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Nucleic Acids Encoding Sarcocystis Neurona Antigen And Uses Thereof, Daniel K. Howe

Veterinary Science Faculty Patents

The present invention provides novel isolated nucleic acids encoding antigenic proteins derived from Sarcocystis neurona, or unique fragments thereof. In particular, the invention provides novel isolated nucleic acids encoding membrane-associated polypeptides SnSAG2, SnSAG3, and SnSAG4. Also provided are purified antigenic polypeptide fragments encoded by the novel nucleic acid sequences set forth herein that encode for SnSAG2, SnSAG3, and SnSAG4. Also provided are isolated nucleic acids capable of selectively hybridizing with the nucleic acid from Sarcocystis neurona. The invention also provides vectors comprising the nucleic acids of the invention encoding an antigenic protein derived from Sarcocystis neurona or a …

Forage News [2007-08], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• UK All Commodity Field Day
• 8^th Kentucky Grazing Conference
• Hay Hotline Helps Farmers in Search of Forage
• Beware of Hay Payment Scam
• Judge Amends Roundup Ready Alfalfa Ruling
• Corn Acres Soar, Soy Acres Plunge
• Relative Feed Value (RFV) and Relative Forage Quality (RFQ)
• KFGC Awards
• Forage Spokesman Nominations
• Upcoming Events

Impacts Of T-Phylloplanin Gene Knockdown And Of Helianthus And Datura Phylloplanins On Peronospora Tabacina Spore Germination And Disease Potential, Antoaneta B. Kroumova, Ryan W. Shepherd, George J. Wagner

Plant and Soil Sciences Faculty Publications

T-phylloplanin proteins secreted to aerial surfaces of tobacco (Nicotiana tabacum) by short procumbent trichomes inhibit spore germination and blue mold disease caused by the oomycete pathogen Peronospora tabacina. Many other plants were found to contain water-washed leaf surface proteins (phylloplanins), but the functions and properties of these are not known. Here we extend earlier evidence for the antifungal activity of T-phylloplanins using a reverse genetics approach. RNA interference of the T-phylloplanin gene in tobacco ‘T.I. 1068’ resulted in loss of T-phylloplanin mRNA and protein, loss of in vitro spore germination inhibition activity, and leaf infection …

Chronic Administration Of R-Flurbiprofen Attenuates Learning Impairments In Transgenic Amyloid Precursor Protein Mice, Thomas Kukar, Sonya Prescott, Jason L. Eriksen, Vallie Holloway, M. Paul Murphy, Edward H. Koo, Todd E. Golde, Michelle M. Nicolle

Molecular and Cellular Biochemistry Faculty Publications

BACKGROUND: Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD). We and others have shown that certain NSAIDs reduce secretion of Abeta42 in cell culture and animal models, and that the effect of NSAIDs on Abeta42 is independent of the inhibition of cyclooxygenase by these compounds. Since Abeta42 is hypothesized to be the initiating pathologic molecule in AD, the ability of these compounds to lower Abeta42 selectively may be associated with their protective effect. We have previously identified R-flurbiprofen (tarenflurbil) as a selective Abeta42 lowering agent with greatly reduced cyclooxygenase activity that …

Forage News [2007-07], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Forages Losses Exceed $40 Million
• Forage & Beef Tours at UKREC Field Day
• Grazing Conference Date Change
• Forage Spokesman Nominations
• KFGC Awards
• AFGC Report from Pennsylvania
• Top 14 Invasive Species in Kentucky
• Switchgrass Incentives May Be in Farm Bill
• Double Whammy…
• Eastern Gamagrass Meeting & Tour
• KFGC Field Day
• Upcoming Events

Retinol Binding Protein 4 Expression In Humans: Relationship To Insulin Resistance, Inflammation, And Response To Pioglitazone, Aiwei Yao-Borengasser, Vijayalakshmi Varma, Angela M. Bodles, Neda Rasouli, Bounleut Phanavanh, Mi-Jeong Lee, Tasha Starks, Leslie M. Kern, Horace J. Spencer Iii, Amir Adel Rashidi, Robert E. Mcgehee Jr., Susan K. Fried, Philip A. Kern

Clinical and Translational Science Faculty Publications

Context: Retinol binding protein 4 (RBP4) was recently found to be expressed and secreted by adipose tissue, and was strongly associated with insulin resistance.

Objective: The aim was to determine the relationship between RBP4 and obesity, insulin resistance, and other markers of insulin resistance in humans.

Design and Patients: RBP4 mRNA levels in adipose tissue and muscle of nondiabetic human subjects with either normal or impaired glucose tolerance (IGT) were studied, along with plasma RBP4. RBP4 gene expression was also measured in adipose tissue fractions, and from visceral and sc adipose tissue (SAT) from surgical patients.

