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Functional Polymorphisms Of Alcohol Metabolism Genes And Their Protection Against Alcoholism Via Gene Therapy: A Systematic Review, Olivia Tzeng

Psychological Science Undergraduate Honors Theses

Around 45% of East Asians are unable to fully metabolize ethanol due to functional

polymorphisms of alcohol metabolism genes, specifically alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). These individuals display high levels of toxic blood acetaldehyde when consuming alcohol, causing symptoms such as tachycardia, vomiting, and flushing. The studies included in this review examine how functional polymorphisms of ADH and ALDH protect against alcoholism in addition to how polymorphisms can be utilized as protection against alcoholism via gene therapy. The studies included found that carriers of the ADH and ALDH polymorphisms were 66 to 99% genetically protected against alcoholism. Through …

Annual Financial Report Supporting Schedules, 2017-2018, University Of Arkansas, Fayetteville

Annual Financial Report

No abstract provided.

Compositions And Methods Of Enhancing Immune Responses, Walter G. Bottje, Billy M. Hargis, Luc Berghman, Young M. Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton

Patents Granted

Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.

Animal Science E-Newsletter, June 2018, University Of Arkansas, Fayetteville. Department Of Animal Sciences

Animal Science e-Newsletter

No abstract provided.

Designing A Distributed Network Of Air Quality Sensors, Kaylee Rauso

Computer Science and Computer Engineering Undergraduate Honors Theses

The deterioration of human and environmental health due to worsening outdoor air quality is a serious global threat. A step towards improving the current state of ambient air worldwide is the increased collection of data for government policy, research, and general public use. Currently, reliable data is only collected at a handful of sites in the state of Arkansas and sparsely across the country. The purpose of this project was to design an inexpensive air quality sensor to saturate entire cities with nodes which transmit air data to a sensor for a web application to display. The prototype node was …

Agricultural Information Needs And Food Access In The Stann Creek District Of Belize, Sam Harris

Agricultural Education, Communications and Technology Undergraduate Honors Theses

The purpose of this study was to describe agricultural information sources available to farmers and to describe food access and availability for the people of Dangriga, Stann Creek, Belize. This study used descriptive survey research methods with convenience sampling of the general public (n=22) and of farmers (n = 38) in the summer of 2017. Farmers use a variety of agricultural information sources with the extension service cited most often, followed by friends and fellow farmers. Weather, lack of information, pests, and inadequate access to capital were of primary concern for farmers. Face to face meetings were …

Effects Of Mitochondrial Nadp+-Dependent Isocitrate Dehydrogenase Deficiency On Fructose-Induced Obesity In Mice, Allison Michelle Montalbano, Kaleigh Elizabeth Beane

Human Nutrition and Hospitality Management Undergraduate Honors Theses

Obesity prevalence in the United States continues to increase and is associated with health consequences such as type 2 diabetes, hypertension, atherosclerosis, and hyperlipidemia. Among many contributing factors to obesity, fructose may be one of the major reasons as it disrupts the antioxidant system thereby resulting in an accumulation of reactive oxidative species and leading to obese conditions. The enzyme, isocitrate dehydrogenase 2 (IDH2), reduces nicotinamide adenine dinucleotide phosphate from the TCA Cycle, hence might be implicated with not only energy metabolism but also cellular redox homeostasis. Therefore, the hypothesis was that IDH2 deficiency in mice would exacerbate hepatic lipid …

Barriers To Local Food Producers In Arkansas, Courtney Cooper, Zola Moon

Horticulture Undergraduate Honors Theses

The purpose of this study is to identify and describe the barriers that prevent local food producers from selling their food in a mainstream market. This study utilized both qualitative and quantitative analysis through a mixed-methods survey. Information collected through the study had a two-fold focus: barriers that producers face (or that they are providing assistance for) and what are consumers looking for in products that these producers are supplying. The major barriers found for local food producers in Arkansas were lack of capital and obtaining infrastructure for packaging, processing, and storing products. Qualitative analysis of textual interviews was done …

