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Assesing The Degree Of Intereron Gamma Induced Stat1 Activation On Peripheral Lymphocytes In Patietns With Rheumatoid Arthritis, Vishal Sharma Jan 2021

Assesing The Degree Of Intereron Gamma Induced Stat1 Activation On Peripheral Lymphocytes In Patietns With Rheumatoid Arthritis, Vishal Sharma

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Rheumatoid Arthritis (RA) is a systemic autoimmune disease with debilitating side effects, from joint swelling to bone erosion and bone deformation. Geographically, RA affect 0.5 – 1% of the worldwide populations, affecting women more than men. Studies have shown that CD4 T cells infiltrate RA synovium and are key to the pathogenesis of RA. Furthermore, drugs targeting co-stimulatory T cell molecules such as abatacept can be beneficial in controlling RA disease activity.Interferon gamma (IFN) is a pleotropic cytokine that contributes to inflammation by aiding in CD4 T cell differentiation into Th1 subtype, enhancing MHC class II presentation, supplementing lymphocyte trafficking, …

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Mechanism Of Stat3 Mediated Drug Persistence In Chronic Myeloid Leukemia Stem Cells, Sweta B. Patel Jan 2021

Mechanism Of Stat3 Mediated Drug Persistence In Chronic Myeloid Leukemia Stem Cells, Sweta B. Patel

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Drug persistence is one of the major impediments for cancer therapeutics. There are two known evolutionary models for tumor drug persistence. First, a pre-existing sub-population is inherently resistant to treatment; and second, a sub-population acquires resistance by drug-induced molecular reprograming. One ideal model to study the mechanism of drug persistence is chronic myeloid leukemia (CML), a hematopoietic stem cell (HSC) disorder. HSCs acquire a single translocation between chromosome 9 and 22, forming BCR-ABL, a constitutively active tyrosine kinase. Tyrosine kinase inhibitors (TKI), the standard regimen, have been able to efficaciously control CML and yet many patients relapse upon treatment discontinuation …

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Examining Approaches For Peacebuilding In Post-Conflict, Post-Good Northern Ireland, Evan Wiley Smith Jan 2021

Examining Approaches For Peacebuilding In Post-Conflict, Post-Good Northern Ireland, Evan Wiley Smith

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In this paper, I broadly describe the timeline of the conflict in Northern Ireland, examine negative and positive peace approaches to peacebuilding including political (or consociationalism-based), human rights-based, and reconciliation-based methods, and present my own conclusions based on the literature review I conducted as to the most efficacious strategy for ensuring long-lasting peace in Northern Ireland. To do this, I reviewed numerous articles, papers, and chapters on the conflict in Northern Ireland, approaches in post-conflict reconciliation, and conflict resolution theory. Because the conflict in Northern Ireland ended approximately twenty years ago, much of the research referenced in this paper is …

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The Kinetic Effects Of Nanoconfinement, Aggregate Phase Type, And Pressure On Some Thermally Stimulated Processes, Victoria Lynn Stanford Jan 2021

The Kinetic Effects Of Nanoconfinement, Aggregate Phase Type, And Pressure On Some Thermally Stimulated Processes, Victoria Lynn Stanford

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This research explores the effects of nanoconfinement, aggregate state type, and an inert gas pressure on the kinetics of thermally stimulated processes. The processes considered are solution crystallization and thermal decomposition. The kinetic effects are measured via differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and high pressure differential scanning calorimetry (HPDSC), combined with isoconversional kinetic analysis. The first chapter demonstrates that DSC can be applied to measure the kinetics of nonisothermal crystallization. The crystallization of potassium nitrate and ammonium perchlorate are from unsaturated and saturated aqueous solutions. An advanced isoconversional method demonstrates that the process is represented by negative values …

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Waffle, Ashley Tippit Jan 2021

Waffle, Ashley Tippit

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Waffle is a novel about a high school senior realizing she has an anxiety disorder and is pansexual. Aside from wanting to tell a version of my own story, I want this to be a young adult novel that has appropriate, diverse representation. Given that several characters have identities different than mine (Jay having a single parent, Ginger being Black and having Type One Diabetes, Ella being transgender with divorced parents, and Birdie being Taiwanese-Korean American), I will need a lot of research and help to write these characters well. I want the information and experiences regarding race, gender, sexuality, …

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An Investigation Into The Effects Of Diet On Pain And Pain Disparities, Larissa Jane Strath Jan 2021