Setting: The study was …

Energizing Mirna Research: A Review Of The Role Of Mirnas In Lipid Metabolism, With A Prediction That Mir-103/107 Regulates Human Metabolic Pathways, Bernard R. Wilfred, Wang-Xia Wang, Peter T. Nelson

Sanders-Brown Center on Aging Faculty Publications

MicroRNAs (miRNAs) are powerful regulators of gene expression. Although first discovered in worm larvae, miRNAs play fundamental biological roles-including in humans-well beyond development. MiRNAs participate in the regulation of metabolism (including lipid metabolism) for all animal species studied. A review of the fascinating and fast-growing literature on miRNA regulation of metabolism can be parsed into three main categories: (1) adipocyte biochemistry and cell fate determination; (2) regulation of metabolic biochemistry in invertebrates; and (3) regulation of metabolic biochemistry in mammals. Most research into the 'function' of a given miRNA in metabolic pathways has concentrated on a given miRNA acting upon …

The Health Implications Of Violence Against Women: Untangling The Complexities Of Actual And Chronic Effects: Part Two, Carol E. Jordan

Office for Policy Studies on Violence Against Women Publications

No abstract provided.

Compounds Of Use In The Treatment Of Epilepsy, Seizure, And Electroconvulsive Disorders, Peter A. Crooks, Aimee K. Bence, David Robert Worthern

Pharmaceutical Sciences Faculty Patents

The present invention provides pharmaceutical preparations and the uses thereof for preventing and/or treating seizures and other electroconvulsive disorders by administering a pharmaceutically effective amount of a therapeutic compound . . .

To view the rest of this abstract, please download this patent.

Forage News [2007-06], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• KFGC Summer Grazing Tour
• UK Field Day Offers Something for Everyone
• KADB Approves $650,000 For Biomass Project
• USDA-ARS and Cooperative Extension Sponsors Eastern Gamagrass Field Day
• Roundup Ready Alfalfa Injunction is Permanent
• No Roundup Ready Harvest Restrictions Yet
• Effects of Forage on Steer Performance
• Effects of Forage on Stocker Profits
• Grazing Days – Fescue vs. Small Grains
• Forage Has Cellulosic Ethanol Potential
• Maintaining Forage Harvester for Fuel Efficiency
• Upcoming Events

Improve Safety Of Workers During Highway Construction And Maintenance, Donn E. Hancher, Kenneth Bussey, Robin Meagher, Jonathan Ross, Kristin Smith

Kentucky Transportation Center Research Report

There is an inherent risk of injury or fatality in all occupations. Even secretarial occupations face jobsite hazards such as carpal tunnel and back injury. The nature of the construction industry combined with the required physical demand and rigorous work processes, make it an industry with higher risk of injury or fatality. In an effort to decrease that inbuilt jobsite risk that construction workers face, this study will analyze the current best safety practices, examine new safety technologies, and collaborate with construction workers themselves to gain a better perspective of what jobsite hazards they face.

Specifically, this study will focus …

Recycling Practices For Environmental Materials, Sudhir Palle, Steve Higgins, Theodore Hopwood Ii

Kentucky Transportation Center Research Report

Two environmental materials, tree and brush debris and large animal roadkill carcasses were investigated. The disposal methods for these materials were reviewed as opportunities/methods for possible recycling. KYTC established several pilot composting operations in 2006. These were monitored during their preliminary stages of operation.

Gender-Specific Effects Of Hiv Protease Inhibitors On Body Mass In Mice, Melinda E. Wilson, Kimberly F. Allred, Elizabeth M. Kordik, Deana K. Jasper, Amanda N. Rosewell, Anthony J. Bisotti

Physiology Faculty Publications

Protease inhibitors, as part of highly active anti-retroviral therapy (HAART), have significantly increased the lifespan of human immunodeficiency virus (HIV) infected patients. Several deleterious side effects including dyslipidemia and lipodystrophy, however, have been observed with HAART. Women are at a higher risk of developing adipose tissue alterations and these alterations have different characteristics as compared to men. We have previously demonstrated that in mice the HIV protease inhibitor, ritonavir, caused a reduction in weight gain in females, but had no effect on male mice. In the present study, we examined the potential causes of this difference in weight gain. Low-density …

Soil Microbial Community Response To Hexavalent Chromium In Planted And Unplanted Soil, Ioannis Ipsilantis, Mark S. Coyne

Plant and Soil Sciences Faculty Publications

Theories suggest that rapid microbial growth rates lead to quicker development of metal resistance. We tested these theories by adding hexavalent chromium [Cr(VI)] to soil, sowing Indian mustard (Brassica juncea), and comparing rhizosphere and bulk soil microbial community responses. Four weeks after the initial Cr(VI) application we measured Cr concentration, microbial biomass by fumigation extraction and soil extract ATP, tolerance to Cr and growth rates with tritiated thymidine incorporation, and performed community substrate use analysis with BIOLOG GN plates. Exchangeable Cr(VI) levels were very low, and therefore we assumed the Cr(VI) impact was transient. Microbial biomass was reduced …

