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Deepfake Detection And Defense: An Analysis Of Techniques And Robustness, Nigel Francis Jan 2025

Deepfake Detection And Defense: An Analysis Of Techniques And Robustness, Nigel Francis

Graduate Thesis and Dissertation post-2024

The rise of deepfake media powered by the abrupt and rapid advances in generative AI, has introduced serious concerns and challenges in digital content verification. Although there is a wide range of detection strategies currently in use and being proposed, many remain limited in their ability to generalize across manipulation types, defend against adversarial attacks, or operate efficiently in real world scenarios. This paper presents a survey of deepfake detection and defense techniques, organized into ten technical categories: frequency-based, spatial-based, temporal-based, physiological-based, multimodal detection, adversarial attacks and defenses, forensic noise-based methods, watermarking and prevention strategies and dataset contributions. Drawing on …


Increasing Bystander And Environmental Awareness Through Haptic Feedback, Jose-Valentin T. Sera-Josef Jan 2025

Increasing Bystander And Environmental Awareness Through Haptic Feedback, Jose-Valentin T. Sera-Josef

Graduate Thesis and Dissertation post-2024

The Chariot System is a bystander and environmental awareness system that uses vibrotactile haptic feedback delivered via a wearable. It was designed with the goal of using a subject's haptic channel to keep them aware of their surroundings thus freeing their visual channel to focus on and enjoy a virtual reality (VR) experience. This work contributes to the space of VR research that aims to keep users aware of the outside world while in VR, an area that typically focuses on using visual notifications but rarely applies haptics. A user study involving 24 participants was conducted comparing the Chariot System …


Modeling Data Metrics And Distributions For Representation And Efficient Transfer Learning, Li Ren Jan 2025

Modeling Data Metrics And Distributions For Representation And Efficient Transfer Learning, Li Ren

Graduate Thesis and Dissertation post-2024

Representation Learning and Transfer Learning are fundamental challenges in deep learning, particularly for downstream computer vision tasks. While existing research predominantly focuses on loss functions and network architectures, this dissertation explores how modeling distance metrics and data distributions can enhance representation and transfer learning efficiency in computer vision applications, specifically focusing on image captioning and retrieval tasks.

We make contributions primarily in three subareas. First, we develop an image captioning system that leverages geometric relationships among objects using a novel object graph structure, enhancing global visual representations for more accurate caption generation. We further incorporate adversarial learning to model data …


Haptics Based Grasping Of Novel Objects Using Robotic Manipulator, Nicolas C. Leocadio Jan 2025

Haptics Based Grasping Of Novel Objects Using Robotic Manipulator, Nicolas C. Leocadio

Graduate Thesis and Dissertation post-2024

This work is focused on extending and demonstrating the generalizability of previous interactive perception-based work done on a model-free, non-neural algorithm for robotic gripper envelopment of objects using haptic feedback. Using a 6-axis force and torque sensor placed behind the wrist of a robotic arm's manipulator, appropriate motions are generated in order to achieve contact with, align the manipulator with, and place the manipulator around some desired object in a position where grasp is possible by simply closing the manipulator. The algorithm relies on generating restoring (reactive) and frictional forces by rapid multidirectional oscillation of gripper fingers about an initial …


Enhancing The Hardness Of The Multispectral Zns Transparent Ceramics Through Ga2s3 Incorporation: A Comparative Study Of Vapor Transport Deposition And Solid-Solid Reaction Methods, Hayat Soufiani Jan 2025

Enhancing The Hardness Of The Multispectral Zns Transparent Ceramics Through Ga2s3 Incorporation: A Comparative Study Of Vapor Transport Deposition And Solid-Solid Reaction Methods, Hayat Soufiani