An Investigation Into The Effects Of Diet On Pain And Pain Disparities, Larissa Jane Strath

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Chronic pain is one of the most common and disabling disorders in Westernsociety. Recently, it has been suggested that dietary quality may play a key role in the development and maintenance of pain. Additionally, diet differs between demographic groups, as does physiological differences in response to metabolites. We sought to explore 1) the central way in which diet influences pain sensitivity and 2) if dietary patterns affected various demographic groups differently. We first employed a rat model to observe diet-related changes in the dorsal horn of the spinal cord. In the absence and presence of an injury, rats fed a …

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Characterization Of Color Centers In Diamond For Laser Applications, Shova Devi Subedi Jan 2021

Characterization Of Color Centers In Diamond For Laser Applications, Shova Devi Subedi

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Diamond has been gaining a lot of interest in the field of photonics such as quantum optics, nano-photonics, quantum computation, magnetometry, sensing, laser development, and color center physics as it provides a remarkable platform to combine its non-linear optical properties in conjunction with the unique optical and spin properties of its color centers. Besides that, energetic pulsed lasers operating in the visible to near IR spectral range are mostly obtained from non-linear frequency conversion which is less efficient, expensive, and requires nonlinear crystal with excellent optical quality, a special cut to meet the perfect phase-matching condition. Another alternative is dye …

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From Deviance To Disease: How Congress Frames Opioid Use, 1994-2019, Stephanie Kirkland Jan 2021

From Deviance To Disease: How Congress Frames Opioid Use, 1994-2019, Stephanie Kirkland

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Over the past thirty years, the use of opioids like heroin, fentanyl, oxycodone, and hydrocodone led to tens of thousands of deaths from overdoses and caused a public health crisis. Researchers have noted the roles of various social organizations and groups in creating a public discourse around this topic and have studied the changing public views of opioid use in light of new scientific research. And yet, there remains a gap in research on the role of the members of Congress in this public discourse. These legislators pass policies that directly affect people who live with or who know someone …

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Mothering Ourselves To Wholeness: Employing Black Feminist Criticism & Critical Narrative Methods To Trace Black Maternal Archetypes & Restory The Praxas Of Socio-Politically Engaged Black Mothers In Rural, Suburban, & Urban Contexts, Martez D. Files Jan 2021

Mothering Ourselves To Wholeness: Employing Black Feminist Criticism & Critical Narrative Methods To Trace Black Maternal Archetypes & Restory The Praxas Of Socio-Politically Engaged Black Mothers In Rural, Suburban, & Urban Contexts, Martez D. Files

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Mothering Ourselves to Wholeness: Employing Black Feminist Criticism & Critical Narrative Methods to Trace Black Maternal Archetypes & Restory the Praxes of Socio-Politically Engaged Black Mothers,” is a project that seeks to uncover the myriad ways Black mothers in diverse geographic spaces in Alabama and in select works of Black literature have forged communal wholeness, protected the most vulnerable, and healed harm outside and within communities. Black Mothering Praxis constellates the communal practices that counter exploitation, center care, accountability, and foster wholeness in a world that breaks and fragments Black bodies and beings. The research begins with identifying the various …

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Embodied Fat Stigma And Health Beliefs About Exercise And Diet, Brie Scrivner Jan 2021

Embodied Fat Stigma And Health Beliefs About Exercise And Diet, Brie Scrivner

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The purpose of this dissertation is to examine how individuals navigate the cultural mandate for thinness, which pressured individuals to pursue weight loss through exercise and restrictive diets. While sustainable weight loss is not probable for the majority of people, there are still significant physical and mental health benefits to be had from engaging in regular, enjoyable movement. For many, physical activity is an important component of a healthy lifestyle. It can improve quality of life for individuals regardless of weight, body size, chronic illness, or disability. However, many fitness facilities focus on weight loss as the most essential goal …

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Characterizing The Role Of Necroptosis Of Airway Epithelial Cells In The Immune Response To Respiratory Pathogens, Ashleigh Nichole Riegler Jan 2021

Characterizing The Role Of Necroptosis Of Airway Epithelial Cells In The Immune Response To Respiratory Pathogens, Ashleigh Nichole Riegler

