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Articles 1741 - 1770 of 7189
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Imagining Communicative Success: How Imagined Interactions Affect Conflict Management In Romantic Relationships, Melinda Shaw
Imagining Communicative Success: How Imagined Interactions Affect Conflict Management In Romantic Relationships, Melinda Shaw
Graduate Theses and Dissertations
Currently, there are no bodies of research that examine the relationship between imagined interactions, relational maintenance, conflict management, and gender identity. Previous research has primarily relied on quantitatively measuring the functionality of imagined interactions and generating an understanding as to why individuals use them. However, this study qualitatively examined the connection between these concepts, specifically how gender identity affects how individuals use imagined interactions to manage conflict with their partner and maintain their relationship. Fifteen participants who are currently in long-term relationships were interviewed and then required to complete the Thomas-Kilmann (1974) conflict management mode survey. Afterward, the responses were …
Preparation Of Proteins And Peptides From Heat-Stabilized Defatted Rice Bran Via Solid State Fermentation And Investigating For Skin Health, Ali A. Bisly
Graduate Theses and Dissertations
Heat-stabilized defatted rice bran (HDRB) is an abundant and inexpensive agro-industrial by-product of rice milling and rice oil extraction process. Furthermore, HDRB is a potential source of proteins. However, the direct protein extraction has low yield of protein due to the impact of heat stabilization and oil extraction process which made the HDRB proteins bound and interact with other components. This research is based on using solid-state fermentation (SSF), which is a natural and cost-effective approach to facilitate protein extraction from HDRB using Bacillus subtilis (natto) Takahashi as a microorganism.
Response surface methodology (RSM) analysis was used with Box-Behnken design …
Managing Stress Tolerance On Warm-Season Putting Greens In The Transition Zone, Thomas Edward Walton
Managing Stress Tolerance On Warm-Season Putting Greens In The Transition Zone, Thomas Edward Walton
Graduate Theses and Dissertations
The use of warm-season putting greens in the transition zone has increased in recent years. Ultradwarf bermudagrass (Cynodon dactylon (L.) Pers x C. transvaalensis Burtt-Davy) is the most prevalent warm-season putting green selection in the transition zone, however, newly developed greens-type zoysiagrass (Zoysia spp.) cultivars represent another potential selection for golf courses. The two major limitations of warm-season grasses in the transition zone are a general lack of cold- and shade-tolerance. Protective covers are essential to protect ultradwarf bermudagrass putting greens in the winter months. Unfortunately, golf courses can still experience winterkill underneath protective covers. Two field trials were conducted …
Making Connections: Understanding How Social Interaction Patterns Influence Work-Related Outcomes For Individuals With Disabilities, Christine Marie Manno
Making Connections: Understanding How Social Interaction Patterns Influence Work-Related Outcomes For Individuals With Disabilities, Christine Marie Manno
Graduate Theses and Dissertations
In the United States, approximately eight million individuals with disabilities are active in the workforce (Erickson et al., 2008). These individuals seek employment that allows for full use of their education, experience, and abilities, and provides growth and development opportunities (Ali et al., 2011). Despite protective legislation and inclusive organizational policies, individuals with disabilities are at least twice as likely as individuals without disabilities to experience underemployment and reduced access to advancement opportunities (Schur et al., 2009). Evidence suggests that some of these issues may be related to social interaction patterns. It appears that individuals with disabilities have a strong …
“Implacement”: The Importance Of Place And Community In Schooling, Emily Coady
“Implacement”: The Importance Of Place And Community In Schooling, Emily Coady
Graduate Theses and Dissertations
This dissertation consists of three chapters exploring my overarching research question: How does sense of place shape a teacher’s orientation to their profession? My first chapter empirically answers the question: Is there a relationship between place attachment and measured aspects of teacher quality? In an attempt to qualify the strength of bond between a teacher and his or her community, I adapted a place attachment instrument developed by Raymond, Brown, and Weber (2010). Each teacher is given a place attachment score informed by their responses on the 21-item survey. Next, I correlated these scores to other aspects of teacher quality …
How Nonbinary College Students At Southern Universities Explore Identity Through Gender Expression, Charles Jesse Thompson
How Nonbinary College Students At Southern Universities Explore Identity Through Gender Expression, Charles Jesse Thompson
Graduate Theses and Dissertations
As the number of young people identifying as nonbinary continues to increase (Davis, 2018), our need, as educators, to understand their experiences on college campuses also increases. Using narrative inquiry and photovoice, framed by critical queer theory and genderism, this examined both institutionalized and socially constructed expectations and influences that affect the development of nonbinary gender expression and identity for the college students by addressing the research question: What are the experiences of nonbinary college students in the Southern United States in exploring their gender expression at research universities? The five major themes that emerged from this study were as …