Expansion Of The Calcium Hypothesis Of Brain Aging And Alzheimer's Disease: Minding The Store, Olivier Thibault, John C. Gant, Philip W. Landfield

Pharmacology and Nutritional Sciences Faculty Publications

Evidence accumulated over more than two decades has implicated Ca2+ dysregulation in brain aging and Alzheimer's disease (AD), giving rise to the Ca2+ hypothesis of brain aging and dementia. Electrophysiological, imaging, and behavioral studies in hippocampal or cortical neurons of rodents and rabbits have revealed aging-related increases in the slow afterhyperpolarization, Ca2+ spikes and currents, Ca2+transients, and L-type voltage-gated Ca2+ channel (L-VGCC) activity. Several of these changes have been associated with age-related deficits in learning or memory. Consequently, one version of the Ca2+ hypothesis has been that increased L-VGCC activity drives many of the other Ca2+-related biomarkers of hippocampal aging. …

Functional Dissociation In Frontal And Striatal Areas For Processing Of Positive And Negative Reward Information, Xun Liu, David K. Powell, Hongbin Wang, Brian T. Gold, Christine R. Corbly, Jane E. Joseph

Neuroscience Faculty Publications

Reward-seeking behavior depends critically on processing of positive and negative information at various stages such as reward anticipation, outcome monitoring, and choice evaluation. Behavioral and neuropsychological evidence suggests that processing of positive (e.g., gain) and negative (e.g., loss) reward information may be dissociable and individually disrupted. However, it remains uncertain whether different stages of reward processing share certain neural circuitry in frontal and striatal areas, and whether distinct but interactive systems in these areas are recruited for positive and negative reward processing. To explore these issues, we used a monetary decision-making task to investigate the roles of frontal and striatal …

A Story Of Disgust, Ellen Hostetter

disClosure: A Journal of Social Theory

No abstract provided.

Editor's Preface And Acknowledgements, Brandon Absher

disClosure: A Journal of Social Theory

No abstract provided.

"Things That Lie On The Surface:" Modernism, Impersonality, And Emotional Inexpressibility, Rochelle Rives

disClosure: A Journal of Social Theory

No abstract provided.

Subdivision Surface-Based Geometric Modeling System, Fuhua Cheng

Computer Science Faculty Patents

A method for surface modeling of images to produce realistic images or to provide simulations with accurate surface information is provided. More particularly, the present invention relates to a new subdivision depth computation technique and to an improved label-driven adaptive subdivision technique for use in Catmull-Clark subdivision surface modeling systems. The method comprises computing a subdivision depth to determine the number of recursive subdivisions which may be performed on a control mesh to generate a plurality of finer mesh elements while preserving a predetermined error tolerance, and using the computed subdivision depth to construct an adaptively refined mesh that is …

Conspiracy Theories: Is There A Place For Civil Conspiracy In Products Liability Litigation?, Richard C. Ausness

Law Faculty Scholarly Articles

A civil conspiracy is a group of two or more persons acting together to achieve an unlawful objective or to achieve a lawful objective by unlawful or criminal means. During the past two decades, plaintiffs have brought numerous civil conspiracy claims against product manufacturers. The defendants in these cases have included manufacturers or producers of tobacco products, asbestos, pharmaceuticals, lead-based paint, multi-rim truck wheels, and gasoline additives. Surprisingly, less than half of the civil conspiracy claims have made it to trial. This unimpressive success rate suggests that courts are not very receptive to civil conspiracy claims even when there is …

Poster Session, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Identification of potential bacterial sources and levels, Red Duck Creek, Mayfield, Kentucky, Brooke Vorbeck, Travis Martin, and Mike Kemp, Dept of Industrial and Engineering Technology, Murray State University
• Water-quality trend analysis for streams in Kentucky, A.S. Crain and G.R. Martin, USGS, Louisville
• Preliminary Results of a Fecal Microbe Survey in a Eutrophic Lake, Wilgreen Lake, Madison County, Kentucky, W.S. Borowski and M.S. Albright, Depts of Earth Sciences and Geography, EKU
• Preliminary Physical and Chemical Characteristics of an Eutrophic Lake, Wilgreen Lake, Madison County, Kentucky, E.C. Jolly and W.S. Borowski, Dept of Earth Sciences, EKU
• Lethal and …

