Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Central Florida

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 2551 - 2580 of 7872

Full-Text Articles in Entire DC Network

Evaluation Of Intestinal Microbial Diversity And A New Antibiotic Regimen In Crohn's Disease Patients, Karel Alcedo Jan 2015

Evaluation Of Intestinal Microbial Diversity And A New Antibiotic Regimen In Crohn's Disease Patients, Karel Alcedo

Electronic Theses and Dissertations

Crohn's disease (CD) is a chronic granulomatous inflammatory bowel disease involving Mycobacterium avium subspecies paratuberculosis (MAP). Other microorganisms such as adherent-invasive Escherichia coli (AIEC) have also been proposed in CD association. To date, only one study investigated both MAP and AIEC simultaneously using peripheral blood but not in affected intestinal tissues. A standardized and effective antibiotic therapy against MAP and/or AIEC is needed for better treatment. Three antibiotic drugs – Clarithromycin (CLA), Rifabutin (RIF), and Clofazimine (CLO) have been used to treat CD patients suspected with MAP infection. However, the outcome has been controversial. The treatment dosage is high, the …

Go to article

Genetically-Programmed Suicide Of Adrenergic Cells In The Mouse Leads To Severe Left Ventricular Dysfunction, Impaired Weight Gain, And Symptoms Of Neurological Dysfunction, Aaron Owji Jan 2015

Genetically-Programmed Suicide Of Adrenergic Cells In The Mouse Leads To Severe Left Ventricular Dysfunction, Impaired Weight Gain, And Symptoms Of Neurological Dysfunction, Aaron Owji

Electronic Theses and Dissertations

Phenylethanolamine-N-methyltransferase (Pnmt) catalyzes the conversion of noradrenaline to adrenaline and is the last enzyme in the catecholamine biosynthetic pathway. Pnmt serves as a marker for adrenergic cells, and lineage-tracing experiments have identified the embryonic heart and hindbrain region as the first sites of Pnmt expression in the mouse. Pnmt expression in the heart occurs before the adrenal glands have formed and prior to sympathetic innervation, suggesting that the heart is the first site of catecholamine production in the mouse. The function of these Pnmt+ cells in heart development remains unclear. In the present study, we test the hypothesis that (i) …

Go to article

The Ct20 Peptide As An Agent For Cancer Treatment, Rania Bassiouni Jan 2015

The Ct20 Peptide As An Agent For Cancer Treatment, Rania Bassiouni

Electronic Theses and Dissertations

Due to cancer recurrence and the development of drug resistance, metastatic breast cancer is a leading cause of death in women. In the search for a new therapeutic to treat metastatic disease, we discovered CT20p, an amphipathic peptide based on the C-terminus of Bax. Due to inherent properties of its sequence and similarity to antimicrobial peptides, CT20p is a promising cytotoxic agent whose activity is distinct from the parent protein (e.g. does not cause apoptosis). CT20p is not membrane permeable but can be introduced to cells using polymeric nanoparticles, a method that promotes efficient delivery of the peptide into the …

Go to article

Differential Expression Of Proteins Involved In Vldl Trafficking Causes Reduced Vldl Secretion In Male Ames Dwarf Mice, Faisal Ahmed Moinuddin Jan 2015

Differential Expression Of Proteins Involved In Vldl Trafficking Causes Reduced Vldl Secretion In Male Ames Dwarf Mice, Faisal Ahmed Moinuddin

Electronic Theses and Dissertations

Cardiovascular diseases (CVDs) have been recorded as the number one cause of death worldwide, accounting for 32% of total deaths annually. More than two-thirds of all CVD cases are associated with atherosclerosis, which is the accumulation of fats and other substances causing plaque formation in the interior walls of major arteries. This leads to narrowing of the lumen and hardening of the arteries, ultimately resulting in angina, heart attack and/or stroke. Studies have shown that the pathogenesis of atherosclerosis and associated CVDs is strongly linked to elevated secretion of liver-specific lipoproteins called very-low-density-lipoprotein (VLDL). VLDLs are crucial lipoproteins responsible for …

