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Respiratory Cycle Influence On Lumbosacral Muscle Function: A Tensiomyographic Analysis, Anthony Trombetta Jan 2025

Respiratory Cycle Influence On Lumbosacral Muscle Function: A Tensiomyographic Analysis, Anthony Trombetta

Honors Undergraduate Theses

Introduction:

Tensiomyography (TMG) has significant potential in examining muscle functionality while evading the limitations found in other methods muscle analysis. Specifically, the erector spinae and other lumbosacral muscles can be analyzed with little challenge. Such analyses include data on muscle displacement (Dm), delay time (Td), contraction time (Tc), half-relaxation time (Tr), and sustain time (Ts). Of these parameters, the most evaluated and with the highest level of reliability are Dm, Td, and Tc. However, stiffness of the lumbar spine and lumbosacral muscles fluctuates throughout the respiratory cycle. These fluctuations may pose an issue when examining the functionality of muscles. This …


Quantifying The Performance Of The Sparta Toolkit For Use In Planetary Regolith Characterization Missions, Abigail S. Glover Jan 2025

Quantifying The Performance Of The Sparta Toolkit For Use In Planetary Regolith Characterization Missions, Abigail S. Glover

Honors Undergraduate Theses

This research investigates the use of the Soil Properties Assessment, Resistance, and Thermal Analysis (SPARTA) Cone Penetration Tester (CPT) to quantify bulk density in lunar regolith simulant LHS-1E. Twenty-five penetration tests were conducted across five density profiles to derive slope parameters (G), which represent the rate of increase in resistance with depth. Results showed a consistent, nonlinear relationship between G and bulk density, validating the use of G slope as a diagnostic parameter and supporting the primary hypothesis that SPARTA CPT measurements vary meaningfully with density. Compared to prior work by Lucas et al. (2024), G values from SPARTA were …


Parisians' Perceptions Of The 2024 Olympics: A Mixed-Methods Analysis Of Local Attitudes Towards Housing Epidemics Using Social Exchange Theory, Place Attachment, And Media Framing Theory, Tyler Borges Jan 2025

Parisians' Perceptions Of The 2024 Olympics: A Mixed-Methods Analysis Of Local Attitudes Towards Housing Epidemics Using Social Exchange Theory, Place Attachment, And Media Framing Theory, Tyler Borges

Honors Undergraduate Theses

The Paris 2024 Olympics introduced significant socio-economic transformations to the city, particularly in the areas of housing policy, urban development, and community displacement. This study examines Paris residents' perceptions of these changes using a mixed-methods approach that integrates sentiment analysis and media framing analysis. The research is guided by Social Exchange Theory (SET), Place Attachment Theory, and Media Framing Theory to understand the relationship between public sentiment, urban transformation, and media narratives. Findings indicate that the perceived effects of the Paris 2024 Olympics on its host city were overwhelmingly negative, with consistent concerns centered on housing insecurity, displacement, and a …


The Association Between Parental Bipolar Symptoms And Offspring Identity Formation: The Role Of Parental Attachment And Emotion Regulation, Alexa D. Loonam Jan 2025

The Association Between Parental Bipolar Symptoms And Offspring Identity Formation: The Role Of Parental Attachment And Emotion Regulation, Alexa D. Loonam

Honors Undergraduate Theses

Identity development involves integrating various aspects of oneself into a unified self-concept; however, maladaptive identity formation can lead to negative mental health outcomes (Berman & Weems, 2016). Growing up with a caregiver exhibiting unpredictable behaviors may hinder this process, leaving children vulnerable during this critical stage (Schwartz & Petrova, 2018). The current study evaluated how bipolar symptoms among parents may impact one’s identity. College students (N = 399) completed an anonymous online survey battery for course credit. Results revealed that parental bipolar symptoms were positively correlated with ruminative identity exploration, identity distress, disturbed (unstable) identity, and lack of identity, …


From Vinyl To Viral: Evaluating The Mere Exposure Effect Through Music And Technological Advancements, Ariana R. Deboo Jan 2025

From Vinyl To Viral: Evaluating The Mere Exposure Effect Through Music And Technological Advancements, Ariana R. Deboo

