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Multiomic Hypotheses Underlying Behavioral Manipulation Of Camponotus Floridanus Ants By Ophiocordyceps Camponoti-Floridani Fungi, Ian Will Jan 2022

Multiomic Hypotheses Underlying Behavioral Manipulation Of Camponotus Floridanus Ants By Ophiocordyceps Camponoti-Floridani Fungi, Ian Will

Electronic Theses and Dissertations, 2020-2023

Parasitic manipulation of host behavior lies at the intersection of disease, animal behavior, and coevolutionary processes. In many of these interactions, the underpinning biology is brought into sharp focus as they are obligate relationships, under strong selection to bring about specific changes in host behavior that determine if the parasite will transmit or die. However, experimental and molecular techniques to understand these interactions are still developing and identification of the mechanisms of manipulation is a primary goal in the field. As such, we investigated host-parasite interactions between Camponotus floridanus (Florida carpenter ant) and Ophiocordyceps camponoti-floridani (Florida zombie ant fungus) from …

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Uncooled Microbolometer Imaging Systems For Machine Vision, Robert Grimming Jan 2022

Uncooled Microbolometer Imaging Systems For Machine Vision, Robert Grimming

Electronic Theses and Dissertations, 2020-2023

Over the last 20 years, the cost of uncooled microbolometer-based imaging systems has drastically decreased while performance has increased. In the simplest terms, the figure of merit for these types of thermal detectors is given in terms of the τ-NETD product, the combination of the thermal time constant and the noise equivalent temperature difference. Considering these factors, optimal system design parameters are investigated to maximize visual information content. This dissertation focuses on improving scene information in the longwave infrared (LWIR) spectrum that has had its validity and quality degraded by noise, blur, and reflected radiance. Taken together, noise and blur …

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The Effect Of Audiovisual And Written Interactivity On Teacher-Candidates' Application Of Instructional Support Practices For English Learners In An Online Tesol Course, Sophie Cuocci Jan 2022

The Effect Of Audiovisual And Written Interactivity On Teacher-Candidates' Application Of Instructional Support Practices For English Learners In An Online Tesol Course, Sophie Cuocci

Electronic Theses and Dissertations, 2020-2023

With the increased number of English learners in the United States, teacher candidates need to be prepared to address their needs in their future classrooms. Teacher preparation programs around the nation are continuously exploring solutions to better develop teacher candidates' skills. Simultaneously, the rise in popularity of online education has pushed universities to identify and integrate technology tools which best promote students' learning. This study, connecting both challenges, aims to identify which type of interactivity promoted by technology, in an undergraduate online teaching English for speakers of other languages (TESOL) course, most benefits pre-service teachers in their ability to apply …

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Financial Sustainability Of Florida Cities: Comparative, Retrospective Modeling For Prospective Municipal Financial Health, Terry Henley Jan 2022

Financial Sustainability Of Florida Cities: Comparative, Retrospective Modeling For Prospective Municipal Financial Health, Terry Henley

Electronic Theses and Dissertations, 2020-2023

The Great Recession produced rising debt, deficits, and exposed vulnerabilities for municipalities in a globalist economy. The two-month COVID recession in 2020 accelerated these burdens; a lagging downturn recently added pressures of reduced economic activity, record inflation, and rising costs in 2022. This dissertation studies how local financial sustainability (FS) and financial condition (FC) approaches can work in concert towards a set of indicators with internal and external categorization to explain municipal financial health (MFH). Unassigned fund balance plus select formal stabilizations measure MFH, are conceptually supported in having retrospective (FC) and prospective (FS) value as an intergenerational resource and …

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Compulsory Conformity In Modern Japanese Culture: An Exploration Of Asexuality In The Works Of Murata Sayaka, Kawakami Mieko, And Kamatani Yuki, Nicholas Colecio Jan 2022

Compulsory Conformity In Modern Japanese Culture: An Exploration Of Asexuality In The Works Of Murata Sayaka, Kawakami Mieko, And Kamatani Yuki, Nicholas Colecio

