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Method For Inhibition Of Photocarcinogenesis Or Photoimmunosuppression Using Niacin, Elaine L. Jacobson, Helen L. Gensler

Graduate Center for Nutritional Sciences Faculty Patents

The invention is directed to novel methods for the suppression of photocarcinogenesis and photoimmunosuppression in mice. The novel methods comprises the step of administering to a subject a pharmaceutical composition comprising niacin and a pharmaceutical carrier.

Synthases, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase with or without a substrate bound in the active site.

Forage News [2002-12], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Grazing Conference
• Forages at KCA
• 23^RD Annual Conference Set for February 20
• What is ArkPlus Tall Fescue?
• Grazing Can Be Just as Profitable
• Fertility of Kentucky Pasture Fields
• Meat Goat Wether Performance on Endophyte-Infected Tall Fescue – A Pilot Study
• Spoilage Losses in Large Round Bales
• KFGC Awards
• Upcoming Events

Assessment Of The 1997 Commodity Flow Survey For State-Level Freight Transportation Planning, Darren M. Scott

Kentucky Transportation Center Research Report

Urban travel demand modeling in the United States has a rich history in both practice and academic research. The same cannot be said, however, of freight demand modeling despite the intermodel planning requirements of IS TEA and TEA21. In most instances, agencies responsible for state transportation planning (e.g. Kentucky Transportation Cabinet) have applied, in a limited way, the methodology developed for urban travel demand modeling (i.e., Urban Transportation Modeling System or UTMS 1) to the freight arena (see, for example, Black 1997). Obviously, this methodological similarity implies that the fundamental data requirements for both types of demand modeling are also …

Gag Proteins Of The Two Drosophila Telomeric Retrotransposons Are Targeted To Chromosome Ends, Svetlana Rashkova, Sarah E. Karam, Rebecca Kellum, Mary-Lou Pardue

Biology Faculty Publications

Drosophila telomeres are formed by two non-LTR retrotransposons, HeT-A and TART, which transpose only to chromosome ends. Successive transpositions of these telomeric elements yield arrays that are functionally equivalent to the arrays generated by telomerase in other organisms. In contrast, other Drosophila non-LTR retrotransposons transpose widely through gene-rich regions, but not to ends. The two telomeric elements encode very similar Gag proteins, suggesting that Gag may be involved in their unique targeting to chromosome ends. To test the intrinsic potential of these Gag proteins for targeting, we tagged the coding sequences with sequence of GFP and expressed the constructs …

Forage News [2002-11], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Grazing Conference Approaching
• Fall Grazing School
• Forage Survey Complete
• Preference of Grazing Goats for Cool-Season Annual Clovers
• Relative Forage Quality (RFQ): Even Better Than RFV
• Upcoming Events

Mechanical Properties Of Corn And Soybean Meal, Marek Molenda, Michael D. Montross, Jozef Horabik, Ira Joseph Ross

Biosystems and Agricultural Engineering Faculty Publications

Ground corn and soybean meal are common ingredients in feed mixes. The knowledge of their mechanical properties is important to the feed manufacturer and consumer. Changes in these properties can lead to abnormally high or low levels of active ingredients in finished feed, thus decreasing its quality. Mechanical properties of wheat, corn meal, and soybean meal were investigated using a modified direct shear apparatus. The moisture content (wet basis), uncompacted bulk density, and particle density were: 10.4%, 733 kg/m³, and 1410 kg/m³ for soft red winter wheat; 11.4%, 583 kg/m³, and 1350 kg/m³ for …

Methods Of Making Modified Polypeptides, Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks

Pharmaceutical Sciences Faculty Patents

Novel polypeptides and the corresponding nucleic acids encoding such polypeptides are disclosed herein. The invention provides methods of making modified polypeptides by altering one or more amino acid residues involved in the active site of a preselected polypeptide.

Topical Micronutrient Delivery System And Uses Of Thereof, Elaine L. Jacobson, Myron Jacobson, Jaber G. Qasem, Hyuntae Kim, Moonsun Kim

Graduate Center for Nutritional Sciences Faculty Patents

The invention involves methods and compositions useful in delivering micronutrients to cells. By formulating the micronutrient in the form of an ester that is convertible to the active form of the micronutrient, one can combine it with a co-ester that inhibits esterases, so that the micronutrient can reach the targeted cells prior to degradation. Both methods and compositions are described.

