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Resolution Of Crohn's Disease And Complex Regional Pain Syndrome Following Treatment Of Paratuberculosis, J. Todd Kuenstner, William Chamberlin, Saleh A. Naser, Michael T. Collins, Coad Thomas Dow, John M. Aitken, Stuart Weg, Grzegorz Telega, Kuruvilla John, David Haas, Torsten M. Eckstein, Maher Kali, Christine Welch, Thomas Petrie Jan 2015

Resolution Of Crohn's Disease And Complex Regional Pain Syndrome Following Treatment Of Paratuberculosis, J. Todd Kuenstner, William Chamberlin, Saleh A. Naser, Michael T. Collins, Coad Thomas Dow, John M. Aitken, Stuart Weg, Grzegorz Telega, Kuruvilla John, David Haas, Torsten M. Eckstein, Maher Kali, Christine Welch, Thomas Petrie

Faculty Bibliography 2010s

A cohort of family members with various chronic diseases including Crohn's disease, asthma, complex regional pain syndrome, hypothyroidism, type 1 diabetes mellitus, and lymphangiomatosis and/or evidence of infection by Mycobacterium avium subsp. paratuberculosis (MAP) are described in this series of case reports. MAP was cultured from the blood of three members affected by the first five diseases and there was accompanying elevated anti-MAP IgG in two members. The patient affected by the sixth disease has a markedly elevated anti-MAP titer. The two patients affected by the first four diseases have been treated with a combination of anti-MAP antibiotics and ultraviolet …

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The Third Island: A Novella, Iris Mora Jan 2015

The Third Island: A Novella, Iris Mora

HIM 1990-2015

The Third Island is a novella about a Puerto Rican woman of Spanish descent who faces her biggest fear—death. Death comes in many forms and for Laura Maria De La Esperanza Castel, it comes in the form of a man with whom she thinks she is in love. Vacationing on an island in the Bahamas, novelist Laura Castel finds that the only way to survive is to overcome her fear and reject being controlled by the figure who is trying to take her. She overcomes many obstacles and is taught about self-sufficiency, the history of repression of minorities groups or …

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Evaluation Of Strength And Hydraulic Properties Of Buried Pipe Systems Used For Stormwater Harvesting, Mario Samson Mena Jan 2015

Evaluation Of Strength And Hydraulic Properties Of Buried Pipe Systems Used For Stormwater Harvesting, Mario Samson Mena

Electronic Theses and Dissertations

Water scarcity has been identified as a global issue. Both water harvesting and an efficient water piping system are some of the important factors to meet the water demand. In this study, high-density polyethylene (HDPE) pipes used as an underground storage was evaluated and a Microsoft EXCEL based model was developed, called PIPE-R Model. To study the structural integrity of the pipes, laboratory and field testing were conducted. For the water harvesting, UCF Stormwater Management Academy designed an EXCEL based model to simulate the system's performance to store and redistribute water for an average year. The purpose of PIPE-R Model …

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The Design Plan For A Comprehensive Financial Literacy Program, Karemah Manselle Jan 2015

The Design Plan For A Comprehensive Financial Literacy Program, Karemah Manselle

Electronic Theses and Dissertations

The need for financial literacy among Americans has become a national topic of interest. Economists, financial professionals, educators, and government officials recognize there is an overall deficit of financial knowledge. More specifically, higher education administrators have become increasingly concerned with ensuring that financial literacy tools are available to college students. Students of today face higher tuition and education-related costs, are less likely to receive grant funding to assist with their educational expenses, and are more likely to be in debt, carrying higher student debt loads than previous generations. Further, students lack the financial knowledge needed to make sound financial decisions. …

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Overexpression Of Human Cu/Zn Superoxide Dismutase In Mice; The Effect Of Increase Superoxide Scavenging On Autonomic Control Of The Heart., Jeffrey Hatcher Jan 2015

Overexpression Of Human Cu/Zn Superoxide Dismutase In Mice; The Effect Of Increase Superoxide Scavenging On Autonomic Control Of The Heart., Jeffrey Hatcher

