market. In order to achieve this, they introduce a leveled stream of cars in the beginning of the production line. But because of many reasons this leveled stream gets disturbed in its course. In order to re-level the stream, buffers are used between the shops. One such buffer is called as selectivity bank and it sits between paint shop and assembly shop. This buffer receives a …

The Place Of Dietary Practices In The Lives Of Older Women, Lisa Marie Curch

University of Kentucky Doctoral Dissertations

Studies have supported the benefits of positive dietary behaviors in preventing or reducing morbidity and extending longevity, as well as the psychosocial function of dietary practices for quality of life. Research is needed though on the dietary behaviors of elders in general and older women in particular, for whom gender affects lifelong dietary patterns. Health behavior theory has typically focused on psychological factors, to the neglect of sociocultural processes. This investigation utilized a life course perspective, enhanced by social interactionist elements, to address aspects of development and change in behavior neglected by health behavior theories, such as temporal dimensions and …

Spatio-Temporal Variation In Activation Intervals During Ventricular Fibrillation, Sachin Anil Moghe

University of Kentucky Doctoral Dissertations

Spatio-temporal variation in activation rates during ventricular fibrillation (VF)provides insight into mechanisms of sustained re-entry during VF. This study had three objectives related to spatio-temporal dynamics in activation rates during VF.

The first objective was to quantify spatio-temporal variability in activation rates,that is, in dominant frequencies, computed from epicardial electrograms recorded during VF in swine. Results showed that temporally and spatially, dominant frequencies variedas much as 20% of the mean dominant frequency, and the mean dominant frequencies increased during first 30 sec of VF. These results suggest that activation rates are nonstationary during VF.

The second objective of the study …

Multigenerations And Multidisciplines: Inheriting Fifty Years Of Gwembe Tonga Research, Lisa Cliggett

Anthropology Faculty Publications

No abstract provided.

Creation Of A Bacterial Mutagenicity Assay Highly Sensitive To Dialkylnitrosamines, Matthew Troy Cooper

University of Kentucky Doctoral Dissertations

Although dialkylnitrosamines are environmentally significant carcinogens, the use of short-term bioassays to assess the mutagenic potential of these compounds remains problematic. The Ames test, a mutagenicity assay based on the reversion of Salmonella typhimurium histidine auxotrophs, is the most widely used bioassay in genetic toxicology, but the traditional Ames tester strains are largely insensitive to dialkylnitrosamine mutagenicity. I have constructed several mutagenicity tester strains that co-express combinations of full-length human cytochrome P450 2E1, rat cytochrome P450 reductase, and human cytochrome b5 in S. typhimurium lacking ogt and ada methyltransferases (YG7104ER, ogt-; and YG7108ER, ogt-, ada-). These new strains are susceptible …

The Efficiacy Of Various Salmonella Intervention Methods Applied To Pork Carcasses During Slaughter, Nathan C. Clayton

University of Kentucky Master's Theses

Twenty-one market-age swine slaughtered in the University of Kentuckyabattoir were inoculated with fecal slurry containing two strains of nalidixic acidresistant Salmonella typhimurium on the ham, belly, and jowl regions on eachside of the carcass. Trial 1 revealed that a 10 s hot water spray was just aseffective as the 20 s spray in removing S. typhimurium, as there was nodistinguishable difference in population. The shorter flame singe (10 s) was aseffective as the 20 s application and the two chlorine solutions (100, 200 ppm)had similar results. The 2% lactic acid spray reduced S. typhimurium populationssignificantly more than the 1% treatment. …

Coarse Orange Pottery Exchange In Southern Veracruz: A Compositional Perspective On Centralized Craft Production And Exchange In The Classic Period, Wesley Durrell Stoner

University of Kentucky Master's Theses

This research seeks to elucidate the role of relatively large-scale ceramic productionindustries located at the Classic period center of Matacapan in the Sierra de los Tuxtlas, SouthernVeracruz, Mexico. Arnold et al. (1993) have suggested that the specialized production atComoapan, the largest production locality at Matacapan, was oriented toward supplying theregion with ceramics. This production locality overwhelmingly specialized in manufacturingone standardized ware, Coarse Orange, into necked and neckless jars, which are found in manyparts of the region.The compositional techniques of instrumental neutron activation analysis (INAA) andpetrography were employed to investigate the distribution of this ware. Control groups weresampled from known production …

The Jak-Stat Pathway Is Required For Multiple Early Events In Drosophila Oogenesis, Jennifer Renee Matlock

University of Kentucky Master's Theses

The Janus kinase (JAK) pathway is an integral part of signaling through a variety of ligands and receptors in mammals. The extensive reutilization and pleiotropy of this pathway in vertebrate development is conserved in other animals as well. In Drosophila melanogaster, JAK signaling is involved in embryonic pattern formation, sex determination, larval blood cell development, wing venation, planar polarity in the eye, and formation of other adult structures. Here we describe several roles for JAK signaling in Drosophila oogenesis. The gene for a JAK pathway ligand, unpaired, is expressed specifically in the polar follicle cells, two pairs of somatic cells …

