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Recollections: An Internal Analysis Of Memory And Perception, Samuel Jimenez Jan 2014

Recollections: An Internal Analysis Of Memory And Perception, Samuel Jimenez

Electronic Theses and Dissertations

I investigate the depths of memory, the entanglement of personal recollections with communal knowledge (learned semantic information from media and society such as facts and social norms) and the changing perceptions of environments over time. Memories define us. Throughout life we are exposed to vast quantities of imagery through a variety of media and personal experiences. Over time our firsthand experiences and what we witness in film, print, photography, and the internet become indistinguishable in our memory. My work recreates consequential scenes from my past through technical drawings and blended imagery while exploring the possibilities provided by the interaction of …

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An Uncooled Mid-Wave Infrared Detector Based On Optical Response Of Laser-Doped Silicon Carbide., Geunsik Lim Jan 2014

An Uncooled Mid-Wave Infrared Detector Based On Optical Response Of Laser-Doped Silicon Carbide., Geunsik Lim

Electronic Theses and Dissertations

This dissertation focuses on an uncooled Mid-Wave Infra-Red (MWIR) detector was developed by doping an n-type 4H-SiC with Ga using the laser doping technique. 4H-SiC is one of the polytypes of crystalline silicon carbide, a wide bandgap semiconductor. The dopant creates an energy level of 0.30 eV, which was confirmed by optical spectroscopy of the doped sample. This energy level corresponds to the MWIR wavelength of 4.21 µm. The detection mechanism is based on the photoexcitation of electrons by the photons of this wavelength absorbed in the semiconductor. This process modifies the electron density, which changes the refraction index and, …

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Pen-Based Methods For Recognition And Animation Of Handwritten Physics Solutions, Salman Cheema Jan 2014

Pen-Based Methods For Recognition And Animation Of Handwritten Physics Solutions, Salman Cheema

Electronic Theses and Dissertations

There has been considerable interest in constructing pen-based intelligent tutoring systems due to the natural interaction metaphor and low cognitive load afforded by pen-based interaction. We believe that pen-based intelligent tutoring systems can be further enhanced by integrating animation techniques. In this work, we explore methods for recognizing and animating sketched physics diagrams. Our methodologies enable an Intelligent Tutoring System (ITS) to understand the scenario and requirements posed by a given problem statement and to couple this knowledge with a computational model of the student's handwritten solution. These pieces of information are used to construct meaningful animations and feedback mechanisms …

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A Spatial Analysis Of Chachapoya Mortuary Practices At La Petaca, Chachapoyas, Peru, Lori Epstein Jan 2014

A Spatial Analysis Of Chachapoya Mortuary Practices At La Petaca, Chachapoyas, Peru, Lori Epstein

Electronic Theses and Dissertations

Diversity of Chachapoya mortuary practices is not well understood archaeologically, even though the region has received some attention for the monumental constructions and visually striking mortuary complexes located high on open cliff faces. This may be due to the difficult accessibility and often poor state of preservation consistent with many Chachapoya mortuary and occupation sites. This thesis reconstructs mortuary practices at La Petaca in the Chachapoyas region of Peru, applying paleodemographic and GIS methodological approaches to facilitate and improve the bioarchaeological study of commingled skeletal remains in an open, disturbed communal funerary context. Research focused on SUP CF-01, a natural …

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Keren, Shelly Bradon Jan 2014

Keren, Shelly Bradon

Electronic Theses and Dissertations

The intent of this thesis is to recognize the everyday victories of a child living with physical disabilities. This complicated subject matter has forced the exploration of a variety of media to successfully communicate the story; drawing, painting, china painting, altered books and sculpture have all become part of the process. At the age of 8 months the subject, Keren Hernandez, was diagnosed with Bilateral Closed- lip Schizencephaly, a rare disorder that inhibits development. Since the diagnosis seven years ago her family has struggled to overcome these challenges, committing to avail themselves to every resource possible. I began painting and …

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The State Of The Anti-Union Address: A Rhetorical Critique Of Select Service Worker Training Methods, Richard Ries Jan 2014

The State Of The Anti-Union Address: A Rhetorical Critique Of Select Service Worker Training Methods, Richard Ries

Electronic Theses and Dissertations

This is an interdisciplinary master's level thesis that explores links among technical writing, training manuals, surveillance, and anti-union rhetoric used with service workers in select American chains and franchises. Brief histories are provided, including those of technical writing, the rise of unions in America, and how technical writing became inextricably linked with labor. A major shift occurred in the 20th century when workers began interacting less with products and more with the public. The research focuses on training manuals, techniques, and rehearsed dialogues of McDonald's, Wal-Mart, Starbucks, Whole Foods, Panera, and Publix, though similar organizations are referenced. Service worker language, …

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Wild Florida: Tourism Before Disney, Exhibit Brochure, Amanda Richards Jan 2014

Wild Florida: Tourism Before Disney, Exhibit Brochure, Amanda Richards

Rosen Library Exhibits

No abstract provided.

