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Identification And Characterization Of Interactors Of Plasmodium Falciparum Pfpk6, An Atypical Protein Kinase, Andi J. Cummins

Honors Undergraduate Theses

Plasmodium falciparum, the organism that causes the most prevalent and most virulent cases of malaria in humans, poses a major health burden on the developing world, especially in the tropical regions of Sub-Saharan Africa, Southeast Asia, and Latin America. The burden of the disease is intensified by the fact that the parasite has developed widespread resistance to all current antimalarial therapies, such as chloroquine. This drug resistance underscores the need to develop novel therapeutics that target the parasite, but show low toxicity in the human host. Protein kinases, because of their integral roles in cell signaling networks, are considered to …

Novel Photodynamic Cancer Therapy Agent And Biochemical Phosphate Sensor Based On Nanomaterials, Alaa Fadhel

Electronic Theses and Dissertations

Biochemical research and clinical studies have revolutionized the field of medicine in both diagnosis and therapy. Researchers in the field of biochemistry and biotechnology are using nanomaterials in different applications to develop devices and materials that offer benefits to both patients and the health care industry. These include biochemical sensors, enzyme encapsulation, biomarkers, and drug delivery improvements for the treatment of cancer. This dissertation focuses on investigating two biochemical aspects using nanomaterials; namely therapy and clinical diagnosis. For therapy purposes, Silica nanoparticles were used as drug delivery system to develop a new photodynamic cancer therapy agent photo-acid generator (PAG) that …

A Mathematical Model For Feral Cat Ecology With Application To Disease., Jeff Sharpe

Electronic Theses and Dissertations

We formulate and analyze a mathematical model for feral cats living in an isolated colony. The model contains compartments for kittens, adult females and adult males. Kittens are born at a rate proportional to the population of adult females and mature at equal rates into adult females and adult males. Adults compete with each other in a manner analogous to Lotka-Volterra competition. This competition comes in four forms, classified by gender. Native house cats, and their effects are also considered, including additional competition and abandonment into the feral population. Control measures are also modeled in the form of per-capita removal …

Understanding Hydroclimatic Controls On Stream Network Dynamics Using Lidar Data, Seoyoung Kim

Electronic Theses and Dissertations

This dissertation investigates the hydroclimatic controls on drainage network dynamics and characterizes the variation of drainage density in various climate regions. The methods were developed to extract the valley and wet channel networks based on Light Detection and Ranging (LiDAR) data including the elevation and intensity of laser returns. The study watersheds were selected based on the availability of streamflow observations and LiDAR data. Climate aridity index was used as a quantitative indicator for climate. The climate controls on drainage density were re-visited using watersheds with minimal anthropogenic interferences and compared with the U-shape relationship reported in the previous studies. …

Causal Factors Of Cryptorchidism And Endocrine Disurpting Chemicals Such As Prenatal Maternal Cigarette Smoke: A Narrative Review, Andrew R. Morrissey

Honors Undergraduate Theses

Cryptorchidism is a male congenital disorder with an unspecified, multifactorial etiology. This review evaluated the strength of select factors in the development of cryptorchidism to better understand its etiology. The strength of relationship between factors and their respective functions during testicular descent was evaluated. Factors evaluated in the causal pathway include the signaling mechanisms Desert Hedgehog (DHH), Insulin-like Hormone 3 (INSL3) and Platelet-Derived Growth Factor (PDGF), as well as sex hormone regulation (androgen: estrogen ratio, aromatase expression). Articles supporting a factor in testicular descent were evaluated and scored. These scores were summed to create the “Step Score” for each step …

The Effects Of Kangaroo Care On The Neurodevelopment Of Preterm Infants In The Neonatal Intensive Care Unit (Nicu), Tiffany Sarg

Honors Undergraduate Theses

Preterm birth disrupts the development of the brain and other critical organs of the infant body. Since the brain is one of the last organs to finish developing during pregnancy, the risk for substantial neurological deficits increases as the gestational age decreases. One way to combat these deficits is to reconnect the preterm infant with the mother via skin-to-skin contact, also known as kangaroo care (KC). This intimate touch helps to replicate aspects of the environment that the preterm infant experienced in utero. The purpose of this literature review was to analyze the current literature to better understand the effects …

