Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Central Florida

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 2881 - 2910 of 7872

Full-Text Articles in Entire DC Network

Ancient Maya Regional Settlement And Inter-Site Analysis: The 2013 West-Central Belize Lidar Survey, Arlen F. Chase, Diane Z. Chase, Jaime J. Awe, John F. Weishampel, Gyles Iannone, Holley Moyes, Jason Yaeger, Kathryn Brown, Ramesh L. Shrestha, William E. Carter, Juan Fernandez Diaz Jan 2014

Ancient Maya Regional Settlement And Inter-Site Analysis: The 2013 West-Central Belize Lidar Survey, Arlen F. Chase, Diane Z. Chase, Jaime J. Awe, John F. Weishampel, Gyles Iannone, Holley Moyes, Jason Yaeger, Kathryn Brown, Ramesh L. Shrestha, William E. Carter, Juan Fernandez Diaz

Faculty Bibliography 2010s

During April and May 2013, a total of 1057 km(2) of LiDAR was flown by NCALM for a consortium of archaeologists working in West-central Belize, making this the largest surveyed area within the Mayan lowlands. Encompassing the Belize Valley and the Vaca Plateau, West-central Belize is one of the most actively researched parts of the Maya lowlands; however, until this effort, no comprehensive survey connecting all settlement had been conducted. Archaeological projects have investigated at least 18 different sites within this region. Thus, a large body of archaeological research provides both the temporal and spatial parameters for the varied ancient …

Go to article

Matrix Metalloproteinase-3 Causes Dopaminergic Neuronal Death Through Nox1-Regenerated Oxidative Stress, Dong-Hee Choi, Ji-Hye Kim, Joo-Ha Seo, Jongmin Lee, Wahn Soo Choi, Yoon-Seong Kim Jan 2014

Matrix Metalloproteinase-3 Causes Dopaminergic Neuronal Death Through Nox1-Regenerated Oxidative Stress, Dong-Hee Choi, Ji-Hye Kim, Joo-Ha Seo, Jongmin Lee, Wahn Soo Choi, Yoon-Seong Kim

Faculty Bibliography 2010s

In the present study we investigated the interplay between matrix metalloproteinase 3 (MMP3) and NADPH oxidase 1 (Nox1) in the process of dopamine (DA) neuronal death. We found that MMP3 activation causes the induction of Nox1 via mitochondrial reactive oxygen species (ROS) production and subsequently Rac1 activation, eventually leading to Nox1-derived superoxide generation in a rat DA neuronal N27 cells exposed to 6-OHDA. While a MMP3 inhibitor, NNGH, largely attenuated mitochondrial ROS and subsequent Nox1 induction, both apocynin, a putative Nox inhibitor and GKT137831, a Nox1 selective inhibitor failed to reduce 6-OHDA-induced mitochondrial ROS. However, both inhibitors for MMP3 and …

Go to article

An Acyl-Coa Synthetase In Mycobacterium Tuberculosis Involved In Triacylglycerol Accumulation During Dormancy, Jaiyanth Daniel, Tatiana Sriakova, Pappachan Kolattukudy Jan 2014

An Acyl-Coa Synthetase In Mycobacterium Tuberculosis Involved In Triacylglycerol Accumulation During Dormancy, Jaiyanth Daniel, Tatiana Sriakova, Pappachan Kolattukudy

Faculty Bibliography 2010s

Latent infection with dormant Mycobacterium tuberculosis is one of the major reasons behind the emergence of drug-resistant strains of the pathogen worldwide. In its dormant state, the pathogen accumulates lipid droplets containing triacylglycerol synthesized from fatty acids derived from host lipids. In this study, we show that Rv1206 (FACL6), which is annotated as an acyl-CoA synthetase and resembles eukaryotic fatty acid transport proteins, is able to stimulate fatty acid uptake in E. coli cells. We show that purified FACL6 displays acyl-coenzyme A synthetase activity with a preference towards oleic acid, which is one of the predominant fatty acids in host …