Increasing Active Learning And Achievement In A Large Lecture Calculus Class Through A Flipped Classroom Model, Kimberly King
Increasing Active Learning And Achievement In A Large Lecture Calculus Class Through A Flipped Classroom Model, Kimberly King
Graduate Theses and Dissertations
University Calculus I courses serve as a means of access into high demand STEM fields and large lecture style passive calculus courses can be difficult for students. A mixed methods research design was used to compare a flipped instructional approach to a traditional lecture approach in large section Calculus I courses. The flipped lecture model required students to view videos of calculus instruction that included embedded quiz questions to allow for problem solving explorations during face-to-face class time. The traditional format included content from the video and limited time for additional problem solving. A professor with prior experience teaching Calculus …
Examination Of The Colorful Semantic Approach Via Telepractice For Children Who Are Deaf Or Hard Of Hearing, Samadhi Pusuba Devayalage
Examination Of The Colorful Semantic Approach Via Telepractice For Children Who Are Deaf Or Hard Of Hearing, Samadhi Pusuba Devayalage
Graduate Theses and Dissertations
Introduction: Hearing loss, deafness or hard of hearing are considered to be the inabilityof perceiving sounds beyond 20 dB. Due to a direct impact of a hearing loss, a developing brain undergoes difficulties in acquiring age-appropriate syntax and speech sounds. As a result, children with hearing loss present language, speech, and literacy disabilities. The current study discusses the efficacy of the colorful semantics approach in order to see its impact on sentence structure development. Methodology: A single subject withdrawal experimental study conducted following ABAB model. Two participants (6 years and 10 years) were recruited to the study following an inclusion …
Implementing An Exercise Referral Scheme For Promoting Physical Activity In University Mental Health Care, Bryce Daniels
Implementing An Exercise Referral Scheme For Promoting Physical Activity In University Mental Health Care, Bryce Daniels
Graduate Theses and Dissertations
Introduction. Mental health symptoms and conditions are prevalent and increasing on college campuses with anxiety and depression having the highest increases in prevalence. Many college students are also physically inactive which is problematic as physical activity benefits mental health. Exercise referral schemes (ERS) can promote physical activity, though no studies have investigated the implementation of an ERS within a college counseling center. Purpose. The purpose of this dissertation was to investigate the implementation of an ERS for promoting physical activity in university mental health care. Methods. Study 1 used a qualitative descriptive design of 14 certified counselors to explore perceptions …
Introduction Of Human Acidic Fibroblast Growth Factor (Fgf1) Variant With Increased Stability And Bioactivity, Azadeh Tavousi Tabatabaei
Introduction Of Human Acidic Fibroblast Growth Factor (Fgf1) Variant With Increased Stability And Bioactivity, Azadeh Tavousi Tabatabaei
Graduate Theses and Dissertations
Human acidic Fibroblast Growth Factor 1 (FGF-1) involves in a broad spectrum of biological processes, including cell growth, proliferation, differentiation, migration, angiogenesis, wound healing, and embryonic development. hFGF1 non-selectively binds to cell surface hFGF receptor isoforms to elicit these cell-signaling processes. Since hFGF1 plays a significant role in tissue repair activity, that is a prime candidate for novel wound healing therapeutics. However, hFGF1 has been found to unfold near physiological temperature due to a strong electrostatic repulsion created by a dense cluster of positively charged amino acids near the c-terminus. The problem not only leads to proteolytic degradation of the …
The Lived Experiences Of Transmasculine Speakers: A Phenomenological Investigation Of Vocal Quality And Function In Relation To Gender, Micah Wylie
Graduate Theses and Dissertations
The objective of this study was to learn how transmasculine individuals perceive the quality and function of their voices, and how those perceptions influence how they experience gender identity and communicate with others. This qualitative study adopted a hermeneutical phenomenological approach that involved using content analysis and thematic analysis to describe and interpret phenomena. This approach assumes that the researcher is not biased, but is a part of the world being studied and, therefore, understands the phenomenon by interpretive means. Saturation was achieved when all relevant information was introduced, and patterns of information had been identified. Sixteen interviews were conducted. …
Science Teachers' Perceptions Of Culturally Responsive Teaching In Majority Native American Schools In Oklahoma, Michelle Childress
Science Teachers' Perceptions Of Culturally Responsive Teaching In Majority Native American Schools In Oklahoma, Michelle Childress
Graduate Theses and Dissertations
Native American students have consistently scored less than their white peers on high school academic achievement tests, have the lowest high school graduation rates, and have the lowest college enrollment rates. Research has evidenced challenges and struggles Native American children are faced with that negatively effects their success in the classroom. Native American students often encounter a disconnect between their home and school life resulting in difficulties of navigating two opposing worlds. When Native American students are associated with negative stereotype’s indicative of Native American culture as opposed to the dominant culture, this creates a conflict between their cultural identity …