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Necroptosis, a programmed form of lytic cell death, is initiated by various viral and bacterial pathogens through irreparable ion dysregulation and energy depletion. This cellular damage results in the activation of the cellular kinases RIPK1 and RIPK3, consecutively, and the activation and membrane targeting of MLKL, the latter responsible for lysis. Here we have demonstrated that necroptosis of airway epithelial cells is key in the development of the adaptive immune response to asymptomatic colonization by Streptococcus pneumoniae (Spn). Briefly, necroptotic deficient animals or wildtype animals colonized with Spn lacking the necroptosis-triggering pneumolysin toxin, failed to recruit CD11c+ leukocytes to the …

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Cns Antigen Presentation And Immune Cell Infiltration In An Α-Syn Model Of Parkinson Disease, Aubrey Michelle Schonhoff Jan 2021

Cns Antigen Presentation And Immune Cell Infiltration In An Α-Syn Model Of Parkinson Disease, Aubrey Michelle Schonhoff

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Parkinson disease (PD) is a neurodegenerative movement disorder that is characterized by aggregated alpha-synuclein (a-syn), loss of dopaminergic neurons, and neuroinflammation. This neuroinflammation includes the activation of immune cells that reside in the CNS, such as microglia and border associated macrophages (BAMs), in addition to the infiltration of peripheral leukocytes and increased cytokine and chemokine production. Because of the involvement of both the innate and adaptive immune systems, we sought to investigate their interaction through antigen presentation and determine what role this played in disease progression. Using an a-syn based mouse model of PD, our studies have provided evidence via …

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The Cellular Role Of Tyrosyl-Dna Phosphodiesterase 1 N-Terminal Domain In Topoisomerase 2-Dna Covalent Complex Repair In Yeast, Isaac Andres Segura Jan 2021

The Cellular Role Of Tyrosyl-Dna Phosphodiesterase 1 N-Terminal Domain In Topoisomerase 2-Dna Covalent Complex Repair In Yeast, Isaac Andres Segura

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Tyrosyl-DNA phosphodiesterase 1 (Tdp1) removes adducts from DNA-ends, including damaged nucleotides and protein-DNA crosslinks such as DNA topoisomerases (Topo1 and Topo2) and Tdp1 itself. The N-terminal domain (NTD) of Tdp1 has been understudied, structurally unresolved, and seemingly dispensable for in vitro catalytic activity. However, our lab made the novel observation that the NTD is critical for Tdp1 cellular activity in removing Topo1-DNA covalent complexes (Topo1cc). Removal of the first 80 residues (yeast Tdp1 NTD) results in the loss of the toxic phenotype induced by full-length Tdp1 catalytic mutants. This suggests that in cells the NTD has a critical function in …

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Added Sugar Consumption And Prediabetes In U.S. Adults: A Cross-Sectional Analysis Of The National Health And Nutrition Examination Survey, 2013-2018, Nadia Markie Sneed Jan 2021

Added Sugar Consumption And Prediabetes In U.S. Adults: A Cross-Sectional Analysis Of The National Health And Nutrition Examination Survey, 2013-2018, Nadia Markie Sneed

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Prediabetes is a modifiable risk factor for type 2 diabetes (T2D) that effects 88- million U.S. adults. Added sugar is linked to the risk for prediabetes through direct and indirect mechanisms that promote hepatic and whole-body insulin resistance. Added sugar is overconsumed and totals ~13% of American’s daily caloric intake, with consumption highest for non-Hispanic Blacks and Hispanic minority populations also disproportionality affected by prediabetes and T2D. The effects of total added sugar on prediabetes have been mixed; however, total added sugar intake has primarily been examined using added sugar proxies (e.g., sugar-sweetened beverages, fructose), likely increasing systemic measurement error …

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Association Of Abdominal Obesity And Risk Of Atrial Fibrillation: Findings From The Reasons For Geographic And Racial Differences In Stroke (Regards) Study, Joonseok Kim Jan 2021

Association Of Abdominal Obesity And Risk Of Atrial Fibrillation: Findings From The Reasons For Geographic And Racial Differences In Stroke (Regards) Study, Joonseok Kim

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Background: Our knowledge of the association between abdominal obesity (AO) and the risk of atrial fibrillation (AF) after adjusting for body mass index (BMI) is limited. Methods: We included 11,617 black and white participants (mean age 63.0 + 8.4 years) from the REGARDS (REasons for Geographic and Racial Differences in Stroke) national cohort study who were free of AF at baseline between 2003 and 2007, and completed a follow-up exam between 2013 and 2016 with assessment of AF. A multivariable logistic regression model was used to estimate the odds ratio (OR) with 95% confidence interval of incident AF associated with …

