Entire DC Network | Open Access Articles | Digital Commons Network™

A New Hope For Depression: Nv-5138’S Game-Changing Potential, Mina Takahashi, Clinton Martin, Richard Shelton

UAB Huntsville Research Day - All Presentations

No abstract provided.

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Comparative Analysis Of Lewy Body Dementia And Other Dementia Types, Mina Takahashi, Muskan Vankwani, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin

UAB Huntsville Research Day - All Presentations

No abstract provided.

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Exploring Alzheimer’S Disease: Advances In Understanding And Care, Mina Takahashi, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin

UAB Huntsville Research Day - All Presentations

No abstract provided.

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Inside Pick’S Disease: A Case Of Frontotemporal Dementia, Mina Takahashi, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin

UAB Huntsville Research Day - All Presentations

No abstract provided.

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Vascular Dementia: Protect Your Blood Flow, Preserve Your Memory, Muskan Vankwani, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin

UAB Huntsville Research Day - All Presentations

No abstract provided.

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The Association Of Social Determinants Of Health And Type Ii Diabetes Self-Management Among Persons Living With Physical Disability (Mobility & Visual Impairments), Anita Aboagye

All ETDs from UAB

Type II Diabetes (T2D) management yield positive outcomes in glycemic control, lifestyle behaviors, knowledge enhancement, and self-care. Persons with disability (PWDs) - regardless of disability type - are faced with additional challenges in diabetes self- management. Moreover, PWDs exhibit adverse outcomes across various measures of social determinants of health (SDOH) compared to individuals without disabilities. This dissertation explored four research aims to examine the impact of adverse SDOH experiences on T2D self- management among persons with physical disability utilizing a preprint/reprint format - with each aim leading to a manuscript. Secondary data analysis using the 2022 Behavioral Risk Factor Surveillance …

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Numerical Analysis And The Deal.Ii Implementation Of An Efficient And Robust Parameterized Ensemble Algorithm For Navier Stokes Flow In The Convection-Dominated Regimes, Brandiece Berry

All ETDs from UAB

Ensemble methods are widely used to approximate solutions for the Navier-Stokes Equations to account for inherent uncertainties within the system. This work goes about the numerical analysis and efficiency assessment of a fully discretized Ensemble Eddy Viscosity (EEV) model for the incompressible Stochastic Navier-Stokes Equations. The model is efficient due to the use of ensemble methods. Through a single coefficient matrix for $J$ realizations, we reduce computational cost and thereby ensure computational efficiency. It is found that the model is robust with the inclusion of the eddy viscosity term, as an additional uncertainty quantification. Finally, we verify theoretical convergence rates …

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Family Narratives Of Immigration And Identity, Miranda Victoria Brunn

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This study investigates themes and lessons present in diverse intergenerational family stories of immigration. Effects of participant perceptions of lesson valence on resilience and relational closeness were observed in an emerging adult sample (N = 42), using the lens of Communicated Narrative Sensemaking Theory (CNSM). Additionally, participant perception of lesson utility was observed in relation to emerging adults’ prior thought and intent to share their family stories. Lastly, with whom emerging adults share their family stories was considered. A mixed methods approach was employed, utilizing an online survey with scales and open-ended text boxes. Findings revealed thirty-three distinct themes and …

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Rural Adolescent Girls' Experiences With Female Antiheroes: A Phenomenological Study Of Literature Discussions And Mentorship, Candice Kennedy Byers

All ETDs from UAB

This phenomenological research study focused on the experiences of rural adolescent girls reading female led multicultural young adult literature with the guidance of a female mentor teacher. Using two multicultural young adult novels one with a strong female protagonist and one with a female antihero protagonist, this five-week study sought to explore the lived experiences of 14 adolescent girls in the rural Southeast. The theoretical frameworks of Radical Feminism (Lawford-Smith, 2022; hooks, 2015; Kreps 1972; Rhodes, 2005), Critical Race Theory (Crenshaw, 1988; Ladson-Billings. 2003; Delgado, 1989; Harris 1993), and Multicultural Young Adult Literature (Nieto, 2002; Fox & Short, 2003; Boyd …