Go to article

Advancing Catchment Hydrology To Deal With Predictions Under Change, U. Ehret, H. V. Gupta, M. Sivapalan, S. V. Weijs, S. J. Schymanski, G. Blöschl, A. N. Gelfan, C. Harman, A. Kleidon, T. A. Bogaard, D. Wang, T. Wagener, U. Scherer, E. Zehe, M. F. P. Bierkens, G. Di Baldassarre, J. Parajka, L. P. H. Van Beek, A. Van Griensven, M. C. Westhoff, H. C. Winsemius Jan 2014

Advancing Catchment Hydrology To Deal With Predictions Under Change, U. Ehret, H. V. Gupta, M. Sivapalan, S. V. Weijs, S. J. Schymanski, G. Blöschl, A. N. Gelfan, C. Harman, A. Kleidon, T. A. Bogaard, D. Wang, T. Wagener, U. Scherer, E. Zehe, M. F. P. Bierkens, G. Di Baldassarre, J. Parajka, L. P. H. Van Beek, A. Van Griensven, M. C. Westhoff, H. C. Winsemius

Faculty Bibliography 2010s

Throughout its historical development, hydrology as an earth science, but especially as a problem-centred engineering discipline has largely relied (quite successfully) on the assumption of stationarity. This includes assuming time invariance of boundary conditions such as climate, system configurations such as land use, topography and morphology, and dynamics such as flow regimes and flood recurrence at different spatio-temporal aggregation scales. The justification for this assumption was often that when compared with the temporal, spatial, or topical extent of the questions posed to hydrology, such conditions could indeed be considered stationary, and therefore the neglect of certain long-term non-stationarities or feedback …

Go to article

High-Performance Near-Infrared Imaging For Breast Cancer Detection, Yasser H. El-Sharkway, Ashraf F. El-Sherif Jan 2014

High-Performance Near-Infrared Imaging For Breast Cancer Detection, Yasser H. El-Sharkway, Ashraf F. El-Sherif

Faculty Bibliography 2010s

We present a method for the noninvasive determination of the size, position, and optical properties of tumors in the human breast. The tumor is first detected by photothermal imaging. It is then sized, located, and optically characterized using designed digital image processing and edge-detection pattern recognition. The method assumes that the tumor is spherical and inhomogeneous and embedded in an otherwise homogeneous tissue. Heat energy is deposited in the tissue by absorption of near-infrared (NIR) Nd:YAG laser radiation, and its subsequent conversion to heat via vibrational relaxation causes a rise in temperature of the tissue. The tumor absorbs and scatters …

Go to article

Probealign: Incorporating High-Throughput Sequencing-Based Structure Probing Information Into Ncrna Homology Search, Ping Ge, Cuncong Zhong, Shaojie Zhang Jan 2014

Probealign: Incorporating High-Throughput Sequencing-Based Structure Probing Information Into Ncrna Homology Search, Ping Ge, Cuncong Zhong, Shaojie Zhang

Faculty Bibliography 2010s

Background: Recent advances in RNA structure probing technologies, including the ones based on high-throughput sequencing, have improved the accuracy of thermodynamic folding with quantitative nucleotide-resolution structural information. Results: In this paper, we present a novel approach, ProbeAlign, to incorporate the reactivities from high-throughput RNA structure probing into ncRNA homology search for functional annotation. To reduce the overhead of structure alignment on large-scale data, the specific pairing patterns in the query sequences are ignored. On the other hand, the partial structural information of the target sequences embedded in probing data is retrieved to guide the alignment. Thus the structure alignment problem …

Go to article

Intravesical Alt-803 And Bcg Treatment Reduces Tumor Burden In A Carcinogen Induced Bladder Cancer Rat Model; A Role For Cytokine Production And Nk Cell Expansion, Evan Gomes-Giacoia, Makito Miyake, Steve Goodison, Aravindhan Sriharan, Ge Zhang, Lijing You, Jack O. Egan, Peter R. Rhode, Alexander S. Parker, Karl X. Chai, Hing C. Wong, Charles J. Rosser Jan 2014