Aeromonas Hydrophila In Amphibians: Harmless Bystander Or Opportunistic Pathogen, Zachary P. Rivas

Honors Undergraduate Theses

For several decades amphibian populations have been declining. Historically, the bacterium A. hydrophila (Ah) was hypothesized to be the causal factor in amphibian disease and population declines. However, with the discovery of a chytrid fungus, Batrachochytrium dendrobatidis (Bd) in 1998, which was identified on the skin of amphibians during documented mortality events, Ah research became of minor interest as focus shifted to Bd. Recent studies into the immunocompromising abilities of Bd, however, have opened new questions about its relationship with Ah and their combined effects on a host.

In this study, I explore the …

Music And Memory: A Qualitative Look At How Music Affects Episodic Memory, Jonathan A. Coad

Honors Undergraduate Theses

This study was designed to examine qualitative data regarding gender and age differences about significant life events that are recalled when music is remembered. Two groups of participants were recruited, younger adults (M = 19.78, SD = 4.99) and older adults (M = 49.31, SD = 8.72). Data were collected by creating a survey and allowing participants to choose whichever songs, from their own experience, they like and asking them to list detailed memories that are attached to the song. Using the Linguistic Inquiry Word Count (2015) software, data was coded into categories of word count, positive and negative emotions, …

Attitudes Of Mothers And Daughters Towards Menstrual Suppression, Jacqueline M. Devaney

Honors Undergraduate Theses

Recent biomedical advancements, cultural practices, and individual preferences have altered the ways in which biological process such as menstruation are perceived and managed. Increasingly, women are interested in suppressing menstruation to alleviate its negative symptoms, including bloating, menstrual cramps, fatigue, and irritability. This topic is especially relevant for adolescent girls, as mothers and daughters might have to negotiate attitudes towards daughters’ menstrual suppression. Therefore this study aims to examine how this topic is discussed and understood within the mother-daughter dyad. It is also important to consider how these attitudes are shaped by cultural background, ethnicity, socioeconomic class, and religion. Through …

Music Therapy As An Intervention To Reduce Anxiety In Mechanically-Ventilated Patients, Stephanie L. Levine

Honors Undergraduate Theses

Patients receiving mechanical ventilation endure high levels of stress and anxiety due to the invasiveness of the procedure. These critically ill patients are often uncomfortable as a result of their serious conditions and the high-intensity environments in which they are placed. Health care workers heavily sedate these patients to minimize pain and induce a state of relaxation. However, sedatives are known for their wide-ranging, and often deleterious, side effects. Music therapy is an intervention that has been studied in a variety of hospital settings to determine any potential beneficial effects on patients. Many studies have demonstrated a relationship between music …

Perception Of Facial Expressions In Social Anxiety And Gaze Anxiety, Aaron Necaise

Honors Undergraduate Theses

This study explored the relationship between gaze anxiety and the perception of facial expressions. The literature suggests that individuals experiencing Social Anxiety Disorder (SAD) might have a fear of making direct eye contact, and that these individuals also demonstrate a hypervigilance towards the eye region. It was thought that this increased anxiety concerning eye contact might be related to the tendency of socially anxious individuals to mislabel emotion in the faces of onlookers. A better understanding of the cognitive biases common to SAD could lead to more efficient intervention and assessment methods. In the present study, the Depression Anxiety Stress …

Cardiac Consequences Of Selective Adrenergic Cell Ablation In Mice, Lahari Tumuluri

Honors Undergraduate Theses

Phenylethanolamine-N-methyltransferase (Pnmt), is the enzyme that catalyzes the conversion of noradrenaline to adrenaline. It has been found in the embryonic heart and in certain adult heart cells, including intrinsic cardiac adrenergic cells, intracardiac neurons, and cardiomyocytes, but their physiological role in the heart is not well understood. To determine the function of Pnmt-expressing cells in the developing heart, a novel genetically-targeted mouse model that causes selective cellular suicide of Pnmt-expressing cells was created by mating Pnmt-Cre Recombinase knock-in mice (Pnmt^Cre/Cre) with ROSA26-eGFP-DTA (R26R^+/DTA). The “cellular suicide” allele is the Diptheria Toxin A (DTA) gene …

