Digital Commons Network^™

Foreword [2005], Garry D. Lacefield, Christi L. Forsythe

Forage Symposium at the Kentucky Cattlemen’s Convention

No abstract provided.

Hierarchical Hybrid-Model Based Design, Verification, Simulation, And Synthesis Of Mission Control For Autonomous Underwater Vehicles, Siddhartha Bhattacharyya

University of Kentucky Doctoral Dissertations

The objective of modeling, verification, and synthesis of hierarchical hybrid mission control for underwater vehicle is to (i) propose a hierarchical architecture for mission control for an autonomous system, (ii) develop extended hybrid state machine models for the mission control, (iii) use these models to verify for logical correctness, (iv) check the feasibility of a simulation software to model the mission executed by an autonomous underwater vehicle (AUV) (v) perform synthesis of high-level mission coordinators for coordinating lower-level mission controllers in accordance with the given mission, and (vi) suggest further design changes for improvement. The dissertation describes a hierarchical architecture …

Developmental Fmri Study: Face And Object Recognition, Ann D. Gathers

University of Kentucky Doctoral Dissertations

Visual processing, though seemingly automatic, is complex. Typical humansprocess objects and faces routinely. Yet, when a disease or disorder disrupts face andobject recognition, the effects are profound. Because of its importance and complexity,visual processing has been the subject of many adult functional imaging studies.However, relatively little is known about the development of the neural organization andunderlying cognitive mechanisms of face and object recognition. The current projectused functional magnetic resonance imaging (fMRI) to identify maturational changes inthe neural substrates of face and object recognition in 5-8 year olds, 9-11 year olds, andadults. A passive face and object viewing task revealed cortical …

Microelectrode Array Studies Of Normal And Disease-Altered L-Glutamate Regulation In The Mammalian Central Nervous System, Brian Keith Day

University of Kentucky Doctoral Dissertations

L-glutamate (Glu) is the major excitatory neurotransmitter in the mammalian central nervous system. Monitoring extracellular Glu is critical to understanding Glu regulation to discriminate physiological and pathological roles. To overcome the limitations of previous in vivo extracellular Glu studies, we developed Glu selective microelectrode arrays with better spatial and temporal resolutions than commonly used techniques like microdialysis. We used these microelectrode arrays to characterize basal and potassium-evoked Glu neurotransmission in the normal rat brain. We then investigated disease-related Glu alterations in a rat model of Parkinson's disease and normal Glu regulation in young and aged rhesus monkeys. In the normal …

Forage News [2005-01], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• 25^TH Kentucky Alfalfa Conference
• UK All Commodity Field Day
• Ray Smith Joins Our Kentucky Forage
• Team This Month
• Forages at KCA
• Gene Olson to Head Kentucky Variety Testing Program
• Heart of America Grazing Conference – January 19-20-2005
• Integrating Habitat for Bobwhite Quail and Grassland Birds into Livestock Forage and Grazing Systems
• Storage Losses and Nutritive Value of Warm-Season Forages Conserved as Baleage
• Upcoming Events

Reducing Private Violence Against Women In Public Housing: Can Second Generation Cpted Make A Difference?, Walter S. Dekeseredy, Alvi Shahid, Claire M. Renzetti, Martin D. Schwartz

CRVAW Faculty Journal Articles

No abstract provided.

Characteristics Of Beef Cattle That Determine The Price Difference Between Traditional And Cph Sales, Terry L. Lunsford

University of Kentucky Master's Theses

Cattle producers are faced with difficult decisions on how they market theircalves. This study examines the different characteristics that play a role in determiningthe price of a group of animals. Identifying characteristics that determine pricedifferentials relative to the price premium given to producers participating in CPH salesis important information when producers are making a marketing decision. The modeldeveloped in this study provides producers with evidence of what characteristics generatethe highest price, as well as relative differences between sales locations and types ofsales. The more information available to producers, the better equipped they are to makedecisions.