Optimizing Virus Prefiltration For Biopharmaceutical Manufacturing, Solomon Isu
Optimizing Virus Prefiltration For Biopharmaceutical Manufacturing, Solomon Isu
Graduate Theses and Dissertations
Virus filters are single-use devices that use a size-based separation process. In virus filters, contaminating virus particles are retained while the therapeutic molecules pass through the membrane pores. Virus filters are an essential component of the overall virus clearance strategy. Sections 1 and 2 of this dissertation provide an introduction and extensive review of monoclonal antibody (mAb) process development, where virus filtration is pivotal. In section 3, prefiltration studies were performed with an industrially relevant IgG1 type mAb using adsorptive and size-exclusion-based prefilters with different mechanisms of action. This mAb has an isoelectric point range of 7.1 to 8.0 and …
Efficacy Of Multivitamin-Mineral Supplementation On Measures Of Anxiety, Depression, Self-Esteem, Dysregulation, And Perceived Stress In Young Adults, Courtney Gorden
Efficacy Of Multivitamin-Mineral Supplementation On Measures Of Anxiety, Depression, Self-Esteem, Dysregulation, And Perceived Stress In Young Adults, Courtney Gorden
Graduate Theses and Dissertations
Mental health in the United States is at an all-time low with 21% of adults 18+ suffering from depression or anxiety. When compared with other categories, emerging adults (18-25 years old) have the highest prevalence of mental health disorders at 30%. Young adults face an inordinate amount of stress given the COVID-19 pandemic, being in a unique developmental stage, experiencing new relationships, and transitioning from high school to their professional lives. Vitamins and minerals have roles in neurobiochemistry and have been investigated for effects on mental health with mixed results. Few studies factor in the unique emerging adult developmental stage …
Using Thermal Units To Predict Biomass Accumulation And Total Nitrogen Uptake For Cover Crops In Arkansas, Mila Victório Pessotto
Using Thermal Units To Predict Biomass Accumulation And Total Nitrogen Uptake For Cover Crops In Arkansas, Mila Victório Pessotto
Graduate Theses and Dissertations
Including cover crops in agricultural production systems is an important management practice. Cover cropping can improve soil health, increase plant-available nitrogen (N), provide surface residue to prevent erosional soil loss, increase water infiltration, and increase weed suppression. Cover crops growth can be predicted using thermal days or growing degree days [GDD] similar to commodity crops such as corn (Zea mays L.) or rice (Oryza sativa). Growing degree day calculations are a well-known tool to predict crop growth stage or development stage and can be adapted for use in any plant species, including cover crops. Identifying and developing the relationship between …
Genetic Control Of Prickles And Plant Height In Blackberry, Carmen Johns
Genetic Control Of Prickles And Plant Height In Blackberry, Carmen Johns
Graduate Theses and Dissertations
The fresh-market blackberry (Rubus L. subgenus Rubus Watson) industry has been expanding for the past two decades. Blackberry market growth can be attributed to many factors including expanded production regions, improved production systems, and release of superior cultivars. Blackberry breeding is a time- and labor-intensive process which would benefit from implementation of molecular markers for highly heritable, important traits. Next generation sequencing, a high-quality reference genome, and software capable of analyzing this complex genome were applied in a genome-wide association study (GWAS) to reveal maker-trait associations related to prickles and plant height variation in fresh-market blackberry. In 2020 and 2021, …
Aberrant Responding With Underlying Dominance And Unfolding Response Processes: Examining Model Fit And Performance Of Person-Fit Statistics, Jennifer A. Reimers
Aberrant Responding With Underlying Dominance And Unfolding Response Processes: Examining Model Fit And Performance Of Person-Fit Statistics, Jennifer A. Reimers
Graduate Theses and Dissertations
Researchers have recognized that respondents may not answer items in a way that accurately reflects their attitude or trait level being measured. The resulting response data that deviates from what would be expected has been shown to have significant effects on the psychometric properties of a scale and analytical results. However, many studies that have investigated the detection of aberrant data and its effects have done so using dominance item response theory (IRT) models. It is unknown whether the impacts of aberrant data and the methodology used to identify aberrant responding when using dominance IRT models apply similarly when scales …
“Young Adult Books Don’T Realize They Have That Power”: Reader Response To Ideology In Young Adult Dystopian Fiction, Zane Emīlija Sarma
“Young Adult Books Don’T Realize They Have That Power”: Reader Response To Ideology In Young Adult Dystopian Fiction, Zane Emīlija Sarma
Graduate Theses and Dissertations
The purpose of this research is to find out how readers interact with novels in the Young Adult dystopian genre. I will examine the ways in which readers resist the dominant patriarchal ideological discourses in the YA dystopian novel and how readers submit to this ideology. Through an interaction with the text, the reader produces oppositional, negotiated, or preferred meanings. I will argue that readers’ response to ideology in the YA dystopian novel is affected by their active participation in reader communities such as the Bookish community online.
