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Preparing For The Inevitable: Sensemaking In Parent-Child Discussions Of Death, Carrie Ann Wartmann Jan 2016

Preparing For The Inevitable: Sensemaking In Parent-Child Discussions Of Death, Carrie Ann Wartmann

Electronic Theses and Dissertations

Death is something everyone will eventually encounter, yet American society has a tendency to avoid or deny death in everyday life and language. Death makes people uncomfortable, and many view it as a topic too complex for children to understand. Children, however, witness big and little deaths in their lives: of pets, relatives, plants, and favorite fairy tale characters. When a child experiences a death, he or she may have questions for parents or other trusted adults which our current avoidance-geared society does not prepare adults for. Children exist in a specific cultural context, and learn rules and expectations of …

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The Owl Sensor: A Smart Nanostructure For Single Nucleotide Variation Analysis, Rebekah Karadeema Jan 2016

The Owl Sensor: A Smart Nanostructure For Single Nucleotide Variation Analysis, Rebekah Karadeema

Electronic Theses and Dissertations

Analysis of single nucleotide variations (SNVs) in DNA and RNA sequences is extensively used in healthcare for detection of genetic mutations and analysis of drug resistant pathogens. Here we developed a nucleic acid sensor able to differentiate between a fully matched analyte and one with a SNV in a wide temperature range of 5°C-32°C. The sensor, dubbed here the 'Owl Sensor' due to the complex's resemblance to owl eyes, utilizes recent developments in DNA nanotechnology and synthetic biology to self-assemble a fluorescent DNA nanostructure called a Double Crossover, or DX Tile, capable of differentiating SNVs in a large temperature range, …

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Bioarchaeological Investigations Of The Red House Archaeological Site, Port Of Spain, Trinidad: A Pre-Columbian, Mid-Late Ceramic Age Caribbean Population., Patrisha Meyers Jan 2016

Bioarchaeological Investigations Of The Red House Archaeological Site, Port Of Spain, Trinidad: A Pre-Columbian, Mid-Late Ceramic Age Caribbean Population., Patrisha Meyers

Electronic Theses and Dissertations

In 2013 structural assessments associated with ongoing renovations of the Red House, Trinidad and Tobago's Parliament building, revealed human remains buried beneath the foundation. Excavations and radiocarbon dating indicate the remains are pre-Columbian with 14C dates ranging between approximately AD 125 and AD 1395. Due to the small overall sample size and the inability to attribute all individuals to a specific Amerindian period, the skeletal sample was considered as an aggregate. A bioarchaeological assessment of excavated graves and associated human skeletal material was conducted to determine the demographic profile and the pathological conditions exhibited by the collective skeletal 'population.' Osteological …

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Ubiquitous Computing In Public Education: The Effects Of One-To-One Computer Initiatives On Student Achievement On Florida Standardized Assessments, Fernando Lobeto Jan 2016

Ubiquitous Computing In Public Education: The Effects Of One-To-One Computer Initiatives On Student Achievement On Florida Standardized Assessments, Fernando Lobeto

Electronic Theses and Dissertations

The purpose of this study was to examine the effects of one-to-one computer initiatives on student achievement in reading and mathematics. This study compared the differences in FCAT 2.0 Reading and Mathematics scores between schools implementing one-to-one computer initiatives and schools implementing traditional modes of instruction. A second purpose of this study was to determine what effects one-to-one computer initiatives had on student FCAT 2.0 scores overall and by grade level, gender, and socio-economic status. The study used an independent-samples t-test, a repeated measures ANOVA, and a factorial ANCOVA to answer four research questions in order to achieve the purpose …

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Setting The Agenda For Stem Literacy In Higher Education: A Content Analysis Of The Chronicle Of Higher Education, Maya Abdallah Jan 2016

Setting The Agenda For Stem Literacy In Higher Education: A Content Analysis Of The Chronicle Of Higher Education, Maya Abdallah

Electronic Theses and Dissertations

Enhancing achievement in Science, Technology, Engineering, and Mathematics (STEM) is a long-standing national concern. The current national agenda, to instill an "all hands on deck" approach to creating a STEM literate citizenry, calls for broadening the scope of inclusion in STEM efforts. A critical population, higher education administrators, faculty, and staff are a valuable resource to advancing this agenda. Under the proposed Agenda Setting Communication Theory (ASCT) model developed for this study, their level of exposure to needed information is an important indicator of their potential participation in this agenda. As the leading news medium for the higher education community, …