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Risk Of Delirium With Opioid Use Among Older Adults In The Emergency Department, Rachel Michelle Skains Jan 2021

Risk Of Delirium With Opioid Use Among Older Adults In The Emergency Department, Rachel Michelle Skains

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Objectives: Delirium affects 7-17% of older Emergency Department (ED) patients. Inadequate pain control and opioid pain management have been reported to increase risk for delirium. The aim of this study was to evaluate the association between pain severity, opioid exposure, and delirium among older ED patients.Methods: A single-center retrospective cohort study was conducted in an academic Geriatric ED. Patients aged ≥65 years with an Identification of Seniors at Risk (ISAR) score ≥2 and an Emergency Severity Index (ESI) level 3 were enrolled into the Geriatric ED Pathway. Those who received a delirium screening using the Nursing Delirium Screening Scale (NuDESC) …

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Influence Of Race, Gender, Rurality, And Dyadic Health On Symptom Pattern Trajectories In Persons With Advanced Heart Failure, Macy Lynn Stockdill Jan 2021

Influence Of Race, Gender, Rurality, And Dyadic Health On Symptom Pattern Trajectories In Persons With Advanced Heart Failure, Macy Lynn Stockdill

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Individuals living with heart failure experience a high symptom burden that must be addressed to improve their quality of life as well as the quality of life of their family caregivers. This is a challenging task as different situational and individual factors, including clinical/physiological factors and cultural factors, can affect an individual’s symptom experience. The purpose of this dissertation study was to examine existing symptom pattern trajectories and associated factors (sociodemographic, clinical/physiological characteristics, dyadic health) among a sample of under-resourced and racially diverse older adults with advanced heart failure living in the Deep South. This purpose was accomplished through four …

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Attitudes, Beliefs, And Perceived Self-Efficacy Pre- And Post- Suicide Prevention Training, Angela Marie Sullivan Jan 2021

Attitudes, Beliefs, And Perceived Self-Efficacy Pre- And Post- Suicide Prevention Training, Angela Marie Sullivan

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A 2017 World Health Organization (WHO) data brief included suicide in the top 20 causes of death worldwide. The WHO also listed suicide as the second leading cause of death for those aged 15 – 29 worldwide. In the US, suicide is the leading cause of violent death and has been consistently ranked as the 10th leading cause of death among all age groups in the US since 2008. In Alabama, the CDC reports suicide as the 11th leading cause of death in the state and the second leading cause of death for those aged 15 – 34. This study …

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Developing A Core Set Of Nursing-Sensitive Indicators For International Pediatric Oncology Nursing Practice, Courtney Erin Sullivan Jan 2021

Developing A Core Set Of Nursing-Sensitive Indicators For International Pediatric Oncology Nursing Practice, Courtney Erin Sullivan

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Although nursing sensitive indicators (NSIs) have been developed to measure factors influencing nursing care quality and patient outcomes in general and in select specialty areas, a core set of NSIs for international pediatric oncology nursing practice does not exist. Quality nursing care delivery in pediatric oncology is essential to achieving optimal patient outcomes and closing the 50% survival gap between high-income and low- and middle-income countries. To enhance global childhood cancer outcomes influenced by nursing, this dissertation research was conducted with the purpose of developing a preliminary core set of NSIs for international pediatric oncology nursing that is important, actionable, …

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The Impact Of Storm Surge, High Intensity Rainfall And Sea Level Rise On Coastal Cities, Qing Sun Jan 2021

The Impact Of Storm Surge, High Intensity Rainfall And Sea Level Rise On Coastal Cities, Qing Sun

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Storm surge, high-intensity rainfall, and sea level rise have seriously threatened the critical infrastructure of these coastal cities and the lives and properties of urban residents. Understanding the impact of a single extreme event and a cascade of extreme events on coastal cities can help people better understand the expected damage, thereby providing a theoretical basis for delineating the path of mitigation and recovery plans. Therefore, this thesis takes the two coastal cities of New York City (NYC) and the City of Mobile as case studies. Two different research methods are used to evaluate the impact of storm surge, high-intensity …

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An Evaluation Of The Impact Of Medical Home Structures And Care Processes On Temporary Profile Days Among Active-Duty U.S. Army Soldiers, Tanekkia M. Taylor-Clark Jan 2021