Dynamic 3d Network Data Visualization, Brok Stafford

Computer Science and Computer Engineering Undergraduate Honors Theses

Monitoring network traffic has always been an arduous and tedious task because of the complexity and sheer volume of network data that is being consistently generated. In addition, network growth and new technologies are rapidly increasing these levels of complexity and volume. An effective technique in understanding and managing a large dataset, such as network traffic, is data visualization. There are several tools that attempt to turn network traffic into visual stimuli. Many of these do so in 2D space and those that are 3D lack the ability to display network patterns effectively. Existing 3D network visualization tools lack user …

The Effect Of Magnetic Water On Feed Conversion Ratio, Body Weight Gain, Feed Intake And Livability Of Male Broiler Chickens, Kenia Mitre

Poultry Science Undergraduate Honors Theses

Passing water through a magnetic field has been shown to have positive effects in agricultural activities such as crops, cattle and poultry production (Ali, Samaneh and Kavakebian, 2014). Several experiments performed in Middle Eastern countries have evaluated the effect of magnetizing drinking water on poultry performance, but results are inconsistent. The current project was conducted to evaluate the effect of magnetizing the drinking water on key aspects of poultry production such as Feed Conversion Ratio, Body Weight Gain, Feed Intake and Livability. Four hundred and forty-nine male Cobb-500 chicks were randomly placed in 6 replicate pens for each of 3 …

Consumer Preferences For Gm Food Labeling: A Market Segments Analysis, Colton Henderson

Agricultural Economics and Agribusiness Undergraduate Honors Theses

Consumer demand for labeling information regarding the genetically modified (GM) content of foods has increased in recent years. This had led to a growing number of products labeled as non-GMO in the marketplace under a voluntary GM labeling program. However, many consumers support stricter regulation in the food industry via a mandatory labeling program for GM ingredients. Although considerable research exists documenting consumers’ willingness to pay to avoid GM foods, less in known about how two such labeling programs affect individual decision making in the marketplace. The goal of this project is to better understand how individuals value GM foods, …

Effects Of Fescue Toxicosis On Whole Blood Gene Expression In Beef Cattle, Julie Atchley

Animal Science Undergraduate Honors Theses

Effects of Fescue Toxicosis on Whole Blood Gene Expression in Beef Cattle

The consumption of endophyte-infected tall fescue causes negative effects on the growth, reproduction, longevity, and overall health of beef cattle; this condition, termed fescue toxicosis by researchers and producers today, costs the United States over $1 billion in losses each year. To mitigate these production losses, it is important for producers to understand how fescue toxicosis affects gene expression and physiological pathways in beef cattle. This study examined the whole blood gene expression and affected pathways in beef cows grazing both endophyte-infected (toxic) tall fescue and (non-toxic) tall …

Modified Landscapes, Esther Nooner

Graduate Theses and Dissertations

Modified Landscapes is a body of work that reflects serious thought regarding Nature and its future. My personal experience and beliefs are at the core of why I believe this subject to be of great importance and why it will sustain many artists’ investigations for the time to come. The influences that informed this process are explored through experiences I had traveling, reading and exploring the photograph as a material object. The manipulation of the photograph is meant to question the beautiful, untouched scene and break the Romantic gaze that is historically tied to representations of Nature and insist upon …

A Numerical Investigation Of Bio-Inspired Scaffolds And Surface Textures, Yucong Gu

Graduate Theses and Dissertations

Synthetic scaffolds are widely used as implants to repair bone fracture. Without a proper design, scaffolds could pose significant health risks to the patient and fail to heal the bone properly. A good synthetic scaffold needs to have high porosity and large pore size to allow new bone cells to form on it. However, a scaffold with higher porosity and larger pore size tends to have reduced mechanical strength. Thus, it is important to find a structural design which allows the implant to have a high porosity and large pore size while retaining high strength. In this research, a 3D-printable …