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Preparation, Characterization, And Delivery Of Antibodies Binding To A Model Oncogenic Rna, Human Initiator Trna, Jennifer Archer Jan 2014

Preparation, Characterization, And Delivery Of Antibodies Binding To A Model Oncogenic Rna, Human Initiator Trna, Jennifer Archer

Electronic Theses and Dissertations

Non-coding RNAs (ncRNAs) account for a higher percent of the genome than coding mRNAs, and are implicated in human disease such as cancer, neurological, cardiac and many others. While the majority of ncRNAs involved in disease were originally attributed to a class of RNAs called micro RNAs (miRNAs) with a small size of only about 19 -24 base pairs, emerging research has now demonstrated a class of long non-coding RNAs (lncRNAs) that have a size of over 200 base pairs to be responsible for gene regulation and other functional roles and have also found to contribute to pathogenesis in humans. …

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Creating Constructs Through Categorization: Gender And Race, Joshua Simpkins Jan 2014

Creating Constructs Through Categorization: Gender And Race, Joshua Simpkins

Electronic Theses and Dissertations

In U.S. society, the systems of gender and race operate to privilege and oppress individuals based on their location within these systems. All of the interactions an individual experiences as they go about their day-to-day lives are shaped by these interlocking systems. As a result, there is an extensive body of sociological literature addressing how individuals in U.S. society are privileged and oppressed on the basis of their perceived membership in gender and race categories; however, relatively little research exists examining how individuals come to be seen by others as members of gender and race categories in the first place. …

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Functional Scaffolding For Musical Composition: A New Approach In Computer-Assisted Music Composition, Amy K. Hoover Jan 2014

Functional Scaffolding For Musical Composition: A New Approach In Computer-Assisted Music Composition, Amy K. Hoover

Electronic Theses and Dissertations

While it is important for systems intended to enhance musical creativity to define and explore musical ideas conceived by individual users, many limit musical freedom by focusing on maintaining musical structure, thereby impeding the user's freedom to explore his or her individual style. This dissertation presents a comprehensive body of work that introduces a new musical representation that allows users to explore a space of musical rules that are created from their own melodies. This representation, called functional scaffolding for musical composition (FSMC), exploits a simple yet powerful property of multipart compositions: The pattern of notes and rhythms in different …

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A Framework For Workforce Management An Agent Based Simulation Approach, Mario Marin Jan 2014

A Framework For Workforce Management An Agent Based Simulation Approach, Mario Marin

Electronic Theses and Dissertations

In today's advanced technology world, enterprises are in a constant state of competition. As the intensity of competition increases the need to continuously improve organizational performance has never been greater. Managers at all levels must be on a constant quest for finding ways to maximize their enterprises' strategic resources. Enterprises can develop sustained competitiveness only if their activities create value in unique ways. There should be an emphasis to transfer this competitiveness to the resources it has on hand and the resources it can develop to be used in this environment. The significance of human capital is even greater now, …

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Thermoregulatory Strategy May Shape Immune Investment In Drosophila Melanogaster, Ian C. Kutch, Hasan Sevgili, Tyler Wittman, Kenneth M. Fedorka Jan 2014

Thermoregulatory Strategy May Shape Immune Investment In Drosophila Melanogaster, Ian C. Kutch, Hasan Sevgili, Tyler Wittman, Kenneth M. Fedorka

Faculty Bibliography 2010s

As temperatures change, insects alter the amount of melanin in their cuticle to improve thermoregulation. However, melanin is also central to insect immunity, suggesting that thermoregulatory strategy may indirectly impact immune defense by altering the abundance of melanin pathway components (a hypothesis we refer to as thermoregulatory-dependent immune investment). This may be the case in the cricket Allonemobius socius, where warm environments (both seasonal and geographical) produced crickets with lighter cuticles and increased pathogen susceptibility. Unfortunately, the potential for thermoregulatory strategy to influence insect immunity has not been widely explored. Here we address the relationships between temperature, thermoregulatory strategy and …