Intravesical Alt-803 And Bcg Treatment Reduces Tumor Burden In A Carcinogen Induced Bladder Cancer Rat Model; A Role For Cytokine Production And Nk Cell Expansion, Evan Gomes-Giacoia, Makito Miyake, Steve Goodison, Aravindhan Sriharan, Ge Zhang, Lijing You, Jack O. Egan, Peter R. Rhode, Alexander S. Parker, Karl X. Chai, Hing C. Wong, Charles J. Rosser

Faculty Bibliography 2010s

Intravesical Bacillus Calmette-Guerin (BCG) has been shown to induce a specific immunologic response (i.e., activation of IL-2 and effector T-cells), while preclinical studies using ALT-803 (mutated IL-15 analogue combined with IL-15R alpha-Fc fusion) have shown promising results by prolonging the agent's half-life and stimulating CD8+ T-cells. Based on these results, we hypothesized that the intravesical administration of ALT-803 along with BCG will generate an immunologic response leading to significant bladder tumor burden reduction. Using a well-established carcinogen induced rat non-muscle invasive bladder cancer (NMIBC) model, we studied the effects of intravesical ALT-803 with and without BCG. Rat tissues were evaluated …

Go to article

Quantifying Ancient Maya Land Use Legacy Effects On Contemporary Rainforest Canopy Structure, Jessica N. Hightower, A. Christine Butterfield, John F. Weishampel Jan 2014

Quantifying Ancient Maya Land Use Legacy Effects On Contemporary Rainforest Canopy Structure, Jessica N. Hightower, A. Christine Butterfield, John F. Weishampel

Faculty Bibliography 2010s

Human land use legacies have significant and long-lasting ecological impacts across landscapes. Investigating ancient ( > 400 years) legacy effects can be problematic due to the difficulty in detecting specific, historic land uses, especially those hidden beneath dense canopies. Caracol, the largest (similar to 200 km(2)) Maya archaeological site in Belize, was abandoned ca. A.D. 900, leaving behind myriad structures, causeways, and an extensive network of agricultural terraces that persist beneath the architecturally complex tropical forest canopy. Airborne LiDAR enables the detection of these below-canopy archaeological features while simultaneously providing a detailed record of the aboveground 3-dimensional canopy organization, which is …

Go to article

Beta-Alanine Supplementation Improves Tactical Performance But Not Cognitive Function In Combat Soldiers, Jay R. Hoffman, Geva Landau, Jeffrey R. Stout, Matan Dabora, Daniel S. Moran, Nurit Sharvit, Mattan W. Hoffman, Yuval Ben Moshe, William P. Mccormack, Gil Hirschhorn, Ishay Ostfeld Jan 2014

Beta-Alanine Supplementation Improves Tactical Performance But Not Cognitive Function In Combat Soldiers, Jay R. Hoffman, Geva Landau, Jeffrey R. Stout, Matan Dabora, Daniel S. Moran, Nurit Sharvit, Mattan W. Hoffman, Yuval Ben Moshe, William P. Mccormack, Gil Hirschhorn, Ishay Ostfeld

Faculty Bibliography 2010s

Background: There are no known studies that have examined beta-alanine supplementation in military personnel. Considering the physiological and potential neurological effects that have been reported during sustained military operations, it appears that beta-alanine supplementation may have a potential benefit in maintaining physical and cognitive performance during high-intensity military activity under stressful conditions. The purpose of this study was to examine the effect of 28 days of beta-alanine ingestion in military personnel while fatigued on physical and cognitive performance. Methods: Twenty soldiers (20.1 +/- 0.9 years) from an elite combat unit were randomly assigned to either a beta-alanine ( BA) or …

Go to article

No Evidence Of Metabolic Depression In Western Alaskan Juvenile Steller Sea Lions (Eumetopias Jubatus), Lisa A. Hoopes, Lorrie D. Rea, Aaron Christ, Graham A. J. Worthy Jan 2014