Go to article

Modeling Network Worm Outbreaks, Evan Foley Jan 2015

Modeling Network Worm Outbreaks, Evan Foley

Electronic Theses and Dissertations

Due to their convenience, computers have become a standard in society and therefore, need the utmost care. It is convenient and useful to model the behavior of digital virus outbreaks that occur, globally or locally. Compartmental models will be used to analyze the mannerisms and behaviors of computer malware. This paper will focus on a computer worm, a type of malware, spread within a business network. A mathematical model is proposed consisting of four compartments labeled as Susceptible, Infectious, Treatment, and Antidotal. We shall show that allocating resources into treating infectious computers leads to a reduced peak of infections across …

Go to article

The Relationship Between Dna's Physical Properties And The Dna Molecule's Harmonic Signature, And Related Motion In Water--A Computational Investigation, Victor Boyer Jan 2015

The Relationship Between Dna's Physical Properties And The Dna Molecule's Harmonic Signature, And Related Motion In Water--A Computational Investigation, Victor Boyer

Electronic Theses and Dissertations

This research investigates through computational methods whether the physical properties of DNA contribute to its harmonic signature, the uniqueness of that signature if present, and motion of the DNA molecule in water. When DNA is solvated in water at normal 'room temperature', it experiences a natural vibration due to the Brownian motion of the particles in the water colliding with the DNA. The null hypothesis is that there is no evidence to suggest a relationship between DNA's motion and strand length, while the alternative hypothesis is that there is evidence to suggest a relationship between DNA's vibrational motion and strand …

Go to article

Response Of Streamflow And Sediment Loading In The Apalachicola River, Florida To Climate And Land Use Land Cover Change, Paige Hovenga Jan 2015

Response Of Streamflow And Sediment Loading In The Apalachicola River, Florida To Climate And Land Use Land Cover Change, Paige Hovenga

Electronic Theses and Dissertations

Located in Florida's panhandle, the Apalachicola River is the southernmost reach of the Apalachicola-Chattahoochee-Flint (ACF) River basin. Streamflow and sediment drains to Apalachicola Bay in the Northern Gulf of Mexico, directly influencing the ecology of the region, in particular seagrass and oyster production. The objective of this study is to evaluate the response of runoff and sediment loading in the Apalachicola River under projected climate change scenarios and land use / land cover (LULC) change. A hydrologic model using the Soil Water Assessment Tool (SWAT) was developed for the Apalachicola region to simulate daily discharge and sediment load under present …

Go to article

Examining The Impact Of A Fatigue Intervention On Job Performance: A Longitudinal Study Across United States Hospitals, Megan Gregory Jan 2015

Examining The Impact Of A Fatigue Intervention On Job Performance: A Longitudinal Study Across United States Hospitals, Megan Gregory

Electronic Theses and Dissertations

Fatigue in healthcare providers has been linked to dangerous outcomes for patients, including medical errors, surgical complications, and accidents. Resident physicians, who traditionally work long hours on minimal sleep, are among the most fatigued. In attempt to mitigate the impact of fatigue on resident physician performance and improve patient safety, the Accreditation Council for Graduate Medical Education (ACGME) implemented a fatigue intervention program in 2011 for medical residency programs in the United States. This caused a significant decrease in the number of hours that first-year residents were permitted to work, compared with hours worked by first-year residents in prior years. …

Go to article

Effect Of Particles On Evaporation Of Droplet Containing Particles, Yan Wei Jan 2015

Effect Of Particles On Evaporation Of Droplet Containing Particles, Yan Wei

Electronic Theses and Dissertations

The evaporation of droplet containing insoluble particles has grown into an active area of research due to the needs for nanofluids for applications in heat transfer, combustion, and manufacturing desired micro/nano particles in the pharmaceutical industry. The evaporation of droplets containing particles involves complicated multiphase heat and mass transport. The evaporation process consists of two stages: the first stage consists of evaporation until a shell of particle forms or when the solid to liquid ratio is sufficiently large and the second stage, where the droplet size is commonly assumed to be unchanged. The dissertation investigates the evaporation kinetics in the …

Go to article

Drinking Water Infrastructure Assessment With Teleconnection Signals, Satellite Data Fusion And Mining, Sanaz Imen Jan 2015

Drinking Water Infrastructure Assessment With Teleconnection Signals, Satellite Data Fusion And Mining, Sanaz Imen

Electronic Theses and Dissertations

Adjustment of the drinking water treatment process as a simultaneous response to climate variations and water quality impact has been a grand challenge in water resource management in recent years. This desired and preferred capability depends on timely and quantitative knowledge to monitor the quality and availability of water. This issue is of great importance for the largest reservoir in the United States, Lake Mead, which is located in the proximity of a big metropolitan region - Las Vegas, Nevada. The water quality in Lake Mead is impaired by forest fires, soil erosion, and land use changes in nearby watersheds …