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Evaluation Of The Expectancy Challenge Alcohol Literacy Curriculum (Ecalc) For High School Students, Alyssa Dietz Jan 2016

Evaluation Of The Expectancy Challenge Alcohol Literacy Curriculum (Ecalc) For High School Students, Alyssa Dietz

Electronic Theses and Dissertations

Prevention efforts targeted at children and adolescents are important because alcohol consumption contributes to the three leading causes of death in this among 12-20 year-olds: unintentional injury, homicide, and suicide. Research on the causes of alcohol misuse traditionally focused on pharmacological and genetic explanations, but models have expanded to include cognitive processes in the development of alcohol use patterns. Alcohol expectancies, or beliefs about the effects of alcohol, are an important influence on drinking behavior. Expectancies exist prior to the initial drinking experience, predict the onset of alcohol consumption, differentiate both children and adults in terms of light- and heavy-drinking …

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Pasture Management, The Red Imported Fire Ant (Solenopsis Invicta) And Dung Beetle Mediated Ecosystem Services, Christen Steele Jan 2016

Pasture Management, The Red Imported Fire Ant (Solenopsis Invicta) And Dung Beetle Mediated Ecosystem Services, Christen Steele

Electronic Theses and Dissertations

Grazing animals in Florida deposit over 20 million metric tons of dung per year, making dung a significant non-point source of pollution (extrapolated from Fincher, 1981). Degradation of this dung occurs naturally, primarily due to a diverse group of beetles (Order Coleoptera) primarily in the families Scarabaeidae and Geotrupidae(hereafter dung beetles). Dung that is not degraded becomes a non-point source of pollutants and may be leached into water bodies. Additionally, dung provides an incubation site for the pests and parasites of both humans and livestock. Thus, as dung beetles consume and degrade dung, they provide a multitude of ecosystem services …

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Vicarious Trauma, Emotional Intelligence, And The Impact On Job Satisfaction In Residence Life Staff, Lynell Hodge Jan 2016

Vicarious Trauma, Emotional Intelligence, And The Impact On Job Satisfaction In Residence Life Staff, Lynell Hodge

Electronic Theses and Dissertations

"There are wounds that never show on the body that are deeper and more hurtful than anything that bleeds." -Laurell K. Hamilton, Due to the proximity of working with and engaging students, residence life staff members, have a unique work experience. This functional area of student affairs is responding to myriad student needs. Staff are responding to varying levels of campus emergencies, student illness, and assault (physical or sexual) on a given workday or workweek (Ojo & Thomas, 2012). One study found college students' on-campus lifestyle and routine activities can create opportunities for victimization (Fisher, Sloan, Cullen, Lu, & 1998). …

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Mothers' History Of Child Maltreatment And Regulation Abilities: Interactions Among Young Children's Temperament, Attachment, And Maltreatment Potential, Jayme Puff Jan 2016

Mothers' History Of Child Maltreatment And Regulation Abilities: Interactions Among Young Children's Temperament, Attachment, And Maltreatment Potential, Jayme Puff

Electronic Theses and Dissertations

Given the impact that parents' and young children's characteristics have on the potential for child maltreatment, the present study sought to examine how mothers' ratings of their own childhood maltreatment, their psychological symptoms, their regulation abilities (i.e., emotion regulation, reflective functioning, attributions, and coping with young children's negative emotions), and their perceptions of their young children's temperament were related to their narratives of their attachment relationships with their young children and their child maltreatment potential. As part of this study, 54 mothers rated themselves and their young children on the aforementioned variables. Binary logistic hierarchical regression analysis suggested that mothers' …

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Vulture Scavenging Of Child-Sized Pig Carcasses In Central Florida: Utilizing Gis To Analyze Site Variables Affecting Skeletal Dispersal, Alexander Mitchell Jan 2016

Vulture Scavenging Of Child-Sized Pig Carcasses In Central Florida: Utilizing Gis To Analyze Site Variables Affecting Skeletal Dispersal, Alexander Mitchell