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The Ct20 Peptide Causes Detachment And Death Of Metastatic Breast Cancer Cells By Promoting Mitochondrial Aggregation And Cytoskeletal Disruption, M. W. Lee, R. Bassiouni, N. A. Sparrow, A. Iketani, R. J. Boohaker, C. Moskowitz, P. Vishnubhotla, A. S. Khaled, J. Oyer, A. Copik, C. Fernandez-Valle, J. M. Perez, A. R. Khaled Jan 2014

The Ct20 Peptide Causes Detachment And Death Of Metastatic Breast Cancer Cells By Promoting Mitochondrial Aggregation And Cytoskeletal Disruption, M. W. Lee, R. Bassiouni, N. A. Sparrow, A. Iketani, R. J. Boohaker, C. Moskowitz, P. Vishnubhotla, A. S. Khaled, J. Oyer, A. Copik, C. Fernandez-Valle, J. M. Perez, A. R. Khaled

Faculty Bibliography 2010s

Metastasis accounts for most deaths from breast cancer, driving the need for new therapeutics that can impede disease progression. Rationally designed peptides that take advantage of cancer-specific differences in cellular physiology are an emerging technology that offer promise as a treatment for metastatic breast cancer. We developed CT20p, a hydrophobic peptide based on the C terminus of Bax that exhibits similarities with antimicrobial peptides, and previously reported that CT20p has unique cytotoxic actions independent of full-length Bax. In this study, we identified the intracellular actions of CT20p which precede cancer cell-specific detachment and death. Previously, we found that CT20p migrated …

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A Unified Framework For Individualized Avatar-Based Interactions, Arjun Nagendran, Remo Pillat, Adam Kavanaugh, Greg Welch, Charles Hughes Jan 2014

A Unified Framework For Individualized Avatar-Based Interactions, Arjun Nagendran, Remo Pillat, Adam Kavanaugh, Greg Welch, Charles Hughes

Faculty Bibliography 2010s

This paper presents a framework to interactively control avatars in remote environments. The system, called AMITIES,. serves as the central component that connects people controlling avatars (inhabiters), various manifestation's of these avatars (surrogates), and people interacting with these avatars (participants). A multiserver client architecture, based on a low-demand network protocol, connects the participant environment(s), the inhabiter station(s), and the avatars. A human-in-the-loop metaphor provides an interface for remote operation, with support for multiple inhabiters, multiple avatars, and multiple participants. Custom animation blending routines and a gesture-based interface provide inhabiters with an intuitive avatar control paradigm. This gesture control is enhanced …

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The Effect Of Normally Consumed Amounts Of Sucrose Or High Fructose Corn Syrup On Lipid Profiles, Body Composition And Related Parameters In Overweight/Obese Subjects, Joshua Lowndes, Stephanie Sinnett, Sabrina Pardo, Von T. Nguyen, Kathleen J. Melanson, Zhiping Yu, Britte E. Lowther, James M. Rippe Jan 2014

The Effect Of Normally Consumed Amounts Of Sucrose Or High Fructose Corn Syrup On Lipid Profiles, Body Composition And Related Parameters In Overweight/Obese Subjects, Joshua Lowndes, Stephanie Sinnett, Sabrina Pardo, Von T. Nguyen, Kathleen J. Melanson, Zhiping Yu, Britte E. Lowther, James M. Rippe

Faculty Bibliography 2010s

The American Heart Association (AHA) has advocated that women and men not consume more than 100 and 150 kcal/day, respectively, from added sugars. These levels are currently exceeded by over 90% of the adult population in the United States. Few data exist on longer-term metabolic effects when sucrose and High Fructose Corn Syrup (HFCS), the principal sources of added dietary sugars, are consumed at levels typical of the general population. Sixty five overweight and obese individuals were placed on a eucaloric (weight stable) diet for 10-weeks, which incorporated sucrose- or HFCS-sweetened, low-fat milk at 10% or 20% of calories in …

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The Effects Of Fructose-Containing Sugars On Weight, Body Composition And Cardiometabolic Risk Factors When Consumed At Up To The 90th Percentile Population Consumption Level For Fructose, Joshua Lowndes, Stephanie Sinnett, Zhiping Yu, James Rippe Jan 2014