Go to article

Trihalomethane Removal And Re-Formation In Spray Aeration Processes Treating Disinfected Groundwater, Cassandra Smith Jan 2015

Trihalomethane Removal And Re-Formation In Spray Aeration Processes Treating Disinfected Groundwater, Cassandra Smith

Electronic Theses and Dissertations

Historically, chlorination has been widely utilized as a primary and secondary disinfectant in municipal water supplies. Although chlorine disinfection is effective in inactivating pathogenic microbes, the use of chlorine creates the unintentional formation of regulated chemicals. On January 4, 2006, the United States Environmental Protection Agency (EPA) promulgated the Stage 2 Disinfectants/Disinfection by-product rule (DBPR) that focuses on public health protection by limiting exposure to four trihalomethanes (THM) and five haloacetic acids (HAA5), formed when chlorine is used for microbial pathogen control. This thesis examines post-aeration TTHM formation when employing spray-aeration processes to remove semi-volatile TTHMs from chlorinated potable water …

Go to article

Evaporative Vapor Deposition For Depositing 2d Materials, Kevin Gleason Jan 2015

Evaporative Vapor Deposition For Depositing 2d Materials, Kevin Gleason

Electronic Theses and Dissertations

The development of a new deposition technique called evaporative vapor deposition (EVD) is reported, allowing deposition and formation of atomically-thin, large area materials on arbitrary substrates. This work focuses on the highly popular monolayer material – graphene oxide (GO). A droplet of a GO solution is formed on a heated polymer substrate, and maintained at steady-state evaporation (all droplet parameters are held constant over time). The polymer substrate is laser patterned to control the droplet's contact line dynamics and the droplet's contact angle is maintained using a computer controlled syringe pump. A room temperature silicon wafer is translated through the …

Go to article

Tidal Hydrodynamic Response To Sea Level Rise And Coastal Geomorphology In The Northern Gulf Of Mexico, Davina Passeri Jan 2015

Tidal Hydrodynamic Response To Sea Level Rise And Coastal Geomorphology In The Northern Gulf Of Mexico, Davina Passeri

Electronic Theses and Dissertations

Sea level rise (SLR) has the potential to affect coastal environments in a multitude of ways, including submergence, increased flooding, and increased shoreline erosion. Low-lying coastal environments such as the Northern Gulf of Mexico (NGOM) are particularly vulnerable to the effects of SLR, which may have serious consequences for coastal communities as well as ecologically and economically significant estuaries. Evaluating potential changes in tidal hydrodynamics under SLR is essential for understanding impacts to navigation, ecological habitats, infrastructure and the morphologic evolution of the coastline. The intent of this research is to evaluate the dynamic effects of SLR and coastal geomorphology …

Go to article

Characterization Of A Spiking Neuron Model Via A Linear Approach, Amirhossein Jabalameli Jan 2015

Characterization Of A Spiking Neuron Model Via A Linear Approach, Amirhossein Jabalameli

Electronic Theses and Dissertations

In the past decade, characterizing spiking neuron models has been extensively researched as an essential issue in computational neuroscience. In this thesis, we examine the estimation problem of two different neuron models. In Chapter 2, We propose a modified Izhikevich model with an adaptive threshold. In our two-stage estimation approach, a linear least squares method and a linear model of the threshold are derived to predict the location of neuronal spikes. However, desired results are not obtained and the predicted model is unsuccessful in duplicating the spike locations. Chapter 3 is focused on the parameter estimation problem of a multi-timescale …

Go to article

Investigating Biological Assumptions Through Radical Reimplementation, Joel Lehman, Kenneth O. Stanley Jan 2015

Investigating Biological Assumptions Through Radical Reimplementation, Joel Lehman, Kenneth O. Stanley

Faculty Bibliography 2010s

An important goal in both artificial life and biology is uncovering the most general principles underlying life, which might catalyze both our understanding of life and engineering lifelike machines. While many such general principles have been hypothesized, conclusively testing them is difficult because life on Earth provides only a singular example from which to infer. To circumvent this limitation, this article formalizes an approach called radical reimplementation. The idea is to investigate an abstract biological hypothesis by intentionally reimplementing its main principles to diverge maximally from existing natural examples. If the reimplementation successfully exhibits properties resembling biology, it may support …