Honors Undergraduate Theses

The Mere Exposure Effect (MEE) refers to a psychological pattern in which a person develops preference for a stimulus that has been repeatedly presented to them. The present study examined environmental influences of preference through repeated exposure to music. Social media platforms such as TikTok, Reels, and Shorts influence where people listen to music. The fast-paced consumption algorithm for new media is provided by quick, entertaining videos that allow users to scroll past content that does not keep their attention. A total of 406 participants (n=406) were involved in this study. The purpose for this study was to identify how …


Cannabis Use And Functional Independence Among Older Adults: The Health And Retirement Study, Jade Alaine Perry Jan 2025

Cannabis Use And Functional Independence Among Older Adults: The Health And Retirement Study, Jade Alaine Perry

Honors Undergraduate Theses

As people age, negative cognitive effects become more common, and the likelihood of chronic disease diagnoses increases. Many older adults suffer from one or more chronic health issues that have serious impacts on both their mental and physical health. Chronic pain is also known to increase in prevalence as we age. Opioid use to treat chronic pain among older adults is worrisome due to the likelihood of drug-drug interactions due to polypharmacy and the risk of problematic opioid use that can lead to overdose. Cannabis use both medical and recreational has become more acceptable among the aging adult population in …


Impact Of Tgf-Β And Twist1 On Motility And Proliferation In Estradiol-Treated Mcf-7 Tamr Cells In-Vitro, Thomas L. Scott Iii Jan 2025

Impact Of Tgf-Β And Twist1 On Motility And Proliferation In Estradiol-Treated Mcf-7 Tamr Cells In-Vitro, Thomas L. Scott Iii

Honors Undergraduate Theses

Breast cancer is a highly malignant cancer and is known to be grouped into three main types: adenocarcinoma, invasive ductal carcinoma (IDC) and ductal carcinoma. Breast cancer commonly arises as adenocarcinoma, located in the milk ducts, and becomes IDC when it spreads into the surrounding tissue from the influence of cytokines and hormones. This study outlines the rate of proliferation and motility of a type of adenocarcinoma, MCF-7-TamR, to become invasive ductal carcinoma when Twist1 is downregulated and exposed to TGF- and estradiol (E2) in-vitro. We hypothesize that the downregulation of Twist1 will reduce cell adhesion and cytoskeleton proteins …


The Aerodynamics Of Bird Perching: Understanding Wing And Body Interactions In Pigeon Flight, Anirudh Sriram Jan 2025

The Aerodynamics Of Bird Perching: Understanding Wing And Body Interactions In Pigeon Flight, Anirudh Sriram

Honors Undergraduate Theses

During landing, birds often execute a perching maneuver. The perching maneuver refers to the complex series of actions that birds, and pigeons in particular, will perform when landing. They will typically decelerate by pitching their body to a high angle of attack and spreading their wings. It is believed to help achieve better control and reach optimal lift and drag coefficients. This study seeks to better understand the vortex interactions between the main and tail wings during this maneuver. However, it is still an unexplored phenomenon. Thus, two bird models were conceived to analyze it, one with and one without …


Tools And Trends: An Analysis Of Maya Dental Modification, Channing M. Cook Jan 2025

Tools And Trends: An Analysis Of Maya Dental Modification, Channing M. Cook

Honors Undergraduate Theses

The ancient Maya practiced dental modification, intentionally filing, incising, and inlaying stones into the front teeth, potentially to display identity and status. The literature surrounding Maya dental modification tends to overlook mechanical aspects of the process, and many studies approach dental modification through limiting or destructive means. Optical microscopy presents an adaptable, cost-effective option for closer inquiry. Preliminary research suggests the process of dental modification leaves distinct patterns of tool use, depending on style, that can be identified through optical microscopy. The sample selected includes 25 incisors and canines from 14 Classic period Maya individuals from Altun Ha, representing 12 …


The Impact Of Religiosity On Political Knowledge Among Youth Voters, Norah Sackett Jan 2025

The Impact Of Religiosity On Political Knowledge Among Youth Voters, Norah Sackett

Honors Undergraduate Theses

As political engagement trends among young voters have continued to shift in the United States' political atmosphere, understanding the cognitive factors that influence these decisions is becoming increasingly important. Political efficacy, or the feeling that individual political action can impact the political process, impacting their civic duties, has long been regarded as a key determinant of an individual's political engagement. This study investigates how young voters' understanding of prominent political arguments relates to their sense of political efficacy, with a specific lens on individual religiosity.