Graduate Thesis and Dissertation post-2024

Multispectral zinc sulfide (MS-ZnS) is an important optical ceramic widely used in broadband imaging systems due to its wide transmission range and relatively low cost. However, its modest mechanical properties limit its durability in harsh environments. This dissertation investigates two solute strengthening methods, vapor transport deposition (VTD) and diffusion coupling (DC), to enhance the hardness of MS-ZnS windows through Ga2S3 incorporation while maintaining optical transparency. The VTD process successfully incorporated gallium in the subsurface, resulting in up to 120 % increase in microhardness compared to untreated samples, but with slight discrepancies in lateral gallium distribution. The DC technique demonstrated superior …


A New Dawn Of Joy: How Joy Is Cultivated Among Black Transgender And Nonbinary Young Adults In Florida, Courtney Marciá Gardner Jan 2025

A New Dawn Of Joy: How Joy Is Cultivated Among Black Transgender And Nonbinary Young Adults In Florida, Courtney Marciá Gardner

Graduate Thesis and Dissertation post-2024

The state of Florida had a record-breaking number of implemented and proposed policies between 2023-2024 that impacted transgender and nonbinary individuals. Black transgender and nonbinary people are particularly impacted by these policies due to the compounded effects of their race and gender identity. Nonetheless, despite the growing literature on Black transgender and nonbinary individuals, a lack of research exists examining positive aspects of intersectional experiences among Black transgender and nonbinary individuals. This qualitative study shifts away from deficit centered frameworks by investigating how Black transgender and nonbinary young adults in Florida cultivate joy in their lives. This study uses a …


Reentry Realities: Examining The Role Of Aftercare Programs In Supporting Justice-Involved Youth, Lynda Girven Jan 2025

Reentry Realities: Examining The Role Of Aftercare Programs In Supporting Justice-Involved Youth, Lynda Girven

Honors Undergraduate Theses

The current study examined if aftercare and reentry programs helped to reduce recidivism among youth who have been involved in the juvenile system, and specifically, youth released from residential placement facilities. Different components of aftercare programs were also examined, such as the inclusion of mentoring or family support, how many services were offered, and if the program followed the Risk-Need-Responsivity (RNR) model. Through completing a systematic review of studies published since 2008, five studies met the inclusion and exclusion criteria. All five studies found that the youth who received services through aftercare programs were less likely to reoffend than youth …


Examining The Impact Of Resilience And Sense Of Community On Mental Health And Academic Performance, Samara B. Coleman Jan 2025

Examining The Impact Of Resilience And Sense Of Community On Mental Health And Academic Performance, Samara B. Coleman

Honors Undergraduate Theses

Within the United States, a third of college-aged young adults are diagnosed with at least one psychological disorder. Resilience, the ability to bounce back from adversity, has been shown to help mitigate the adverse effects of burnout and stress, and support academic performance in some cases. Additionally, a sense of community has also been shown to be crucial in buffering the negative consequences of adversity. The following research questions guide this study: 1) How significant a role does the community play in resilience and mental health? 2) How does resiliency relate to the academic performance of students experiencing varying levels …


The Association Between Pain Sensitivity And Low Energy Availability, Sleep, Mental Health, And Stress In Female Endurance Athletes, Taylor R. Moler Jan 2025

The Association Between Pain Sensitivity And Low Energy Availability, Sleep, Mental Health, And Stress In Female Endurance Athletes, Taylor R. Moler

Honors Undergraduate Theses

The disruption of certain physiological functions due to low energy availability (LEA) in female endurance athletes is a prominent concern. This condition resulting from LEA has been described as Relative Energy Deficiency in Sport (RED-S), which can include alterations in metabolism, menstrual function, bone deposition and resorption, mental well-being, and more. The goal of this study was to determine whether pain sensitivity was associated with LEA, sleep, mental health, and stress in female endurance athletes. Participants completed a demographic survey, the Low Energy Availability in Females Questionnaire (LEAF-Q), the Pittsburgh Sleep Quality Index (PSQI), the Patient Health Questionnaire (PHQ-4), and …