YA dystopian fiction was highly popular in the early 2010s, but the …
Evaluation Of The Effect Of A Lippia Organoides Essential Oil Extract On Clostridium Perfringens Proliferation In Vitro And Necrotic Enteritis In Broiler Chickens, Makenly E. Coles
Evaluation Of The Effect Of A Lippia Organoides Essential Oil Extract On Clostridium Perfringens Proliferation In Vitro And Necrotic Enteritis In Broiler Chickens, Makenly E. Coles
Graduate Theses and Dissertations
The purpose of the present research was to assess the effects of essential oils derived from the plant Lippia organoides on performance parameters, intestinal integrity, and necrotic enteritis (NE) in broiler chickens. To do this, a previously established challenge model for NE was utilized which included challenging with Salmonella Typhimurium on day 0, Eimeria maxima on day 18, and Clostridium perfringens on days 22 and 23. Treatment groups included a 1) non-challenged, negative control, 2) challenged control, and 3) challenged, Lippia origanoides (37ppm in the diet). Group 1 (negative control) had significantly (P < 0.05) higher body weight gain from d8-25 and d0-25 compared to both challenged groups. Feed intake was significantly different for all three groups (P < 0.05) at 8-25 days and 0-25 days with group 1 having the highest feed intake for both time periods. Total mortality was greater in the positive control when compared to both the negative and treatment groups. NE lesion scores were significantly different between all groups with the positive control having the highest mean lesion scores and the negative control having a mean lesion score of 0. The positive control group had the highest FITC-d amounts detected in the sera, being statistically higher than both the treatment group and negative group which were both statistically different from each other. At the present inclusion rate for the essential oil (37 ppm), there was an overall reduction in the negative impact from the NE infection. Further studies should be conducted to reach more significant conclusions.
Making Meaning Of The Shared Experience Of Participants In An Undergraduate Lgbtq+ Mentorship Program, Brendan Corbett Csaposs
Making Meaning Of The Shared Experience Of Participants In An Undergraduate Lgbtq+ Mentorship Program, Brendan Corbett Csaposs
Graduate Theses and Dissertations
The purpose of this phenomenological study was to examine the ways in which LGBTQ+ students at the University of Miami make meaning of their shared experiences in the LGBTQ+ Mentorship Program that the university offers, in order to explore ways in which higher education institutions might consider better supporting this key group of students. This study draws upon a variety of theories of sexual identity development, building on the work of Rosario et al. (2011) in looking at the ways that students make meaning of their sexual identity based on self-identification, association with the larger community, and engagement in a …
Diffusive Dynamics Of Biological Macromolecules In The Cytoplasm Of Live Bacteria, Asmaa Ali Sadoon
Diffusive Dynamics Of Biological Macromolecules In The Cytoplasm Of Live Bacteria, Asmaa Ali Sadoon
Graduate Theses and Dissertations
Bacteria are small organisms that play important roles in our bodies and in maintaining our surrounding environment. However, bacterial infections are considered as one of the health diseases that threatens the lives of humans. Resistance of bacteria to antibiotics has made treating bacterial infections more challenging. With the emergence of many developed optical techniques, it has become possible to study various biological mechanisms of molecules inside these small organisms with high resolution and precise localization. In this research, single particle tracking photoactivation localization microscopy (sptPALM) technique was used to investigate the dynamics of fluorescent histonelike nucleoid-structuring proteins (H-NS) in live …
Experimental Cyclic Heat Stress On Intestinal Permeability, Bone Mineralization, Leukocyte Proportions And Meat Quality In Broiler Chickens, Alessandro Rocchi, Jared Ruff, Clay J. Maynard, Aaron J. Forga, Roberto Señas-Cuesta, Elizabeth S. Greene, Juan D. Latorre, Christine N. Vuong, Brittany D. Graham, Xochitl Hernandez-Velasco, Guillermo Tellez Jr., Victor Petrone-Garcia, Lauren Laverty, Billy Hargis, Gisela Erf, Casey M. Owens, Guillermo Tellez-Isaias