Go to article

Adjusting Lidar-Derived Digital Terrain Models In Coastal Marshes Based On Estimated Aboveground Biomass Density, Stephen Medeiros, Scott Hagen, John Weishampel, James Angelo Jan 2015

Adjusting Lidar-Derived Digital Terrain Models In Coastal Marshes Based On Estimated Aboveground Biomass Density, Stephen Medeiros, Scott Hagen, John Weishampel, James Angelo

Faculty Bibliography 2010s

Digital elevation models (DEMs) derived from airborne lidar are traditionally unreliable in coastal salt marshes due to the inability of the laser to penetrate the dense grasses and reach the underlying soil. To that end, we present a novel processing methodology that uses ASTER Band 2 (visible red), an interferometric SAR (IfSAR) digital surface model, and lidar-derived canopy height to classify biomass density using both a three- class scheme (high, medium and low) and a two-class scheme (high and low). Elevation adjustments associated with these classes using both median and quartile approaches were applied to adjust lidar-derived elevation values closer …

Go to article

The Large Ribosomal Subunit Protein L9 Enables The Growth Of Ef-P Deficient Cells And Enhances Small Subunit Maturation, Anusha Naganathan, Matthew P. Wood, Sean D. Moore Jan 2015

The Large Ribosomal Subunit Protein L9 Enables The Growth Of Ef-P Deficient Cells And Enhances Small Subunit Maturation, Anusha Naganathan, Matthew P. Wood, Sean D. Moore

Faculty Bibliography 2010s

The loss of the large ribosomal protein L9 causes a reduction in translation fidelity by an unknown mechanism. To identify pathways affected by L9, we identified mutants of E. coli that require L9 for fitness. In a prior study, we characterized L9-dependent mutations in the essential GTPase Der (EngA). Here, we describe a second class of L9-dependent mutations that either compromise or inactivate elongation factor P (EF-P, eIF5A in eukaryotes). Without L9, Delta efp cells are practically inviable. Cell fractionation studies revealed that, in both the Der and EF-P mutant cases, L9's activity reduces immature 16S rRNA in 30S particles …

Go to article

Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation And Attenuates Adverse Cardiac Remodeling In The Infarcted Diabetic Heart, Dinender K. Singla, Reetu D. Singla, Latifa S. Abdelli, Carley Glass Jan 2015

Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation And Attenuates Adverse Cardiac Remodeling In The Infarcted Diabetic Heart, Dinender K. Singla, Reetu D. Singla, Latifa S. Abdelli, Carley Glass

Faculty Bibliography 2010s

Inflammation has been implicated as a perpetrator of diabetes and its associated complications. Monocytes, key mediators of inflammation, differentiate into pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages upon infiltration of damaged tissue. However, the inflammatory cell types, which propagate diabetes progression and consequential adverse disorders, remain unclear. The current study was undertaken to assess monocyte infiltration and the role of fibroblast growth factor-9 (FGF-9) on monocyte to macrophage differentiation and cardioprotection in the diabetic infarcted heart. Db/db diabetic mice were assigned to sham, myocardial infarction (MI), and MI+FGF-9 groups. MI was induced by permanent coronary artery ligation and animals were …

Go to article

Effects Of Beta-Hydroxy-Beta-Methylbutyrate Free Acid Ingestion And Resistance Exercise On The Acute Endocrine Response, Jeremy R. Townsend, Jay R. Hoffman, Adam M. Gonzalez, Adam R. Jajtner, Carleigh H. Boone, Edward H. Robinson, Gerald T. Mangine, Adam J. Wells, Maren S. Fragala, David H. Fukuda, Jeffrey R. Stout Jan 2015

Effects Of Beta-Hydroxy-Beta-Methylbutyrate Free Acid Ingestion And Resistance Exercise On The Acute Endocrine Response, Jeremy R. Townsend, Jay R. Hoffman, Adam M. Gonzalez, Adam R. Jajtner, Carleigh H. Boone, Edward H. Robinson, Gerald T. Mangine, Adam J. Wells, Maren S. Fragala, David H. Fukuda, Jeffrey R. Stout

