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Identification Of Candidate Genes And Genomic Selection For Seed Protein In Soybean Breeding Pipeline, Jun Qin, Fengmin Wang, Qingsong Zhao, Ainong Shi, Tiantian Zhao, Qijian Song, Waltram Ravelombola, Hongzhou An, Long Yan, Chunyan Yang, Mengchen Zhang

Horticulture Faculty Publications and Presentations

Soybean is a primary meal protein for human consumption, poultry, and livestock feed. In this study, quantitative trait locus (QTL) controlling protein content was explored via genome-wide association studies (GWAS) and linkage mapping approaches based on 284 soybean accessions and 180 recombinant inbred lines (RILs), respectively, which were evaluated for protein content for 4 years. A total of 22 single nucleotide polymorphisms (SNPs) associated with protein content were detected using mixed linear model (MLM) and general linear model (GLM) methods in Tassel and 5 QTLs using Bayesian interval mapping (IM), single-trait multiple interval mapping (SMIM), single-trait composite interval mapping maximum …

Targeting Tor And Snrk1 Genes In Rice With Crispr/Cas9, Bhuvan Pathak, Chandan Maurya, Maria C. Faria, Zahra Alizada, Soumen Nandy, Shan Zhao, Muhammed Jamsheer K, Vibha Srivastava

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Genome targeting with CRISPR/Cas9 is a popular method for introducing mutations and creating knock-out effects. However, limited information is currently available on the mutagenesis of essential genes. This study investigated the efficiency of CRISPR/Cas9 in targeting rice essential genes: the singleton TARGET OF RAPAMYCIN (OsTOR) and the three paralogs of the Sucrose non-fermenting-1 (SNF1)-related kinase 1 (OsSnRK1α), OsSnRK1αA, OsSnRK1αB and OsSnRK1αC. Strong activity of constitutively expressed CRISPR/Cas9 was effective in creating mutations in OsTOR and OsSnRK1α genes, but inducible CRISPR/Cas9 failed to generate detectable mutations. The rate of OsTOR mutagenesis was relatively lower and only the …

Brain Tract Structure Predicts Relapse To Stimulant Drug Use, Loreen Tisdall, Kelly H. Macniven, Claudia B. Padula, Josiah K. Leong, Brian Knutson

Psychological Science Faculty Publications and Presentations

Diffusion tractography allows identification and measurement of structural tracts in the human brain previously associated with motivated behavior in animal models. Recent findings indicate that the structural properties of a tract connecting the midbrain to nucleus accumbens (NAcc) are associated with a diagnosis of stimulant use disorder (SUD), but not relapse. In this preregistered study, we used diffusion tractography in a sample of patients treated for SUD (n = 60) to determine whether qualities of tracts projecting from medial prefrontal, anterior insular, and amygdalar cortices to NAcc might instead foreshadow relapse. As predicted, reduced diffusion metrics of a tract …

Editorial: Engineering Nucleic Acids-Based Functional Nanomaterials, Nanodrugs, And Biosensors, Jabrane Jouha, Fengli Li, Wen-Ta Su, Chenguang Fan, Dayong Yang, Hai Xiong

Chemistry & Biochemistry Faculty Publications and Presentations

Editorial on the Research Topic: Engineering Nucleic Acids-Based Functional Nanomaterials, Nanodrugs, and Biosensors

Stability Of Polyethylene Glycol-Coated Copper Nanoparticles And Their Optical Properties, Deborah Okyere, Ryan H. Manso, Xiao Tong, Jingyi Chen

Chemistry & Biochemistry Faculty Publications and Presentations

Oxidation is a corrosion reaction where the corroded metal forms an oxide. Prevention of oxidation at the nanoscale is critically important to retain the physicochemical properties of metal nanoparticles. In this work, we studied the stability of polyethylene glycol (PEG) coated copper nanoparticles (PEGylated CuNPs) against oxidation. The freshly-prepared PEGylated CuNPs mainly consist of metallic Cu which are quite stable in air although their surfaces are typically covered with a few monolayers of cuprous oxide. However, they are quickly oxidized in water due to the presence of protons that facilitate oxidation of the cuprous oxide to cupric oxide. PEG with …