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Food Insecurity Among Graduate Students At The University Of Alabama At Birmingham, Amy Elizabeth Callahan

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College food insecurity (FI) has grown steadily as a field of research over the past fifteen years. Existing research primarily has demonstrated that FI is a persistent problem with various risk factors and myriad potential impacts on students, though graduate students are largely understudied in favor of undergraduate and aggregated student populations. Given the unique circumstances graduate students face, as well as expected demographic differences such as age and household characteristics, this is a serious gap in the literature. This dissertation aims to investigate graduate student food insecurity in the United States, and particularly at the University of Alabama at …

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Platal Expansion Using The Invisalign Palatal Expander "Ipe", Hassan Chihab

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Palatal expansion has been used in orthodontics to treat a narrow maxilla and to primarily correct posterior dental crossbites. In younger patients, palatal expansion can readily be achieved through opening of the mid-palatal suture, as it is not fused at that age. As the mid-palatal suture matures, expansion will gradually be difficult to achieve, and more dental expansion is obtained rather than skeletal. In addition, there is a tendency to get more dental tipping. Palatal expansion has been recommended not only to correct crossbites but also to improve breathing in patients with sleep disorders such as obstructive sleep apnea (OSA). …

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Analysing Post-Mortem Interval By Blood Metabolomics, Nishitha Reddy Nishitha Chitla

All ETDs from UAB

Accurate estimation of the postmortem interval (PMI) is a critical aspect of forensic investigations, aiding in time-of-death determination. This study employs High-Performance Liquid Chromatography Mass Spectroscopy (HPLCMS) and Gas Chromatography-Mass Spectrometry (GC-MS) to analyze postmortem metabolic changes and identify potential biomarkers for PMI estimation analyses through metabolomics. Blood serum samples from ante mortem samples (AMS) and postmortem samples (PMS) were categorized into Control (0 hrs), Early PMI (25–58 hrs), and Late PMI (92–163 hrs) groups. Multivariate statistical analyses, including Partial Least Squares-Discriminant Analysis (PLS-DA), Variable Importance in Projection (VIP) scoring, and metabolic pathway evaluations, were conducted to assess biochemical alterations …

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Co-Creating A Social, Emotional, And Mental Health Well-Being Group For College Students With Disabilities And/Or Chronic Health Conditions And Are Registered With Disability Support Services, Consuelo A. Click Copeland

All ETDs from UAB

ABSTRACT Nearly one in four adults in the United States report living with a disability (Centers for Disease Control and Prevention, 2024). According to the National Center for Educational Statistics (2023), approximately 21 percent of undergraduate students and 11 percent of postbaccalaureate students report having a disability. Students with disabilities in college encounter considerable obstacles that can adversely affect their mental health, academic performance, and general well-being. These obstacles encompass social isolation, stigma, and insufficient personalized support services, resulting in increased levels of anxiety, depression, and dropout rates compared to students without disabilities. Despite the critical need, there is a …

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Mandatory Grade Retention: A Phenomenological Study Of The Lived Experiences Of Principals During The Implementation Of The Alabama Literacy Act, Kiana Billings Coleman

All ETDs from UAB

ABSTRACT For over 40 years, the standards-based reform movement has significantly influenced educational policy in the United States (Shanahan, 2014). Educators across the country are under increasing pressure to improve student achievement as states implement policies that link test scores to accountability measures. Recently, the adoption of mandatory grade retention policies has emerged as a popular intervention for addressing low academic performance. Effective leadership is vital to the success of policy initiatives. However, there is limited research on how school principals experience mandatory retention policies. Understanding how administrators navigate retention policies is essential for identifying effective leadership strategies that facilitate …

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Evaluation Of The Niosh Sound Level Meter App In Real Work Settings, Maxwell Scott Costlow

All ETDs from UAB

With the significant presence of occupational noise exposure, the development of mobile sound measurement applications has been reported. These apps have the potential to help reduce purchasing costs of sampling equipment for small businesses. One of the most promising apps is the National Institute for Occupational Safety and Health (NIOSH) Sound Level Meter (SLM), but most studies on the accuracy of the app have been conducted in controlled labs. The purpose of this study was to examine the differences between the NIOSH SLM and type 2 noise measuring instruments in real work settings. Both short-term and long-term noise sampling was …