Faculty Bibliography 2010s

Objective. To examine the endocrine response to a bout of heavy resistance exercise following acute beta-hydroxy-beta-methylbutyrate free acid (HMB-FA) ingestion. Design. Twenty resistance trained men were randomized and consumed either 1 g of HMB-FA (BetaTor) or placebo (PL) 30 min prior to performing an acute heavy resistance exercise protocol. Blood was obtained before (PRE), immediately after (IP), and 30 min after exercise (30P). Circulating concentrations of testosterone, growth hormone (GH), insulin-like growth factor (IGF-1), and insulin were assayed. Data were analyzed with a repeated measures ANOVA and area under the curve (AUC) was analyzed by the trapezoidal rule. Results. The …

Go to article

Determining Origin In A Migratory Marine Vertebrate: A Novel Method To Integrate Stable Isotopes And Satellite Tracking, Hannah B. Vander Zanden, Anton D. Tucker, Kristen M. Hart, Margaret M. Lamont, David S. Addison, Katherine L. Mansfield, Katrina F. Phillips, Michael B. Wunder, Gabriel J. Bowen, Mariela Pajuelo, Alan B. Bolten, Karen A. Bjorndal Jan 2015

Determining Origin In A Migratory Marine Vertebrate: A Novel Method To Integrate Stable Isotopes And Satellite Tracking, Hannah B. Vander Zanden, Anton D. Tucker, Kristen M. Hart, Margaret M. Lamont, David S. Addison, Katherine L. Mansfield, Katrina F. Phillips, Michael B. Wunder, Gabriel J. Bowen, Mariela Pajuelo, Alan B. Bolten, Karen A. Bjorndal

Faculty Bibliography 2010s

Stable isotope analysis is a useful tool to track animal movements in both terrestrial and marine environments. These intrinsic markers are assimilated through the diet and may exhibit spatial gradients as a result of biogeochemical processes at the base of the food web. In the marine environment, maps to predict the spatial distribution of stable isotopes are limited, and thus determining geographic origin has been reliant upon integrating satellite telemetry and stable isotope data. Migratory sea turtles regularly move between foraging and reproductive areas. Whereas most nesting populations can be easily accessed and regularly monitored, little is known about the …

Go to article

A Thermodynamic Interpretation Of Budyko And L'Vovich Formulations Of Annual Water Balance: Proportionality Hypothesis And Maximum Entropy Production, Dingbao Wang, Jianshi Zhao, Yin Tang, Murugesu Sivapalan Jan 2015

A Thermodynamic Interpretation Of Budyko And L'Vovich Formulations Of Annual Water Balance: Proportionality Hypothesis And Maximum Entropy Production, Dingbao Wang, Jianshi Zhao, Yin Tang, Murugesu Sivapalan

Faculty Bibliography 2010s

The paper forms part of the search for a thermodynamic explanation for the empirical Budyko Curve, addressing a long-standing research question in hydrology. Here this issue is pursued by invoking the Proportionality Hypothesis underpinning the Soil Conservation Service (SCS) curve number method widely used for estimating direct runoff at the event scale. In this case, the Proportionality Hypothesis posits that the ratio of continuing abstraction to its potential value is equal to the ratio of direct runoff to its potential value. Recently, the validity of the Proportionality Hypothesis has been extended to the partitioning of precipitation into runoff and evaporation …

Go to article

Mbbc: An Efficient Approach For Metagenomic Binning Based On Clustering, Ying Wang, Haiyan Hu, Xiaoman Li Jan 2015

Mbbc: An Efficient Approach For Metagenomic Binning Based On Clustering, Ying Wang, Haiyan Hu, Xiaoman Li

Faculty Bibliography 2010s

Background: Binning environmental shotgun reads is one of the most fundamental tasks in metagenomic studies, in which mixed reads from different species or operational taxonomical units (OTUs) are separated into different groups. While dozens of binning methods are available, there is still room for improvement. Results: We developed a novel taxonomy-independent approach called MBBC (Metagenomic Binning Based on Clustering) to cluster environmental shotgun reads, by considering k-mer frequency in reads and Markov properties of the inferred OTUs. Tested on twelve simulated datasets, MBBC reliably estimated the species number, the genome size, and the relative abundance of each species, independent of …

Go to article

Defining The Catalytic Activity Of Nanoceria In The P23h-1 Rat, A Photoreceptor Degeneration Model, Lily L. Wong, Quentin N. Pye, Lijuan Chen, Sudipta Seal, James F. Mcginnis Jan 2015

Defining The Catalytic Activity Of Nanoceria In The P23h-1 Rat, A Photoreceptor Degeneration Model, Lily L. Wong, Quentin N. Pye, Lijuan Chen, Sudipta Seal, James F. Mcginnis