Novel Neurostimulation-Based Haptic Feedback Platform For Grasp Interactions With Virtual Objects, Aliyah K. Shell, Andres E. Pena, James J. Abbas, Ranu Jung

Biomedical Engineering Faculty Publications and Presentations

Haptic perception is a vital part of the human experience that enriches our engagement with the world, but the ability to provide haptic information in virtual reality (VR) environments is limited. Neurostimulation-based sensory feedback has the potential to enhance the immersive experience within VR environments by supplying relevant and intuitive haptic feedback related to interactions with virtual objects. Such feedback may contribute to an increase in the sense of presence and realism in VR and may contribute to the improvement of virtual reality simulations for future VR applications. This work developed and evaluated xTouch, a neuro-haptic platform that extends the …

Vaccines Using Clostridium Perfringens Sporulation Proteins Reduce Necrotic Enteritis In Chickens, Ying Fu, Mohit Bansal, Tahrir Jatli Alenezi, Ayidh Almansour, Hong Wang, Xiaolun Sun

Poultry Science Faculty Publications and Presentations

Clostridium perfringens is the prevalent enteric pathogen in humans and animals including chickens, and it remains largely elusive on the mechanism of C. perfringens-induced enteritis because of limited animal models available. In this study, we investigated the role of C. perfringens sporulation proteins as vaccine candidates in chickens to reduce necrotic enteritis (NE). C. perfringens soluble proteins of vegetative cells (CP-super1 and CP-super2) and spores (CP-spor-super1 and CP-spor-super2) were prepared, and cell and chicken experiments were conducted. We found that deoxycholic acid reduced C. perfringens invasion and sporulation using the Eimeria maxima and C. perfringens co-infection necrotic enteritis (NE) …

Wastewater-Recycled Struvite As A Phosphorus Source In A Wheat-Soybean Double-Crop Production System In Eastern Arkansas, Niyi Sunday Omidire, Kristofor R. Brye

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Fertilizer-phosphorus (P) sources are mainly derived from rock phosphate (RP), which is a finite, actively mined resource. With growing human populations globally, alternative P sources are vitally important to ensure future food security. Precipitation of the mineral struvite (MgNH₄PO₄·6H₂O) from wastewater could be a potential alternative fertilizer-P option from crop production. The objective of this study was to evaluate the effects of chemically precipitated struvite (CPST), compared with triple superphosphate (TSP) and an unamended control (UC) treatment, and irrigation (irrigated and non-irrigated/dryland) on above- (dry matter, yield, and tissue-N, -P, and -Mg concentrations and …

Field-Evolved Δg210-Ppo2 From Palmer Amaranth Confers Pre-Emergence Tolerance To Ppo-Inhibitors In Rice And Arabidopsis, Pamela Carvalho-Moore, Gulab Rangani, Ana Claudia Langaro, Vibha Srivastava, Aimone Porri, Steven J. Bowe, Jens Lerchl, Nilda R. Burgos

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Resistance to protoporphyrinogen IX oxidase (PPO)-inhibitors in Amaranthus palmeri and Amaranthus tuberculatus is mainly contributed by mutations in the PPO enzyme, which renders herbicide molecules ineffective. The deletion of glycine210 (ΔG210) is the most predominant PPO mutation. ΔG210-ppo2 is overexpressed in rice (Oryza sativa c. ‘Nipponbare’) and Arabidopsis thaliana (Col-0). A foliar assay was conducted on transgenic T1 rice plants with 2× dose of fomesafen (780 g ha−1), showing less injury than the non-transgenic (WT) plants. A soil-based assay conducted with T2 rice seeds confirmed tolerance to fomesafen applied pre-emergence. In agar medium, root growth of WT …