Mechanistic Insights Into The Antimicrobial Action Of Fungus-Derived Xanthoquinodins Against Clostridioides Difficile, Erika A. Serravalle Jan 2025

Mechanistic Insights Into The Antimicrobial Action Of Fungus-Derived Xanthoquinodins Against Clostridioides Difficile, Erika A. Serravalle

Graduate Thesis and Dissertation post-2024

The bacterial pathogen Clostridioides difficile is the leading cause of antibiotic- and healthcare-associated diarrhea, imposing significant clinical and economic impacts. The emergence of hypervirulent strains, such as PCR ribotype 027 (RT027), has exacerbated disease severity, recurrence rates, antibiotic resistance, and epidemiological spread. Expanding resistance profiles among C. difficile strains continue to limit the effectiveness of current IDSA-SHEA recommended therapies, which are already compromised by high recurrence rates due to antibiotic-induced disruption of the gut microbiota. These challenges highlight the urgent clinical need to identify and characterize antimicrobial compounds targeting alternative pathways in C. difficile physiology. We report the discovery and …


On High-Speed Breakup Of Water Droplets Behind High Mach Number Shocks, Sydney M. Briggs Jan 2025

On High-Speed Breakup Of Water Droplets Behind High Mach Number Shocks, Sydney M. Briggs

Graduate Thesis and Dissertation post-2024

Water droplet breakup in high-speed flow is a relatively popular experimental study to analyze breakup mechanisms. There is a plethora of experiments performed at low Mach number and low Weber number, but studies with higher speed flows and higher Weber numbers are less common. In this study, water droplet breakup is assessed using high-speed shock waves (Mach 2.3-above Mach 5) in a shock tube. Multiple methods are used to introduce droplets, and multiple different water purity levels are considered. An assessment was made into whether cavitation played a role in the breakup process physically, as this has been a budding …


Synthesis And Evaluation Of Chalcones As Treatment For Negative Sense Single Stranded Rna Viruses And Applications As Broad-Spectrum Antivirals, Lorael Kirton Jan 2025

Synthesis And Evaluation Of Chalcones As Treatment For Negative Sense Single Stranded Rna Viruses And Applications As Broad-Spectrum Antivirals, Lorael Kirton

Graduate Thesis and Dissertation post-2024

Chalcones are a class of compounds naturally found in plants and are predicated upon a 1,3-diphenylprop-2-en-1-one scaffold. Chalcones possess many biological activities ranging from anticancer to antiviral activities. This thesis investigates the broad-spectrum antiviral properties of chalcones. Some chalcones have been reported to affect host cell mechanisms such as mammalian target of rapamycin (mTOR) signaling cascade or the cell cycle to reduce viral replication. Previously, a series of chalcones 8 were synthesized and investigated in human cytomegalovirus virus (HCMV) and human immunodeficiency virus (HIV). In this study, ten new chalcones predicated upon the design of 8 were synthesized and a …


Faith Amid Chaos: Does Religiosity Buffer Youth Delinquency In Disordered Neighborhoods?, Mason T. High Jan 2025

Faith Amid Chaos: Does Religiosity Buffer Youth Delinquency In Disordered Neighborhoods?, Mason T. High

Honors Undergraduate Theses

This study examines whether religiosity moderates the relationship between neighborhood disorder and delinquent behavior among juvenile offenders. Drawing on Social Disorganization Theory and Neighborhood Disorder, the study hypothesizes that religiosity, both as an attitude and as a behavior, serves as a protective factor against delinquency in disordered neighborhoods. Using data from the Pathways to Desistance study, this research employs Ordinary Least Squares (OLS) regression with and without interaction terms to assess how individual perceptions of disorder interact with religiosity in influencing minor and major delinquency. Results indicate a significant positive association between perceived neighborhood disorder and delinquency, reinforcing the notion …