Faculty Bibliography 2010s

Purpose Inorganic catalytic nanoceria or cerium oxide nanoparticles (CeNPs) are bona fide antioxidants that possess regenerative radical scavenging activities in vitro. Previously, we demonstrated that CeNPs had neuroprotective and anti-angiogenic properties in rodent retinal degeneration and neovascularization models. However, the cellular mechanisms and duration of the catalytic activity of CeNPs in preventing photoreceptor cell loss are still unknown. In this study, we sought to answer these questions using the P23H-1 rat, an autosomal dominant retinitis pigmentosa (adRP) model. Methods A single dose of either saline or CeNPs was delivered intravitreally into the eyes of P23H-1 rats at 2-3 weeks of …

Go to article

Gene Expression Of Key Regulators Of Mitochondrial Biogenesis Is Sex Dependent In Mice With Growth Hormone Receptor Deletion In Liver, Ilona Zawada, Michal M. Masternak, Edward O. List, Michael B. Stout, Darlene E. Berryman, Andrzej Lewinski, John J. Kopchick, Andrzej Bartke, Malgorzata Karbownik-Lewinska Jan 2015

Gene Expression Of Key Regulators Of Mitochondrial Biogenesis Is Sex Dependent In Mice With Growth Hormone Receptor Deletion In Liver, Ilona Zawada, Michal M. Masternak, Edward O. List, Michael B. Stout, Darlene E. Berryman, Andrzej Lewinski, John J. Kopchick, Andrzej Bartke, Malgorzata Karbownik-Lewinska

Faculty Bibliography 2010s

Mitochondrial biogenesis is an essential process for cell viability. Mice with disruption of the growth hormone receptor (GHR) gene (Ghr gene) in the liver (LiGHRKO), in contrast to long-lived mice with global deletion of the Ghr gene (GHRKO), are characterized by lack of improved insulin sensitivity and severe hepatic steatosis. Tissue-specific disruption of the GHR in liver results in a mouse model with dramatically altered GH/IGF1 axis. We have previously shown increased levels of key regulators of mitochondrial biogenesis in insulin-sensitive GHRKO mice. The aim of the present study is to assess, using real-time PCR, the gene expression of key …

Go to article

Connectivity Conservation And Endangered Species Recovery: A Study In The Challenges Of Defining Conservation-Reliant Species, Carlos Carroll, Daniel J. Rohlf, Ya-Wei Li, Brett Hartl, Michael K. Phillips, Reed F. Noss Jan 2015

Connectivity Conservation And Endangered Species Recovery: A Study In The Challenges Of Defining Conservation-Reliant Species, Carlos Carroll, Daniel J. Rohlf, Ya-Wei Li, Brett Hartl, Michael K. Phillips, Reed F. Noss

Faculty Bibliography 2010s

Many species listed under the US Endangered Species Act (ESA) face continuing threats and will require intervention to address those threats for decades. These species, which have been termed conservation-reliant, pose a challenge to the ESA's mandate for recovery of self-sustaining populations. Most references to conservation-reliant species by federal agencies involve the restoration of population connectivity. However, the diverse threats to connectivity faced by different species have contrasting implications in the context of the ESA's mandate. For species facing long-term threats from invasive species or climate change, restoration of natural dispersal may not be technically feasible in the foreseeable future. …

Go to article

Role Of Neuronal Nadph Oxidase 1 In The Peri-Infarct Regions After Stroke, Dong-Hee Choi, Ji-Hye Kim, Kyoung-Hee Lee, Hahn-Young Kim, Yoon-Seong Kim, Wahn Soo Choi, Jongmin Lee Jan 2015

Role Of Neuronal Nadph Oxidase 1 In The Peri-Infarct Regions After Stroke, Dong-Hee Choi, Ji-Hye Kim, Kyoung-Hee Lee, Hahn-Young Kim, Yoon-Seong Kim, Wahn Soo Choi, Jongmin Lee