Generalized Geologic Map For Land-Use Planning: Boone County, Kentucky, Richard A. Smath, Bart Davidson, Daniel I. Carey, John D. Kiefer, Ken Daniels

Map and Chart--KGS

This map is not intended to be used for selecting individual sites. Its purpose is to inform land-use planners, government officials, and the public in a general way about geologic bedrock conditions that affect the selection of sites for various purposes. The properties of thick soils may supercede those of the underlying bedrock and should be considered on a site-to-site basis. At any site, it is important to understand the characteristics of both the soils and the underlying rock.

Book Review: Buller Does To Evolutionary Psychology What Kitcher Did To Sociobiology, Harmon R. Holcomb Iii

Philosophy Faculty Publications

No abstract provided.

Kentucky Traffic Collision Facts 2005 Report, Kentucky Transportation Center, Kentucky State Police

Kentucky Transportation Center Research Report

KENTUCKY’S TRAFFIC COLLISION FACTS report for 2005 is based on collision reports submitted to the Kentucky State Police Records Branch. As required by Kentucky Revised Statutes 189.635, “every law enforcement agency whose officers investigate a vehicle accident of which a report must be made...shall file a report of the accident...within ten days after investigation of the accident upon forms supplied by the bureau.” The stated purpose of this requirement is to utilize data on traffic collisions for such purposes as will improve the traffic safety program in the Commonwealth. Data contained in this report are based solely on the observations …

Interleukin-10 Receptor Dysfunction In Peritoneal Macrophages By Toll-Like Receptor Ligands, Surjya Bhattacharyya

University of Kentucky Master's Theses

Interleukin-10 (IL-10) is a pleiotropic cytokine which limits inflammatory responses by balancing the hosts immune response against infection. Mammalian Toll-like receptors (TLRs) are pattern recognition receptors that recognize specific molecular pattens on microbial pathogens and activate intracellular signaling via the transcription factors NF-B and IRF-3. In this study we evaluate the contribution of the TLR ligands Poly I:C, Pam3CSK4, LPS and LTA to IL-10 receptor dysfunction in murine peritoneal macrophages (PM). We examine how these ligands are able to alter IL-10 mediated STAT3 phosphorylation and CCR5 gene expression in PM. The ability of Poly I:C and Pam3CSK4 to alter the …

Changes In Groundwater Quality In A Conduit-Flow-Dominated Karst Aquifer As A Result Of Best Management Practices, James C. Currens

Report of Investigations--KGS

Water quality in the Pleasant Grove Spring karst groundwater basin was monitored to determine the effectiveness of best management practices (BMP’s) implemented through the U.S. Department of Agriculture’s Water Quality Incentive Program (WQIP). The project was divided into three phases. Phase I, beginning in August 1990, was the initial reconnaissance of the hydrogeology and water quality of the basin. Phase II, beginning in October 1993, monitored the water quality for 1 year prior to BMP implementation. This phase was followed by a 1-year interim extension, which continued the monitoring. Phase III monitored the water quality during and following BMP implementation. …

Streambank Erosion Associated With Grazing Practices In The Humid Region, Carmen T. Agouridis, Dwayne R. Edwards, Stephen R. Workman, José R. Bicudo, Benjamin K. Koostra, Eric S. Vanzant, Joseph L. Taraba

Biosystems and Agricultural Engineering Faculty Publications

The effects of cattle grazing on stream stability have been well documented for the western portion of the U.S., but are lacking for the east. Stream and riparian damage resulting from grazing can include alterations in watershed hydrology, changes to stream morphology, soil compaction and erosion, destruction of vegetation, and water quality impairments. However, few studies have examined the successes of best management practices (BMPs) for mitigating these effects. The objective of this project was to assess the ability of two common BMPs to reduce streambank erosion along a central Kentucky stream. The project site consisted of two replications of …

Is The Monopoly Theory Of Trademarks Robust Or A Bust?, Harold R. Weinberg

Law Faculty Scholarly Articles

The "monopoly theory of trademarks" would "antitrustize" trademark law by incorporating antitrust legal precedent, economics, policies, reasoning, and terminology. The theory is comprised of six interrelated postulates contained in trademark law and scholarship. The postulates are (1) trademarks are monopolies; (2) trademark monopolies are like illegal antitrust monopolies because both harm competition; (3) trademark law is like antitrust law because both value competition; (4) trademark law is like antitrust law because both apply economic methodology to product markets; (5) an antitrust lens can help one understand trademarks and trademark law; and (6) an antitrust lens can help one decide whether …