Sports And Rhetorical Marginalization: A Case Study Of Angel Reese & Caitlin Clark, Diamond R. Williams Jan 2025

Sports And Rhetorical Marginalization: A Case Study Of Angel Reese & Caitlin Clark, Diamond R. Williams

Honors Undergraduate Theses

This thesis explores the manifestation of racism, sexism, and capitalism in the language and rhetoric of sports media through a case study of WNBA players Angel Reese and Caitlin Clark. This study theorizes that sports media has referred to Reese and Clark with damaging language tied to the intersections of their respective identities. This thesis also identifies and analyzes the presence of repeated themes throughout select sports media that mirror relevant theories surrounding stereotypes, biases, and marginalization in sports. Examining and analyzing the subtle nuances at play allows one to understand how language implicitly reinforces harmful narratives and, thus, how …


A Kinder Panopticon? Examining Effects Of Fairness And Justice On Performance Outcomes Under Advanced Electronic Monitoring Systems, William F. Tang Jan 2025

A Kinder Panopticon? Examining Effects Of Fairness And Justice On Performance Outcomes Under Advanced Electronic Monitoring Systems, William F. Tang

Honors Undergraduate Theses

The adoption of Electronic Performance Monitoring (EPM) systems has increased with the prevalence of remote workers post-COVID. Research indicates EPM yields conflicting performance and behavioral outcomes. EPM-related behavior can be predicted by organizational justice (the extent to which workplaces are perceived as fair in nature); environments with higher justice ratings are less likely to induce issues like stress and distrust. However, advanced EPM like electroencephalograms (EEG) may modulate the relationships between perceived fairness, stress, and work performance. This study assigned 42 participants to a modified vigilance test (based on Temple, et al., 2001), which participants took under 3 placebo monitoring …


Exploring The Effects Of Looping On First And Second Grade English Language Learners (Ells) Students' Reading And Science Achievement, Kiera A. Palmer Jan 2025

Exploring The Effects Of Looping On First And Second Grade English Language Learners (Ells) Students' Reading And Science Achievement, Kiera A. Palmer

Honors Undergraduate Theses

The purpose of this study is to compare the reading and science achievement of first grade ELL students who looped with their teacher to second grade with the reading and science achievement of first grade ELL students who had a different teacher in second grade. Looping is an educational practice that allows teachers to stay with their class for two or more years, it was hypothesized that it would have a positive effect on ELL students’ reading and science achievement. Using a comparative methodology, the study tracked the end-of-year scores of the ELL students in their Florida Assessment of Student …


Creating A Criteria Set To Evaluate The Use Of Cai Resources In K-6 Language Arts Education, Matthew T. Bates Jan 2025

Creating A Criteria Set To Evaluate The Use Of Cai Resources In K-6 Language Arts Education, Matthew T. Bates

Honors Undergraduate Theses

The purpose of this creative project was to research adequate educational practices regarding implementing technology and specifically CAI (Computer-Assisted Instruction) technology in the context of elementary education. This information was compiled into distinct categories based on research articles and policy statements. Then, the implications of each category were explored within the classroom. From this review of research, I created a criteria set for elementary educators to follow to evaluate CAI in the framework of their own educational methods and classroom. This thesis presents an address on the issue of student engagement in elementary literacy classrooms by assisting students in actively …


Beyond The Bench: Historical Injustices And Future Pathways For Florida’S Family Court, David J. Blum Jan 2025

Beyond The Bench: Historical Injustices And Future Pathways For Florida’S Family Court, David J. Blum

Honors Undergraduate Theses

This thesis examines systemic inequities in Florida’s family law system, focusing on how legal doctrines, discretionary practices, and enforcement patterns disadvantage unwed and noncustodial fathers. Drawing on statutory analysis, case law, empirical studies, and psychological research, it evaluates several reforms designed to promote fairness while protecting child welfare. These include mandatory paternity testing at birth, a rebuttable presumption of equal custody, stronger enforcement of visitation orders, equitable tax restructuring, and improved training for legal professionals. Current Voluntary Acknowledgment of Paternity (VAP) procedures often create binding obligations without confirming biological parentage, resulting in long-term emotional, legal, and financial consequences. Research shows …