Electronic Theses and Dissertations

Dysregulation of the autonomic cardiovascular control is a complication of diseases including diabetes, hypertension, sleep apnea, and aging. A common factor in these conditions is an increase in reactive oxygen species (ROS) in neural, cardiac, and endothelial tissues. Cu/Zn superoxide dismutase (SOD1) is an intracellular anti-oxidant enzyme that catalyzes dismutation of the superoxide anion (O2.-) to hydrogen peroxide (H2O2). Expression and function of this enzyme are diminished in pathologies that impair cardiovascular autonomic control. This study employed mice overexpressing a transgene for human SOD1 (hSOD1) to determine if its overexpression would alter autonomic regulation of BP, HR, and BRS in …

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Exploring Social Identity Through Stable Isotope Analysis In The Kellis 2 Cemetery, Kaitlin East Jan 2015

Exploring Social Identity Through Stable Isotope Analysis In The Kellis 2 Cemetery, Kaitlin East

Electronic Theses and Dissertations

The material remains of ancient Egypt provide extensive and wide ranging data about the empire throughout its history. However, little evidence is available from ancient Egypt, or any past culture, with which to rebuild an image of social identity or individual experiences. This is especially problematic when the dominant narrative ignores experiences of minorities and minimizes the variation existing throughout the empire. Stable isotope analysis has the potential to reveal variability in lived experience of past peoples by acting as a proxy for behavior that can be analyzed from bone. Such an approach has been applied on individuals from the …

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Nano And Nanostructured Materials For Optical Applications, Panit Chantharasupawong Jan 2015

Nano And Nanostructured Materials For Optical Applications, Panit Chantharasupawong

Electronic Theses and Dissertations

Nano and nanostructured materials offer unique physical and chemical properties that differ considerably from their bulk counterparts. For decades, due to their fascinating properties, they have been extensively explored and found to be beneficial in numerous applications. These materials are key components in many cutting-edge optic and photonic technologies, including photovoltaics, waveguides and sensors. In this dissertation, the uses of nano and nanostructured materials for optical applications are investigated in the context of optical limiting, three dimensional displays, and optical sensing. Nanomaterials with nonlinear optical responses are promising candidates for self-activating optical limiters. In the first part of this study, …

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Identification Of The Domain(S) In Protein Disulfide Isomerase Required For Binding And Disassembly Of The Cholera Holotoxin, Laura Herndon Jan 2015

Identification Of The Domain(S) In Protein Disulfide Isomerase Required For Binding And Disassembly Of The Cholera Holotoxin, Laura Herndon

HIM 1990-2015

Cholera, caused by the secretion of cholera toxin (CT) by Vibrio cholerae within the intestinal lumen, triggers massive secretory diarrhea which may lead to life-threatening dehydration. CT is an AB5-type protein toxin that is comprised of an enzymatically active A1 chain, an A2 linker, and a cell-binding B pentamer. Once secreted, the CT holotoxin moves from the cell surface to the endoplasmic reticulum (ER) of a host target cell. To cause intoxication, CTA1 must be displaced from CTA2/CTB5 in the ER and is then transferred to the cytosol where it induces a diarrheal response by stimulating the efflux of chloride …

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Detection And Characterization Of Pathogenic Mycobacteria Using Binary Deoxyribozymes, Bradley Rosenkrantz Jan 2015

Detection And Characterization Of Pathogenic Mycobacteria Using Binary Deoxyribozymes, Bradley Rosenkrantz

HIM 1990-2015

The genus Mycobacterium contains many pathogenic bacteria that are known to cause serious diseases in humans. One of the most well-known of these bacteria is Mycobacterium tuberculosis, or Mtb, which is the causative agent of tuberculosis. It infects nearly one-third of the world’s population and kills 1.4 million people annually. Another important mycobacterial pathogen is Mycobacterium abscessus, or Mabs, which causes respiratory infections in cystic fibrosis patients. One of the biggest difficulties in combating these pathogens is the lack of effective diagnostics, as current strategies hold many pitfalls and can be unreliable. One common method used is sputum smear microscopy …

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Hepatic Lipase Regulates Lipoprotein Trafficking In Hepatocytes, Simeon Thibeaux Jan 2015