Tell Me What You Eat, And I Will Tell Whom To Sue: Big Trouble Ahead For “Big Food"?, Richard C. Ausness

Law Faculty Scholarly Articles

Overweight consumers are seeking damages from purveyors of fast food for obesity-related health problems. Plaintiffs claim that products that are high in fat, sugar, salt and cholesterol are defective. Other potential liability theories include product category liability, failure to warn, failure to disclose nutritional information, deceptive advertising, and negligent marketing. However, in order to prevail at trial, plaintiffs must overcome problems with causation, duty and proximate cause, shifting responsibility, federal preemption, comparative fault, and assumption of risk. If such litigation is successful, it may induce fast-food companies to produce healthier products. Nevertheless, this Article concludes that the problem of obesity, …

Viral Rna Elements And Host Genes Affecting Rna Recombination In Tombusviruses, Chi-Ping Cheng

University of Kentucky Doctoral Dissertations

RNA recombination is a major factor driving viral evolution and contributing to new disease outbreaks. Therefore, understanding the mechanism of RNA recombination can help scientists to develop longer lasting antiviral strategies. Tombusviruses are one of the best model RNA viruses to study RNA virus recombination. My goals were to dissect the mechanism of tombusviral RNA recombination. To do so, in my thesis, I describe my results on the roles of (i) the viral replicase and the viral RNA templates; and (ii) the effect of host factors on tombusvirus recombination events. To study the mechanism of RNA recombination without the influence …

Exogenous Enzymes And Organic Acids In The Nutrition Of Broiler Chicks: Effects On Growth Performance And In Vitro And In Vivo Digestion, Tuoying Ao

University of Kentucky Doctoral Dissertations

Studies were conducted to investigate the interactive effects of exogenous enzymes andorganic acids on in vitro and in vivo nutrient digestion and growth performance of broiler chicks.In Study 1, five exogenous enzyme products including ??-glucanase, xylanase, amylase, ??-galactosidase and protease, were assayed in triplicate at their optimum pH levels and at pH levelsof 3.0, 6.0, 6.5, 7.0 and 7.5, which were used to simulate pH levels found in the gizzard, the diet,the crop, and the proximal and distal parts of small intestine, respectively. The pH gradient wasobtained by dissolving the enzymes in different buffers. Results suggested that the pH levelscommonly …

Stages Of Evil: Occultism In Western Theater And Drama, Robert Lima

Studies in Romance Languages Series

“The evil that men do” has been chronicled for thousands of years on the European stage, and perhaps nowhere else is human fear of our own evil more detailed than in its personifications in theater. In Stages of Evil, Robert Lima explores the sociohistorical implications of Christian and pagan representations of evil and the theatrical creativity that occultism has engendered. By examining examples of alchemy, astronomy, demonology, exorcism, fairies, vampires, witchcraft, hauntings, and voodoo in prominent plays, Stages of Evil explores American and European perceptions of occultism from medieval times to the modern age.

Effects Of Glial Cell Line-Derived Neurotrophic Factor (Gdnf) On Stem/Progenitor Cell Proliferation And Differentiation, Yan Chen

University of Kentucky Doctoral Dissertations

Stem/progenitor cells are present in the adult brain; they undergo constantproliferation and differentiate into mature neurons in certain brain areas, a phenomenoncalled neurogenesis. This study investigated the effects of GDNF, a potent trophic factorof dopaminergic neurons, on neurogenesis in the brain. Nestin and 5-Bromo-2'-deoxyuridine (BrdU) were used as stem/progenitor cells markers.First, we observed extensive bilateral increases of stem/progenitor cells in thedentate gyrus and substantia nigra after continuous infusion of GDNF into the normal ratbrain. However, none of the BrdU+ cells showed neuronal features in the substantia nigraas characterized by immunocytochemical procedures. Next, we identified themorphology of BrdU+ cells after infusing …

Design Of A Gait Acquisition And Analysis System For Assessing The Recovery Of Mice Post-Spinal Cord Injury, Casey Harr