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Elucidating The Proteolytic Determinants Of Flavivirus Infection, Lochlain C. Corliss

All ETDs from UAB

Flaviviruses, recently renamed to orthoflaviviruses, are small, enveloped viruses with positive-sense, single-stranded RNA (ssRNA) genomes of about 11 kilobases. Upon cell entry and uncoating, the viral RNA (vRNA) is directly translated at the endoplasmic reticulum (ER) as a single polyprotein that is then processed by the viral and cellular proteases into 10 functional subunits, consisting of three structural proteins and seven nonstructural (NS) proteins. Among the NS proteins are NS2B and NS3, which form the viral protease complex. NS3 consists of a serine protease domain while NS2B is anchored to the ER and contains a cytoplasmic loop that serves as …

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Effects Of Single-Cell Dietary Protein Sources On Feeding, Growth, And Resource Allocation In The Juvenile Sea Urchin Lytechinus Variegatus, Darrien Jamila De Jesus

All ETDs from UAB

An understanding of nutrition can improve culture of sea urchins, whether as a research model or in the production of seafood products. Macronutrients, including dietary protein sources, can affect growth and reproductive profiles and alter resource allocation to somatic and gametic tissues. Although sea urchins in culture can be fed natural products, diet formulations using various ingredients can be developed to reliably produce desired outcomes. Single-cell protein sources represent a potential alternative to current industry standards of animal-derived protein sources such as fish and squid meal, which are becoming increasingly overfished and expensive. In the present study, we evaluated the …

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Optimizing Recruitment Strategies, Outcome Measures, And Intervention In Clinical Research With Adults With Multiple Sclerosis: Insights From The Tele-Exercise And Multiple Sclerosis (Teams) Study, Tracy Flemming Tracy

All ETDs from UAB

Background: Recruiting people with multiple sclerosis (PwMS) into research can be a significant challenge. This is often due to limited awareness of the research objectives, lack of accessibility, and restrictive inclusion criteria. In addition to a general reluctance to participate, assessing multiple sclerosis (MS) and assigning appropriate interventions can be challenging due to the heterogeneity of symptoms. Identifying outcome measures that accurately reflect a participant’s perception and functional performance, while remaining sensitive to change across different levels of disability, poses a challenge. Methods: Data from the Tele-Exercise and Multiple Sclerosis (TEAMS) trial was analyzed to identify effective recruitment strategies (Study …

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Effect Of Pre-Treatment Lab-Based Comorbidities On Treatment Related Outcomes Among Patients With Cancer, Jeffrey Alan Franks

All ETDs from UAB

Cancer is one of the leading causes of mortality and morbidity in the United States. In addition to their cancer, nearly 50% of individuals have a comorbid condition. This adds complexity to the treatment of these patients as it may delay cancer diagnosis or treatment or prevent treatment all together. Lab-values are an important tool to measure comorbidities and end-organ damage as they are routinely captured as part of standard of care and the basis of clinician decision making. However, despite the widespread multimorbidity and how crucial they are to decision making, few studies assess the association of lab abnormalities …

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Context-Dependent Functional Connectivity During Attention Orienting And Reorienting: Comparing Individuals With Schizophrenia And Controls, Hyun Freeman

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Attentional deficits are a well-established feature of schizophrenia, impacting various functional domains. Previous research suggested altered connectivity within attention networks may underlie these deficits, but few studies have examined how these net-works dynamically interact during different types of attention processes. In this study, we investigated functional connectivity patterns during attentional orienting and reori-enting to social and nonsocial cues in 25 individuals with schizophrenia and 25 controls. Participants completed a modified Posner spatial cueing task with both social (eyes) and nonsocial (arrows) cues during fMRI scanning. Using generalized psychophysiological interaction analysis with the left lateral occipital cortex (LOC) as a seed …