Got Breadfruit? Marshallese Foodways And Culture In Springdale, Arkansas, Diana Kay Chen

Graduate Theses and Dissertations

Understanding human food choices is essential in the examination of cultural knowledge and decision-making among members of any ethnic group. Ethnographic and cognitive anthropology methods, including a novel calculation of cognitive salience, were used in this study to explore the domain of traditional Marshallese foods in Springdale, Arkansas. Springdale is home to the highest population of Marshallese people outside of the Republic of the Marshall Islands (RMI); the population is expected to rise as people continue to migrate from the RMI because of global climate change and other factors such as family ties. Studies of traditional foodways are increasingly crucial …

Milk, Lindsey Heiden

Graduate Theses and Dissertations

My work is a composition of contemporary fairy tales of visual, written and oral forms. I examined the historical evolution of formula, from animal milk, to powder formula and now to a combination of animal milk, human milk and powder. The current scientific research being done with formula and animals, coupled with a fairy tale is the inspiration behind my current tale. The importance of women both in regards to the historical development of keeping a cultural tradition alive through oral tale-telling and the much larger role of keeping humankind alive through reproduction and birth, further build the base that …

For Wintonbury: An Expansion Of Narrative And Painting, Cassaundra Kayla Sanderson

Graduate Theses and Dissertations

In March 2017, I began planning the narratives of what would become my Thesis Exhibition. One year later marked my installation of the exhibit: For Wintonbury, located at the Fine Art Center Gallery at the University of Arkansas.

A merging of the visual arts and literary fiction, For Wintonbury offers a more immersive experience in storytelling. The painted scenes, drawings, three-dimensional compositions, and short stories each serve their own purposes in presenting partial glimpses into the longer narratives of Wintonbury. Through multiple media and entry points, the viewer is given the choice in which sequence and manner to take in …

Relationships Among Beef Cow Productivity Traits And Single Nucleotide Polymorphisms In The Bovine Heat Shock Protein 70 Gene, Ashley Finney

Animal Science Undergraduate Honors Theses

When eukaryotes are exposed to stressors such as heat, toxins, and low oxygen levels, heat shock proteins (HSPs) are synthesized to maintain normal cellular function within the body. Single nucleotide polymorphisms in the heat shock protein 70 (Hsp70) gene have been associated with calving percentage, and Julian calving date in spring-calving crossbred Brahman cows (Rosenkrans, et al., 2010). Our objective was to determine associations between previously identified polymorphisms in the promoter region and coding sequence of the bovine Hsp70 gene and beef cow efficiency. We evaluated productivity traits, including Julian calving date and calving rates, of fall-calving cows at each …

Cancer Cachexia: Metabolic Changes That Occur In Oxidative Capacity And Carbohydrate And Lipid Metabolism Of The Liver, Sarah Ramey

Health, Human Performance and Recreation Undergraduate Honors Theses

BACKGROUND: Cancer cachexia is defined as cancer-associated muscle wasting, and is a cancer side effect that dramatically affects cancer prognosis, is thought to be at least partially mediated by increased energy expenditure, and is directly responsible for the death of 20-40% of all cancer patients. Although the liver is known to be a predominant regulator of whole body metabolism, there is little known about its relationship to the development of cancer cachexia. PURPOSE: The purpose of this exploratory study was to investigate alterations in liver metabolism by examining measures of hepatic glycogen storage, oxidative phenotype and lipid content throughout the …

Changes In Hepatic Extracellular Matrix During The Development Of Cancer-Cachexia In Mice, Kyle Turner

Health, Human Performance and Recreation Undergraduate Honors Theses

CHANGES IN HEPATIC EXTRACELLULAR MATRIX DURING THE DEVELOPMENT OF CANCER-CACHEXIA IN MICE

Turner K.W.¹, Rosa-Caldwell M.E.¹, Brown J.L.¹, Lee D.E.¹, Perry R.A.¹, Haynie W.A.¹ Washington T.A.¹, Wiggs M.P.², Greene N.P.¹: ¹University of Arkansas, Fayetteville, Arkansas; ²Univeristy of Texas at Tyler, Tyler, Texas