University of Kentucky Master's Theses

Current methods of determining spinal cord recovery in mice, post-directed injury, are qualitative measures. This is due to the small size and quickness of mice. This thesis presents a design for a gait acquisition and analysis system able to capture the footfalls of a mouse, extract position and timing data, and report quantitative gait metrics to the operator. These metrics can then be used to evaluate the recovery of the mouse. This work presents the design evolution of the system, from initial sensor design concepts through prototyping and testing to the final implementation. The system utilizes a machine vision camera, …

Bone Engineering Of The Ulna Of Rabbit, Amanda Peter Hart

University of Kentucky Master's Theses

Repair of bone defects is a major challenge in orthopaedic surgery. Current bone graft treatments, including autografts, allografts and xenografts, have many limitations making it necessary to develop a biomaterial to be a bone graft substitute. One such biomaterial is bioactive resorbable silica-calcium phosphate nanocomposite (SCPC). SCPC was processed using a 3D rapid prototyping technique and sintered at different temperatures to create porous scaffolds. SEM analyses and mercury intrusion porosimetry showed SCPC to be highly porous with micro- and nanopores. BET analysis indicated that SCPC had high surface area. Mechanical testing demonstrated that SCPC had a compressive strength similar to …

The Effect Of Polychlorinated Biphenyls On Liver Tumor Promotion: A Role For Kupffer Cells?, Rodica Petruta Bunaciu

University of Kentucky Doctoral Dissertations

Polychlorinated biphenyls (PCBs) are ubiquitious lipophilic environmental pollutants. At least some of the PCB congeners and mixtures are hepatic tumor promoters. The mechanisms are not fully understood and might be multifactorial Besides being the most abundant congener in the environment, 2,2,4,4,5,5-hexachlorobiphenyl (PCB-153), has been previously shown to increase hepatocyte proliferation 48h after exposure in rats. The goal of this study was to determine whether hepatic Kupffer cells are important in the promoting activity of PCBs. The hypothesis of this study was that modulation of Kupffer cell activity by PCBs may contribute to PCB-induced liver tumor promotion. The experimental approach consisted …

Effect Of Combination Exposure To Zidovudine And Sulfamethoxazole-Trimethoprim On Immune Response In Mice And Humans, David James Feola

University of Kentucky Doctoral Dissertations

The drug-drug interaction involving zidovudine and sulfamethoxazole-trimethoprim was investigated using an in vitro culture system, an in vivo mouse model, and a clinical trial in HIV-infected patients. We hypothesized that combination exposure causes immune cell populations in the bone marrow to undergo apoptotic cell death, and that the toxicity would affect the host response to an infectious stimulus. Mice were dosed with zidovudine, sulfamethoxazole-trimethoprim, the combination of both drugs, or vehicle only control via oral gavage. Focusing on B-lineage cells in the bone marrow, we determined that cells of the rapidly cycling, early pre-B cell subset are targeted, as well …

Modulation Of The Adrenal Medullary Response To Stress By Estradiol In The Female Rat, Julye Marie Adams

University of Kentucky Doctoral Dissertations

The present study has established that physiological concentrations of estradiol can modulate stress-induced increases in plasma epinephrine (EPI). In anesthetized female rats, insulin-induced hypoglycemia (0.25 U/kg) increased plasma EPI concentration to a significantly greater extent in 14-day ovariectomized (OVEX) rats compared to sham-operated controls. In 17-estradiol (E2)-replaced OVEX rats, the hypoglycemia-induced rise in plasma EPI was significantly reduced compared to OVEX rats. This suppression was due to both decreased adrenal medullary output and increased clearance of EPI. Adrenal venous EPI concentration was significantly reduced in OVEX+E2 rats, suggesting that EPI secretion from the adrenalmedulla was decreased by E2 replacement. The …

Genetic Regulation Of Hematopoietic Stem Cell Numbers In Mice, Ying Liang

University of Kentucky Doctoral Dissertations

Hematopoietic stem cells (HSCs) transplantations are widely used for the treatment of hematological and non-hematological disorders in clinic. Successful transplantation requires sufficient number and efficient homing of HSCs. Many studies have focused on developing an effective strategy to expand functional HSC population. Some regulatory molecules have been recently shown great promise for controlling the amplification of HSCs. In these dissertation studies, I first aim to identify gene(s) and their allelic variants contributing to strain-specific difference in HSC numbers between C57BL/6 (B6, low) and DBA/2 (D2, high) mice by using a classic forward genetic approach. Firstly, 3 quantitative trait loci (QTL) …