Electronic Theses and Dissertations, 2020-2023

This thesis investigates the representation of asexual individuals in the works of Murata Sayaka, Kawakami Mieko, and Kamatani Yuki, all of whom are contemporary Japanese writers that portray near–suffocating social environments in their depictions of modern-day Japan. Their texts illustrate the augmented demands Japanese society places upon a cross-section of asexual and neurodivergent individuals. Despite the thematic and character–related similarities in their works, I argue that each author presents a unique interpretation of how these asexual individuals interact with—and try to integrate into—wider Japanese society and mainstream culture. Murata's texts demonstrate an unapologetically radical separatism by invoking an idealized queer …

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Development Of An Hipsc-Cortical Neuron Long-Term Potentiation Model And Its Application To Alzheimer's Disease Modeling And Drug Evaluation, Kaveena Autar Jan 2022

Development Of An Hipsc-Cortical Neuron Long-Term Potentiation Model And Its Application To Alzheimer's Disease Modeling And Drug Evaluation, Kaveena Autar

Electronic Theses and Dissertations, 2020-2023

Alzheimer's disease (AD) is commonly characterized by a loss of cognitive function due to the deterioration of neuronal synapses from the presence of senile amyloid beta-42 (Aß42) plaques. Evaluating cognitive deficits caused by Aß42 using human cortical neurons poses a challenge due to sourcing difficulties, and the use of animal models to assess drug efficacy creates biological hurdles from lack of species translatability. Recent advances in induced-pluripotent stem cell technology have enabled the development of mature, human-based cortical neuron models. The development of an hiPSC-cortical neuron differentiation protocol facilitates the exploration of disease onset and functional analysis from a patient-derived …

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Investigating Mobility Through An Oxygen Isotope Study Of The Medieval Cemetery At Kilroot, County Antrim, Northern Ireland, Hannah Pytleski Jan 2022

Investigating Mobility Through An Oxygen Isotope Study Of The Medieval Cemetery At Kilroot, County Antrim, Northern Ireland, Hannah Pytleski

Electronic Theses and Dissertations, 2020-2023

Mobility is an important, multifaceted process involving complex interactions of culture, politics, and economics while also intersecting with individual identities, like religion, status, gender, and age. As such, a multitude of people from different origins can comprise a settlement or a community, which may be detectable through biogeochemical assessment. This study employs stable oxygen and carbon isotopic analysis to evaluate evidence for residential mobility within the early to late Medieval Kilroot cemetery (c. 6th to 16th centuries A.D.) at County Antrim, Northern Ireland. The site is 2.8 miles (4.5 kilometers) east of Carrickfergus Castle and the surrounding town, which was …

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Spectrally-Based Color Calibration Of Microscopes For Birefringence Analysis, Olivia Feild Jan 2022

Spectrally-Based Color Calibration Of Microscopes For Birefringence Analysis, Olivia Feild

Electronic Theses and Dissertations, 2020-2023

The analysis of colors is omnipresent in forensics. While their use for macroscopic evidence such as soil sees a large amount of research, their correct handling is more challenging when observed under a microscope. Either for hairs or textile fibers, their color (from melanin, dyes or for birefringence analysis) is crucial in being able to compare between fibers found at a crime scene. Typically, color is quantified using a color space, such as RGB, XYZ, L*a*b*, and L*u*v*. Unfortunately, color is very subjective and often difficult to quantify accurately, even using digital detectors. Finding true matches of colors has been …

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Fibropapillomatosis And Chelonid Herpesvirus 5 Dynamics In Juvenile Green Turtles Of The Indian River Lagoon, Florida, Usa, Jake Kelley Jan 2022

Fibropapillomatosis And Chelonid Herpesvirus 5 Dynamics In Juvenile Green Turtles Of The Indian River Lagoon, Florida, Usa, Jake Kelley

Electronic Theses and Dissertations, 2020-2023

Fibropapillomatosis (FP) is a tumor-forming sea turtle disease that mainly affects juvenile green turtles (Chelonia mydas) in coastal foraging sites. The cause of FP is unclear, but likely involves the putative pathogen chelonid herpesvirus 5 (ChHV5). The overall dynamics of this disease are poorly understood, in part due to the difficulty of inferring disease and infection statuses of turtles without evidence of FP. In this study, I investigated the FP disease system in juvenile green turtles of the Indian River Lagoon (IRL), Florida, USA, to better understand disease and pathogen dynamics. First, I developed a hierarchical model for predicting FP …