Hepatic Lipase Regulates Lipoprotein Trafficking In Hepatocytes, Simeon Thibeaux

HIM 1990-2015

The production of very low density lipoprotein and high density lipoprotein particles by the liver is a tightly regulated process, which begins with synthesis and assembly of core protein components in the rough endoplasmic reticulum. Factors influencing the production and metabolism of these particles are of immediate medical relevance, as their malfunction or hyperactivity can lead to an assortment of disease states. Hepatic lipase is a secreted liver enzyme, with many previously described roles in the metabolism and clearance of both high and low density lipoproteins. Increased production and assembly of this enzyme is an indicator of metabolic dysfunction, while …

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Empowerment Unit Plan For Haitian Restavek Children, Ashley Craig Jan 2015

Empowerment Unit Plan For Haitian Restavek Children, Ashley Craig

HIM 1990-2015

Restavek, French for "one who stays with", is a word used to describe child slaves in Haiti. These children are given away by their parents at a young age because of financial hardships or for hopes of life in the urban areas to be better than life in the rural areas. The Restaveks, far from their family and anyone they know, end up as slaves without access to education, healthcare, and sometimes food. As a result, many of these children suffer from malnutrition, abuse, and illnesses. The majority of Restaveks are young girls. In the communities, they are shunned and …

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Exploring The Legal Liability Of Genetically Modified Organisms And Their Impact On Society, Jarrett Davis Jan 2015

Exploring The Legal Liability Of Genetically Modified Organisms And Their Impact On Society, Jarrett Davis

HIM 1990-2015

Controversy surrounds the use of Genetically Modified organisms (GMOs): whether the process of developing GMOs should be allowed, and if so, how they should be labeled. Efforts by activist groups have caused food associated with GMOs to carry a stigma, but farmers across the nation are fighting to continue to grow GMO crops and maximize their yield. In the 1970’s, GMOs were credited for assisting in the attempt to defeat world hunger and had a positive image. However, there has been a recent trend toward political and consumer resistance of food items that contains GMOs. A prediction of an abrupt …

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Colloquia Education: An Examination Of Roman Second Language Education For Social Implications, Jennifer Newton Jan 2015

Colloquia Education: An Examination Of Roman Second Language Education For Social Implications, Jennifer Newton

HIM 1990-2015

The expansion of the Roman Empire had compelled disparate cultures to mingle and assimilate. In relation to education this fact meant that teachers used a variety of curricula to convey an amalgamation of cultural dynamics. Evidence for this phenomenon is found in the content Colloquia, a fourth-century elementary language textbook, which displays aspects Greek and Roman culture through the explicit and implicit instruction of the text. The existence of this mixture education displays the motivations of the author, as well as information about the values of the contemporary culture.

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Deciphering Holland's Code, Dennis D. Turner Jan 2015

Deciphering Holland's Code, Dennis D. Turner

HIM 1990-2015

The Party Exercise found on countless career guidance websites and popularized by the best-selling, job-hunting book What Color Is Your Parachute (Bolles, 2015) purports to provide an estimate of an individual's Holland's code. This study examines whether this commonly used Party Exercise accurately predicts an individual's Holland's code (Holland, 1997). Undergraduate students (N=473) completed The Party Exercise and then the Self- Directed Search (Holland & Messer, 2013). The results of this study do not support the use of this popular “Party Exercise” as a valid estimate of an individual's Holland code.

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Polyamine Transport Inhibitor Effects On Pancreatic Cancer Proliferation Cells In Vivo, Frederick Hogan Jan 2015

Polyamine Transport Inhibitor Effects On Pancreatic Cancer Proliferation Cells In Vivo, Frederick Hogan

HIM 1990-2015

Pancreatic cancer is a serious disease, one in which the survival rate over five years is less than 6%. (1) Often, malignant tumors will exhibit uncontrolled proliferation and it is postulated that they have high metabolic needs. One of the areas of interest in cancer metabolism is the unique need for large amounts of polyamines in order to sustain this uncontrolled proliferation. Polyamines are organic compounds that all cells need for proliferation and differentiation. (2) Cells obtain polyamines by manufacture of them directly or obtain them from the environment through their transport across the cell membrane. When cancer cells have …

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Mir-9 Promotes Microglial Activation By Targeting Mcpip1, Honghong Yao, Rong Ma, Guoku Hu, Xufeng Chen, Ming Duan, Yeonhee Kook, Fang Niu, Ke Liao, Minggui Fu, Gang Hu, Pappachan Kolattukudy, Shilpa Buch Jan 2015