Feed Composition And Isolate Of Histomonas Meleagridis Alter Horizontal Transmission Of Histomonosis In Turkeys. Proof Of Concept, Thaina L. Barros, Christine N. Vuong, Juan D. Latorre, Roberto S. Cuesta, Elizabeth Mcgill, Samuel J. Rochell, Guillermo Tellez-Isaias, Billy Hargis

Poultry Science Faculty Publications and Presentations

Outbreaks of histomonosis in turkeys are typically initiated by the ingestion of contaminated embryonated eggs of Heterakis gallinarum, potentially present in earthworms and mechanical vectors. Once an outbreak is started, infected turkeys can transmit the disease by horizontal transmission. Factors influencing horizontal transmission of histomonosis are poorly understood. Replication of horizontal transmission in experimental conditions has not been consistent, presenting an obstacle in searching for alternatives to prevent or treat the disease. Two pilot experiments and three validation experiments were conducted in the present study. In pilot experiment 1, one isolate of Histomonas meleagridis (named Buford) was used. Turkeys …

Functional Analysis Of The Cortical Transcriptome And Proteome Reveal Neurogenesis, Inflammation, And Cell Death After Repeated Traumatic Brain Injury In Vivo, Celeste Dunn, Lais A. Ferreira, Sara M. Venier, Syed F. Ali, Jeffery Wolchok, Kartik Balachandran

Biomedical Engineering Faculty Publications and Presentations

The pathological effects of repeated traumatic brain injuries (TBIs) are largely unknown. To gain a detailed understanding of the cortical tissue acute biological response after one or two TBIs, we utilized RNA-sequencing and protein mass spectrometry techniques. Using our previously validated C57Bl/6 weight-drop model, we administered one or two TBIs of a mild or moderate severity. Double injury conditions were spaced 7 days apart, and cortical tissue was isolated 24 h after final injury. Analysis was carried out through functional gene annotation, utilizing Gene Ontology, for both the proteome and transcriptome. Major themes across the four different conditions include: neurogenesis; …

Duodenal Metabolic Profile Changes In Heat-Stressed Broilers, Jalila S. Dridi, Elizabeth Greene, Craig W. Maynard, Giorgio Brugaletta, Alison Ramser, Courtney J. Christopher, Shawn R. Campagna, Hector F. Castro, Sami Dridi

Poultry Science Faculty Publications and Presentations

Heat stress (HS) is devastating to poultry production sustainability worldwide. In addition to its adverse effects on growth, welfare, meat quality, and mortality, HS alters the gut integrity, leading to dysbiosis and leaky gut syndrome; however, the underlying mechanisms are not fully defined. Here, we used a high-throughput mass spectrometric metabolomics approach to probe the metabolite profile in the duodenum of modern broilers exposed to acute (AHS, 2 h) or chronic cyclic (CHS, 8 h/day for 2 weeks) HS in comparison with thermoneutral (TN) and pair-fed birds. Ultra high performance liquid chromatography coupled with high resolution mass spectrometry (UHPLC–HRMS) identified …

Arkansas High School Freshmen Course Failures 2009-11 -- 2018-19, Sarah R. Morris, Sarah C. Mckenzie

Arkansas Education Reports

This study assesses the course failures among Arkansas high school freshmen by different student demographic and programmatic characteristics. We analyze 10 independent cohorts of Arkansas freshmen for descriptive analyses, and then we limit our analytic sample to the two most recent years of data. Algebra I is the most commonly failed course among Arkansas freshmen. Using logit analyses, we find economically disadvantaged students are nine percentage points more likely to fail a course their freshman year than their more advantaged peers after controlling for prior academic achievement and district characteristics and fixed effects. This study is the first research study …

Introduction To The National Institutes Of Health Funding, Stacy Stuart

Research and Innovation Events

This video presentation gives an overview of NIH as a federal funding agency. It covers NIH’s funding priorities, solicitation types, and proposal resources. It also includes information from on-campus NIH awardees Drs. Philip Massey, Feng Wang, Kevin Murach, and Adam Pare.