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The Use Of Stable Carbon And Nitrogen Isotope Analyses To Examine Diet, Life Course, And Social Identities Among The Meroitic Elite Of Sai Island, Sudan, Rachel Lotze Jan 2022

The Use Of Stable Carbon And Nitrogen Isotope Analyses To Examine Diet, Life Course, And Social Identities Among The Meroitic Elite Of Sai Island, Sudan, Rachel Lotze

Electronic Theses and Dissertations, 2020-2023

The focus of this thesis is to learn more about the diets and lives of Nubian individuals who lived on Sai Island during the Meroitic period (250 BC to AD 250) using an approach based in life history, gender, and social identity theory. These individuals were in buried the cemetery 8-B-52.B and they were part of the elite social class. Dietary analysis was conducted by analyzing the stable carbon and nitrogen isotopes from bulk samples of human bone collagen. A total of 34 bone samples were analyzed, and 31 of those samples were determined to be well-preserved. These data were …

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Analyzing Cut Mark Characteristics On Bone From Chopping/Hacking Tools: Implications For Forensic Analysis, Kelly Mcgehee Jan 2022

Analyzing Cut Mark Characteristics On Bone From Chopping/Hacking Tools: Implications For Forensic Analysis, Kelly Mcgehee

Electronic Theses and Dissertations, 2020-2023

Sharp force trauma (SFT) is a mechanism of traumatic injury in which a tool with a pointed or slanted edge impacts the skin and/or bone, producing a penetrating cut mark. Current assessment of forensic and bioarchaeological contexts typically focuses on evaluating and interpreting traumatic injuries to bone due to cutting and stabbing using small, bladed tools, primarily knives and saws. Minimal research focuses on the damage inflicted by a larger class of chopping/hacking tools. Therefore, the purpose of this research was to experimentally evaluate and analyze macroscopic characteristics of chopping/hacking trauma inflicted on pig bones (Sus scrofa domesticus) to determine …

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Deciphering The Role And Clinical Application Of The Fgfr4-Klb-Fgf19 Axis In Colorectal Neoplastic Progression, Michael Rohr Jan 2022

Deciphering The Role And Clinical Application Of The Fgfr4-Klb-Fgf19 Axis In Colorectal Neoplastic Progression, Michael Rohr

Electronic Theses and Dissertations, 2020-2023

Colorectal cancer (CRC) is the third most common and third deadliest cancer worldwide with rising incidence rates attributed to environmental risk factors like diet. Investigating how these factors impact carcinogenesis requires an understanding of how transcriptional events evolve with respect to neoplastic progression. We employed meta-transcriptomics and latent trajectory modeling to establish a compendium of profiled healthy, adenoma, and CRC samples scored by their position along a pseudotemporal axis. By interpolating a continuous scale from cross-sectional data, dynamic processes occurring throughout disease progression can be analyzed more accurately. For example, smaller pseudotimes represented pre-malignant dysplasia and was characterized by cellular …

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Endless Curiosity, Ryan Price Jan 2022

Endless Curiosity, Ryan Price

Electronic Theses and Dissertations, 2020-2023

Growing up in an image-based society with television, computer screens, and a massive swell of visual media leaves me overloaded with imagery and information. I seek to find beauty in the strangeness of interconnected nostalgia of family memories, loss and grief, escapism, and video games. I process and excavate my personal history by romanticizing memories, relationships, and the passage of time. I do this with constructed visual worlds created through the physical processes of drawing, bookbinding, ceramics, printmaking, and painting. I use references and influences from 20th-century artists Paul Klee, James Ensor, and Jim Nutt to connect and interweave video …

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Development Of A Computational Application To Aid With Chemometric And Forensic Analysis Of Fire Debris Samples, Michelle Corbally Jan 2022

Development Of A Computational Application To Aid With Chemometric And Forensic Analysis Of Fire Debris Samples, Michelle Corbally

Electronic Theses and Dissertations, 2020-2023

Fire debris analysis is a forensic science discipline that determines if an ignitable liquid residue is present or absent in a fire debris sample. Currently, fire debris analysis results in categorical statements based on qualitative data, not the quantitative evidentiary value of data. The purpose of this research was to develop a novel software application to aid fire debris analysts in the identification and classification of ignitable liquid residues that are found in fire debris samples. The developed application uses target factor analysis (TFA) and Pearson correlation for compound identification in gas chromatograms using mass spectral comparison and allows for …