Determining Factors That Influence Smooth Cordgrass (Spartina Alterniflora Loisel) Transplant Success In Community-Based Living Shoreline Projects, Steven A. Carrion

Honors Undergraduate Theses

Efforts to mitigate shoreline erosion through living shoreline methods along the USA Atlantic seaboard have often incorporated the cultivation and transplantation of smooth cordgrass, Spartina alterniflora. Assessments of these transplants at several sites in the Indian River Lagoon have shown that survival is variable after a year (survival: 10-93%). Lower survival has been attributed to environmental variables such as dislodgement by wave energy, and transplant shock due to salinity changes from cultivation to estuarine conditions. To improve living shoreline projects, we examined the effects of cultivation salinity (0 ppt, 15ppt) on transplantation success, and the success of anchoring plants …

Dining With The Cyborgs: Disembodied Consumption And The Rhetoric Of Food Media In The Digital Age, Maggie Cotto

Electronic Theses and Dissertations

This project explores digital media productions based specifically on food and cooking in order to demonstrate that new communication technologies are increasingly incorporating all five of the bodily senses. In doing so, they contribute significantly to the emergence of new ideological apparatuses appropriate for a global community. These apparatuses – including the formation of a posthumanist subject, the use of technology to support embodied cognition, and the establishment of entertainment as an ideological institution – have become the harbingers of a rhetorical evolution. Based on the work of Gregory Ulmer, along with Jacques Derrida, N. Katherine Hayles, Donna Haraway, and …

University Of Central Florida Libraries, Annual Report 2015-2016, University Libraries

Libraries' Documents

No abstract provided.

Using Fluorescence To Characterize Four Day Simulated Distribution System Trihalomethane Content In Florida Groundwaters, Jonathan Ousley

Electronic Theses and Dissertations

The United States Environmental Protection Agency (USEPA) regulates public water systems and has established limits for certain disinfection by products (DBPs) that have been linked to health effects, such as bladder cancer. The regulation of DBPs, specifically total trihalomethanes (TTHMs) and haloacetic acids (HAAs), have encouraged water treatment professionals to assess the type and amount of organic precursors in their supplies. Three of the more common water quality parameters that are monitored as DBP surrogates include dissolved organic carbon (DOC), ultraviolet absorbance (UV254), and specific ultraviolet absorbance (SUVA). Although DOC, UV254, and SUVA have been effectively correlated to DBP formation, …

Self-Efficacy And Coping In Transition Of Care After Remission Of Cancer In Adolescents, Leah M. Mcdonnell

Honors Undergraduate Theses

The improvement in cancer remission rates in children and adolescents due to advances in cancer treatment and therapy has led to the development of guidelines that address long-term follow up for survivors of childhood cancers. Adolescents often experience negative emotions related to the fear of uncertainty about long-term survival after cancer remission, yet often report feelings of hope and optimism for the future more than adult cancer survivors. The purpose of this study was to understand the role of self-efficacy and coping in adolescents after remission of cancer. A secondary purpose was to analyze which coping strategies supported long-term survival …

Vitamin D Clinical Relevance In The Recovery From Traumatic Brain Injury Among The Military Population, Yuisa M. Colón

Honors Undergraduate Theses

Background: Traumatic brain injury (TBI) still remains a difficult disorder to treat. TBI has been associated to chronic neuroinflammation and a high risk for neurodegenerative disorders. Since 2001 between ten to twenty percent of all deployed military members have suffered a combat-related TBI. Nearly twenty to thirty percent of those will experience chronic cognitive, behavioral and somatic symptoms after suffering a TBI.
Methods: The objective of this review is to evaluate current literature examining vitamin D as a neurosteroid with protective properties and its clinical relevance after traumatic brain injury. Vitamin D is known to participate in neurobiological …

Vo-Ohpic Treatment Reduces Cardiac Remodeling In Doxorubicin-Induced Cardiomyopathy, Taylor Johnson