Ad Astra Per Aspera: Legal Revision Of Space Laws And Intellectual Property To Cultivate Global Alliance And Innovation, Jaiden E. Haggiag Jan 2025

Ad Astra Per Aspera: Legal Revision Of Space Laws And Intellectual Property To Cultivate Global Alliance And Innovation, Jaiden E. Haggiag

Honors Undergraduate Theses

This thesis explores the inadequate nature of the current legal space regime and points out the gaps in outer space laws, including the following: Jurisdictional Challenges, Frameworks of Liability, and IP (Intellectual Property) Enforcement, utilizing laws such as the Outer Space Treaty (OST), the Liability Convention, the Registration Convention, the Moon Agreement, the Patent Cooperation Treaty (PCT), and TRIPS, along with national laws like the U.S. Commercial Space Launch Competitiveness Act and The Inventions in Outer Space Act (35 U.S.C. § 105.). Through analysis of current scholarly proposals and treaty evolution and synthesize to provide policy options, the goal of …


An Analysis Of The Constitutionality Of Florida's 2024 Hb 3: “Online Protections For Minors,” Comparative To Other State Regulations Of The Internet, Evan J. Siegel Jan 2025

An Analysis Of The Constitutionality Of Florida's 2024 Hb 3: “Online Protections For Minors,” Comparative To Other State Regulations Of The Internet, Evan J. Siegel

Honors Undergraduate Theses

This thesis examines the constitutionality of the Florida House of Representatives’ 2024 priority bill, HB 3: “Online Protections for Minors,” through its ongoing litigation in North Florida. The broad nature of the bill, which is now Florida law, and its burden on accessing constitutionality protected speech and/or expression may not be consistent with the First and Fourteenth Amendments to the United States Constitution. How the law defines and shapes what material may be accessible to people on the Internet, or the means they would need to use to create a social media account, are questions many other courts have begun …


0th Order Solutions Of The Wavefunctions For The Quantum Elliptical Box And Microstrip Antenna, Nishtha Tikalal Jan 2025

0th Order Solutions Of The Wavefunctions For The Quantum Elliptical Box And Microstrip Antenna, Nishtha Tikalal

Honors Undergraduate Theses

For a quantum particle confined to a two-dimensional elliptical box or electromagnetic wave in a microstrip antenna, geometrical and boundary condition interplay result in a spectrum of spatial patterns. Due to the asymmetrical nature of the ellipse, we are faced with continuous symmetry reductions, leaving both degenerate and nondegenerate solutions. Here, we present a complete derivation of an analytical solution and visualizations of the fundamental wavefunctions for both Dirichlet and Neumann boundary conditions respectively corresponding to the quantum elliptical box and the elliptical microstrip antenna.

We demonstrate that the eigenmodes, governed by eccentricity, directly correspond to the modal field distributions …


Effects Of Invigorating And Relaxing Music On Heart Rate, Blood Pressure, And Heart Rate Variability, Matthew Joshua Faur Jan 2025

Effects Of Invigorating And Relaxing Music On Heart Rate, Blood Pressure, And Heart Rate Variability, Matthew Joshua Faur

Honors Undergraduate Theses

Heart-rate variability (HRV) has been documented to correlate with several health measures, including autonomic nervous system longevity and athletic performance (Zulfiqar, 2010). While increasing age does not affect heart rate, there is a steady decline in HRV, which is a biological marker of aging and the decline of autonomic nervous system function. Furthermore, men who exercise regularly tend to have increased HRV, suggesting a mitigation of the typical age-dependent loss of HRV (Kristal-Boneh et al., 1995). Previous studies have suggested that music may have a physiological effect (e.g., fluctuating vitals, emotional changes) on cardiovascular parameters. However, little is known about …