No Evidence Of Metabolic Depression In Western Alaskan Juvenile Steller Sea Lions (Eumetopias Jubatus), Lisa A. Hoopes, Lorrie D. Rea, Aaron Christ, Graham A. J. Worthy

Faculty Bibliography 2010s

Steller sea lion (Eumetopias jubatus) populations have undergone precipitous declines through their western Alaskan range over the last four decades with the leading hypothesis to explain this decline centering around changing prey quality, quantity, or availability for this species (i.e., nutritional stress hypothesis). Under chronic conditions of reduced food intake sea lions would conserve energy by limiting energy expenditures through lowering of metabolic rate known as metabolic depression. To examine the potential for nutritional stress, resting metabolic rate (RMR) and body composition were measured in free-ranging juvenile Steller sea lions (N = 91) at three distinct geographical locations (Southeast Alaska, …

Go to article

Mediators Of Monocyte Migration In Response To Recovery Modalities Following Resistance Exercise, Adam R. Jajtner, Maren S. Fragala, Jeremy R. Townsend, Adam M. Gonzalez, Adam J. Wells, David H. Fukuda, Jeffrey R. Stout, Jay R. Hoffman Jan 2014

Mediators Of Monocyte Migration In Response To Recovery Modalities Following Resistance Exercise, Adam R. Jajtner, Maren S. Fragala, Jeremy R. Townsend, Adam M. Gonzalez, Adam J. Wells, David H. Fukuda, Jeffrey R. Stout, Jay R. Hoffman

Faculty Bibliography 2010s

Mediators of monocyte migration, complement receptor-3 (CR3), and chemokine ligand-4 (CCL4) were measured in response to recovery modalities following resistance exercise. Thirty resistance-trained men (23.1 +/- 2.9 y; 175.2 +/- 7.1 cm; 82.1 +/- 8.4 kg) were given neuromuscular electric stimulation (NMES), cold water immersion (CWI), or control (CON) treatments immediately following resistance exercise. Blood samples were obtained preexercise (PRE), immediately (IP), 30 minutes (30 P), 24 hours (24 H), and 48 hours (48 H) after exercise for measurement of circulating CCL4 and CR3 expression on CD14+ monocytes, by assay and flow cytometry. Circulating CCL4 showed no consistent changes. Inferential …

Go to article

Lakes And Rivers As Microcosms, Version 2.0, David G. Jenkins Jan 2014

Lakes And Rivers As Microcosms, Version 2.0, David G. Jenkins

Faculty Bibliography 2010s

Limnology has been greatly influenced by The lake as a Microcosm (Forbes, 1887), which described a holistic focus on the internal machinations of singular, island-like aquatic ecosystems. I consider three persistent influences of The lake as a Microcosm: as an organizing paradigm for the teaching of limnology relative to its practice; the idea that inland waters are like islands, and the replicability of types of inland waters. Based on inspection of recent peer-reviewed literature and 32 limnology texts, we teach limnology according to Forbes but do not practice it in that holistic context. Instead, we practice limnology as aquatic ecology. …

Go to article

Bioarchaeological Assessment Of Diet And Changes In Femoral And Humeral Stable Isotopic Values Among Subadults At Medieval Alytus, Lithuania., Katherine Page Jan 2014

Bioarchaeological Assessment Of Diet And Changes In Femoral And Humeral Stable Isotopic Values Among Subadults At Medieval Alytus, Lithuania., Katherine Page

Electronic Theses and Dissertations

Establishing a chronology of variation in isotopic values can reveal frailty associated with biological and social age, as well as highlight individuals who vary from typical patterns. Although general dietary characteristics and infant feeding practices were previously unknown for subadults excavated from the cemetery at Alytus, Lithuania (14th-18th centuries), previous research concludes that Alytus' subadults experienced high rates of physiological, metabolic, non-specific stress, in addition to specific diseases like tuberculosis. To investigate nuanced relationships between diet and mortality, nitrogen and carbon stable isotopes from the femoral and humeral midshaft diaphyses of 70 subadults (32 weeks gestation to16 years) were analyzed. …