Electronic Theses and Dissertations

Scavengers can significantly alter a forensic scene and consume, modify, disarticulate, and disperse bodies. However, little research exists regarding scavenging in Central Florida, specifically scavenging involving Black and Turkey Vultures (Coragyps atratus, Cathartes aura respectively). The purpose of this study is to examine the effects of vulture scavenging on consumption, disarticulation, and dispersal of child-sized carcasses in the Central Florida region. The research sample consisted of four pig (Sus scrofa) carcasses weighing approximately 25kgs that were deposited in two distinct sites (shaded and unshaded) at the Deep Foundations Geotechnical Research Site located on the UCF campus. Two field cameras were …

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Electrical Parasitic Bandwidth Limitations Of Oxide-Free Lithographic Vertical-Cavity Surface-Emitting Lasers, Xu Yang Jan 2016

Electrical Parasitic Bandwidth Limitations Of Oxide-Free Lithographic Vertical-Cavity Surface-Emitting Lasers, Xu Yang

Electronic Theses and Dissertations

Nowadays, Vertical-Cavity Surface-Emitting Lasers (VCSELs) are the most popular optical sources in short-reach data communications. In the commercial oxide VCSEL technology, an oxide aperture is created inside resonant cavity in realizing good mode and current confinement, however, high electrical resistance comes along with forming the oxide aperture and the electrical parasitic bandwidth becomes the main limitation in modulation speed. In this report, electrical bandwidths of oxide-free lithographic VCSELs have been studied along with their general lasing properties. Due to the new ways of fabricating the aperture, record low resistances have been achieved in oxide-free lithographic VCSELs with various sizes, while …

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Role Of Sleep In Exposure Therapy For Posttraumatic Stress Disorder In Oif/Oef Combat Veterans, Franklin Mesa Jan 2016

Role Of Sleep In Exposure Therapy For Posttraumatic Stress Disorder In Oif/Oef Combat Veterans, Franklin Mesa

Electronic Theses and Dissertations

Exposure therapy is theorized to reduce posttraumatic stress disorder (PTSD) symptomatology by promoting habituation/extinction of fear responses to trauma-related cues. Empirical evidence indicates that emotional memory, including habituation/extinction learning, is enhanced by sleep. However, service members with combat-related PTSD often report disturbed sleep. In this study, quality of sleep and indicators of extinction learning were examined in veterans of recent wars who had completed an exposure-based PTSD intervention. Fifty-five participants were categorized into two groups based on self-reported quality of sleep: low sleep disruption severity (LSDS; N = 29) and high sleep disruption severity (HSDS; N = 26). Participants in …

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Teach Them To Eat: Complexities Of Community Based Organization And Nutrition Education Initiatives In The Prevention Of Chronic Disease, Allison Matos Jan 2016

Teach Them To Eat: Complexities Of Community Based Organization And Nutrition Education Initiatives In The Prevention Of Chronic Disease, Allison Matos

Electronic Theses and Dissertations

This thesis examines how participants of an eight-week nutrition education class utilize disseminated information to manage chronic disease, as well as explores the challenges a community based nutrition education resource center faces in the arena of chronic disease prevention. Per the World Health Organization's Global Report on Diabetes, 422 million adults currently live with a diagnosis of type 2 diabetes, a four-fold increase since the 1980s. Within the U.S., approximately nine percent of the adult population suffers from diabetes, and obesity, a major contributor to the disease, afflicts nearly thirty-five percent. While medical professionals frame the controlling of chronic disease …

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Habitat Distribution And Abundance Of Crayfishes In Two Florida Spring-Fed Rivers, Tiffani Manteuffel Jan 2016

Habitat Distribution And Abundance Of Crayfishes In Two Florida Spring-Fed Rivers, Tiffani Manteuffel

Electronic Theses and Dissertations

Crayfish are an economically and ecologically important invertebrate, however, research on crayfish in native habitats is patchy at best, including in Florida, even though the Southeastern U.S. is one of the most speciose areas globally. This study investigated patterns of abundance and habitat distribution of two crayfishes (Procambarus paeninsulanus and P. fallax) in two Florida spring-fed rivers (Wakulla River and Silver River, respectively). Study sites were surveyed once each season from April 2015 to March 2016 with baited minnow traps checked every other day, four times each survey. Habitat and environmental parameters evaluated included dominant vegetation or bottom type, percent …

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Bmp-7 Inhibits P38 And Jnk Pathways And Increases M2 Macrophage Differentiation To Reduce Atherosclerosis In Apolipoprotein E-/- Mice, Heidi Shoulders Jan 2016