Electronic Theses and Dissertations

Doxorubicin (Doxo) is one of multiple anthracycline drugs used to effectively treat various forms of cancer. Unfortunately, Doxo treatment, as a side effect, induces cardiomyopathy and subsequent heart failure. We have previously demonstrated that transplanted embryonic stem (ES) cells and their conditioned medium (CM) modulate the PTEN pathway and reduce apoptosis, fibrosis and hypertrophy in a Doxo induced cardiomyopathy (DIC) model. However, mechanisms of inhibited apoptosis mediated through PTEN pathway are completely unknown. Therefore, we used VO-OHpic (VO), a potent PTEN inhibitor to understand the mechanism of apoptosis as well as its effect on cardiac remodeling in DIC. Animals were …

The Role Of Type-I Interferon In Limiting Spread And Killing Of An Oncolytic Rna Virus In Prostate Cells, Kritika Kedarinath

Electronic Theses and Dissertations

Prostate cancer is the second most prevalent cancer amongst men and there is an urgent need to address viable therapeutic options for its treatment. Development of viruses which target and kill cancer cells has gained momentum due to the first FDA approved oncolytic virus for treating human cancer patients. Our previous work with the RNA virus, Parainfluenza Virus 5 (PIV5), has led to the generation of mutants that are potential candidates for oncolytic viruses: 1) the hyperfusogenic (P/V/F) mutant has a mutated P/V and fusion gene which activates anti-viral responses and causes massive cell-cell fusion respectively, and 2) the Leader …

Malondialdehyde (Mda) And Glutathione Peroxidase (Gpx) Are Elevated In Crohns Disease-Associated With Mycobacterium Avium Subspecies Paratuberculosis (Map), Ahmad Qasem

Electronic Theses and Dissertations

Inflamed tissue in Crohn’s disease (CD) are continuously producing toxic oxygen metabolites leading to cellular injury and apoptosis. Here, we are evaluating the role of Mycobacterium avium subspecies paratuberculosis (MAP) in oxidative stress in CD by evaluation of lipid peroxidation and antioxidant defense activity. Specifically, we measured malondialdehyde (MDA) level and selenium-dependent glutathione peroxidase (GPx) activity in the plasma from patients and cattle infected with MAP. The level of MAP antibodies in bovine sera was determined by IDEXX kit whereas detection of MAP DNA was performed by IS900-based nPCR. A total of 42 cattle (21 infected with MAP and 21 …

Structural And Functional Characterization Of Enzymes Of A Novel Group Of Tryptophylquinone Cofactor Containing Oxidases, Esha Sehanobish

Electronic Theses and Dissertations

Protein-derived cofactors are redox and catalytic centers that are generally formed by the posttranslational modifications of one or more amino acids. An important class of these cofactors are the quinones derived from tyrosine and tryptophan. Amongst redox proteins, it has been known till now that oxidases either contain a flavin or a tyrosylquinone cofactor, whereas tryptophylquinone ones are present within the dehydrogenases. In recent times, oxidases from a marine bacterium, Marinomonas mediterranea, have been shown to possess the latter. This study involves the characterization of two such proteins, lysine-?-oxidase (LodA) and glycine oxidase (GoxA). They have been reported to contain …

A Hybrid Simulation Framework Of Consumer-To-Consumer Ecommerce Space, Oloruntomi Joledo

Electronic Theses and Dissertations

In the past decade, ecommerce transformed the business models of many organizations. Information Technology leveled the playing field for new participants, who were capable of causing disruptive changes in every industry. "Web 2.0" or "Social Web" further redefined ways users enlist for services. It is now easy to be influenced to make choices of services based on recommendations of friends and popularity amongst peers. This research proposes a simulation framework to investigate how actions of stakeholders at this level of complexity affect system performance as well as the dynamics that exist between different models using concepts from the fields of …

Probabilistic-Based Computing Transformation With Reconfigurable Logic Fabrics, Mohammed Alawad

Electronic Theses and Dissertations

Effectively tackling the upcoming "zettabytes" data explosion requires a huge quantum leap in our computing power and energy efficiency. However, with the Moore's law dwindling quickly, the physical limits of CMOS technology make it almost intractable to achieve high energy efficiency if the traditional "deterministic and precise" computing model still dominates. Worse, the upcoming data explosion mostly comprises statistics gleaned from uncertain, imperfect real-world environment. As such, the traditional computing means of first-principle modeling or explicit statistical modeling will very likely be ineffective to achieve flexibility, autonomy, and human interaction. The bottom line is clear: given where we are headed, …