Roles Of The Jak Pathway In Follicular Patterning In Drosophila, Rongwen Xi

University of Kentucky Doctoral Dissertations

The JAK-STAT pathway is an intracellular signaling pathway that is found to have crucial roles in hematopoiesis, immune response and the development of many other tissues in mammals. The pathway is conserved in Drosophila melanogaster, and is much simpler: there is only one Drosophila JAK (Hopscotch, Hop) and STAT (STAT92E) respectively, while there are at least 4 JAKs and 7 STATs in mammals. The pathway has been intensively studied in Drosophila, and has been implicated in many tissue development and cellular processes. In this work, I present several roles of JAK signaling in oogenesis.First, JAK signaling is required for cell …

Improving Farm Management Decisions By Analyzing Site-Specific Economic Data Developed From Yield Maps, Laura A. Powers

University of Kentucky Master's Theses

This thesis examines the use of precision agriculture data, specifically yield maps, for makingsite-specific economic decisions for improved farm management. The adoption of precisionagriculture on farms has allowed producers to collect a greater quantity and more specificinformation about production than ever before. With such information, site-specific decisions canbe made. Incorporating economic data with yield map data, two primary decision examples aredeveloped: defining areas of production and nonproduction and managing temporal risk spatiallyacross a field. Included with the production/ nonproduction decision are the effects that landtenure arrangements and risk aversion levels have on the decision. The risk maps are developedusing break-even …

Identification And Characterization Of Contact Sites Between Human Chorionic Gonadotropin And The Amino Terminal Region Of The Luteinizing Hormone/Choriogonadotropin Receptor, Rebecca Mccaffrey

University of Kentucky Master's Theses

The luteinizing hormone / choriogonadotropin receptor (LH/CG-R) is a member of theG protein-coupled receptor family. The LH/CG-R has seven transmembrane helices, threeexoloops, three cytoloops, a C-terminal tail, and an extensive N-terminal exodomain. Theexodomain is capable of binding hormone with high affinity without hormone action. Previousstudies have shown that the amino-terminal region of the LH/CG receptor contacts both subunitsof human chorionic gonadotropin (hCG). In particular, three residues (Leu20, Cys22, and Gly24)were found to be crucial for hormone binding. In this thesis work, benzoylphenylalanine (Bpa),a photoactivatable reagent, was used to continue investigating the interactions of the N-terminalregion of the LH/CG-R with hCG. …

Pigs In Space: Ghosts, Gender And Sexuality In A Debate About Regulating Industrial Hog Farms In Kentucky, Mary E. Curran

University of Kentucky Doctoral Dissertations

In 1997, Governor Paul Patton of Kentucky asked the state Cabinet of Natural Resources and Environmental Protection to develop administrative regulations for industrial hog farms in the state. The regulatory process has been contentious. From 1997 through 1998, the Cabinet held five public hearings to elicit comments on the proposed regulations. This study is designed to answer two questions. First, how, within parameters of participation established by the Kentucky Cabinet of Natural Resources and Environmental Protection, have participants in the debate deployed notions of risk to privilege certain gendered and sexualized farming identities, farming practices, and notions of rurality? Second, …

Structure And Function Analysis Of Par-4, Nadia M. El-Guendy

University of Kentucky Doctoral Dissertations

Par-4 is a leucine zipper domain protein that induces apoptosis on its own in certain cancer cells and in Ras-transformed cells, but not in normal or immortalized cells. Par-4 induces apoptosis by activation of the Fas death receptor pathway and co-parallel inhibition of NF-B transcription activity. Cells that are resistant to apoptosis by Par-4 alone, however, are greatly sensitized by Par-4 to the action of other pro-apoptotic insults such as growth factor withdrawal, TNF, ionizing radiation, intracellular calcium elevation, or those involved in neuronal degeneration such as Alzheimer's, Parkinson's, Huntington's and Stroke. Previous studies have suggested that the apoptosis-sensitization potential …

The Role Of Nf-Kb Activation In Hepatic Tumor Promotion By Polycholorinated Biphenyls (Pcbs), Zijing Lu

University of Kentucky Doctoral Dissertations

Polychlorinated biphenyls (PCBs) are nongenotoxic hepatic tumor promoters. PCBs have been shown to cause oxidative stress, but the exact mechanism by which PCBs exert their tumor promoting activity is not clear. In our study, PCB-153, a non-coplanar congener, caused a transient increase in hepatic NF-B DNA binding activity and cell proliferation, while PCB-77, a coplanar congener, showed no effect. Our second study using a mouse model that was deficient in the p50 subunit of NF-kB (p50-/-) showed that NF-kB contributes to the changes in hepatocyte proliferation and apoptosis in response to PCB-153 treatment: a single dose of PCB-153 increased hepatic …

Protection Against Ischemia And Reperfusion Injury, Peter R. Oeltgen, Paul D. Bishop, Mark S. Kindy, Juan A. Sanchez

Molecular and Cellular Biochemistry Faculty Patents

A compound and method for using the compound to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.