Sponsored by the Division of Research and Innovation.

Gender Perceptions And Female Students' Academic Engagement And Success In Stem Fields, Rheanna Morgan

School of Social Work Undergraduate Honors Theses

Despite an increase of females in higher education and the workforce, fields such as science, technology, engineering, and mathematics (STEM) continue to be male-dominated. One explanation for this trend is the lack of gender representation and counterstereotypical role models to encourage female engagement in these fields at the university level. Previous research has looked at instructor gender, classroom gender composition, and involvement in extracurricular activities as possible factors influencing students' engagement and success in the classroom. However, few studies have investigated how gender perceptions influence female students in STEM fields. This study uses self-report data from a voluntary survey to …

Gauging The State-Of-The-Art For Foresight Weight Pruning On Neural Networks, Noah James

Computer Science and Computer Engineering Undergraduate Honors Theses

The state-of-the-art for pruning neural networks is ambiguous due to poor experimental practices in the field. Newly developed approaches rarely compare to each other, and when they do, their comparisons are lackluster or contain errors. In the interest of stabilizing the field of pruning, this paper initiates a dive into reproducing prominent pruning algorithms across several architectures and datasets. As a first step towards this goal, this paper shows results for foresight weight pruning across 6 baseline pruning strategies, 5 modern pruning strategies, random pruning, and one legacy method (Optimal Brain Damage). All strategies are evaluated on 3 different architectures …

Exercise Counteracts The Deleterious Effects Of Cancer Cachexia, Stavroula Tsitkanou, Kevin A. Murach, Tyrone Washington, Nicholas P. Greene

Health, Human Performance and Recreation Faculty Publications and Presentations

Cancer cachexia (CC) is a multifactorial syndrome characterised by unintentional loss of body weight and muscle mass in patients with cancer. The major hallmarks associated with CC development and progression include imbalanced protein turnover, inflammatory signalling, mitochondrial dysfunction and satellite cell dysregulation. So far, there is no effective treatment to counteract muscle wasting in patients with CC. Exercise training has been proposed as a potential therapeutic approach for CC. This review provides an overview of the effects of exercise training in CC-related mechanisms as well as how factors such as cancer comorbidities, exercise modality and biological sex can influence exercise …

The Relationship Between Trait Emotional Intelligence And Problematic Alcohol Use Among College Students, Robert E. Davis, Nicole A. Doyle, Krishen D. Samuel, Amanda H. Wilkerson, Vinayak K. Nahar

Health, Human Performance and Recreation Faculty Publications and Presentations

Background: Problematic alcohol use among college students is a significant public health concern. Emotional intelligence (EI), or the ability to detect one’s own and others’ emotions and to use this information to direct behavior, is suggested to mitigate problematic alcohol use. The purpose of this study was to examine the relationship between EI and problematic alcohol use among college students while controlling for drug use covariates.

Methods: This cross-sectional study utilized an online survey comprised of previously validated measures to determine EI, problematic alcohol use, and drug use among college students from a large, public university in the south-central United …

The Art Of Nutrition, Kylanna Hardaway

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Many colleges and universities offer students access to on-campus food pantries, yet very few students utilize these services despite reporting high rates of food insecurity. Considering the importance of a healthy diet on the developing minds of young adults, it is pertinent that colleges and universities find innovative ways to reach food insecure students. The purpose of this hybrid creative-research project was to creatively address commonly cited barriers of seeking food assistance (i.e., negative stigma, embarrassment, unknown location, awareness of resource, etc.) using public art. A mural was designed to encourage healthy eating behaviors and provide signage for the Jane …

A Versatile Python Package For Simulating Dna Nanostructures With Oxdna, Kira Threlfall