Choice Programs And Market-Based Separationism, Paul E. Salamanca

Law Faculty Scholarly Articles

The Supreme Court's recent decision in Zelman v. Simmons-Harris appears to clear the way for a wide variety of educational and charitable choice plans. In this decision, the Court upheld against Establishment Cause Challenge a formally neutral school choice program that encompassed a wide variety of options in the public and private sector, including private sectarian schools. The Court reasoned that, when the government makes aid available to a broad class of recipients without regard to their religious or non-religious affiliation, and when the recipients have a genuine choice as to whether to obtain that aid from a religious or …

Compounds Encoding The Protective M-Like Protein Of Streptococcus Equi And Assays Therefor, John F. Timoney, Sergey Artiushin

Veterinary Science Faculty Patents

The present invention relates generally to molecular compounds which encode the protective M-like protein of Streptococcus equi (SeM), the amino acid compound which is thereby encoded, and compositions of matter which incorporate either the encoding compounds or the cellular components for which they encode. For instance, vaccines which utilize the amino acid compounds or vectors and cell lines useful to make the amino acid compounds described herein are subjects of the present invention. The present invention provides methods to stimulate S. equi-specific immune response in horses. It also provides diagnostic assays for Streptococcus equi.

Forage News [2002-10], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Forage Survey Near Completion
• Fall Grazing School
• KFGC Beef-Forage Field Day
• A Proposal for Replacing Relative Feed Value with an Alternative: Relative Forage Quality
• Yield, Quality, and Toxicity of Stockpiled Tall Fescue
• Production and Persistence of Max-Q Tall Fescue Under Grazing in Alabama
• Upcoming Events

Brain Uptake, Retention, And Efflux Of Aluminum And Manganese, Robert A. Yokel

Pharmaceutical Sciences Faculty Publications

My colleagues and I investigated the sites and mechanisms of aluminum (Al) and manganese (Mn) distribution through the blood-brain barrier (BBB). Microdialysis was used to sample non-protein-bound Al in the extracellular fluid (ECF) of blood (plasma) and brain. Brain ECF Al appearance after intravenous Al citrate injection was too rapid to attribute to diffusion or to transferrin-receptor-mediated endocytosis, suggesting another carrier-mediated process. The brain:blood ECF Al concentration ratio was 0.15 at constant blood and brain ECF Al concentrations, suggesting carrier-mediated brain Al efflux. Pharmacological manipulations suggested the efflux carrier might be a monocarboxylate transporter (MCT). However, the lack of Al …

Forage News [2002-09], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• KFGC Forage-Beef Field Day
• Kentucky Grazing Conference - November 26
• Perennial Forages: Preserving Your Future
• Pasture Thoughts
• Forage Production in Kentucky
• Upcoming Events

A Mechanical System For Soil Reconstruction, John Patrick Fulton, Larry G. Wells, Timothy D. Smith

Biosystems and Agricultural Engineering Faculty Publications

One of the most perplexing problems associated with reclaiming surface–mined lands is excessive compaction of soil due to the heavy earthmoving equipment used during the reclamation process. Over the years, some innovative material handling schemes have been devised to limit vehicle traffic during reclamation on reconstructed soil. However, final grading operations can often create root–limiting bulk densities, which affect plant growth and yield. The purpose of this article is to describe a mechanism designed at the University of Kentucky whereby mine soil can be reconstructed without introducing compaction caused by surface traffic in order for the soil to sustain desirable …

Defective Cd19-Dependent Signaling In B-1a And B-1b B Lymphocyte Subpopulations., Goutam Sen, Hsin-Jung Wu, Gabriel Bikah, Chandrasekar Venkataraman, Darrell A Robertson, E Charles Snow, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Peritoneal and pleural cavities in mice and humans contain a unique population of B-lymphocytes called B-1 cells that are defective in B cell antigen receptor (BCR) signaling but have an increased propensity to produce autoantibodies. Several molecules such as Btk, Vav, and CD19 known to be important for BCR signaling have been shown to be critical for the development of B-1 cells from undefined precursors. Here we demonstrate that B-1 cell unresponsiveness to BCR cross-linking is in part due to defective signaling through CD19, a molecule known to modulate signaling thresholds in B cells. The defective CD19 signaling is manifested …

Forage News [2002-08], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky “Shines” at National Conference
• Kentucky Farmer Wins National Hay Contest
• Kentucky Farmer Becomes National Forage Spokesman
• Forage Extension Specialist Receives Nation’s Highest Forage Award
• Program Set for Kentucky Grazing Conference
• U.K. All Commodity Field Day Attracts 2000+
• KFGC Forage-Beef Field Day - September 5
• 2002 Kentucky Grazing School
• Upcoming Events

Soy Products Having Improved Odor And Flavor And Methods Related Thereto, William L. Boatright

Animal and Food Sciences Faculty Patents

The present invention provides improved soy protein products, soy plants and seeds, and methods to produce the soy protein products.

Water Soluble Amine Esters Of Testosterone For Intranasal Administration, Anwar A. Hussain

Pharmaceutical Sciences Faculty Patents

The present invention provides novel water soluble testosterone analogs. These testosterone analogs are suitable for intranasal administration to patients requiring increased plasma testosterone levels. The present invention also provides pharmaceutical compositions containing the testosterone analogs of the present invention. The present invention further provides a method of increasing plasma testosterone levels in patients in need of such treatment comprising the intranasal administration of the water-soluble testosterone analogs and pharmaceutical compositions of the present invention.