The Effects Of Fructose-Containing Sugars On Weight, Body Composition And Cardiometabolic Risk Factors When Consumed At Up To The 90th Percentile Population Consumption Level For Fructose, Joshua Lowndes, Stephanie Sinnett, Zhiping Yu, James Rippe

Faculty Bibliography 2010s

The American Heart Association (AHA) and World Health Organization (WHO) have recommended restricting calories from added sugars at lower levels than the Institute of Medicine (IOM) recommendations, which are incorporated in the Dietary Guidelines for Americans 2010 (DGAs 2010). Sucrose (SUC) and high fructose corn syrup (HFCS) have been singled out for particular concern, because of their fructose content, which has been specifically implicated for its atherogenic potential and possible role in elevating blood pressure through uric acid-mediated endothelial dysfunction. This study explored the effects when these sugars are consumed at typical population levels up to the 90th percentile population …

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Tcr Triggering By Pmhc Ligands Tethered On Surfaces Via Poly(Ethylene Glycol) Depends On Polymer Length, Zhengyu Ma, David N. Lebard, Sharon M. Loverde, Kim A. Sharp, Michael L. Klein, Dennis E. Discher, Terri H. Finkel Jan 2014

Tcr Triggering By Pmhc Ligands Tethered On Surfaces Via Poly(Ethylene Glycol) Depends On Polymer Length, Zhengyu Ma, David N. Lebard, Sharon M. Loverde, Kim A. Sharp, Michael L. Klein, Dennis E. Discher, Terri H. Finkel

Faculty Bibliography 2010s

Antigen recognition by T cells relies on the interaction between T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC). The pMHC-TCR interaction is two-dimensional (2D), in that both the ligand and receptor are membrane-anchored and their movement is limited to 2D diffusion. The 2D nature of the interaction is critical for the ability of pMHC ligands to trigger TCR. The exact properties of the 2D pMHC-TCR interaction that enable TCR triggering, however, are not fully understood. Here, we altered the 2D pMHC-TCR interaction by tethering pMHC ligands …

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The Contribution Of Visceral Fat To Improved Insulin Signaling In Ames Dwarf Mice, Vinal Menon, Xu Zhi, Tanvir Hossain, Andrzej Bartke, Adam Spong, Adam Gesing, Michal M. Masternak Jan 2014

The Contribution Of Visceral Fat To Improved Insulin Signaling In Ames Dwarf Mice, Vinal Menon, Xu Zhi, Tanvir Hossain, Andrzej Bartke, Adam Spong, Adam Gesing, Michal M. Masternak

Faculty Bibliography 2010s

Ames dwarf (Prop1df, df/df) mice are characterized by growth hormone (GH), prolactin, and thyrotropin deficiency, remarkable extension of longevity and increased insulin sensitivity with low levels of fasting insulin and glucose. Plasma levels of anti-inflammatory adiponectin are increased in df/df mice, while pro-inflammatory IL-6 is decreased in plasma and epididymal fat. This represents an important shift in the balance between pro- and anti-inflammatory adipokines in adipose tissue, which was not exposed to GH signals during development or adult life. To determine the role of adipose tissue in the control of insulin signaling in these long-living mutants, we examined the effects …

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Notch-1 Mediated Cardiac Protection Following Embryonic And Induced Pluripotent Stem Cell Transplantation In Doxorubicin-Induced Heart Failure, Hilda Merino, Dinender K. Singla Jan 2014

Notch-1 Mediated Cardiac Protection Following Embryonic And Induced Pluripotent Stem Cell Transplantation In Doxorubicin-Induced Heart Failure, Hilda Merino, Dinender K. Singla

Faculty Bibliography 2010s

Doxorubicin (DOX), an effective chemotherapeutic drug used in the treatment of various cancers, is limited in its clinical applications due to cardiotoxicity. Recent studies suggest that transplanted adult stem cells inhibit DOX-induced cardiotoxicity. However, the effects of transplanted embryonic stem (ES) and induced pluripotent stem (iPS) cells are completely unknown in DOX-induced left ventricular dysfunction following myocardial infarction (MI). In brief, C57BL/6 mice were divided into five groups: Sham, DOX-MI, DOX-MI+ cell culture (CC) media, DOX-MI+ ES cells, and DOX-MI+ iPS cells. Mice were injected with cumulative dose of 12 mg/kg of DOX and 2 weeks later, MI was induced …