Go to article

Bio-Inspired Attitude Control Of Micro Air Vehicles Using Rich Information From Airflow Sensors, He Shen Jan 2014

Bio-Inspired Attitude Control Of Micro Air Vehicles Using Rich Information From Airflow Sensors, He Shen

Electronic Theses and Dissertations

Biological phenomena found in nature can be learned and customized to obtain innovative engineering solutions. In recent years, biologists found that birds and bats use their mechanoreceptors to sense the airflow information and use this information directly to achieve their agile flight performance. Inspired by this phenomenon, an attitude control system for micro air vehicles using rich amount of airflow sensor information is proposed, designed and tested. The dissertation discusses our research findings on this topic. First, we quantified the errors between the calculated and measured lift and moment profiles using a limited number of micro pressure sensors over a …

Go to article

Effects Of Weaning Age On Body Composition And Growth Of Ex Situ California Sea Lion (Zalophus Californianus) Pups, Brandon Davis Jan 2014

Effects Of Weaning Age On Body Composition And Growth Of Ex Situ California Sea Lion (Zalophus Californianus) Pups, Brandon Davis

Electronic Theses and Dissertations

Pinnipeds exhibit a wide range of lactation strategies that vary from just a few days to nearly three years in duration. Phocids have a relatively short, intense nursing period culminating with weaning after just a few days or weeks, while dependent otariids generally take several months of consuming a combined milk and solid food diet before being completely independent. The transition to nutritional independence can be particularly challenging for newly weaned pups, which must adjust to behavioral, physiological and nutritional changes as a milk diet is replaced with solid food. An interruption in energy resources during this formative stage could …

Go to article

Particle Manipulation Via Optical Forces And Engineering Soft-Matter Systems With Tunable Nonlinearities., Shima Fardad Jan 2014

Particle Manipulation Via Optical Forces And Engineering Soft-Matter Systems With Tunable Nonlinearities., Shima Fardad

Electronic Theses and Dissertations

One of the most intriguing properties of light-matter interaction is the ability of an electromagnetic field to exert mechanical forces on polarizable objects. This phenomenon is a direct consequence of the fact that light carries momentum, which in turn can be transferred to matter. Mediated by scattering, this interaction usually manifests itself as a “pushing force” in the direction of beam propagation. However, it is possible to judiciously engineer these optical forces, either by tailoring particle polarizability, and/or by structuring the incident light field. As a simple example, a tightly focused laser beam demonstrates strong gradient forces, which may attract …

Go to article

Frequency Selective Detection Of Infrared Radiation In Uncooled Optical Nano-Antenna Array, Sushrut Modak Jan 2014

Frequency Selective Detection Of Infrared Radiation In Uncooled Optical Nano-Antenna Array, Sushrut Modak

Electronic Theses and Dissertations

Mid-infrared (mid-IR) detection and imaging over atmospheric transparent 3-5 μm and 8-12 μm bands are increasingly becoming important for various space, defense and civilian applications. Various kinds of microbolometers offer uncooled detection of IR radiation. However, broadband absorption of microbolometers makes them less sensitive to spectrally resolved detection of infrared radiation and the fabrication is also very tedious involving multiple complex lithography steps. In this study, we designed an optical nano-antenna array based detector with narrow frequency band of operation. The structure consists of a two-element antenna array comprised of a perforated metallic hole array coupled with an underneath disk …

Go to article

Fluorescence Off-On Sensors For F-, K+, Fe3+, And Ca2+ Ions, Binglin Sui Jan 2014