Through an examination of this relationship between religiosity and overall comprehension of political arguments, this …


The Inverse Scattering Transform For The Nonlinear Schrödinger Equation, Ivan Casas-Rocha Jan 2025

The Inverse Scattering Transform For The Nonlinear Schrödinger Equation, Ivan Casas-Rocha

Honors Undergraduate Theses

The Nonlinear Schrödinger (NLS) Equation, iψt + 1/2 ψxx ± |ψ|2ψ = 0, is a nonlinear partial differential equation which is used to model several physical phenomena including nonlinear effects inside optical fibers and the formation of rogue waves in shallow water. It is particu- larly difficult to study solutions to this equation due to the nonlinearity, and the nonlinearity leads to incredibly interesting solutions not found in linear PDEs such as solitons. In this thesis, we highlight two methods of obtaining solutions to the (NLS) equation: the Inverse Scattering Transform and the Dressing Method. Furthermore, …


Effects Of Resistance Exercise On Post Stroke Patients: Systematic Review Of The Literature, Jeslin Patel Jan 2025

Effects Of Resistance Exercise On Post Stroke Patients: Systematic Review Of The Literature, Jeslin Patel

Honors Undergraduate Theses

Individuals who suffer from post-stroke effect face loss of function in mobility and quality of life. Mobility issues lead to changes in walking patterns, strength ability, daily independence, and more. Resistance training is an effective rehabilitation method used to test improve recovery by enhancing well-being, reducing spasticity, and increasing control. The purpose of this study was to explore the effects of resistance exercise on post-stroke patient's recovery and return to activities of daily living. A systemic literature review using databases, key terms, and various strategies. Databases used consisted of UCF Libraries, PubMed, Google Scholar, SagePub, Medline, ScienceDirect, and EBSCOhost. These …


Digital Recess, Screen Time Split: The Impact Of Online Schooling On Recreational Screen Time And Their Dual Impact On Anxiety, Meagan Allender Jan 2025

Digital Recess, Screen Time Split: The Impact Of Online Schooling On Recreational Screen Time And Their Dual Impact On Anxiety, Meagan Allender

Honors Undergraduate Theses

This study explores the influence of online schooling, anxiety, and recreational screen time in college aged students. Previous studies have shown a positive correlation between screen usage and anxiety scores, assessing either online school or total screen time on anxiety. However, no study had looked at the correlation between online schooling and recreational screen time, nor had any study assessed both their effects on anxiety at the same time. Using a sample of 71 participants, a bivariate regression was conducted to evaluate the correlation of each type of screen time with one another, then another regression was run to assess …


Users' Trust Perceptions Of Ai Search Results, Leilani J. Cordoves Jan 2025

Users' Trust Perceptions Of Ai Search Results, Leilani J. Cordoves

Honors Undergraduate Theses

Utilizing a repeated measure design, this experiment analyzes users’ perceptions of artificial intelligence embedded within search engines compared to traditional linked search engines in various contextual situations. The purpose of this study is to find the differences in confidence for differing search methods and the variables of trust that lead to these perceived differences. Using screenshots of AI overview search results and linked search results, we asked participants questions of confidence and human-computer trust to gauge their perceptions of the varying search methods. We find evidence of a significant interaction effect in confidence scores between the search method and the …


Lost Innocence, Mateo Valdivieso Jan 2025

Lost Innocence, Mateo Valdivieso

Honors Undergraduate Theses

Human trafficking is defined as involving “force, fraud, or coercion to obtain some type of labor or commercial sex act” (U.S. Department of Homeland Security). It disproportionately affects vulnerable populations, particularly children within the U.S. welfare system. This research aims to analyze the characteristics of this system that produce vulnerabilities in welfare children that heighten their risk of being trafficked. The study focuses on socio-economic, psychological, and environmental vulnerabilities, examining how these factors, combined with increased internet accessibility, exacerbate the risks of trafficking. Using a qualitative approach, the research uses secondary data from peer-reviewed journal articles, government reports, and reputable …


Investigating The Effects Of A Psychoplastogen On Depressive-Like Behaviors In Huntington Disease Model Mice, Kaleigh M. Hanley Jan 2025

Investigating The Effects Of A Psychoplastogen On Depressive-Like Behaviors In Huntington Disease Model Mice, Kaleigh M. Hanley