Mir-9 Promotes Microglial Activation By Targeting Mcpip1, Honghong Yao, Rong Ma, Guoku Hu, Xufeng Chen, Ming Duan, Yeonhee Kook, Fang Niu, Ke Liao, Minggui Fu, Gang Hu, Pappachan Kolattukudy, Shilpa Buch

Faculty Bibliography 2010s

Microglia participate in innate inflammatory responses within the central nervous system. The highly conserved microRNA-9 (miR-9) plays critical roles in neurogenesis as well as axonal extension. Its role in microglial inflammatory responses, however, remains poorly understood. Here we identify a unique role of miR-9 in mediating the microglial inflammatory response via distinct signalling pathways. MiR-9-mediated regulation of cellular activation involved downregulated expression of the target protein, monocyte chemotactic protein-induced protein 1 (MCPIP1) that is crucial for controlling inflammation. Results indicate that miR-9-mediated cellular activation involved signalling via the NF-kappa B pathway, but not the beta-catenin pathway.

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Complete Issue, Volume 34, Issue 1 Jan 2015

Complete Issue, Volume 34, Issue 1

Journal of the Association for Communication Administration

This is the complete issue for Volume 34, Issue 1 of the Journal of the Association for Communication Administration.

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From “Safe Spaces” To “Communicative Spaces”: Semiotic Labor, Authentic Civility And The Basic Communication Course, Hannah Karolak, Craig T. Maier Jan 2015

From “Safe Spaces” To “Communicative Spaces”: Semiotic Labor, Authentic Civility And The Basic Communication Course, Hannah Karolak, Craig T. Maier

Journal of the Association for Communication Administration

Difficult conversations and controversial topics are common in the basic communication classroom, raising difficult challenges for course directors, instructors, and students. In response to this problem, many in higher education promote the development of “safe spaces.” Drawing from Eicher-Catt’s work on civility, this essay suggests shifting the focus from safe spaces to the development and maintenance of what Eicher-Catt calls communicative spaces. The notion of communicative spaces, when extended into the classroom, reorients our understanding of classroom civility and suggests practices for course directors, instructors, and students that affirm the dignity of students by attending not to their emotional needs …

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Urban Agriculture Within The Valley Of Oaxaca: Investigations And Implications Of Agricultural Terracing At Monte Alban, Oaxaca, Anthony Tricarico Jan 2015

Urban Agriculture Within The Valley Of Oaxaca: Investigations And Implications Of Agricultural Terracing At Monte Alban, Oaxaca, Anthony Tricarico

Electronic Theses and Dissertations

The implementation of geographic information systems for the analysis of Late Classic (500-800 C.E.) terraces at Monte Albán, reveals a spatial pattern not visible through prior pedestrian site surveys. The Valley of Oaxaca Settlement Pattern Project concluded that nearly all of the 1,464 Late Classic terraces at Monte Albán were used for residential purposes. Spatial analysis tools reveal a greater human-ecological complexity. The goal of this study was to use ArcGIS to map the 1,273 terraces near Monte Albán's ceremonial center and combine them with individually identifiable data sets. Analysis of each terrace, particularly based upon water availability, ceramic distribution, …

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Black Skies And Gray Matter, Jacquelyn Bennett Jan 2015

Black Skies And Gray Matter, Jacquelyn Bennett

Electronic Theses and Dissertations

Black Skies and Gray Matter is a collection of stories thematically centered on characters that are lonely or lost in the world. These stories explore the characters' personalities through their interactions with others (strangers, family, friends, and spouses) and the difficulties they face being misunderstood. Their journeys are ones of trying to find happiness and their place in society (or rejecting it). As they face alienation, they must endure the trials of everyday life (some more extreme than others) and, at the same time, search for kindred spirits, a sense of belonging. Some stay true to themselves while others conform …

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Genetic Structure And Demographic Analysis Of Key Deer (Odocoileus Virginianus Clavium), Vicki Villanova Jan 2015

Genetic Structure And Demographic Analysis Of Key Deer (Odocoileus Virginianus Clavium), Vicki Villanova