Forage News [2001-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Grazing Conference November 29^th
• Alfalfa Yield vs. Stand Age
• Feed & Forage Composition
• Upcoming Events

Return To Fertility After Extended Chemical Castration With A Gnrh Antagonist, Janusz W. Kostanski, Ge Jiang, Bhas A. Dani, Santos B. Murty, Wei Qiu, Bruce Schrier, B. C. Thanoo, Patrick P. Deluca

Pharmaceutical Sciences Faculty Publications

BACKGROUND: Antagonistic analogues of GnRH for the treatment of prostate cancer may be used clinically in persons for whom return to fertility after such treatment is important or desirable. The purpose of this study was, therefore, to evaluate the effects of a long term treatment with orntide, a GnRH antagonist, on testosterone levels and fertility in male rats.

METHODS: Two groups of male rats received either 120-day orntide microspheres (8.8 mg orntide/kg/120 days) or vehicle alone (control group). Serum orntide and testosterone levels in both groups were monitored at certain intervals for 9 months from the initiation of treatment. After …

Cheese Making With Bacteriophage Resistant Bacteria, Clair D. Hicks

Animal and Food Sciences Faculty Patents

A method is provided for reducing or preventing bacteriophage attack on bacteria used in a cheese making process. The method includes (a) treating a blocker peptide precursor with a protease enzyme that hydrolyzes the precursor to produce blocker peptides; (b) collecting the blocker peptides so produced; (c) formulating a starter media with the blocker peptides; (d) growing bulk cultures of cheese making bacteria in the inoculated starter media; and (e) adding bacteria grown in the inoculated starter media to a fermentation medium for producing cheese. The present invention also includes a method of making cheese and cheese produced by the …

Evidence And Trial Practice, Office Of Continuing Legal Education At The University Of Kentucky College Of Law

Continuing Legal Education Materials

Materials from the conference on Evidence and Trial Practice held by UK/CLE in October 2001.

Forage News [2001-10], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Grazing Conference
• Beware of Prussic Acid as Frost Approaches
• Forage Conference Set for Farm Bureau Convention
• Hay Testing is Best Bargain
• Crop Residue: Questions & Answers
• KFGC Award Nominations Deadline October 15
• Upcoming Events

Method For Treating Ischemia, Peter R. Oeltgen, Mark S. Kindy, Paul D. Bishop

Molecular and Cellular Biochemistry Faculty Patents

A method for treating ischemia by administering deltorphins to a mammal. Deltorphin I SEQ ID NO:1, delntorphin II SEQ ID NO:2 or combinations of deltorphins I SEQ ID NO:1 and II SEQ ID NO:2 may be administered. A deltorphin concentration of about 0.5-20 mg/kg body weight, or alternatively a lower concentration of about 1-1000 μg/kg body weight of the mammal in a physiologically acceptable formulation is administered up to four hours after an ischemic episode. Deltorphins may also be administered prior to or concurrently with onset of ischemia. Cerebral or spinal cord ischemia or ischemic heart disease may be treated …

Farnesyl Pyrophosphate Analogs, Hans Peter Spielmann, Douglas A. Andres, Kareem A.H. Chehade

Molecular and Cellular Biochemistry Faculty Patents

The post-translational addition of a farnesyl moiety to the Ras oncoprotein is essential for its membrane localization and is required for both its biological activity and ability to induce malignant transformation. The present invention describes design and synthesis of a farnesylpyrophosphate (FPP) analog, 8-anilinogeranyl pyrophosphate (AGPP) that is transferred to Ras by farnesyltransferase (FTase), in which the ω-terminal isoprene unit of the farnesyl group has been replaced with an aniline functionality. AGPP potently inhibited FTase activity in vitro (IC₅₀=0.6 μM) and is highly selective showing little inhibitory activity against either geranylgeranyl-protein transferase type I (GGTase I) (IC_{50 …}

Forage News [2001-08], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Grazing School
• Comparative Assessment of Autotoxicity Research and Management Recommendations
• Forage Legume Information on the Web
• Value-Added Traits of Alfalfa
• Kentucky Grazing Conference
• Upcoming Events

Neuronal Cell Model And Methods Of Use Therefor, Craig S. Miller, Robert J. Danaher, Robert J. Jacob

Microbiology, Immunology and Molecular Genetics Faculty Patents

The present invention provides, inter alia, a PC12 cell quiescently infected with a neurotropic virus. Preferred quiescently-infected neural cells are those wherein the neurotropic virus is a neurotropic herpes virus. Methods related to these and other materials are also provided.