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Cholera Transmission Dynamic Model With Environmental Impacts Of Plankton Reservoirs, Sweety Sarker Jan 2022

Cholera Transmission Dynamic Model With Environmental Impacts Of Plankton Reservoirs, Sweety Sarker

Electronic Theses and Dissertations, 2020-2023

Cholera is an acute disease that is a global threat to the world and can kill people within a few hours if left untreated. In the last 200 years, seven pandemics occurred, and, in some countries, it remains endemic. The World Health Organization (WHO) declared a global initiative to prevent cholera by 2030. Cholera dynamics are contributed by several environmental factors such as salinity level of water, water temperature, presence of plankton especially zooplankton such as cladocerans, rotifers, copepods, etc. Vibrio cholerae (V. cholerae) bacterium is the main reason behind the cholera disease and the growth of V. cholerae depends …

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Uncovering Ophelia: The Reclamation Of Women's Madness Through Feminist Disability Studies, Amy Crawford Jan 2022

Uncovering Ophelia: The Reclamation Of Women's Madness Through Feminist Disability Studies, Amy Crawford

Electronic Theses and Dissertations, 2020-2023

In his essay "The Philosophy of Composition," Edgar Allan Poe proclaims that "the death of a beautiful woman is unquestionably the most poetical topic in the world," and this sentiment remains curiously persistent within the literary world. Artists have looked towards their beautiful muses for centuries as a source of inspiration and introspection, and the faces that these muses wear were often swooning, longing, or even dead. Nineteenth-century British aesthetics solidified a gendered ideology that remains prevalent to this day; in particular, one subculture of Victorian aesthetics that emerged during this period was the Cult of Ophelia: a collection of …

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Un-Portalable! An Animated Exploration In Boundaries And Relational Design, Ira Klages Jan 2022

Un-Portalable! An Animated Exploration In Boundaries And Relational Design, Ira Klages

Electronic Theses and Dissertations, 2020-2023

Un-Portalable! is an animated multimedia short film about two friends who become fused together after using a faulty teleporter. They attempt to conceal their deformity while simultaneously navigating a social situation with one of their friends. The main focus in the film is the concept that boundaries tend to become clearer as they begin to break. This conceptual focus merges into the visual theory of the film in which highly expressive character design and hybrid media utilization are driven by relational and narrative design choices. This film serves as a condensed pilot and proof of concept for a larger prospective …

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The Universal Story: Coming-Of-Age In Contemporary Animation, Christina Christie Jan 2022

The Universal Story: Coming-Of-Age In Contemporary Animation, Christina Christie

Electronic Theses and Dissertations, 2020-2023

Cycles is a 3D animated short film about a father who struggles to keep up with his daughter as she races through life. Whereas most coming-of-age films focus solely on the journey of the adolescent, Cycles subverts the expectations of the genre by exploring the impact growing up has on both the parent and child in tandem. As a film, Cycles relies on the careful and deliberate use of tropes, informed character and environment design, and established cinematic devices to support the story's theme of accepting change. Though my personal experience inspired this film, it evolved into a contemporary and …

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Evaluating Novel Combinations Of Polyamine Targeting Therapeutics In Pancreatic Ductal Adenocarcinoma, Sai Preethi Nakkina Jan 2022

Evaluating Novel Combinations Of Polyamine Targeting Therapeutics In Pancreatic Ductal Adenocarcinoma, Sai Preethi Nakkina

Electronic Theses and Dissertations, 2020-2023

Pancreatic cancer overall has a poor five-year survival rate of less than 8%. Well-tolerated regimens and immune cell infiltration to promote anti-cancer treatments are major challenges. Studies described herein leveraged testing different combinations/doses of polyamine targeting inhibitors to further understand the impact of targeting key polyamine pathway mediators in pancreatic ductal adenocarcinoma (PDAC). Placebo controls were compared to groups treated with difluoromethylornithine (DFMO, a polyamine biosynthesis inhibitor of ornithine decarboxylase), different polyamine transport inhibitors, and compound combinations in strategies for polyamine blockage therapy (PBT). Informatic analyses showed that the dysregulation of key polyamine pathway mediators are associated with poor patient …