Fluorescence Off-On Sensors For F-, K+, Fe3+, And Ca2+ Ions, Binglin Sui

Electronic Theses and Dissertations

Fluorescence spectroscopy has been considered to be one of the most important research techniques in modern analytical chemistry, biochemistry, and biophysics. At present, fluorescence is a dominant methodology widely used in a great number of research domains, including biotechnology, medical diagnostics, genetic analysis, DNA sequencing, flow cytometry, and forensic analysis, to name just a few. In the past decade, with the rapid development of fluorescence microscopy, there has been a considerable growth in applying fluorescence technique to cellular imaging. The distinguished merits of fluorescence techniques, such as high sensitivity, non-invasiveness, low cytotoxicity, low cost, and convenience, make it a promising …

Go to article

Assessment Of Instructional Presentation For Emergency Evacuation Assistive Technology, Michael Boyce Jan 2014

Assessment Of Instructional Presentation For Emergency Evacuation Assistive Technology, Michael Boyce

Electronic Theses and Dissertations

It is often the case that emergency first responders are well equipped and trained to deal with a situation that involves evacuation of someone with a physical disability. However, emergency responders are not always the first line of defense, or they may be otherwise occupied with assisting others. This research examined the effects of instructions for emergency stair travel devices on untrained or novice users. It was hypothesized that through redesign of the evacuation instructions, untrained individuals would be able to successfully prepare an evacuation chair and secure someone with a disability more effectively and efficiently. A prepost study design …

Go to article

Human-Robot Interaction For Multi-Robot Systems, Bennie Lewis Jan 2014

Human-Robot Interaction For Multi-Robot Systems, Bennie Lewis

Electronic Theses and Dissertations

Designing an effective human-robot interaction paradigm is particularly important for complex tasks such as multi-robot manipulation that require the human and robot to work together in a tightly coupled fashion. Although increasing the number of robots can expand the area that the robots can cover within a bounded period of time, a poor human-robot interface will ultimately compromise the performance of the team of robots. However, introducing a human operator to the team of robots, does not automatically improve performance due to the difficulty of teleoperating mobile robots with manipulators. The human operator’s concentration is divided not only among multiple …

Go to article

Learning Collective Behavior In Multi-Relational Networks, Xi Wang Jan 2014

Learning Collective Behavior In Multi-Relational Networks, Xi Wang

Electronic Theses and Dissertations

With the rapid expansion of the Internet and WWW, the problem of analyzing social media data has received an increasing amount of attention in the past decade. The boom in social media platforms offers many possibilities to study human collective behavior and interactions on an unprecedented scale. In the past, much work has been done on the problem of learning from networked data with homogeneous topologies, where instances are explicitly or implicitly inter-connected by a single type of relationship. In contrast to traditional content-only classification methods, relational learning succeeds in improving classification performance by leveraging the correlation of the labels …

Go to article

Nonlinear Integrated Photonics On Silicon And Gallium Arsenide Substrates, Jichi Ma Jan 2014

Nonlinear Integrated Photonics On Silicon And Gallium Arsenide Substrates, Jichi Ma

Electronic Theses and Dissertations

Silicon photonics is nowadays a mature technology and is on the verge of becoming a blossoming industry. Silicon photonics has also been pursued as a platform for integrated nonlinear optics based on Raman and Kerr effects. In recent years, more futuristic directions have been pursued by various groups. For instance, the realm of silicon photonics has been expanded beyond the well-established near-infrared wavelengths and into the mid-infrared (3 - 5 µm). In this wavelength range, the omnipresent hurdle of nonlinear silicon photonics in the telecommunication band, i.e., nonlinear losses due to two-photon absorption, is inherently nonexistent. With the lack of …

Go to article

Using Land Cover Mapping And Landscape Metrics To Evaluate Effects Of Urban Development On Ecological Integrity In Florida, Michael Gilbrook Jan 2014

Using Land Cover Mapping And Landscape Metrics To Evaluate Effects Of Urban Development On Ecological Integrity In Florida, Michael Gilbrook