Experimental Cyclic Heat Stress On Intestinal Permeability, Bone Mineralization, Leukocyte Proportions And Meat Quality In Broiler Chickens, Alessandro Rocchi, Jared Ruff, Clay J. Maynard, Aaron J. Forga, Roberto Señas-Cuesta, Elizabeth S. Greene, Juan D. Latorre, Christine N. Vuong, Brittany D. Graham, Xochitl Hernandez-Velasco, Guillermo Tellez Jr., Victor Petrone-Garcia, Lauren Laverty, Billy Hargis, Gisela Erf, Casey M. Owens, Guillermo Tellez-Isaias
Poultry Science Faculty Publications and Presentations
The goal of this research was to assess cyclic heat stress on gut permeability, bone mineralization, and meat quality in chickens. Two separate trials were directed. 320 day-of-hatch Cobb 500 male chicks were randomly assigned to four thermoneutral (TN) and four cyclic heat stress (HS) chambers with two pens each, providing eight replicates per treatment in each trial (n = 20 chicks/replicate). Environmental conditions in the TN group were established to simulate commercial production settings. Heat stress chickens were exposed to cyclic HS at 35 °C for 12 h/day from days 7–42. Performance parameters, intestinal permeability, bone parameters, meat quality, …
Histomonosis In Poultry: A Comprehensive Review, Lesleigh C. Beer, Victor M. Petrone-Garcia, B. Danielle Graham, Billy M. Hargis, Guillermo Tellez-Isaias, Christine N. Vuong
Histomonosis In Poultry: A Comprehensive Review, Lesleigh C. Beer, Victor M. Petrone-Garcia, B. Danielle Graham, Billy M. Hargis, Guillermo Tellez-Isaias, Christine N. Vuong
Poultry Science Faculty Publications and Presentations
Histomonas meleagridis, the etiological agent of histomonosis, is a poultry parasite primarily detrimental to turkeys. Characteristic lesions occur in the liver and ceca, with mortalities in turkey flocks often reaching 80–100%. Chickens and other gallinaceous birds can be susceptible but the disease was primarily considered sub-clinical until recent years. Treating and preventing H. meleagridis infection have become more difficult since 2015, when nitarsone was voluntarily removed from the market, leaving the poultry industry with no approved prophylactics, therapeutics, or vaccines to combat histomonosis. Phytogenic compounds evaluated for chemoprophylaxis of histomonosis have varied results with in vitro and in vivo …
Supervised Representation Learning For Improving Prediction Performance In Medical Decision Support Applications, Phawis Thammasorn
Supervised Representation Learning For Improving Prediction Performance In Medical Decision Support Applications, Phawis Thammasorn
Graduate Theses and Dissertations
Machine learning approaches for prediction play an integral role in modern-day decision supports system. An integral part of the process is extracting interest variables or features to describe the input data. Then, the variables are utilized for training machine-learning algorithms to map from the variables to the target output. After the training, the model is validated with either validation or testing data before making predictions with a new dataset. Despite the straightforward workflow, the process relies heavily on good feature representation of data. Engineering suitable representation eases the subsequent actions and copes with many practical issues that potentially prevent the …
Heritability Of Maxillary Dental Arch Dimensions In A Pedigreed Sample Of Hamadryas Baboons, Samuel Park
Heritability Of Maxillary Dental Arch Dimensions In A Pedigreed Sample Of Hamadryas Baboons, Samuel Park
Crop, Soil and Environmental Sciences Undergraduate Honors Theses
This thesis presents a study of heritability of maxillary dental arch dimensions in a captive baboon colony. Arch dimensions are important subject because they influence the entirety of the craniofacial and masticatory complex. The goal of this study was to quantify the relative genetic influence on arch dimensions and the nature of this influence at different points along the maxillary arcade. Referencing virtual, three-dimensional dental cast scans, widths were measured at different points between the a) maxillary left and right canines, and b) maxillary left and right first molars (M1). Specifically, measurements were taken at the inner (lingual) gingival margin, …
Quantifying The Relationship Between Pond Size And Water Quality, Rebekah Mason