Honors Undergraduate Theses

Huntington Disease (HD) is a neurodegenerative disorder caused by an expansion in the trinucleotide CAG repeat on exon 1 of the huntingtin gene. In HD one of the first symptoms is often depression. In cases where SSRIs fail, treatments for treatment-resistant depression often become a patient’s only option. These rigorous treatments, such as electroconvulsive therapy, are not suitable for this patient population as it can worsen motor symptoms. In order to search for potential alternatives, we queried whether depressive-like behavior could be reduced in Hu97/18 and Q175FDN HD mice by administering tabernanthalog, a non-hallucinogenic psychedelic analog. Our study is not …


Heritage And Archaeological Knowledge Dissemination Strategies: A Kurd Qaburstan Case Study, Myli R. Sangria Jan 2025

Heritage And Archaeological Knowledge Dissemination Strategies: A Kurd Qaburstan Case Study, Myli R. Sangria

Honors Undergraduate Theses

This thesis addresses the long-standing absence of community archaeology initiatives in the Kurdistan Region of Iraq by designing and implementing a pilot public archaeology program at the site of Kurd Qaburstan, a large Middle Bronze Age city (ca. 1800 BCE) located on the Erbil Plain. In summer 2024, the author implemented a community archaeology activity designed as a first step toward sustained engagement with the village that partially overlaps the site. The program—a hands-on lesson in archaeological stratigraphy for K–5 students, followed by a guided site visit—was intentionally simple, affordable, and easy to carry out alongside ongoing fieldwork. The activity …


Measuring Achilles Tendon Stiffness And Kinetics In-Vivo, Chloe L. Pinkston Jan 2025

Measuring Achilles Tendon Stiffness And Kinetics In-Vivo, Chloe L. Pinkston

Honors Undergraduate Theses

This study aims to measure the gastrocnemii Achilles subtendon passive stiffness and energy storage during walking. Stiffness was first determined using a noninvasive method that combines ultrasound, motion capture, musculoskeletal modeling, and a force transducer. Eight healthy participants were tested using this method to obtain the passive force-displacement relationship of the Achilles tendon at two different knee angles to calculate stiffness of the gastrocnemii subtendon. A gait analysis session was then performed using ultrasound, motion capture, and an instrumented treadmill at self-selected slow, normal, and fast walking speeds, using stiffness to calculate the subtendon’s force and energy storage. Gastrocnemii Achilles …


Comparative Efficacy Of Hallucinogens In Treating Mood Disorders Through A Meta-Analysis Of Symptom Reduction, Dosage, And Duration, John Marco D.F. Muniz Jan 2025

Comparative Efficacy Of Hallucinogens In Treating Mood Disorders Through A Meta-Analysis Of Symptom Reduction, Dosage, And Duration, John Marco D.F. Muniz

Honors Undergraduate Theses

Background: Hallucinogens including psilocybin, lysergic acid diethylamide (LSD), ketamine, N,N-dimethyltryptamine (DMT) (as ayahuasca), have re-emerged as potential rapid-acting treatments for mood disorders. We conducted a meta-analysis of placebo-controlled trials evaluating their efficacy in depression and anxiety disorders. Methods: A systematic review identified 12 trials (Total ≈ 670) meeting inclusion criteria (randomized, placebo-controlled). Data on Cohen’s d and Hedges’ g effect sizes for depression- and anxiety-related outcomes were extracted. We computed pooled effect sizes (weighted by sample size and inverse variance), performed subgroup analyses by drug, diagnosis, follow-up duration, and outcome measure type, and assessed heterogeneity (I2, Q …


Effect Of Metal Ions On The Reactive Oxygen Species Scavenging Capabilities Of Cerium Oxide For Biological Applications, Agastya Mittal Jan 2025

Effect Of Metal Ions On The Reactive Oxygen Species Scavenging Capabilities Of Cerium Oxide For Biological Applications, Agastya Mittal

Honors Undergraduate Theses

Ceria nanoparticles' capabilities to defend cells against oxidative stress through superoxide dismutase activity are well-documented. Ceria nanoparticles demonstrate a ratio between 3+/4+ oxidative states on the surface of the particles to exhibit oxygen vacancies, a feature that allows these particles to scavenge Reactive Oxygen Species (ROS) in times of Oxidative Stress. Oxidative stress arises from many wounds in the body, such as wounds in the skin, and can have significant impacts on the health of an individual. Even when receiving treatment for the skin wound, ROS can circulate from around the wound, be generated from an imbalance …