Electronic Theses and Dissertations

The widespread loss and degradation of habitat constitutes the largest threat to biodiversity in North America. While regulatory programs such as the Endangered Species Act of 1973 and wetland permitting under the Clean Water Act have addressed acute assaults on critical habitat, large areas of unprotected uplands have been lost. Urban development, particularly the advent of lower density suburban and rural sprawl, has greatly diminished the extent of contiguous patches of forest habitat and introduced a host of other undesirable effects on ecosystem function. This study sought to evaluate the extent of urban sprawl and its effects on ecological integrity …

Go to article

Purification And Characterization Of A Novel Selenocysteine Lyase From Enterococcus Faecalis, Samantha Nelson Jan 2014

Purification And Characterization Of A Novel Selenocysteine Lyase From Enterococcus Faecalis, Samantha Nelson

Electronic Theses and Dissertations

A previous study identified Enterococcus faecalis as one of two bacteria known to have the selD gene and other selenium related genes without having the genes necessary to make selenocysteine or selenouridine. EF2570, a gene in the cluster, was later shown to be upregulated during biofilm formation and also responsible for a selenite- and molybdate-dependent increase in biofilm formation in vitro. The protein encoded was identified as a selenium dependent molybdenum hydroxylase (SDMH), enzymes that contain a labile selenium atom required for activity. While the process of inserting selenocysteine into a protein is well known, the process by which a …

Go to article

The Anti-Toxin Properties Of Grape Seed Phenolic Compounds, Patrick Cherubin Jan 2014

The Anti-Toxin Properties Of Grape Seed Phenolic Compounds, Patrick Cherubin

Electronic Theses and Dissertations

Corynebacterium diphtheriae, Pseudomonas aeruginosa, Ricinus communis, Shigella dysentariae, and Vibrio cholerae produce AB toxins which share the same basic structural characteristics: a catalytic A subunit attached to a cell-binding B subunit. All AB toxins have cytosolic targets despite an initial extracellular location. AB toxins use different methods to reach the cytosol and have different effects on the target cell. Broad-spectrum inhibitors against these toxins are therefore hard to develop because they use different surface receptors, entry mechanisms, enzyme activities, and cytosolic targets. We have found that grape seed extract provides resistance to five different AB toxins: diphtheria toxin (DT), P. …

Go to article

Synthesis And Study Of Chemo-Hydrothermally Derived Water-Soluble Chitosan And Chiosan-Metal Oxide Composites, Srijita Basumallick Jan 2014

Synthesis And Study Of Chemo-Hydrothermally Derived Water-Soluble Chitosan And Chiosan-Metal Oxide Composites, Srijita Basumallick

Electronic Theses and Dissertations

Chitosan (CS) is a man-made sugar based biopolymer derived from chitin, the second most abundant natural polymer after cellulose. Chitin is sourced from crustacean species such as shrimps and crabs. The chemical structure of chitin contains N-Acetyl D-glucosamine monomer units which forms CS upon deacetylation. In CS, ?-(1-4) linked D-glucosamine units are randomly distributed. Approximately 75% - 80% sugar units contains primary amine groups in commercially available low molecular weight CS. Biodegradability, low toxicity, mucoadhesive and transfecting properties of CS polymer are attractive for applications as oral and nasal drug delivery systems. Chitosan polymer is water insoluble at neutral pH. …

Go to article

Biomarkers Of Muscle Quality: N-Terminal Propeptide Of Type Iii Procollagen And C-Terminal Agrin Fragment Responses To Resistance Exercise Training In Older Adults, Maren S. Fragala, Adam R. Jajtner, Kyle S. Beyer, Jeremy R. Townsend, Nadia S. Emerson, Tyler C. Scanlon, Leonardo P. Oliveira, Jay R. Hoffman, Jeffrey R. Stout Jan 2014

Biomarkers Of Muscle Quality: N-Terminal Propeptide Of Type Iii Procollagen And C-Terminal Agrin Fragment Responses To Resistance Exercise Training In Older Adults, Maren S. Fragala, Adam R. Jajtner, Kyle S. Beyer, Jeremy R. Townsend, Nadia S. Emerson, Tyler C. Scanlon, Leonardo P. Oliveira, Jay R. Hoffman, Jeffrey R. Stout