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Mycobacterium Avium Subspecies Paratuberculosis Causes Crohn's Disease In Some Inflammatory Bowel Disease Patients, Saleh A. Naser, Sudesh R. Sagramsingh,, Abed S. Naser, Saisathya Thanigachalam Jan 2014

Mycobacterium Avium Subspecies Paratuberculosis Causes Crohn's Disease In Some Inflammatory Bowel Disease Patients, Saleh A. Naser, Sudesh R. Sagramsingh,, Abed S. Naser, Saisathya Thanigachalam

Faculty Bibliography 2010s

Crohn's disease (CD) is a chronic inflammatory condition that plagues millions all over the world. This debilitating bowel disease can start in early childhood and continue into late adulthood. Signs and symptoms are usually many and multiple tests are often required for the diagnosis and confirmation of this disease. However, little is still understood about the cause(s) of CD. As a result, several theories have been proposed over the years. One theory in particular is that Mycobacterium avium subspecies paratuberculosis (MAP) is intimately linked to the etiology of CD. This fastidious bacterium also known to cause Johne's disease in cattle …

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A Chemical Biology Approach Identified Pi3k As A Potential Therapeutic Target For Neurofibromatosis Type 2, Alejandra M. Petrilli, Marisa A. Fuse, Mathew S. Donnan, Marga Bott, Nicklaus A. Sparrow, Daniel Tondera, Julia Huffziger, Corina Frenzel, C. Siobhan Malany, Christophe J. Echeverri, Layton Smith, Cristina Fernández-Valle Jan 2014

A Chemical Biology Approach Identified Pi3k As A Potential Therapeutic Target For Neurofibromatosis Type 2, Alejandra M. Petrilli, Marisa A. Fuse, Mathew S. Donnan, Marga Bott, Nicklaus A. Sparrow, Daniel Tondera, Julia Huffziger, Corina Frenzel, C. Siobhan Malany, Christophe J. Echeverri, Layton Smith, Cristina Fernández-Valle

Faculty Bibliography 2010s

Mutations in the merlin tumor suppressor gene cause Neurofibromatosis type 2 (NF2), which is a disease characterized by development of multiple benign tumors in the nervous system. The current standard of care for NF2 calls for surgical resection of the characteristic tumors, often with devastating neurological consequences. There are currently no approved non-surgical therapies for NF2. In an attempt to identify much needed targets and therapeutically active compounds for NF2 treatment, we employed a chemical biology approach using ultra-highthroughput screening. To support this goal, we created a merlin-null mouse Schwann cell (MSC) line to screen for compounds that selectively decrease …

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Kruppel-Like Factor 15 Is A Critical Regulator Of Cardiac Lipid Metabolism, Domenick A. Prosdocimo, Priti Anand, Xudong Liao, Han Zhu, Shamanthika Shelkay, Pedro Artero-Caldero, Lilei Zhang, Jacob Kirsh, D'Vesharronne Moore, Mariana G. Rosca, Edwin Vazquez, Janos Kerner, Kemal M. Akat, Zev Williams, Jihe Zhao, Hisashi Fujioka, Thomas Tuschl, Xiaodong Bai, P. Christina Schulze, Charles L. Hoppel, Mukseh K. Jain, Saptarsi M. Halder Jan 2014

Kruppel-Like Factor 15 Is A Critical Regulator Of Cardiac Lipid Metabolism, Domenick A. Prosdocimo, Priti Anand, Xudong Liao, Han Zhu, Shamanthika Shelkay, Pedro Artero-Caldero, Lilei Zhang, Jacob Kirsh, D'Vesharronne Moore, Mariana G. Rosca, Edwin Vazquez, Janos Kerner, Kemal M. Akat, Zev Williams, Jihe Zhao, Hisashi Fujioka, Thomas Tuschl, Xiaodong Bai, P. Christina Schulze, Charles L. Hoppel, Mukseh K. Jain, Saptarsi M. Halder

Faculty Bibliography 2010s

Background: Metabolic homeostasis is central to normal cardiac function. The molecular mechanisms underlying metabolic plasticity in the heart remain poorly understood. Results: Kruppel-like factor 15 (KLF15) is a direct and independent regulator of myocardial lipid flux. Conclusion: KLF15 is a core component of the transcriptional circuitry that governs cardiac metabolism. Significance: This work is the first to implicate the KLF transcription factor family in cardiac metabolism. The mammalian heart, the body's largest energy consumer, has evolved robust mechanisms to tightly couple fuel supply with energy demand across a wide range of physiologic and pathophysiologic states, yet, when compared with other …