From Vinyl To Viral: Evaluating The Mere Exposure Effect Through Music And Technological Advancements, Ariana R. Deboo Jan 2025

From Vinyl To Viral: Evaluating The Mere Exposure Effect Through Music And Technological Advancements, Ariana R. Deboo

Honors Undergraduate Theses

The Mere Exposure Effect (MEE) refers to a psychological pattern in which a person develops preference for a stimulus that has been repeatedly presented to them. The present study examined environmental influences of preference through repeated exposure to music. Social media platforms such as TikTok, Reels, and Shorts influence where people listen to music. The fast-paced consumption algorithm for new media is provided by quick, entertaining videos that allow users to scroll past content that does not keep their attention. A total of 406 participants (n=406) were involved in this study. The purpose for this study was to identify how …


Impact Of Tgf-Β And Twist1 On Motility And Proliferation In Estradiol-Treated Mcf-7 Tamr Cells In-Vitro, Thomas L. Scott Iii Jan 2025

Impact Of Tgf-Β And Twist1 On Motility And Proliferation In Estradiol-Treated Mcf-7 Tamr Cells In-Vitro, Thomas L. Scott Iii

Honors Undergraduate Theses

Breast cancer is a highly malignant cancer and is known to be grouped into three main types: adenocarcinoma, invasive ductal carcinoma (IDC) and ductal carcinoma. Breast cancer commonly arises as adenocarcinoma, located in the milk ducts, and becomes IDC when it spreads into the surrounding tissue from the influence of cytokines and hormones. This study outlines the rate of proliferation and motility of a type of adenocarcinoma, MCF-7-TamR, to become invasive ductal carcinoma when Twist1 is downregulated and exposed to TGF- and estradiol (E2) in-vitro. We hypothesize that the downregulation of Twist1 will reduce cell adhesion and cytoskeleton proteins …


The Inverse Scattering Transform For The Nonlinear Schrödinger Equation, Ivan Casas-Rocha Jan 2025

The Inverse Scattering Transform For The Nonlinear Schrödinger Equation, Ivan Casas-Rocha

Honors Undergraduate Theses

The Nonlinear Schrödinger (NLS) Equation, iψt + 1/2 ψxx ± |ψ|2ψ = 0, is a nonlinear partial differential equation which is used to model several physical phenomena including nonlinear effects inside optical fibers and the formation of rogue waves in shallow water. It is particu- larly difficult to study solutions to this equation due to the nonlinearity, and the nonlinearity leads to incredibly interesting solutions not found in linear PDEs such as solitons. In this thesis, we highlight two methods of obtaining solutions to the (NLS) equation: the Inverse Scattering Transform and the Dressing Method. Furthermore, …


Investigating The Effects Of A Psychoplastogen On Depressive-Like Behaviors In Huntington Disease Model Mice, Kaleigh M. Hanley Jan 2025

Investigating The Effects Of A Psychoplastogen On Depressive-Like Behaviors In Huntington Disease Model Mice, Kaleigh M. Hanley

Honors Undergraduate Theses

Huntington Disease (HD) is a neurodegenerative disorder caused by an expansion in the trinucleotide CAG repeat on exon 1 of the huntingtin gene. In HD one of the first symptoms is often depression. In cases where SSRIs fail, treatments for treatment-resistant depression often become a patient’s only option. These rigorous treatments, such as electroconvulsive therapy, are not suitable for this patient population as it can worsen motor symptoms. In order to search for potential alternatives, we queried whether depressive-like behavior could be reduced in Hu97/18 and Q175FDN HD mice by administering tabernanthalog, a non-hallucinogenic psychedelic analog. Our study is not …


Heritage And Archaeological Knowledge Dissemination Strategies: A Kurd Qaburstan Case Study, Myli R. Sangria Jan 2025