Quantifying The Relationship Between Pond Size And Water Quality, Rebekah Mason
Crop, Soil and Environmental Sciences Undergraduate Honors Theses
The water quality of ponds, streams, and groundwater is at risk due to agricultural and urban development. Implementation of ponds near developmental areas can act as catchment sites to reduce further water pollution (Bichsel et al., 2015). However, maintenance of pond water quality is necessary for continued water supply to livestock and general recreational use. The present study aimed to determine the relationship between pond size (surface area range from 142 to 5336 m2) and water quality. Analysis of water quality parameters, including dissolved oxygen, nitrate, phosphate, and chlorophyll-a, were conducted during the summer of 2021 and winter …
Breeding Soybean [Glycine Max (L) Merr.] Under Reduced Irrigation, Francia Seconde Ravelombola
Breeding Soybean [Glycine Max (L) Merr.] Under Reduced Irrigation, Francia Seconde Ravelombola
Graduate Theses and Dissertations
Soybean [Glycine max (L) Merr.], a legume species native to East Asia in the Fabaceae family, ranks among the most important food crops in the world. It is widely grown and known for its high protein and oil concentration. Soybean is valuable because its seeds have multiple applications in food, feed, pharmaceutical, and industrial enterprises. Even though seed yield is the most important trait, breeders have recently given a significant attention to quality traits, such as high protein or modified oil concentration. Soybean seed protein inheritance has been extensively studied; however, genetics of high-protein ‘BARC-7’ soybean are still unknown.On the …
Time Course Investigation Of The Dermal Leukocyte Response To Lipoteichoic Acid In Chickens, Ian Gilbert
Time Course Investigation Of The Dermal Leukocyte Response To Lipoteichoic Acid In Chickens, Ian Gilbert
Animal Science Undergraduate Honors Theses
Lipoteichoic acid (LTA) is component of the cell wall of Gram-positive bacteria that stimulates inflammation during bacterial infection. However, few studies have investigated the in vivo immune response to LTA, and none of the in vivo studies done have been performed in birds. For this project, the pulp (a skin-derivative) of growing feathers (GFs) of chickens were used as a test site to investigate the in vivo effects of intradermally injected LTA. In Study 1, the pulp of 12 GFs of 11-week-old Light-brown Leghorn (LBL) males were injected with 10 μL of differing concentrations of LTA (0.1, 1.0, 10, 100 …
Something Like A Phenomenon: High Achieving Women Of Color And Experiences Of Mental Health Resource Utilization, Andrea Hampton Hall
Something Like A Phenomenon: High Achieving Women Of Color And Experiences Of Mental Health Resource Utilization, Andrea Hampton Hall
Graduate Theses and Dissertations
The purpose of this study was to examine, explore, and understand the lived experiences of high-achieving Black and Latina women who had utilized mental health services in the last 18 months. The impact of discrimination and stigma is present today and may manifest itself within communities of color when these individuals attempt to access mental health services. The counseling field and counselor education programs are ethically responsible for integrating social justice counseling into coursework and practice. This informs educators and counselors of barriers that may influence and impact best practices for providing mental health services to communities of color. A …
Growth Differentiation Factor 5 Is A Paracrine Regulator Of Sarcopenic Obesity, Landen W. Saling
Growth Differentiation Factor 5 Is A Paracrine Regulator Of Sarcopenic Obesity, Landen W. Saling
Graduate Theses and Dissertations
Sarcopenic obesity attributes to skeletal muscle loss more than sarcopenia and obesity alone. Individuals with SO suffer from the comorbidity of excess body fat and concurrent muscle mass loss due to aging. Growth differentiation factors (Gdfs) have never been recognized as playing a role in skeletal muscle maintenance in those with SO. Specifically, Gdf5, has been recognized as playing a part in Bone Morphogenic Protein signaling to activate protein synthesis and deactivate protein degradation via SMAD 1/5/8 and SMAD 4 complex. Using RNA sequencing, Gdf5 was identified as being significantly upregulated in SO mice. Purpose: To determine the cellular role …