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Elucidating Non-Canonical Interactions Of Mcl1 With The P53 Family Of Tumor Suppressors, Alexus Marie Acton

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Various signaling mechanisms contribute to a cancers cell’s ability to survive through the stressors of tumorigenesis. Canonically, when a cell is exposed to irreversible stress, the induction to apoptosis is regulated by the Bcl-2 family of apoptotic regulators. However, to accommodate for the stressors of tumor progression, many solid tumors over express one of the pro-survival proteins (e.g., BCL2, BCLxL, MCL1) allowing for persistent growth without the induction to cell death. Over the past 10 years, researchers have investigated how over expression of these pro-survival proteins contribute to chemoresistance to standard of care therapies. To sensitize cells to these apoptotic …

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Stimulation And Quantification Of Dopamine-Associated Behaviors, Hunter Goffinett

All ETDs from UAB

Dopamine (DA) is a neurotransmitter involved in the regulation of essential behaviors, including motor control and reward processing. Alterations in DA levels can significantly modulate these behaviors: increased DA release is associated with heightened locomotion and enhanced preference for rewarding stimuli. Therefore, measuring behavioral changes in vivo provides critical insight into DA release and function. In this study, we quantified DA-associated behaviors by radiolytic stimulation of the Drosophila A-isoform of the transient receptor potential ankyrin type-1 A (dTRPA1(A)) channel and investigated how the human-immunodeficiency virus (HIV) and its secreted protein, the trans-activator of transcription regulatory protein (Tat), alter drug-induced behaviors. …

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Targeting The Thyroid-Stimulating Hormone Receptor (Tshr) In Thyroid Cancer, Grayson Robert Gimblet

All ETDs from UAB

Radioactive iodine (RAI) has been effective in the treatment of thyroid cancer, the most common endocrine neoplasia, since its introduction into clinical use over eighty years ago. However, not all patients benefit from RAI. Up to 20% of patients with well-differentiated thyroid cancer (WDTC) become radioactive iodine refractory (RAI-R). These RAI-R patients have 5-year survival rates of 50% and 10-year survival rates of 10%. In addition, more aggressive subtypes including oncocytic thyroid carcinoma (OC), poorly differentiated thyroid carcinoma (PDTC), and anaplastic thyroid carcinoma (ATC) are less responsive to RAI therapy. Despite accounting for less than 5% of annual thyroid cancer …

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Wear Resistance Of 3d Printed Occlusal Splint Materials, Pierpont Flanders Brown

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Statement of problem: Three-dimensional (3D) printing offers an efficient method to produce occlusal devices (splints). However, their wear resistance is poorly understood. Purpose: The purpose of this in vitro study was to compare the wear resistance of flexible and rigid 3D printed occlusal splint materials to milled and conventionally processed occlusal splint materials. By establishing such a comparison, this study will help provide clinicians with greater knowledge of which materials and methods will provide their patients with the most wear resistant and durable occlusal splint possible. Material and methods: Identical sized blocks (n=8) of 3 flexible 3D printed materials (KeySplint …

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Occupational Exposure To Cooking Emissions And Evaluation Of Ventilation System In Restaurant Kitchens, Matthew Kaleb Hanvey

All ETDs from UAB

Background: In the restaurant environment, there are many harmful contaminants generated during the cooking process that kitchen workers are potentially exposed to. The purposes of this study were to evaluate the potential exposure to aldehydes and respirable particles among restaurant kitchen workers and to examine the ventilation performance of the kitchen exhaust hoods. Methods: There were three restaurants recruited for this study and they cooked seafood/poultry (Restaurant 1), farm style foods (Restaurant 2), and finger foods (Restaurant 3). The three restaurants had wall-mounted canopy hoods. Restaurant 1 had two hoods, Restaurant 2 had two hoods, and Restaurant 3 had one …

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Electrophysiological Integration Of Engineered Tissue Graft With The Host Swine Myocardium, Bijay Guragain