Modified Equations Of Conformal Symplectic Exponential Time Differencing Methods, Taylore M. Keesler Jan 2025

Modified Equations Of Conformal Symplectic Exponential Time Differencing Methods, Taylore M. Keesler

Honors Undergraduate Theses

Planetary orbits, pendulums, and hurricanes are everyday examples of nonlinear systems, often studied using differential equations. However, their exact solutions can not always be computed, and thus, we use numerical methods to approximate their solutions. Certain methods are better suited to preserve special properties of the system like energy and geometry. Through previous numerical simulations, a conformal symplectic method proves more effective in this preservation. To understand why, we find the modified equation of a nonlinear system with damping, which is a differential equation for which the numerical solution is exact. Through backward error analysis, we obtain these modified equations, …


Optimization Of L-Citrulline Production In Corynebacterium Glutamicum, And The Effect Of The Human Small Intestine Environment, Simran S. Ghulldu Jan 2025

Optimization Of L-Citrulline Production In Corynebacterium Glutamicum, And The Effect Of The Human Small Intestine Environment, Simran S. Ghulldu

Honors Undergraduate Theses

L-citrulline is a crucial amino acid involved in nitric oxide production, which supports cardiovascular health, physical performance, and intestinal well-being. Nitric oxide deficiency is linked to conditions like hypertension, highlighting the need for efficient L-citrulline production. This study attempts to enhance L-citrulline synthesis in Corynebacterium glutamicum, a bacterium widely used in industrial amino acid production, as well as test a The hypothesis is that overexpressing carAB, which encodes carbamoyl phosphate synthetase, will increase carbamoyl phosphate levels and boost L-citrulline production. Two C. glutamicum strains were used: a wild type and the CRBG strain, which has mutations that promote …


A Time Series Analysis Of The Macroeconomic Indicators, Mia Houston Jan 2025

A Time Series Analysis Of The Macroeconomic Indicators, Mia Houston

Honors Undergraduate Theses

Understanding inflation—particularly across regions and categories—is crucial for effective policymaking, strategic business decisions, and safeguarding vulnerable populations, as it highlights the diverse drivers and impacts of price changes within the economy. This has become increasingly crucial in recent years between the volatile inflation conditions introduced by the COVID-19 pandemic, energy price shocks, and renewed trade tensions and tariffs. This thesis analyzes 77 U.S. monthly inflation time series from 2003 to 2023 using two forecasting approaches: an elementwise Seasonal Autoregressive Integrated Moving Average (SARIMA) model and a Factor-Augmented Vector Autoregressive (FAVAR) model. The data obtained from the Bureau of Labor Statistics …


Optimizing Crispri Gene Silencing Of Putative Drug Targets In Mycobacterium Abscessus, Max Ivanov Jan 2025

Optimizing Crispri Gene Silencing Of Putative Drug Targets In Mycobacterium Abscessus, Max Ivanov

Honors Undergraduate Theses

Among nontuberculous mycobacteria (NTM), Mycobacterium abscessus (Mab) poses a particular threat to patients with cystic fibrosis and chronic obstructive pulmonary disease due to the lung damage and higher mortality rate it causes. Current treatments involve prolonged multi-antibiotic regimens that are often ineffective, highlighting the need for new drug targets.

The CRISPR Interference (CRISPRi) system uses a deactivated Cas9 protein (dCas9) to enable inducible gene silencing, offering a potential approach to identifying new targets. Genes that lead to a loss of Mab viability when silenced are considered essential, an important attribute of potential drug targets. While CRISPRi has shown …


Synthesis And Characterization Of Multifunctional Cerium Oxide Containing Nanoparticles For Biomedical Applications, Ishaan Patel Jan 2025

Synthesis And Characterization Of Multifunctional Cerium Oxide Containing Nanoparticles For Biomedical Applications, Ishaan Patel

Honors Undergraduate Theses

This study presents the synthesis and comprehensive characterization of a novel core-shell nanoparticle composed of a maghemite (γ-Fe2O3) core and a europium-doped cerium oxide (EuCNP) shell, developed for potential use in cancer theranostics. Using a co-precipitation method, Fe2O3–EuCNP core-shell nanoparticles were synthesized and compared against control samples of CNPs, EuCNPs, and Fe2O3. A variety of characterization techniques, including UV-Vis spectroscopy, fluorescence spectroscopy, TEM, XRD, XPS, DLS, TGA, and DSC confirmed the successful synthesis of core-shell architecture and europium doping. Moreover, Fe2O3–EuCNPs demonstrating strong colloidal …