Faculty Bibliography 2010s

The molecular mechanism underlying the selective vulnerability of neurons to oxidative damage caused by ischemia-reperfusion (I/R) injury remains unknown. We sought to determine the role of NADPH oxidase 1 (Nox1) in cerebral I/R-induced brain injury and survival of newborn cells in the ischemic injured region. Male Wistar rats were subjected to 90 min middle cerebral artery occlusion (MCAO) followed by reperfusion. After reperfusion, infarction size, level of superoxide and 8-hydroxy-20-deoxyguanosine (8-oxo-2dG), and Nox1 immunoreactivity were determined. RNAi-mediated knockdown of Nox1 was used to investigate the role of Nox1 in I/R-induced oxidative damage, neuronal death, motor function recovery, and ischemic neurogenesis. …

Go to article

The Stroke Hyperglycemia Insulin Network Effort (Shine) Trial: An Adaptive Trial Design Case Study, Jason T. Connor, Kristine R. Broglio, Valerie Durkalski, William J. Meurer, Karen C. Johnston Jan 2015

The Stroke Hyperglycemia Insulin Network Effort (Shine) Trial: An Adaptive Trial Design Case Study, Jason T. Connor, Kristine R. Broglio, Valerie Durkalski, William J. Meurer, Karen C. Johnston

Faculty Bibliography 2010s

Background: The 'Adaptive Designs Accelerating Promising Trials into Treatments (ADAPT-IT)' project is a collaborative effort supported by the National Institutes of Health (NIH) and United States Food & Drug Administration (FDA) to explore how adaptive clinical trial design might improve the evaluation of drugs and medical devices. ADAPT-IT uses the National Institute of Neurologic Disorders & Stroke-supported Neurological Emergencies Treatment Trials (NETT) network as a 'laboratory' in which to study the development of adaptive clinical trial designs in the confirmatory setting. The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial was selected for funding by the NIH-NINDS at the start of …

Go to article

Thermally Induced Collision Of Droplets In An Immiscible Outer Fluid, Ashkan Davanlou, Ranganathan Kumar Jan 2015

Thermally Induced Collision Of Droplets In An Immiscible Outer Fluid, Ashkan Davanlou, Ranganathan Kumar

Faculty Bibliography 2010s

Micro-total analysis systems (mu TAS) have attracted wide attention and are identified as a promising solution for sample transport, filtration, chemical reactions, separation and detection. Despite their popularity, the selection of an appropriate mechanism for droplet transport and coalescence has always been a challenge. This paper investigates the use of Marangoni flow as a mechanism for levitating and transporting droplets on immiscible liquid films at higher speeds than is possible currently. For the first time, we show that it is possible to realize the natural coalescence of droplets through Marangoni effect without any external stimulation, and deliver the coalesced droplet …

Go to article

Thyroxine Modifies The Effects Of Growth Hormone In Ames Dwarf Mice, Andrew Do, Vinal Menon, Xu Zhi, Adam Gesing, Denise S. Wiesebborn, Adam Spong, Liou Sun, Andrzej Bartke, Michal M. Masternak Jan 2015

Thyroxine Modifies The Effects Of Growth Hormone In Ames Dwarf Mice, Andrew Do, Vinal Menon, Xu Zhi, Adam Gesing, Denise S. Wiesebborn, Adam Spong, Liou Sun, Andrzej Bartke, Michal M. Masternak

Faculty Bibliography 2010s

Ames dwarf (df/df) mice lack growth hormone (GH), thyroid stimulating hormone and prolactin. Treatment of juvenile df/df mice with GH alone stimulates somatic growth, reduces insulin sensitivity and shortens lifespan. Early-life treatment with thyroxine (T4) alone produces modest growth stimulation but does not affect longevity. In this study, we examined the effects of treatment of juvenile Ames dwarf mice with a combination of GH + T4 and compared them to the effects of GH alone. Treatment of female and male dwarfs with GH + T4 between the ages of 2 and 8 weeks rescued somatic growth yet did not reduce …

Go to article

Estimating Ecological Production From Biomass, David G. Jenkins Jan 2015

Estimating Ecological Production From Biomass, David G. Jenkins

Faculty Bibliography 2010s

Productivity-diversity relationships (P/D) are a vital theme in ecology, but productivity is typically not measured directly in that research. Instead, biomass (B) is the most common proxy for productivity, often as a 1: 1 substitute. Unfortunately, this practice may cause error and uncertainty in P/D research, due to the fundamental difference between B and P and variable P/B ratios among and within systems. As a result, P/D research often measures a B/D relationship but interprets it as P/D. Fortunately, plausible, statistically legitimate and predictive P/B relationships can be found with careful analyses based on model selection of alternative allometric scaling …

Go to article

First Prev Next Last