Computer Science and Computer Engineering Undergraduate Honors Theses

The ability to synthesize custom DNA molecules has led to the feasibility of DNA nanotechnology. Synthesis is time-consuming and expensive, so simulations of proposed DNA designs are necessary. Open-source simulators, such as oxDNA, are available but often difficult to configure and interface with. Packages such as oxdna-tile-binding pro- vide an interface for oxDNA which allows for the ability to create scripts that automate the configuration process. This project works to improve the scripts in oxdna-tile-binding to improve integration with job scheduling systems commonly used in high-performance computing environments, improve ease-of-use and consistency within the scripts compos- ing oxdna-tile-binding, and move …

Ongoing Calculus In The Cerebral Cortex, Luke Long

Physics Undergraduate Honors Theses

Various modes of neuronal computations have long been theorized to be possible based on the structure and geometry of the brain. These computations also seem necessary for many of the integral functions of the brain, like information processing and regulatory processes in the body. However, experimental data directly supporting these claims have been rare.

In this study, data collected in mice from a large number of neurons over a long period of time provided the opportunity to search for some of these computations, specifically change detection and squaring calculations. Using Matlab, the goal of this analysis was to find statistically …

Assessing The Potential Effectiveness Of Diffuse Reflectance Spectroscopy For Quantifying Neonatal Skin Properties Using Tissue Phantoms, Jack Murphy

Biomedical Engineering Undergraduate Honors Theses

Diffuse reflectance spectroscopy (DRS) has previously been shown to be effective at analyzing the optical characteristics of a wide variety of biological tissues, including the skin. In addition to being sensitive to the amount of blood and its oxygenation, DRS can be used to extract bilirubin levels and assess jaundice, a common complication in newborn infants. To assess its potential for being utilized in applications involving neonatal skin, we evaluated the utility of DRS for extracting hemoglobin and bilirubin concentrations from tissue phantoms. Phantom sets were created by including a known amount of scattering and by varying known concentrations of …

Scale-Free Behavioral Dynamics Directly Linked With Scale-Free Cortical Dynamics, Sabrina Jones

Physics Undergraduate Honors Theses

In organisms, an interesting phenomenon occurs in both behavior and neuronal activity: organization with fractal, scale-free fluctuations over multiple spatiotemporal orders of magnitude (1,2). In regard to behavior, this sort of complex structure-- which manifests itself from small scale fidgeting to purposeful, full body movements-- may support goals such as foraging (3-6), visual search (4), and decision making (7,8). Likewise, the presence of this sort of structure in the cerebral cortex in the form of spatiotemporal cascades, coined “neuronal avalanches,” may offer optimal information transfer (9). Thus, when considering the functional relationship between the cerebral cortex and movements of the …

The Effects Of Perinatal Nutrition In The Prevention Of Postpartum Depression, Olivia Glasgow

The Eleanor Mann School of Nursing Undergraduate Honors Theses

With the exponential rise in reported cases of postpartum depression, medical workers within the psychiatric and research communities seek to discover new methods to prevent its onset. The purpose of this study is to compile the available research that has been conducted to investigate the relationship between perinatal nutrition and the prevention of postpartum depression. Nineteen peer-reviewed articles were gathered from medical databases based on their ability to report evidence on the increased consumption of omega-3 fatty acids or vitamin D and their prophylactic therapy against postpartum depression. Overall, many articles suggest a positive association as individuals’ mental health screenings …

A Descriptive Study Of College Students’ Preferences Toward Rhetorical Devices In Advertisements, Rachel Beyer

Agricultural Economics and Agribusiness Undergraduate Honors Theses

Advertisements are specifically created to convince people of the importance to either buy a product or subscribe to an ideal. Companies are the primary users of advertisements, where advertisements are designed to increase profitability (Roberts, 2020). The advertising industry in America is quite large. Food is a diversified and competitive industry, this competition in the food industry causes companies to be dependent on consumer preference and knowledge (UC Davis Nutrition Department, 2020). With Generation Z on the rise, there should be an increased focus on their preferences and needs in all industries, including the food industry (Southgate, 2017). The purpose …