Characterization Of Plant Polyadenylation Transacting Factors-Factors That Modify Poly(A) Polymerse Activity, Kevin Patrick Forbes

University of Kentucky Doctoral Dissertations

Plant polyadenylation factors have proven difficult to purify and characterize, owing to the presence of excessive nuclease activity in plant nuclear extracts, thereby precluding the identification of polyadenylation signal-dependent processing and polyadenylation in crude extracts. As an alternative approach to identifying such factors, a screen was conducted for activities that inhibit the non-specific activity of plant poly(A) polymerases (PAP). One such factor (termed here as Putative Polyadenylation Factor B, or PPF-B) was identified in a screen of DEAE-Sepharose column fractions using a partially purified preparation of a plant nuclear poly(A) polymerase. This factor was purified to near homogeneity. Surprisingly, in …

Biosynthesis Of Trans-2-Hexenal In Response To Wounding In Strawberry Fruit And Interaction Of Trans-2-Hexenal With Botrytis Cinerea, Kyung Myung

University of Kentucky Doctoral Dissertations

Intact strawberry fruit did not produce detectable t-2-H which is derived from -linolenic acid (18:3). However, in response to wounding by gentle bruising, strawberry fruit emitted t-2-H with the largest quantity produced within 10 min following injury. The level of total lipid 18:3 in the fruit increased two-fold in response to wounding whereas free 18:3 declined slightly (about 30%). At 10 min following wounding, fruit exhibited a 25% increase in 13-lipoxygenase (LOX) activity, which leads to the production of 13-hydroperoxyoctadecatrienoic acid (13-HPOT) from 18:3. The activity of hydroperoxide lyase (HPL), which catalyzes formation of cis-3-hexenal (c-3-H), the precursor of t-2-H, …

Genetic Diversity Of Bean Pod Mottle Virus (Bpmv) And Development Of Bpmv As A Vector For Gene Expression In Soybean, Chunquan Zhang

University of Kentucky Doctoral Dissertations

Bean pod mottle virus (BPMV), a member of the genus Comovirus in the family Comoviridae, is widespread in the major soybean-growing areas in the United States. The complete nucleotide sequences of the genomic RNAs of the naturally occurring partial diploid strain IL-Cb1 were determined. Intermolecular RNA1 recombinants were isolated from strain IL-Cb1 and characterized at the molecular level. Structurally similar recombinant RNA1 was also generated after four passages in soybean derived from plants previously inoculated with a mixture of infectious RNA1 transcripts from two distinct strains. BPMV was developed as a plant viral vector that is appropriate for gene expression …

Parent-Child Storytelling During Joint Picture-Book Reading And Relation To Language Scores Of Children With Adhd, Melinda A. Leonard

University of Kentucky Master's Theses

Three questions were investigated in the current study. First, do children with ADHD have language deficiencies in comparison to non-referred peers? Second, are there diagnostic group differences in parent and child storytelling when interacting in a joint picture-book setting or in parent reported home literacy habits? Third, are these differences related to child language scores? Parents of 25 children with ADHD and 39 comparison children, average age 7 years 6 months, told their children a story based on a wordless picture-book, and children then retold the story to an examiner without using the book. In addition, children made up two …

Isolation And Characterization Of The Four Arabidopsis Thaliana Poly(A) Polymerase Genes, Lisa Renee Meeks

University of Kentucky Doctoral Dissertations

Poly(A) tail addition to pre-mRNAs is a highly coordinated and essential step in mRNA maturation involving multiple cis- and trans-acting factors. The trans-acting factor, poly(A) polymerase (PAP) plays an essential role in the polyadenylation of mRNA precursors. The Arabidopsis thaliana genome contains four putative PAP genes. We have found, using in silico analysis and transgenic plants expressing GUS under the control of the four PAP promoters, that each of these genes is expressed in overlapping, yet unique patterns. This gives rise to the possibility that these genes are not redundant and may be essential for plant survival. To further test …