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Mathematical Model For Giraffe Population Dynamics, Huntir Bass Jan 2022

Mathematical Model For Giraffe Population Dynamics, Huntir Bass

Electronic Theses and Dissertations, 2020-2023

Since the 1980s the overall giraffe population has dropped at least 40% causing some researchers to label this rapid decline as the "Silent Extinction." Due to this plummet, understanding the behaviors of the giraffe population is absolutely necessary before they are on the brink of extinction. Through the usage of mathematical modeling methodologies, a general model is created to illustrate the relationship between juvenile and adult female giraffes through numerous interaction parameters. Variations on specific variables generate different simulations, which allows more biological accuracy. With each variation having an established coexistence equilibrium between the juvenile and adult female populations, the …

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2022 International Crisis And Risk Communication Conference Program, Conference Organizers Jan 2022

2022 International Crisis And Risk Communication Conference Program, Conference Organizers

International Crisis and Risk Communication Conference

Program to the to the 11th Annual International Crisis and Risk Communication Conference sponsored by the Nicholson School of Communication and Media.

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Limited Court Access V. Poor And Indigent, Chinyere Anunobi Jan 2022

Limited Court Access V. Poor And Indigent, Chinyere Anunobi

Honors Undergraduate Theses

In criminal cases, poor individuals must qualify as legally indigent to receive legal representation. In civil cases, poor and indigent individuals must find their own resources to support themselves since the government does not guarantee counsel. Without counsel, poor and indigent individuals are forced to find legal representation for these cases on their own, which can be difficult considering the expenses of fees and fines. Cognitive processes, including bias and stereotypes, create a barrier in advocacy because they cloud judgement of decision-makers, which can diminish the voice of this vulnerable community. Barriers like these create an invisible wall where limited …

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A Look Into Alzheimer’S Disease—Interventions At The Molecular Level, Priscila Feliciano Nieves Jan 2022

A Look Into Alzheimer’S Disease—Interventions At The Molecular Level, Priscila Feliciano Nieves

Honors Undergraduate Theses

There are puzzle pieces to the cure for Alzheimer’s Disease (AD), and such can emerge by inspecting the biomolecular interactions and their effects on neuronal cells. The upcoming presented literature review will cover the molecular changes caused by AD pathological progression, explore the relationship between non-AD molecules and AD molecules in the body, and analyze potential contributing factors in AD. In addition, the information to be provided will highlight medicinal alternatives respective to a particular stage in AD.

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Methods For Characterization Of Cl-001 Derived Exosomes As A Stimulating Agent For Nk Cells For Immunotherapy, Ilana Gomez Diaz Jan 2022

Methods For Characterization Of Cl-001 Derived Exosomes As A Stimulating Agent For Nk Cells For Immunotherapy, Ilana Gomez Diaz

Honors Undergraduate Theses

The immune system is a complex set of cells in the body that work to prevent disease or infection by recognizing and eliminating foreign material or unhealthy cells. One essential type of immune cell that is part of the innate immune response are Natural Killer (NK) cells. These cytotoxic effector lymphocytes can detect certain unhealthy cells, such as cancer cells, that normal B and T cells would miss. For example, many tumor cells have evolved to bypass immune system surveillance by not expressing major histocompatibility complex class I molecules (MHC class I), on their surface, reducing recognition by cytotoxic T …

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The Effect Of Young Blood Anti-Aging Treatment On Protein Markers Of Age And Huntington Disease, Sujena H. Koilpillai Jan 2022

The Effect Of Young Blood Anti-Aging Treatment On Protein Markers Of Age And Huntington Disease, Sujena H. Koilpillai

Honors Undergraduate Theses

Huntington disease (HD) is a neurodegenerative disorder caused by expansion of a polyglutamine tract within the huntingtin (HTT) protein, forming mutant HTT (mtHTT). HD patients suffer from psychiatric, behavioral, cognitive, and motor abnormalities, with death typically occurring 15-20 years after symptom onset. Currently, there are no treatments able to slow disease progression or delay onset. HD is a disease of aging. Despite the mtHTT protein being produced throughout life, symptoms do not typically appear until adulthood. Furthermore, many cellular effects of normal aging are also seen in HD, including altered intercellular communication and loss of proteostasis. Recently, our lab found …