Impact Of A Cattle Crossing On Water Quality Along A Tributary Of The Muddy Fork Of The Illinois River, Northwest Arkansas, Nicholas Valentini

Animal Science Undergraduate Honors Theses

Cattle are known to have an effect on water quality in various bodies of water. Studying how cattle impact water quality along various streams and tributaries is important to understanding how certain water parameters may be affected at the individual farm level. It is known that unrestricted access to a cattle crossing has been shown to increase the occurrence of downstream pollutants such as E. coli, ammonium, total kjeldahl nitrogen, total suspended solids, total phosphorus, and turbidity. However, many studies focus on large-scale operations and neglect the individual farm level. In this study, samples were collected twice for each …

Rodent Dental Microwear Texture Analysis As A Proxy For Fine-Scale Paleoenvironment Reconstruction, Jenny H. E. Burgman

Graduate Theses and Dissertations

Dental microwear texture analysis (DMTA) of fossil fauna has become a valuable tool for dietary inference and paleoenvironment reconstruction. Most of this work has utilized larger taxa with larger home ranges. These studies may result in broader-scale habitat inferences that could mask the details of complex mosaic habitats. Rodent DMTA offers an opportunity to work at finer spatial scales because most species have smaller home ranges. Rodents are also keystone species within their ecosystems, abundant, ubiquitous, and found in many fossil deposits. These attributes make them excellent proxies for environmental reconstructions. However, the application of DMTA to rodents remains relatively …

Investigating The Mechanics And Chemistry Of Sickle Polish Development, Justin Jared Dubois

Graduate Theses and Dissertations

This series of experiments is designed to understand the development and chemistry of sickle gloss. Sickles are common in the archaeological record and have long been studied for their eponymous “sickle gloss”. There is debate as to how this gloss is formed. Five experimental sickles containing flint and novaculite blades were used to harvest high and low moisture content rye and common fescue and associated field weeds. The differences in the development of sickle gloss were examined. High moisture content plants create thick, smooth fields of polish with undulating, billowing margins at a higher developmental speed. Low moisture content plants …

The Interaction Of Angiotensin I And Ii On Calcified Aortic Valve Cells, Fah Sysavanh

Biomedical Engineering Undergraduate Honors Theses

Cardiovascular diseases affect the older population with limited treatments available. Aortic valve stenosis is a cardiovascular disease in which the aortic valve narrows, causing blood flow constriction and calcification.¹ The only treatment is to replace the valve, which can be costly and lead to other health complications.

The renin-angiotensin system (RAS) is a pathway that helps with maintaining cardiovascular homeostasis. Angiotensin I (ANGI) and II (ANGII) are hormones in the RAS that cause an increase in inflammation, stress, and blood pressure by binding to the Angiotensin Type 1 Receptor (AT1R).¹ Gelatin-based valve thin film (vTF) platforms were fabricated to investigate …

Alternative Fixation Of Venous Valves For Bioprosthetic Applications, Makenzie Kapales

Biomedical Engineering Undergraduate Honors Theses

Venous valve failure allows for the retrograde, or backward, flow of blood into the lower extremities, which leads to Chronic Venous Insufficiency (CVI). CVI infringes upon quality of life through ulceration and can result in death due to Deep Vein Thrombosis (DVT), or blood clots, causing pulmonary embolism. A successful treatment of CVI restores valve function and prevents retrograde blood flow; however, current bioprosthetic venous valves exhibit low patency and high calcification. To improve upon bioprosthetic venous valves and CVI treatment, the University of Arkansas’s Cardiovascular Biomechanics Lab conducts studies with the purpose of comparing the properties and performance of …