Bmp-7 Inhibits P38 And Jnk Pathways And Increases M2 Macrophage Differentiation To Reduce Atherosclerosis In Apolipoprotein E-/- Mice, Heidi Shoulders

Electronic Theses and Dissertations

We have previously shown that treating atherosclerosis with bone morphogenetic protein-7 (BMP-7) affects the presence of macrophage subtypes in vitro, however it remains unknown whether BMP-7 treatment affects development and progression of atherosclerosis in vivo at an early and mid-stage of the disease. We therefore performed a Day 5 (D5) and Day 28 (D28) study to examine BMP-7's potential to affect monocyte differentiation. Atherosclerotic plaque formation was developed using our standard method and ApoE-/- mice were sacrificed at D5 and D28 post-surgery. Treatment animals received intravenous injections of BMP-7 at 200µg/kg of bodyweight. Hematoxylin and Eosin morphological stain shows that …

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The Development Of Motuporamine Derivatives And An Investigation Into Their Biological Properties, Kristen Skruber Jan 2016

The Development Of Motuporamine Derivatives And An Investigation Into Their Biological Properties, Kristen Skruber

Electronic Theses and Dissertations

This project investigates the synthesis of a class of compounds derived from a marine-based natural product and probes how iterative changes to its structure affect its derivatives' biological efficacy. The compound class of interest are the motuporamines which were isolated from the sea sponge Xestospongia exigua collected off the coast of Motupore island in Papua, New Guinea. The compounds for this project are predicated upon dihydromotuporamine C (Motu33), the compound that has been shown to be both cytotoxic to MDA-MB231 breast carcinoma cells and has antimetastatic efficacy. The motuporamine scaffold contains a large fifteen-membered saturated macrocycle and an appended polyamine …

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Female Student Services Staff Perceptions Of Safety On A State College Campus: An Exploratory Study, Catherine Chimera Jan 2016

Female Student Services Staff Perceptions Of Safety On A State College Campus: An Exploratory Study, Catherine Chimera

Electronic Theses and Dissertations

The purpose of this qualitative research study was to explore the perceptions of female student services staff members' perceptions of safety on a state college campus. Through the lens of social construction theory, six staff members were interviewed about their views of safety both on and off campus. The goal of this study was to better understand how female staff members formed their perceptions of safety on campus, through social, political and cultural processes. The results of this study were that although the informants all were aware of the same threats and dangers on campus, they each had differing views …

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Classification Of Silicone-Based Personal And Condom Lubricants Using Dart-Tofms, Lauren Harvey Jan 2016

Classification Of Silicone-Based Personal And Condom Lubricants Using Dart-Tofms, Lauren Harvey

Electronic Theses and Dissertations

Sexual lubricants are used to enable sexual encounters. There are different types of sexual lubricants such as water-based, oil-based, and silicone-based. They come pre-applied to condoms and separately in bottles as personal lubricants. Although sexual lubricants are intended for consensual use, they are also unfortunately used during the commission of sexual assaults. The analysis of sexual lubricants facilitates sexual assault investigations. With the increased usage of condoms in sexual assault cases, the potential of collected DNA evidence in each case is reduced. In the absence of biological evidence, the presence of sexual lubricants after a sexual assault can provide an …

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Elizabeth Tudor: Her Youth, Education, And The Development Of The Legend Of The Virgin Queen, Katrina Santi Jan 2016

Elizabeth Tudor: Her Youth, Education, And The Development Of The Legend Of The Virgin Queen, Katrina Santi

Electronic Theses and Dissertations

Elizabeth Tudor, the Virgin Queen, has received extensive attention from historians, especially since the advent of gender studies in the last forty years or so. Historical studies, movies, and television shows present Queen Elizabeth I as a remarkable character with legendary skills as a ruler despite her gender and the era in which she ruled. None of these studies delve into Elizabeth's childhood in an attempt to address how her experiences as a child and her education allowed her to establish her power early on in her reign. By looking at her childhood and education, this study shows that her …

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Computational Study Of Traveling Wave Solutions And Global Stability Of Predator-Prey Models, Yi Zhu Jan 2016

Computational Study Of Traveling Wave Solutions And Global Stability Of Predator-Prey Models, Yi Zhu