Use Of The Full Length Transcript (Flt) From Mirabilis Mosaic Caulimovirus To Express Chimeric Genes In Plants, Indu B. Maiti, Nrisingha Dey, Robert J. Shepherd

Kentucky Tobacco Research and Development Center Faculty Patents

A full-length transcript promoter from mirabilis mosaic caulimovirus (MMV) is identified and its DNA sequence given. The promoter functions as a strong and uniform promoter for chimeric genes inserted into plant cells. This strong promoter function is exhibited by histochemical assay in seeds and floral organs and by reproductive scores of transgenic plants including the promoter. The promoter preferably includes a 3′ untranslated region that may be from the MMV itself or from a heterologous source with respect to the promoter. The promoter is used in a chimeric gene and in methods for transforming plant cells to obtain transgenic plants, …

Method For Analyzing Molecular Expression Or Function In An Intact Single Cell, Philip W. Landfield, Olivier Thibault, Eric M. Blalock, Kuey-Chu Chen, Patrick Kaminker

Pharmacology and Nutritional Sciences Faculty Patents

A method for obtaining molecules from a substantially intact single cell is disclosed. The method differs from prior methods that obtain a variable fraction of a cell's contents and therefore cannot quantitatively estimate the number of molecules in the cells. The present method comprises isolating and harvesting a substantially intact single cell from its organ tissue comprising the steps of subjecting a tissue mass to a dissociation method so that the cells are dissociated from the tissue to expose cell bodies or cell processes, contacting a dissociated cell with a device capable of collecting the cell from the tissue substantially …

Forage News [2002-07], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Forage Survey
• U.K. All Commodity Field Day - July 18
• Farm Visits
• Jason Sandefur is Kentucky Forage Spokesperson
• KFGC State Forage Field Day is Sept 5 at New UK Beef Research Farm
• Third Edition of Southern Forages
• Upcoming Events

Gallery Of The Doomed: An Exploration Of Creative Endeavors By The Condemned, Roberta M. Harding

Law Faculty Scholarly Articles

This Article examines creative expressions produced by the death row faction of the incarcerated population. Looking at these works provide insights about what it means to live as a condemned person in our society, and about the people who occupy the death rows across our nation. After reviewing and analyzing a substantial amount of the enormous body of work of this genre, it became apparent that the condemned's creative endeavors reflect how they address and handle serious issues such as their executions and the ways spirituality influences their life. When the individual issues are examined, two general themes are evident: …

Unmasking The Presumption In Favor Of Preemption, Mary J. Davis

Law Faculty Scholarly Articles

It is inescapable: there is a presumption in favor of preemption. Historically, the Supreme Court has said differently-that, rather, there is a presumption against preemption. There is no such presumption any longer, if, indeed, there ever really was one. Preemption doctrine has been exceedingly puzzling in the last decade, but when one recognizes that the Court's doctrine not only favors preemption, but presumes it, preemption doctrine is not a puzzle at all.

This Article argues that the Supreme Court's recent preemption decisions compel the conclusion that the Court's preemption analysis has, in effect, created a presumption in favor of preemption, …

29th Annual Midwest/Midsouth Estate Planning Institute, Office Of Continuing Legal Education At The University Of Kentucky College Of Law

Continuing Legal Education Materials

Materials from the 29th Annual Midwest/Midsouth Estate Planning Institute held by UK/CLE in July 2002.

Morphine-6-Sulfate Analogues And Their Use For The Treatment Of Pain, Peter A. Crooks, Abdulghani A. Houdi, Santosh G. Kottayil, D. Allan Butterfield

Pharmaceutical Sciences Faculty Patents

3-O-Acetylmorphine-6-sulfate analogues are potent, centrally-acting morphine derivatives. The compounds are useful for the treatment of pain.

Spin Trapping Pharmaceutical Compositions And Methods For Use Thereof, John M. Carney, Robert A. Floyd

Pharmacology and Nutritional Sciences Faculty Patents

Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Other preferred spin-trapping agents include 5,5-dimethyl pyrroline N-oxide (DMPO), α-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN), and (TEMPO) and spin-trapping derivatives …

Forage News [2002-05], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Grazing School Sets Record
• How Much Can You Afford to Pay for a Hay Barn?
• 23^RD Kentucky Alfalfa Conference Set for February 20, 2003
• Stockpiled Tall Fescue Provides Lower Cost Wintering System for Fall Calving Cows
• First Hay Cut Approaching
• Upcoming Events

18th Annual Environmental Law Institute, Office Of Continuing Legal Education At The University Of Kentucky College Of Law

Continuing Legal Education Materials

Materials from the 18th Annual Environmental Law Institute held by UK/CLE in May 2002.

Book Review: Delaney, Samuel. Times Square Red, Times Square Blue. New York: New York University Press, 1999., Chad Barbour

disClosure: A Journal of Social Theory

No abstract provided.