Electronic Theses and Dissertations

Recent improvements in genetic analyses have paved the way in using molecular data to answer questions regarding evolutionary history, genetic structure, and demography. Key deer are a federally endangered subspecies assumed to be genetically unique (based on one allozyme study), homogeneous, and have a female-biased population of approximately 900 deer. I used 985bp of the mitochondrial cytochrome b gene and 12 microsatellite loci to test two hypotheses: 1) if the Moser Channel is a barrier to gene flow, I should expect that Key deer are differentiated and have reduced diversity compared to mainland deer and (2) if isolation on islands …

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Instant Conductors, Mary Petralia Jan 2015

Instant Conductors, Mary Petralia

Electronic Theses and Dissertations

Instant Conductors is a collection of poems meant to engage the reader in conversation about the imperfect nature of the world in relation to the imperfect nature of readerly experience. Walt Whitman wrote, “I have instant conductors all over me whether I pass or stop / they seize every object and lead it harmlessly through me.” And so the things on these pages are intent on transmitting what one experiences in the minutiae of memory and routine: the sounds that surround a blackwater tidepool, what one imagines happens behind the closed doors of the friendly neighbors, or what's heard in …

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The Effect Of Precipitation On The Spread Of Mosquito-Borne Diseases: A Case Study Of Florida Counties, Marvin Osbourne Jan 2015

The Effect Of Precipitation On The Spread Of Mosquito-Borne Diseases: A Case Study Of Florida Counties, Marvin Osbourne

Electronic Theses and Dissertations

The state of Florida is the third most populous state in the United States of America, with six (6) of its metropolitan areas dubbed as the fastest growing in the entire country. A mosquito bite may mean the transmission of a virus or disease which might be fatal. Hence, there is a need for the state to control mosquitoes through the various Departments of Mosquito Control in each of its sixty-seven (67) counties. Six locally acquired mosquito-borne viruses which affect humans and animals in the state of Florida were considered. This thesis used statistical methods to examine data for rainfall, …

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An Investigation Of The Impacts Of Face-To-Face And Virtual Laboratories In An Introductory Biology Course On Students' Motivation To Learn Biology., Amber Reece Jan 2015

An Investigation Of The Impacts Of Face-To-Face And Virtual Laboratories In An Introductory Biology Course On Students' Motivation To Learn Biology., Amber Reece

Electronic Theses and Dissertations

The objective of this study was to evaluate and compare the effects of face-to-face and virtual laboratories in a large-enrollment introductory biology course on students* motivation to learn biology. The laboratory component of post-secondary science courses is where students have opportunities for frequent interactions with instructors and their peers (Seymour & Hewitt, 1997; Seymour, Melton, Wiese, & Pederson-Gallegos, 2005) and is often relied upon for promoting interest and motivation in science learning (Hofstein & Lunetta, 2003; Lunetta, Hofstein, & Clough, 2007). However, laboratory courses can be resource intensive (Jenkins, 2007), leading post-secondary science educators to seek alternative means of laboratory …

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"A Memorial And A Name": Construction Of Public Memory Through Chronotopic Arrangement Of Antecedent Genre At Yad Vashem, Emily Brennan Jan 2015

"A Memorial And A Name": Construction Of Public Memory Through Chronotopic Arrangement Of Antecedent Genre At Yad Vashem, Emily Brennan

Electronic Theses and Dissertations

This spring marked the 70th anniversary of the defeat of the Nazis and the end of the Holocaust in Europe. Memory of this genocide has occupied a central place in Israeli identity since the establishment of the state. This thesis explores the history of Holocaust memory in Israel and examines how public memory is constructed in the present, as the era of the survivor draws to a close and commemorative efforts linked to survivors take on a sense of urgency. The contemporary memorial places examined in this study are part of Yad Vashem, Israel*s premier institution for Holocaust commemoration. The …

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A High-Content Multiplexed Screening Platform For The Evaluation And Manipulation Of Force And Fatigue Of Adult Derived Skeletal Muscle Myotubes In Defined Serum-Free Medium, Christopher Mcaleer Jan 2015

A High-Content Multiplexed Screening Platform For The Evaluation And Manipulation Of Force And Fatigue Of Adult Derived Skeletal Muscle Myotubes In Defined Serum-Free Medium, Christopher Mcaleer