Session 1c: Epscor Projects, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Colloidal Arsenic in Poultry-Litter Amended Soils, Lisa Y. Blue and others, Dept of Chemistry, UK
• Environmental Monitoring and Assessment of Arsenic Metal in Groundwater Samples from Ballard, Carlisle, and Graves Counties, Kentucky, H.B. Fannin and others, Dept of Chemistry, Murray State University
• Environmental Monitoring and Assessment of the Groundwater Quality in Calloway County, Kentucky, Dan Kotter and others, KGS, Henderson, KY
• Land-Use Effects on Water Quality Within Lower Howard Creek Watershed, Southwestern Clark County, Kentucky, S.D. Daugherty and J.S. Dinger, Dept Earth & Environmental Sciences and KGS, UK

Session 1b: Student Research Projects, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Experimental Study of the Impact of Upland Sediment Supply upon Cohesive Streambank Erosion Part I: Fluid Turbulence, Brian Belcher and Jimmy Fox, Dept of Civil Engineering, UK
• Toward Using a Three-Dimensional Numerical Model for Simulating Hydrodynamics Near a Dam for Constructing the Rating Curve, Z.S. Shao and S.A. Yost, Dept of Civil Engineering, UK
• Property Taxation and Forest Fragmentation in Kentucky Watersheds, Scott Brodbeck and Tamara Cushing, Dept of Forestry, UK
• Solute and Particle Tracer Movement Under Various Flow Conditions in a Karst Groundwater Basin, Inner Bluegrass Region, Kentucky, J.W. Ward and others, Dept Earth and …

Session 1a: Microbial Source Tracking, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Detecting Multiple Source Origins from Fecal Bacteria Antibiotic Resistance Patterns, Sloane Ritchey and M.S. Coyne, Environmental Research Institute, EKU and Dept of Plant and Soil Sciences, UK
• Microbial Source Tracking; Limits and Application, Steve Evans, Third Rock Consultants, Lexington
• Triplett Creek Focus Study, Brian Reeder and April Haight, Institute for Regional Analysis and Public Policy, Morehead State University

Proceedings Of 2007 Kentucky Water Resources Annual Symposium, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

This conference was planned and conducted as part of the state water resources research annual program with the support and collaboration of the Department of the Interior, U.S. Geological Survey and the University of Kentucky Research Foundation, under Grant Agreement Number 06HQGR0087.

The views and conclusions contained in this document and presented at the symposium are those of the abstract authors and presenters and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the U.S. Government or other symposium organizers and sponsors.

Phase I And Phase Ii Ocular Metabolic Activities And The Role Of Metabolism In Ophthalmic Prodrug And Codrug Design And Delivery, Abeer M. Al-Ghananeem, Peter A. Crooks

Pharmaceutical Sciences Faculty Publications

While the mammalian eye is seldom considered an organ of drug metabolism, the capacity for biotransformation is present. Compared to the liver, the metabolic capabilities of the eye are minuscule; however, phase I and phase II metabolic activities have been detected in various ocular structures. The careful consideration of ocular tissue metabolic processes within the eye has important implications for controlling the detoxification of therapeutic agents and for providing the potential for site-specific bio-activation of certain drug molecules, thus enabling significant improvements in drug efficacy and the minimization of side-effect from either local or systemic drug delivery to the eye. …

Plant Cells And Plants Expressing Chemeric Isoprenoid Synthases, Joseph Chappell, Kyoungwhan Back

Plant and Soil Sciences Faculty Patents

The invention features plant cells and plants that include a nucleic acid molecule encoding a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned homologous domain. The chimeric isoprenoid synthases of the invention catalyze the production of isoprenoid reaction products that are not produced when the asymmetrically positioned homologous domain is positioned at its naturally-occurring site in an isoprenoid synthase polypeptide.

Forage News [2007-03], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Kentucky Alfalfa Awards
• 27^th Kentucky Alfalfa Conference
• Forages at KCA
• 2006 Hay Contest Winners
• Biotech Traits Can Improve Alfalfa
• Newly Updated: Grain and Forage Crop Guide For KY
• New Publication: Long Term Variety Test Summary
• AFGC Will Hold Its Annual Meeting This June in Pennsylvania
• Increase in Alfalfa Acreage & Yield
• Conversion from Corn to Grassland Provides Economic and Environmental Benefits to a Maryland Beef Farm
• Disc, Sickle Mowers Both Have Pluses
• Kentucky Farm Numbers
• Upcoming Events

Characterization Of Dairy Milk House Waste Water In Kentucky, Anshu Singh, Czarena L. Crofcheck, Gail M. Brion

Biosystems and Agricultural Engineering Faculty Publications

This study focuses on characterization of milk house waste water from eight different farms in Kentucky. The farms were separated into three groups based on the number of cows: small (20-30), medium (30-60), and large (over 60 cows). Samples were collected once a month from four farms and twice a month from the remainder. Samples were analyzed for chemical, biochemical, and microbiological characteristics. Results indicated a large and significant variation in the chemical and microbiological characteristics between the farms. Farm size had a significant effect on the nutrient content of the waste water. Though samples exhibited seasonal variation, there was …