BACKGROUND: Cancer is one of the most widespread and deadly diseases in recent history. Cancer-cachexia is a systemic, metabolic disorder that greatly disrupts the patient’s energy balance, causing uncontrollable weight and, specifically, skeletal muscle loss. This cancer-induced cachexia is …

Insuring A Future For Small Farms, Mary Beth Miller, D. Lee Miller

Journal of Food Law & Policy

Congress created Whole Farm Revenue Protection (WFRP) in the 2014 Farm Bill to provide small, diversified, and organic operations with an insurance product tailored to their unique needs. The program stands out from other federal crop insurance programs with its blend of features that, inter alia, incentivize risk management through crop/animal diversification, increase premium subsidies for beginning producers, allow organic price elections, and recognize on-farm processing expenses. For the farmers who use it, WFRP provides more than peace of mind in the face of unpredictable weather and prices. It provides a revenue guarantee that opens up critical financing channels otherwise …

Understanding The Decision-Making Process Of Local Level Emergency Managers And Future Impacts Of Social Data, Justin Taylor

Industrial Engineering Undergraduate Honors Theses

During the course of a natural disaster, affected populations turn to different avenues to attempt to communicate their needs and locations while emergency managers are faced with the task of making quick decisions to aid in the response effort. The decisions that emergency managers face are affected by factors such as available resources, responder safety, and source of information. In this research, we interview emergency managers about the 2009 North American Ice Storm and a flooding event in late April of 2017 to understand the decisions made and the factors that affected these decisions. Using these interviews, a list of …

The Work Of Living Art, Empathy, And The Creation Of An Aesthetics Of Perception In The Early Twentieth Century, Sarah Peil Winstead

Architecture Undergraduate Honors Theses

Adolphe Appia (1862-1928), theorist and pioneering voice of the New Stagecraft Movement in twentieth century theatre, was a transformative influence on the history of scenic design. This paper looks at the links between Appia’s theories in theatre scenic design and contemporaneous German aesthetic theory. At the time German theorists like Adolf Hildebrand and August Schmarsow developed an aesthetic theory, Einfülung or empathy theory, based on the connection between the human body and perception. I will argue this theory influenced not only Appia and his contemporaries it also shaped the landscape of mid-century theatre design. Appia’s own theories revolved around three …

Quantification Of Tumor-Associated Macrophages Following Immunomodulation Therapy In A Murine Allograft Model Of Colorectal Carcinoma, Caroline Spainhour

Biomedical Engineering Undergraduate Honors Theses

Colorectal Carcinoma (CRC) is one of the deadliest cancers in the world, with 150,000 new cases annually in the United States. Traditional treatments include chemotherapy and invasive surgery; however, research has shown that only 25% of patients that undergo traditional treatment have a positive result. Immunotherapy is an emerging form of cancer treatment that utilizes the patients’immune system to fight cancer cells by targeting inflammation, which plays a large role in the proliferation and metastasis of cancer cells.

Tumor-associated macrophages (TAMs) are immune cells that affect the inflammatory microenvironment of tumors. TAMs are M1 in the early stages of tumors, …

Assessing Nonprofit Ceo Compensation: Does The Media Provide A Fair Perspective?, Amanda Atchison

Finance Undergraduate Honors Theses

The media plays an active role in forming external stakeholders’ perception of business matters. When it comes to nonprofit business, the media is a source of information that, in theory, works to bridge the gap between external stakeholders’ unfamiliarity with nonprofit regulation and what is actually required of the nonprofit sector. This concept is especially present regarding the topic of nonprofit CEO compensation. The goal of this paper is to discuss how media addresses nonprofit CEO compensation and to determine whether or not the media fairly portrays the entire story by assessing current data along with trends in historical data, …