Electronic Theses and Dissertations

In this thesis, we study two types of reaction-diffusion systems which have direct applications in understanding wide range of phenomena in chemical reaction, biological pattern formation and theoretical ecology. The first part of this thesis is on propagating traveling waves in a class of reaction-diffusion systems which model isothermal autocatalytic chemical reactions as well as microbial growth and competition in a flow reactor. In the context of isothermal autocatalytic systems, two different cases will be studied. The first is autocatalytic chemical reaction of order $m$ without decay. The second is chemical reaction of order $m$ with a decay of order …

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From Pet To Pest? The Potential Global Range And Food Web Effects Of A Generalist Carnivore, Hannah Bevan Jan 2016

From Pet To Pest? The Potential Global Range And Food Web Effects Of A Generalist Carnivore, Hannah Bevan

Electronic Theses and Dissertations

The Nile monitor lizard [Varanus niloticus (Linnaeus, 1766)] is a generalist carnivore, native to Sub-Saharan Africa and the Nile River but now established in North America as a result of the pet trade. Once introduced, they are a potential invasive threat to native wildlife. Here, I create ensemble species distribution models (SDMs) to predict the global distribution of this generalist carnivore given current and future climate conditions. I then quantify the monitor's potential effects on 85 food webs representing >900 different species within the projected regions based on stomach content data. Climate, vegetation, and elevation data are used for 507 …

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An Evaluation Study Of The Implementation Of Webcam Proctoring For Secure Testing In A K-12 Virtual School, Elena Geiser Hogan Jan 2016

An Evaluation Study Of The Implementation Of Webcam Proctoring For Secure Testing In A K-12 Virtual School, Elena Geiser Hogan

Electronic Theses and Dissertations

The purpose of this evaluative study was to review the implementation of a Webcam Test-Proctoring Program (WTPP) implemented in a Kindergarten through 12th grade public virtual school. Results of the evaluative study will be used to determine if the secure Webcam proctoring method would be a viable solution to a problem of practice—requiring full-time virtual school students to participate in the multitude of required state and Florida school district assessments. At the core of virtual education lies the appeal of flexibility in each student's individual learning path. The rigid nature of secure assessments conflict with the intentions of a K-12 …

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The Longitudinal Relationship Between Moderate Alcohol Use And Cognitive Aging Among Older Adults., Danielle Herring Jan 2016

The Longitudinal Relationship Between Moderate Alcohol Use And Cognitive Aging Among Older Adults., Danielle Herring

Electronic Theses and Dissertations

Cognitive aging appears inconsistent across cognitive domains, indicating that domains may not all decline at the same rate across individuals. Individual trajectories of cognitive aging can vary widely and are affected by numerous lifestyle and health factors. Alcohol use among older adults is known to confer both health risks, typically related to excessive use, and protective effects, often associated with moderate consumption. Moderate alcohol use has been linked with better cognitive functioning as well as a decrease in cardiovascular mortality and systemic inflammation, as compared to heavy or abstinent users. Given that extant research has identified C-reactive protein (CRP) as …

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Neurological Profile Of Older Apoe-Pon1 Double Knockout Mice, Connie Mitra Jan 2016

Neurological Profile Of Older Apoe-Pon1 Double Knockout Mice, Connie Mitra

Electronic Theses and Dissertations

Atherosclerosis is a cardiovascular disease where plaques made up of lipids in the form of cholesterol ester build up in the carotid and innominate arteries that supply blood to the brain. Accumulation of the plaques limit the flow of blood and nutrients to the brain, leading to diminished oxygen supply, increased oxidative stress and cell death. All these have been implicated in Alzheimer's disease (AD). Alzheimer's disease, a chronic, progressive, age related neurodegenerative disorder is the most common form of dementia in the elderly accounting for 60-80% of the cases. Clinically, Alzheimer's disease is characterized by loss of memory, damage …

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Young Children's Fine Motor Ipad Gestures When Performed Alone And In Dyads, Lap Nguyen Jan 2016

Young Children's Fine Motor Ipad Gestures When Performed Alone And In Dyads, Lap Nguyen

Electronic Theses and Dissertations

Since the release of the first iPad in 2010, over 200 million have been sold worldwide. In the short time since the iPad's release, the devices have become popular in classrooms. The purpose of this study was twofold: 1) to document the fine motor iPad gestures of 2 , 3-, and 4-year-old children who used iPads by themselves and in dyads and 2) to conduct international comparisons regarding such observed fine motor iPad gestures. In this study, I examined seven iPad gestures: (a) tap, (b) drag/slide, (c) free rotate, (d) drag and drop, (e) pinch, (f) spread, and (g) flick. …