Adolescent Mothers’ Implementation Of Strategies To Enhance Their Children’S Early Language And Emergent Literacy Skills, Meredith C. Canty

Honors Undergraduate Theses

Previous studies have examined how the language skills of children with adolescent mothers differs from children of older mothers. However, there is limited information on what specific strategies adolescent mothers utilize to increase early language and emergent literacy skills in their children. The aim of the present study is to examine adolescent mothers’ use of strategies to increase the early language and emergent literacy skills of their young children. A sample of 14 adolescent mothers enrolled in a teen parenting program were surveyed on their use of common strategies that are shown to facilitate early development of language and literacy …

The Study Of The Adverse Effects Of Childhood Maltreatment, Katie A. Kennie

Honors Undergraduate Theses

This study explores the link between the presence of childhood trauma and adult criminal behavior. In this study, four distinct categories of childhood trauma (physical abuse, sexual abuse, psychological abuse, and neglect) were examined. In addition, this study conducts a comparative analysis of the United States crime rate with that of Switzerland and Japan. This study examines and compares the policies utilized in ensuring the protection of child welfare. The ultimate goal is to provide research which may build a foundation that will assist in creating and improving policies which will ensure a child's psychological health.

Identity Development, Social Support, And Motherhood, Dayanara Rosado

Honors Undergraduate Theses

Adolescent pregnancy creates challenges for this minority population in balancing their motherhood identity with continuing to develop their identity at the adolescent stage, which presents a social problem today. The intent of this thesis is to explore the relationship between identity, adjustment, and social support among college students who were adolescent mothers. The following surveys: Personal Network Matrix (PNM), The Identity Distress Scale (IDS), and The Dimension of Identity Development Scale (DIDS), were administered through the UCF SONA system. Participants were divided into three groups: mothers who had their first child as a teenager (teen mothers; n = 6), mothers …

Expression Levels Of Virulence Genes In Group A Streptococci: A Response To Aerosolized Propylene Glycol, Michael S. Costello

Honors Undergraduate Theses

Electronic cigarette usage is becoming increasingly prevalent among school age children and young adults. A known bactericidal agent, propylene glycol, is often used as a carrier for nicotine, flavoring, and additional constituents of electronic cigarette juice. This study examined the relationship between propylene glycol and virulence gene expression in Streptococcus pyogenes, a respiratory tract pathogen commonly found in school-age individuals. A variety of virulence genes controlled by the three stand alone regulators mga, RofA, and Rgg/RopB were sampled in an effort to understand the pathway by which virulence is affected. The genes chosen encode C5a peptidase, fibronectin binding protein, hyaluronate …

Forced Motherhood? An Ethnographic Study On State Gender Expectations In Nicaragua, Mikaela M. Mendoza-Cardenal

Honors Undergraduate Theses

The dominant Sandinista party discourse of Nicaragua designates the family as the country’s base social institution, but the prevailing machismo threatens the family’s structure. Men - fathers - leave, either literally as migrant laborers or in the abandonment of their family responsibilities. In order to counteract the men’s socially sanctioned absence, the state deploys a hegemonic expectation of motherhood in the passage of its complete abortion ban, one of the strictest in the world. All forms of abortion, including saving the life of the mother, are banned in Nicaragua and both doctors and women are heavily penalized if an abortion …

The Effect Of Social Media On Sexual Cognitions And Behaviors, Joshua Duarte

Honors Undergraduate Theses

Pop culture and social media have become a prime source of entertainment and communication. The current study focuses on the potential effects of consuming this form of media and how it affects our sexual cognitions and behaviors. A sample of nine hundred and two university students were given self-reporting questionnaires concerning demographics, sexual cognitions, and exposure to sexual content in music. An analysis of music artist’s posts on social media was also performed. It was hypothesized that artists who have sexual content published in their work will also have the same amount of sexual content on social media. However, there …