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Pathophysiology Of Autism Spectrum Disorders: Revisiting Gastrointestinal Involvement And Immune Imbalance, Mohtashem Samsam, Raheleh Ahangari, Saleh A. Naser Jan 2014

Pathophysiology Of Autism Spectrum Disorders: Revisiting Gastrointestinal Involvement And Immune Imbalance, Mohtashem Samsam, Raheleh Ahangari, Saleh A. Naser

Faculty Bibliography 2010s

Autism spectrum disorders (ASD) comprise a group of neurodevelopmental abnormalities that begin in early childhood and are characterized by impairment of social communication and behavioral problems including restricted interests and repetitive behaviors. Several genes have been implicated in the pathogenesis of ASD, most of them are involved in neuronal synaptogenesis. A number of environmental factors and associated conditions such as gastrointestinal (GI) abnormalities and immune imbalance have been linked to the pathophysiology of ASD. According to the March 2012 report released by United States Centers for Disease Control and Prevention, the prevalence of ASD has sharply increased during the recent …

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Toward In Vitro Models Of Brain Structure And Function, Michael L. Shuler, James J. Hickman Jan 2014

Toward In Vitro Models Of Brain Structure And Function, Michael L. Shuler, James J. Hickman

Faculty Bibliography 2010s

No abstract provided.

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Utilization Of Microscale Silicon Cantilevers To Assess Cellular Contractile Function In Vitro, Alec S. T. Smith, Christopher J. Long, Christopher Mcaleer, Nathaniel Bobbitt, Balaji Srinivasan, James J. Hickman Jan 2014

Utilization Of Microscale Silicon Cantilevers To Assess Cellular Contractile Function In Vitro, Alec S. T. Smith, Christopher J. Long, Christopher Mcaleer, Nathaniel Bobbitt, Balaji Srinivasan, James J. Hickman

Faculty Bibliography 2010s

The development of more predictive and biologically relevant in vitro assays is predicated on the advancement of versatile cell culture systems which facilitate the functional assessment of the seeded cells. To that end, microscale cantilever technology offers a platform with which to measure the contractile functionality of a range of cell types, including skeletal, cardiac, and smooth muscle cells, through assessment of contraction induced substrate bending. Application of multiplexed cantilever arrays provides the means to develop moderate to high-throughput protocols for assessing drug efficacy and toxicity, disease phenotype and progression, as well as neuromuscular and other cell-cell interactions. This manuscript …

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Histone Deacetylase Inhibitors Selectively Target Homology Dependent Dna Repair Defective Cells And Elevate Non-Homologous Endjoining Activity, Stephanie Smith, Jennifer Fox, Marco Mejia, Wanvipa Ruangpradit, Alihossein Saberi, Sunmi Kim, Yongjum Choi, Sehyun Oh, Yucai Wang, Kyungho Choi, Lei Li, Eric A. Hendrickson, Shunichi Takeda, Mark Muller, Kyungjae Myung Jan 2014

Histone Deacetylase Inhibitors Selectively Target Homology Dependent Dna Repair Defective Cells And Elevate Non-Homologous Endjoining Activity, Stephanie Smith, Jennifer Fox, Marco Mejia, Wanvipa Ruangpradit, Alihossein Saberi, Sunmi Kim, Yongjum Choi, Sehyun Oh, Yucai Wang, Kyungho Choi, Lei Li, Eric A. Hendrickson, Shunichi Takeda, Mark Muller, Kyungjae Myung

Faculty Bibliography 2010s

Background: We have previously used the ATAD5-luciferase high-throughput screening assay to identify genotoxic compounds with potential chemotherapeutic capabilities. The successful identification of known genotoxic agents, including the histone deacetylase inhibitor (HDACi) trichostatin A (TSA), confirmed the specificity of the screen since TSA has been widely studied for its ability to cause apoptosis in cancer cells. Because many cancers have acquired mutations in DNA damage checkpoints or repair pathways, we hypothesized that these cancers may be susceptible to treatments that target compensatory pathways. Here, we used a panel of isogenic chicken DT40 B lymphocyte mutant and human cell lines to investigate …

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Death And Disability In A Younge Phase Community, Michael W. Spence, Lana J. Williams, Sandra M. Wheeler Jan 2014