Academic Proposals For Combating Authoritarian Populism In The United States: A Review Of The Social Science Literature, Emily A. Padgett Jan 2025

Academic Proposals For Combating Authoritarian Populism In The United States: A Review Of The Social Science Literature, Emily A. Padgett

Honors Undergraduate Theses

Throughout American history, the idea of “democracy” has been taught at a base level throughout the school system. While we have been taught what a democracy is, it is rare to understand what a democracy isn’t. There have been threats identified by academics to our democracy throughout different eras in history. Now, in our current political climate, all main threats to democracy have been enacted at once.

This thesis serves as a literature review of a handful of academics and their idea of what the main threats to democracy are. There will be references to different perspectives and schools of …


From Boredom To Purpose: How Self-Concept Can Affect Motivation In The Workplace, Norma I. Cintron Jan 2025

From Boredom To Purpose: How Self-Concept Can Affect Motivation In The Workplace, Norma I. Cintron

Honors Undergraduate Theses

The present experiment explored whether or not a positive self-concept influences how individuals manage boredom in the workplace. It was hypothesized that individuals with a positive self-concept would cope better with boredom and complete a dull task more accurately. However, these hypotheses were not confirmed, the study found no significant relationship between self-concept and boredom coping, nor between self-concept and task accuracy. In fact, individuals with higher self-concepts were slightly less accurate, though the difference was not statistically significant. Additionally, the study analyzed participants’ written responses to questions about handling boredom using Linguistic Inquiry and Word Count (LIWC) software. The …


Investigating The Role Of Prostasin In Angiogenesis: A Chorioallantoic Membrane Model Approach, Zaima Aline Jan 2025

Investigating The Role Of Prostasin In Angiogenesis: A Chorioallantoic Membrane Model Approach, Zaima Aline

Honors Undergraduate Theses

Prostasin, also known as PRSS8 or CAP1, is a glycosylphosphatidylinositol (GPI)-anchored extracellular serine protease involved in various physiological and pathophysiological processes. Prostasin expression is observed during key phases of trophoblast invasion and placental development, critical steps in embryo implantation in Rhesus monkeys. This suggests a role for prostasin in extracellular matrix remodeling and tissue invasion, both essential for a healthy pregnancy. Moreover, prostasin appears vital for development as studies in mice show that a germline knockout of the gene leads to significant placental defects and eventual embryonic death, highlighting its importance in vascular and structural development within the placenta.

Building …


Examining The Effect Of A High Fat Diet On The Expression Of Adipokines In A Murine Model Of Barrett's Esophagus, Saagar A. Shah Jan 2025

Examining The Effect Of A High Fat Diet On The Expression Of Adipokines In A Murine Model Of Barrett's Esophagus, Saagar A. Shah

Honors Undergraduate Theses

Chronic acid reflux results in injury to the esophagus and the development of Barrett’s Esophagus (BE). BE elevates the lifetime risk for a patient to develop Esophageal Adenocarcinoma (EAC). Clinically, one of the main risk factors for BE and EAC is obesity, which alters the secretion of inflammatory cytokines by adipocytes, also referred to as adipokines. Conflicting reports have been made to the expression of adipokines and their receptors in the progression to esophageal cancer. Utilizing an inflammation-based mouse model for BE, we hypothesize that alterations in the expression of adipokines and their receptors favor an inflammatory environment associated with …


Unravelling The Role Of Two-Component Systems In Mycobacterium Abscessus, Andrea C. Molero Perez Jan 2025

Unravelling The Role Of Two-Component Systems In Mycobacterium Abscessus, Andrea C. Molero Perez

Honors Undergraduate Theses

Mycobacterium abscessus (Mab) is an emerging pathogen within the nontuberculous bacteria (NTM) which poses a threat due to its complex multi-drug resistance and opportunistic nature. It is predicted that only 45.6% of patients will have successful treatment, with immunocompromised and cystic fibrosis patients being the most threatened. Moreover, investigating new treatment approaches is key to responding to this public health issue. Two-component systems (TCS) are regulatory pathways that play a pivotal role in bacterial survival and virulence. These systems are composed of a sensor histidine kinase (HK) and cognate response regulator (RR) protein that senses environmental cues and triggers specific …