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The adult mammalian heart lacks regenerative capacity to replenish cardiomyocytes (CMs) lost due to myocardial infarction (MI). Instead, the damaged heart undergoes extensive remodeling that significantly impairs normal cardiac function and may eventually lead to heart failure. Recent therapies that implant engineered tissues fabricated from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have shown promising results with improved cardiac function and structural integration. However, the extent of electrophysiological coupling between engineered and host tissue remains unclear. This is a critical factor for functional integration of the implant as well as for arrhythmia risk arising from the implant. Our study aims …

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Discarded People, Amber Harris

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ABSTRACT This is the first chapter of the novel, Discarded People, a character-driven story about a group of young Black friends navigating love, identity, and community. As they form deep connections with one another, they face personal struggles that challenge their sense of belonging and self-discovery. The narrative explores themes of family, friendship, and the search for purpose, while highlighting the complexities of building a chosen family amidst personal and societal pressures. In chapter one, the main characters are introduced; Winnie, Franklin, Jelani, Adanna, Eban and Chance. As the characters prepare for their final year in high school while navigating …

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Development Of A Resistive Force Paradigm For The Treatment Of Hemiparesis, Jonathan Daniel Hill

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Hemiparesis is weakening of one side of the body as a result of a stroke that contributes to a decrease in propelling forces (i.e. propulsion) while walking. Existing research to improve propulsion of individuals post-stroke has implemented single-belt and split-belt treadmills, various walking speeds, asynchronous belt speeds (on split-belt treadmills), and a variety of methods for inducing resistive force upon a paretic limb in an attempt to strengthen the paretic limb and improve overall gait symmetry. However, despite this concerted effort of clinicians and scientists, gait deficits remain. Novel methods are required to improve reduced propulsion of individuals post-stroke. Recently, …

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The Role Of Aquaporin-3 Lysine 282 Acetylation In Renal Water Balance, Nha Van Huynh

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Aquaporin-3 (AQP3) mediates basolateral water transport in the kidney collecting duct principal cells, contributing to vasopressin-mediated urine concentration. We previously identified a novel post-translational modification of AQP3, the acetylation of lysine 282 (K282), which we hypothesized as a positive regulator of AQP3 water permeability. First, we found that collecting duct K282 acetylated AQP3 increased upon water deprivation, suggesting an involvement in renal water balance. To decipher the functional role of this modification, we utilized AQP3 acetylation (K282Q or Q) and deacetylation (K282R or R) mimetic mutant mice models generated using CRISPR/Cas9 knock-in technology. Both male and female wild-type (WT) and …

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The Impact Of Transportation Insecurity On No-Show Appointments And Acute Care Utilization In Pediatric Sickle Cell Patients, Seabrook Hannah Jeffcoat

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Sickle cell disease (SCD) patients experience high levels of transportation insecurity. Missed or delayed medical care due to transportation barriers can result in worsened clinical outcomes and increased hospital admissions and emergency department (ED) visits. We hypothesized that the relationship between transportation insecurity and acute care utilization is partially mediated by no-show appointments. This retrospective cohort study included 101 SCD patients aged ≤ 21 treated through the Pediatric Sickle Cell Clinic at Children’s of Alabama (COA) hospital from 2023 to 2024 and completed a social determinants of health (SDoH) questionnaire. Negative binomial or Poisson regression was used to model ED …

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Full-Text Articles in Entire DC Network

A New Hope For Depression: Nv-5138’S Game-Changing Potential, Mina Takahashi, Clinton Martin, Richard Shelton

UAB Huntsville Research Day - All Presentations

Comparative Analysis Of Lewy Body Dementia And Other Dementia Types, Mina Takahashi, Muskan Vankwani, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin

UAB Huntsville Research Day - All Presentations

Exploring Alzheimer’S Disease: Advances In Understanding And Care, Mina Takahashi, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin

UAB Huntsville Research Day - All Presentations

Inside Pick’S Disease: A Case Of Frontotemporal Dementia, Mina Takahashi, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin

UAB Huntsville Research Day - All Presentations

Vascular Dementia: Protect Your Blood Flow, Preserve Your Memory, Muskan Vankwani, Janaki Nimmagadda, Anupama Yedla, Richard Shelton, Clinton Martin