A Farm Bill To Help Farmers Weather Climate Change, Peter H. Lehner, Nathan A. Rosenberg

Journal of Food Law & Policy

The Farm Bill has an enormous impact on climate change. Greenhouse gas emissions from agriculture account for almost 10 percent of total U.S. emissions and up to a quarter of all emissions globally. The Farm Bill encourages the use of carbon-intensive agricultural practices and products responsible for these emissions, but nonetheless offers several opportunities to quickly expand carbon sequestration, making it a critical piece of climate legislation. This essay will examine the climate impact of the Farm Bill, focusing on the commodity, conservation, and crop insurance programs. It then proposes politically feasible changes to these programs aimed at minimizing agricultural …

Building Indian Country’S Future Through Food, Agriculture, Infrastructure, And Economic Development In The 2018 Farm Bill, Janie Simms Hipp, Colby D. Duren, Erin Parker

Journal of Food Law & Policy

With the potential of approximately $1 trillion in spending over 10 years in rural America, the U.S. Department of Agriculture (USDA) programs authorized by the Farm Bill have the ability to build and support thriving economies in rural America. Nowhere is this potential greater, or needed, than in rural Tribal communities. This paper will examine why the unique circumstances of Tribal governments, individual Native American food producers, and Tribal citizens necessitate changes in several USDA programs to serve Indian Country. Further, it will review several policy changes in various titles of the next Farm Bill reauthorization that will help empower …

Cancer-Induced Muscle Wasting, Jacob Levi Brown

Graduate Theses and Dissertations

Cancer-induced muscle wasting, otherwise known as cancer-cachexia, is a wasting syndrome that occurs in approximately 80% of cancer patients that is the primary cause of death for 22%-30% of cancer cases. Cancer-cachexia may be metabolically induced; therefore, the central hypothesis of this dissertation is mitochondrial degeneration occurs before cancer-cachexia, and increased oxidative stress because of mitochondrial degeneration in muscle may instigate cancer-cachexia. Lewis Lung Carcinoma cells (LLC) or PBS (control) were injected into the hind-flank of C57Bl6/J mice at 8 wks age, and tumor allowed to develop for 1, 2, 3 or 4 wks. Mitochondrial quality, function, ROS emission, protein …

Cooking Patties From A Frozen State, Endpoint Temperature, And Post-Cookery Chilling Affect Internal And External Color And Cooking Losses In Ground Beef Patties, Zena Hicks

Animal Science Undergraduate Honors Theses

To determine the effects of cooking state (frozen vs. thawed), endpoint temperature (65.5 vs. 73.9°C), and post-cookery chilling on color of ground beef patties, 85% coarse-ground beef was purchased and ground through a 9.5-mm plate, formed into 115-g patties, and crust frozen before 4 patties were vacuum packaged and stored at -10 °C. Packages were either thawed in a water bath for 2 h prior to cooking or cooked directly from frozen. Within each package, patties were weighed before being cooked to their assigned temperature (65.5 or 73.9^oC) and either allowed to cool at room temperature on paper …

Phylogeny Of The Orangethroat Darter (Etheostoma Spectabile) Species Complex In The Ozark Highlands Of Arkansas, Mckenna George

Animal Science Undergraduate Honors Theses

Darters are small, benthic fishes that live in freshwater rivers and streams and belong to the family Percidae. Pleistocene glaciations fragmented many darter species, resulting in speciation, but new species are often hard to detect if they are morphologically identical to pre-existing species. Intraspecific hybridization and resulting introgression, which occur frequently in glaciated areas, further complicate identification by introducing heterospecific genomes into mitochondrial DNA, making it difficult to accurately resolve phylogenetic relationships. The results of Bossu and Near’s 2009 study highlight this issue, showing a large degree of incongruence between mitochondrial and nuclear gene trees.

This study analyzed samples from …