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Theoretical-Experimental Study Of The Two-Photon Circular Dichroism Of Helicenes And Aromatic Amino Acids In The Uv Region: From The Structure-Property Relationship To The Final Implementation, Yuly Katherine Vesga Prada Jan 2016

Theoretical-Experimental Study Of The Two-Photon Circular Dichroism Of Helicenes And Aromatic Amino Acids In The Uv Region: From The Structure-Property Relationship To The Final Implementation, Yuly Katherine Vesga Prada

Electronic Theses and Dissertations

Two-photon circular dichroism (TPCD) has been recognized for its exceptional spectroscopic ability for the structural and conformational analysis of chiral systems due to its high sensitivity to small peptide structural distortions. In 2008, Hernandez and co-workers demonstrated TPCD experimentally by the development of the Double L-scan technique. Since then, we have been working on a systematic theoretical-experimental study of chiral molecules using TPCD. In this dissertation, I present my contribution to the continuation to the study of the structure-property relationship of TPCD in molecules with axial chirality in solution, as well as the implementation of the TPCD measurements in the …

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An Investigation Of The Academic Impact Of The Freshman Transition Course At One Urban Central Florida High School, Timothy Flynn Jan 2016

An Investigation Of The Academic Impact Of The Freshman Transition Course At One Urban Central Florida High School, Timothy Flynn

Electronic Theses and Dissertations

The purpose of this research was to identify the extent to which a high school freshman transition program aligned with research based recommendations and to determine the extent to which the intervention impacted persistence to the tenth grade, on-track-to-graduation status, and academic success. Documents relevant to the program were collected and analyzed for research based themes. Students in the program at the target school were compared to students in a similar high school and a historical cohort of students who attended the target school. The impact of the course was statistically significant for persistence to the tenth grade, on-track to …

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Promoting Recovery In Trauma Affected Children: Developing A School-Based Professional Development Tool For Teacher Awareness And Intervention, Ellen Julia Ioannides Asher Jan 2016

Promoting Recovery In Trauma Affected Children: Developing A School-Based Professional Development Tool For Teacher Awareness And Intervention, Ellen Julia Ioannides Asher

Electronic Theses and Dissertations

The problem of practice addressed in this paper is the need for professional development training in the educational setting on the social, emotional, academic, cognitive, and behavioral needs of students who have experienced a traumatic event. The need identified exists due to the lack of knowledge, interest, and opportunity to partake in professional development training in an effort to understand the impact trauma has on academic achievement and the toll that is placed on the school environment. The purpose of this paper is to review research on childhood trauma, examine the psychological impact on student academic achievement, foster child resiliency, …

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An Investigation Of The Biomechanical Implications Of Lower Limb Fractures And Leg Length Disparity, Elizabeth Mills Jan 2016

An Investigation Of The Biomechanical Implications Of Lower Limb Fractures And Leg Length Disparity, Elizabeth Mills

Electronic Theses and Dissertations

One of the primary goals of biological anthropology is to develop an accurate understanding of human anatomy, health, disease, and injury in both modern and archaeological populations. Paleopathological analyses are a fruitful means of identifying disease and injury in skeletal assemblages, but the individual long-term biomechanical effects associated with pathological conditions have not yet been adequately explored in the literature. Leg fractures are a common pathological condition in both modern and archaeological populations, the effects of which may alter the biomechanics of gait. A growing body of clinical literature demonstrates that abnormal ambulatory function may have far-reaching effects in the …

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Role Of Kruppel-Like Factor 8 (Klf8) In Cancer And Cardiomyopathy, Satadru Lahiri Jan 2016

Role Of Kruppel-Like Factor 8 (Klf8) In Cancer And Cardiomyopathy, Satadru Lahiri

Electronic Theses and Dissertations

Cancer and cardiovascular diseases are two most fatal diseases causing innumerable death each year. Understanding the mechanisms underlying these diseases is critical for developing proper therapeutic approach. Kruppel-like factor 8 (KLF8) is a member of Kruppel-like family transcription factors that is overexpressed in many types of cancers. There is no report on role of KLF8 in cardiovascular diseases to date. KLF8 transcriptionally activates or represses a host of target genes to promote cancer cell proliferation, migration, invasion and epithelial to mesenchymal transition during tumor progression. Studies proposed in this thesis identified a novel posttranslational modification of KLF8 essential for its …

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