Faculty Bibliography 2010s

Background N-terminal peptide of procollagen type III (P3NP) and C-terminal agrin fragment (CAF) are circulating biomarkers that are related to lean body mass in older adults. P3NP is a circulating marker reflective of muscular structural remodeling while CAF is a circulating marker of neuromuscular remodeling. As resistance exercise is an established intervention that can effectively improve muscle quality, we sought to evaluate circulating biomarker changes corresponding to a resistance exercise intervention in older adults. Methods Twenty-three older adults (aged 61 to 85 years) were randomized into an intervention (6-week resistance training) or control group. Resting circulating P3NP, CAF, lean body …

Go to article

Proteasome Inhibition Augments Cigarette Smoke-Induced Gm-Csf Expression In Trophoblast Cells Via The Epidermal Growth Factor Receptor, Ya-Yuan Fu, Jennifer C. Nergard, Nicole K. Barnette, Yan-Ling Wang, Karl X. Chai, Li-Mei Chen Jan 2014

Proteasome Inhibition Augments Cigarette Smoke-Induced Gm-Csf Expression In Trophoblast Cells Via The Epidermal Growth Factor Receptor, Ya-Yuan Fu, Jennifer C. Nergard, Nicole K. Barnette, Yan-Ling Wang, Karl X. Chai, Li-Mei Chen

Faculty Bibliography 2010s

Maternal cigarette smoking has adverse effects on pregnancy outcomes. The granulocyte-macrophage colony-stimulating factor (GM-CSF) is an essential cytokine for a normal pregnancy. We investigated the impact of cigarette smoke extract (CSE) on GM-CSF expression in human cytotrophoblast cells and suggested a cellular mechanism underlying the CSE-induced GM-CSF expression. An immortalized normal human trophoblast cell line (B6Tert-1) was treated with CSE. The viability and proliferation of the CSE-treated B6Tert-1 cells were evaluated, and the expression of GM-CSF in these cells was quantified at the mRNA and the protein levels by means of reverse-transcription and quantitative polymerase chain reaction (RT-qPCR); and enzyme-linked …

Go to article

A Short Window Granger Causality Approach To Identify Brain Functional Pattern Associated With Changes Of Performance Induced By Sleep Deprivation, Muyuan Li Jan 2014

A Short Window Granger Causality Approach To Identify Brain Functional Pattern Associated With Changes Of Performance Induced By Sleep Deprivation, Muyuan Li

Electronic Theses and Dissertations

The comprehensive effect of sleep deprivation on biological and behavioral functions largely remains unknown. There is evidence to support that human sleep must be of sufficient duration and physiological continuity to ensure neurocognitive performance while we are waking. Insufficient sleep would lead to high risk of human-error related to accidents, injuries or even fatal outcomes. However, in modern society, more and more people suffer from sleep deprivation because of the increasing social, academic or occupational demand. It is important to study the effect of sleep deprivation, not only on task performance, but also on neurocognitive functions. Recent research that has …

Go to article

Analysis Of Commercial Online Training Videos For Teachers Who Instruct Students With Characteristics Of Autism Spectrum Disorder, Kelly Schaffer Jan 2014

Analysis Of Commercial Online Training Videos For Teachers Who Instruct Students With Characteristics Of Autism Spectrum Disorder, Kelly Schaffer

Electronic Theses and Dissertations

A deficit currently exists in teacher preparation programs for teaching students with Autism Spectrum Disorder (ASD) using evidence-based practices, specifically in the area of Applied Behavior Analysis. As communication deficits are a primary characteristic associated with the diagnosis of ASD teaching communication skills is a common educational goal for students with ASD, and this skill needs to be addressed in teacher education. Mand training is one evidence-based practice applied to teach independent requesting skills to students with ASD. In this study, four teachers serving students with characteristics of ASD in the classroom participated in a multiple-probe across-participants study evaluating the …

Go to article

First Prev Next Last