Death And Disability In A Younge Phase Community, Michael W. Spence, Lana J. Williams, Sandra M. Wheeler

Faculty Bibliography 2010s

Roffelsen is an early Younge phase mortuary component in southwestern Ontario. The single burial feature is a pit containing the articulated skeletons of seven successively buried individuals, ranging in age from a few months to late middle age. All had been stripped of soft tissues, except for the connecting tissues that maintained their articulation. Most also had a disk cut from the cranium and a hole drilled near bregma. All but the Want display various forms of developmental failure of the outer and middle ear and the petrous portion of the temporal bone. The pit was apparently the burial facility …

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Growth Hormone Action Predicts Age-Related White Adipose Tissue Dysfunction And Senescent Cell Burden In Mice, Michael B. Stout, Tamara Tchkonia, Tamar Pirtskhalava, Allyson K. Palmer, Edward O. List, Darlene E. Berryman, Ellen R. Lubbers, Carlos Escande, Adam Spong, Michal M. Masternak, Ann L. Oberg, Nathan K. Lebrasseur, Richard A. Miller, John J. Kopchick, Andrzej Bartke, James L. Kirkland Jan 2014

Growth Hormone Action Predicts Age-Related White Adipose Tissue Dysfunction And Senescent Cell Burden In Mice, Michael B. Stout, Tamara Tchkonia, Tamar Pirtskhalava, Allyson K. Palmer, Edward O. List, Darlene E. Berryman, Ellen R. Lubbers, Carlos Escande, Adam Spong, Michal M. Masternak, Ann L. Oberg, Nathan K. Lebrasseur, Richard A. Miller, John J. Kopchick, Andrzej Bartke, James L. Kirkland

Faculty Bibliography 2010s

The aging process is associated with the development of several chronic diseases. White adipose tissue (WAT) may play a central role in age-related disease onset and progression due to declines in adipogenesis with advancing age. Recent reports indicate that the accumulation of senescent progenitor cells may be involved in age-related WAT dysfunction. Growth hormone (GH) action has profound effects on adiposity and metabolism and is known to influence lifespan. In the present study we tested the hypothesis that GH activity would predict age-related WAT dysfunction and accumulation of senescent cells. We found that long-lived GH-deficient and -resistant mice have reduced …

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Targeting The Biophysical Properties Of The Myeloma Initiating Cell Niches: A Pharmaceutical Synergism Analysis Using Multi-Scale Agent-Based Modeling, Jing Su, Le Zhang, Wen Zhang, Dong Song Choi, Jianguo Wen, Beini Jiang, Chung-Che Chang, Xiaobo Zhou Jan 2014

Targeting The Biophysical Properties Of The Myeloma Initiating Cell Niches: A Pharmaceutical Synergism Analysis Using Multi-Scale Agent-Based Modeling, Jing Su, Le Zhang, Wen Zhang, Dong Song Choi, Jianguo Wen, Beini Jiang, Chung-Che Chang, Xiaobo Zhou

Faculty Bibliography 2010s

Multiple myeloma, the second most common hematological cancer, is currently incurable due to refractory disease relapse and development of multiple drug resistance. We and others recently established the biophysical model that myeloma initiating (stem) cells (MICs) trigger the stiffening of their niches via SDF-1/CXCR4 paracrine; The stiffened niches then promote the colonogenesis of MICs and protect them from drug treatment. In this work we examined in silico the pharmaceutical potential of targeting MIC niche stiffness to facilitate cytotoxic chemotherapies. We first established a multi-scale agent-based model using the Markov Chain Monte Carlo approach to recapitulate the niche stiffness centric, pro-oncogenetic …

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In Vitro Selection Of Dna Aptamers Against Prostate Cancer Peptide Biomarkers, Elif Kuguoglu Jan 2014

In Vitro Selection Of Dna Aptamers Against Prostate Cancer Peptide Biomarkers, Elif Kuguoglu

HIM 1990-2015

This project is aimed toward finding DNA aptamers against prostate cancer peptide antigens. DNA aptamers can function to find and indicate the presence of certain molecules in a specimen. These aptamers will be obtained through the process of evolutionary selection, a specific process called SELEX which stands for Systemic Evolution of Ligands by Experimental Enrichment. By conducting several rounds of SELEX, a DNA aptamer will be selected to bind to a known peptide antigen. A biotinylated column will be utilized to stabilize a random library of DNA aptamers, and those peptides that bind to certain aptamers will cause a conformational …

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