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Regulation Of The Protease Activity For The Mitochondrial Omi/Htra2, Simon Larson Jan 2022

Regulation Of The Protease Activity For The Mitochondrial Omi/Htra2, Simon Larson

Honors Undergraduate Theses

Human High Temperature requirement A2 (HtrA2) also known as Omi, is a serine protease located in the mitochondria with an important function in both cell survival and death. My results show the proteolytic activity of Omi/HtrA2 varies under different conditions. I characterized the optimal condition for Omi/HtrA2 protease activity using an in vitro assay system. Additionally, I identified a new allosteric regulation of Omi/HtrA2 through interaction with a specific substrate, the MUL1 protein. MUL1 is a multifunctional E3 ubiquitin ligase anchored in the outer mitochondrial membrane with domains both inside mitochondria and in the cytoplasm. The data shown here strongly …

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The Intertwined Relationship Of Stress And Sleep Quality Of Undergraduate Students During The Covid-19 Pandemic, Jordan Nguyen Jan 2022

The Intertwined Relationship Of Stress And Sleep Quality Of Undergraduate Students During The Covid-19 Pandemic, Jordan Nguyen

Honors Undergraduate Theses

This study aims to examine the relationship between stress and sleep of undergraduate students during the course of the COVID-19 pandemic. The possibly correlational relationship between these two parameters was determined with respect to how this population was faring during recent times, two years into the pandemic. The study also served to examine how this relationship changed over time based on three time frames: before the pandemic, during the advent of the lockdown (March 2020-May 2020), and during recent times. A survey was developed to collect data from the undergraduate participants for correlation and regression analysis to determine the relationship …

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The Use Of Exogenous Acrp30 As A Promising Amelioratory Compound Regarding Insulin Resistance And Type Ii Diabetes Mellitus, Stephen L. Romero Jan 2022

The Use Of Exogenous Acrp30 As A Promising Amelioratory Compound Regarding Insulin Resistance And Type Ii Diabetes Mellitus, Stephen L. Romero

Honors Undergraduate Theses

As numerous bodies of research have characterized the adipocytokine adiponectin (ACRP30) as an anti-diabetic compound, this work serves as an analysis to partly elucidate the potential usage of supplementary adiponectin as a therapeutic compound in the treatment of type II diabetes mellitus. In this work, a meta-analysis was conducted to centralize large amounts of data on adiponectin’s insulin sensitizing characteristics in conjunction with like-minded studies utilizing metformin treatment as the diabetic standard of care. Upon comparison of fasting glucose, fasting insulin, and glucose tolerance test area under the curve reduction percentages, it is quite clear that ACRP30 has significant insulin …

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The Role Of The Prefrontal Cortex And Stress In Huntington Disease-Mediated Aggression, Kadambari Vyas Jan 2022

The Role Of The Prefrontal Cortex And Stress In Huntington Disease-Mediated Aggression, Kadambari Vyas

Honors Undergraduate Theses

Huntington Disease (HD) is a fatal neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric symptoms. Although HD onset is determined by motor symptoms, psychiatric symptoms, like depression and aggression, can develop earlier, have a larger impact on quality of life, and are understudied due to stigma. Our lab has observed hyper aggression in our humanized HD mouse model (Hu97/18) compared to our knock-in HD mouse model (Q175FDN). We characterized these differences and found that the Hu97/18 mice overreact in neutral situations, behaving as if they are in threatening situations. We are now using this novel model of HD-related …

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The Relationship Between Sarcopenia And Diabetes Among Different Ethnic Groups, Rachel K. Williams Jan 2022

The Relationship Between Sarcopenia And Diabetes Among Different Ethnic Groups, Rachel K. Williams

Honors Undergraduate Theses

Sarcopenia and diabetes are two conditions that reflect ongoing changes in global health trends: aging and obesity. Sarcopenia affects approximately 10-40% of the global population and type II diabetes affects around 415 million individuals (6.28% globally), with obesity contributing to a majority of the cases. Currently, approximately 9.3% of the population (727 million individuals) is aged 65 years or older; this number is predicted to reach 16% of the global population (around 1.5 billion individuals) in 2050. Many developed countries are undergoing demographic population pyramid rearrangements whereby an increasingly aging population must be supported by a shrinking youth cohort. Sarcopenia …

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