Electronic Theses and Dissertations

The overall focus of this project has two parts: First, was to develop a protocol utilizing serum-free media formulations and defined plating and culture techniques to create functional in vitro myotubes derived from adult skeletal muscle satellite cells. The second was to manipulate the inherent muscle parameters such as force output and fatigue of these myotubes by employing exercise regimes or by small molecule application. The importance of serum-free medium use for in vitro cultures is becoming increasingly important in creating functional systems that can be validated for drug testing by the Food and Drug Administration (FDA). Also, the study …

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Friendship And Informant Characteristics Associated With Agreement Among Adolescent And Friend Ratings Of Behavior Problems., Brea-Anne Lauer Jan 2015

Friendship And Informant Characteristics Associated With Agreement Among Adolescent And Friend Ratings Of Behavior Problems., Brea-Anne Lauer

Electronic Theses and Dissertations

Although teacher and parent informants often are used to gather information regarding adolescents* emotional and behavioral functioning, research has suggested that agreement among these raters and adolescents* self-ratings tends to be low to moderate. Given that friends typically play an important role in the lives of adolescents, the present study sought to determine the relative agreement amongst adolescent self-reports and those of their friends as well as factors that might impact this agreement. In particular, a sample of 207 culturally diverse high school students were matched based on perceived friendship closeness and asked to provide ratings of their own emotional …

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The Effect Of Pre-Service Teaching On Student Achievement Using A Co-Teaching Model At An Elementary School In A Large, Urban School District In Central Florida, Walton Mchale Jan 2015

The Effect Of Pre-Service Teaching On Student Achievement Using A Co-Teaching Model At An Elementary School In A Large, Urban School District In Central Florida, Walton Mchale

Electronic Theses and Dissertations

This study was focused on the effect of pre-service teaching utilizing a co-teaching model on student achievement at an elementary school in a large, urban school district in central Florida. The contribution of university student teachers (i.e., interns) to elementary school achievement was investigated. Specifically explored was the difference between student achievement scores in classes with interns who participated in a co-teaching model and interns in classes that did not employ any structured approach to intern teaching. The researcher compared seven classes that employed co-teaching, where the university intern teacher and master teacher remained in the class conducting instruction, to …

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Diabetes Phenotypes In Transgenic Pancreatic Cancer Mouse Models, Toya Albury-Warren Jan 2015

Diabetes Phenotypes In Transgenic Pancreatic Cancer Mouse Models, Toya Albury-Warren

Electronic Theses and Dissertations

Protein Kinase B/AKT, a serine/threonine kinase with three isoforms (AKT1-3), is downstream of phosphatidylinositol 3-kinase (PI3K), and signals through the phosphorylation and subsequent activation or inhibition of downstream substrates, such as mammalian target of rapamycin complex 1 (mTORC1) or glycogen synthase kinase 3 beta (GSK-3?), respectively. The AKT1 isoform is predominantly recognized for regulation of cell survival, growth, and proliferation, due to its constitutive activation in pancreatic cancers (e.g., islet cell carcinoma and pancreatic adenocarcinoma). The progression of pancreatic ductal adenocarcinoma (PDAC), the most lethal common cancer, is initiated by activation mutations of the KRas oncogene. This leads to additional …

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Inverse-Consistent Determination Of Young's Modulus Of Human Lung, Behnaz Seyfi Noferest Jan 2015

Inverse-Consistent Determination Of Young's Modulus Of Human Lung, Behnaz Seyfi Noferest

Electronic Theses and Dissertations

Human lung undergoes respiration-induced deformation due to sequential inhalation and exhalation. Accurate determination of lung deformation is crucial for tumor localization and targeted radiotherapy in patients with lung cancer. Numerical modeling of human lung dynamics based on underlying physics and physiology enables simulation and virtual visualization of lung deformation. Dynamical modeling is numerically complicated by the lack of information on lung elastic behavior, structural heterogeneity as well as boundary constrains. This study integrates physics-based modeling and image-based data acquisition to develop the patient-specific biomechanical model and consequently establish the first consistent Young's modulus (YM) of human lung. This dissertation has …

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