Heritage And Archaeological Knowledge Dissemination Strategies: A Kurd Qaburstan Case Study, Myli R. Sangria

Honors Undergraduate Theses

This thesis addresses the long-standing absence of community archaeology initiatives in the Kurdistan Region of Iraq by designing and implementing a pilot public archaeology program at the site of Kurd Qaburstan, a large Middle Bronze Age city (ca. 1800 BCE) located on the Erbil Plain. In summer 2024, the author implemented a community archaeology activity designed as a first step toward sustained engagement with the village that partially overlaps the site. The program—a hands-on lesson in archaeological stratigraphy for K–5 students, followed by a guided site visit—was intentionally simple, affordable, and easy to carry out alongside ongoing fieldwork. The activity …


Comparative Efficacy Of Hallucinogens In Treating Mood Disorders Through A Meta-Analysis Of Symptom Reduction, Dosage, And Duration, John Marco D.F. Muniz Jan 2025

Comparative Efficacy Of Hallucinogens In Treating Mood Disorders Through A Meta-Analysis Of Symptom Reduction, Dosage, And Duration, John Marco D.F. Muniz

Honors Undergraduate Theses

Background: Hallucinogens including psilocybin, lysergic acid diethylamide (LSD), ketamine, N,N-dimethyltryptamine (DMT) (as ayahuasca), have re-emerged as potential rapid-acting treatments for mood disorders. We conducted a meta-analysis of placebo-controlled trials evaluating their efficacy in depression and anxiety disorders. Methods: A systematic review identified 12 trials (Total ≈ 670) meeting inclusion criteria (randomized, placebo-controlled). Data on Cohen’s d and Hedges’ g effect sizes for depression- and anxiety-related outcomes were extracted. We computed pooled effect sizes (weighted by sample size and inverse variance), performed subgroup analyses by drug, diagnosis, follow-up duration, and outcome measure type, and assessed heterogeneity (I2, Q …


Effect Of Metal Ions On The Reactive Oxygen Species Scavenging Capabilities Of Cerium Oxide For Biological Applications, Agastya Mittal Jan 2025

Effect Of Metal Ions On The Reactive Oxygen Species Scavenging Capabilities Of Cerium Oxide For Biological Applications, Agastya Mittal

Honors Undergraduate Theses

Ceria nanoparticles' capabilities to defend cells against oxidative stress through superoxide dismutase activity are well-documented. Ceria nanoparticles demonstrate a ratio between 3+/4+ oxidative states on the surface of the particles to exhibit oxygen vacancies, a feature that allows these particles to scavenge Reactive Oxygen Species (ROS) in times of Oxidative Stress. Oxidative stress arises from many wounds in the body, such as wounds in the skin, and can have significant impacts on the health of an individual. Even when receiving treatment for the skin wound, ROS can circulate from around the wound, be generated from an imbalance …


Optimization Of L-Citrulline Production In Corynebacterium Glutamicum, And The Effect Of The Human Small Intestine Environment, Simran S. Ghulldu Jan 2025

Optimization Of L-Citrulline Production In Corynebacterium Glutamicum, And The Effect Of The Human Small Intestine Environment, Simran S. Ghulldu

Honors Undergraduate Theses

L-citrulline is a crucial amino acid involved in nitric oxide production, which supports cardiovascular health, physical performance, and intestinal well-being. Nitric oxide deficiency is linked to conditions like hypertension, highlighting the need for efficient L-citrulline production. This study attempts to enhance L-citrulline synthesis in Corynebacterium glutamicum, a bacterium widely used in industrial amino acid production, as well as test a The hypothesis is that overexpressing carAB, which encodes carbamoyl phosphate synthetase, will increase carbamoyl phosphate levels and boost L-citrulline production. Two C. glutamicum strains were used: a wild type and the CRBG strain, which has mutations that promote …