UAB Huntsville Research Day - All Presentations

The Association Of Social Determinants Of Health And Type Ii Diabetes Self-Management Among Persons Living With Physical Disability (Mobility & Visual Impairments), Anita Aboagye

All ETDs from UAB

Numerical Analysis And The Deal.Ii Implementation Of An Efficient And Robust Parameterized Ensemble Algorithm For Navier Stokes Flow In The Convection-Dominated Regimes, Brandiece Berry

All ETDs from UAB

Family Narratives Of Immigration And Identity, Miranda Victoria Brunn

All ETDs from UAB

Rural Adolescent Girls' Experiences With Female Antiheroes: A Phenomenological Study Of Literature Discussions And Mentorship, Candice Kennedy Byers

All ETDs from UAB

Food Insecurity Among Graduate Students At The University Of Alabama At Birmingham, Amy Elizabeth Callahan

All ETDs from UAB

Platal Expansion Using The Invisalign Palatal Expander "Ipe", Hassan Chihab

All ETDs from UAB

Analysing Post-Mortem Interval By Blood Metabolomics, Nishitha Reddy Nishitha Chitla

All ETDs from UAB

Co-Creating A Social, Emotional, And Mental Health Well-Being Group For College Students With Disabilities And/Or Chronic Health Conditions And Are Registered With Disability Support Services, Consuelo A. Click Copeland

All ETDs from UAB

Mandatory Grade Retention: A Phenomenological Study Of The Lived Experiences Of Principals During The Implementation Of The Alabama Literacy Act, Kiana Billings Coleman

All ETDs from UAB

Evaluation Of The Niosh Sound Level Meter App In Real Work Settings, Maxwell Scott Costlow

All ETDs from UAB

Elucidating The Proteolytic Determinants Of Flavivirus Infection, Lochlain C. Corliss

All ETDs from UAB

Effects Of Single-Cell Dietary Protein Sources On Feeding, Growth, And Resource Allocation In The Juvenile Sea Urchin Lytechinus Variegatus, Darrien Jamila De Jesus

All ETDs from UAB

Optimizing Recruitment Strategies, Outcome Measures, And Intervention In Clinical Research With Adults With Multiple Sclerosis: Insights From The Tele-Exercise And Multiple Sclerosis (Teams) Study, Tracy Flemming Tracy

All ETDs from UAB

Effect Of Pre-Treatment Lab-Based Comorbidities On Treatment Related Outcomes Among Patients With Cancer, Jeffrey Alan Franks

All ETDs from UAB

Context-Dependent Functional Connectivity During Attention Orienting And Reorienting: Comparing Individuals With Schizophrenia And Controls, Hyun Freeman

All ETDs from UAB

Elucidating Non-Canonical Interactions Of Mcl1 With The P53 Family Of Tumor Suppressors, Alexus Marie Acton

All ETDs from UAB

Stimulation And Quantification Of Dopamine-Associated Behaviors, Hunter Goffinett

All ETDs from UAB

Targeting The Thyroid-Stimulating Hormone Receptor (Tshr) In Thyroid Cancer, Grayson Robert Gimblet

All ETDs from UAB

Wear Resistance Of 3d Printed Occlusal Splint Materials, Pierpont Flanders Brown

All ETDs from UAB

Occupational Exposure To Cooking Emissions And Evaluation Of Ventilation System In Restaurant Kitchens, Matthew Kaleb Hanvey

All ETDs from UAB

Electrophysiological Integration Of Engineered Tissue Graft With The Host Swine Myocardium, Bijay Guragain

All ETDs from UAB

Discarded People, Amber Harris

All ETDs from UAB

Development Of A Resistive Force Paradigm For The Treatment Of Hemiparesis, Jonathan Daniel Hill

All ETDs from UAB

The Role Of Aquaporin-3 Lysine 282 Acetylation In Renal Water Balance, Nha Van Huynh

All ETDs from UAB

The Impact Of Transportation Insecurity On No-Show Appointments And Acute Care Utilization In Pediatric Sickle Cell Patients, Seabrook Hannah Jeffcoat

All ETDs from UAB