An Evaluation Of The Impact Of Medical Home Structures And Care Processes On Temporary Profile Days Among Active-Duty U.S. Army Soldiers, Tanekkia M. Taylor-Clark

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Readiness, the Armed Forces’ ability to carry out a range of military operations, is one of the U.S. Army’s highest strategic priorities. The medical readiness of soldiers is a critical component of overall operational readiness. The greatest threat to medical readiness is acute musculoskeletal injuries (MSIs). Medical providers place soldiers on medical limitations referred to as a “temporary profile” to facilitate treatment and recovery of acute MSIs. Poorly managed temporary profiles negatively impact soldiers’ work attendance and performance, leading to the loss or limitation of over 25 million training/duty days annually. Changes within the primary care setting, including implementing the …

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Is There A Relationship Between Leadership Characteristics And Services Provided Among Ihs Urban Indian Health Programs?, George Grant Tribble Jan 2021

Is There A Relationship Between Leadership Characteristics And Services Provided Among Ihs Urban Indian Health Programs?, George Grant Tribble

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IS THERE A RELATIONSHIP BETWEEN LEADERSHIP CHARACTERISTICS AND SERVICES PROVIDED AMONG IHS URBAN INDIAN HEALTH PROGRAMS?GEORGE G. TRIBBLE HEALTHCARE LEADERSHIP ABSTRACT The Native American population has faced and been impacted by a wide range of actions throughout the last few hundred years. The loss of cultural norms and way of life continues to manifest itself through various socioeconomic concerns. At the center of the Native American leadership model is a disciplined and culturally specific guidance structure. The Urban Indian Health Program (UIHP) was created by the Indian Health Service to establish a culturally appropriate health care delivery model for Native …

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The Two Marys In Bruges: Images Of The Virgin And Child Over The Cityscape And The Reign Of Mary Of Burgundy, Meagan Daughtry Bailey Oates Jan 2021

The Two Marys In Bruges: Images Of The Virgin And Child Over The Cityscape And The Reign Of Mary Of Burgundy, Meagan Daughtry Bailey Oates

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From c.1475 to the early 1480s, a new image type appears in Bruges featuring the Virgin and Child under a cloth of honor with various garden motifs against the backdrop of a contemporaneous cityscape of Bruges. In this thesis, I establish for the first time the images in the Bruges Virgin type as a group in relation to the reign of Mary of Burgundy, Duchess of Burgundy (1477-1482). Analyzing the motifs of the cityscape of Bruges, the enclosed garden theme, and the Virgin and Child, I argue that the Bruges Virgin type alludes to and evokes Mary and her young …

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The Relationships Fathers Have With Their Co-Residential Adult Children With Developmental Disabilities: A Qualitative Exploration Of Fatherhood And Masculinity, Kirsten Leigh Ostergren Clark Jan 2021

The Relationships Fathers Have With Their Co-Residential Adult Children With Developmental Disabilities: A Qualitative Exploration Of Fatherhood And Masculinity, Kirsten Leigh Ostergren Clark

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This dissertation explored the relationships between fathers and their co-residential adult children who have been diagnosed with an intellectual and developmental disability (IDD). This research addressed 1) the ways fathers understand their involvement in the lives of their adult child with developmental disabilities, especially as it relates to their masculinity; 2) how fathers perceive that their experiences fathering their child have impacted their health and health behaviors, including how masculinity plays a part; and 3) what supports fathers stated they have utilized and recommend, along with what challenges and constraints fathers feel they have faced. My analysis of in-depth interviews …

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“Pertinent And Plain”: Robert Barclay And The Transformation Of Quaker Silence, Samuel Phillips Jan 2021

“Pertinent And Plain”: Robert Barclay And The Transformation Of Quaker Silence, Samuel Phillips

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Scholarship on Quaker rhetoric has frequently neglected the subversive possibilities of Quaker pamphleteering, particularly in the period following the publication of Robert Barclay’s Apology. This article develops an epistemological framework based on the Apology and demonstrates that although Quaker pamphleteers during this “Quietist” period asserted the honesty and transparency of their use of language, the Apology works to license certain circumlocutionary moves which Quaker authors used to obscure potentially seditious or heretical ideas. It focuses on two classical rhetorical figures, paralipsis and aposiopesis. Through a close reading of pamphlets written before and after the publication of the Apology, it demonstrates …

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Disrupting The Perioperative Opioid Gateway: Identification Of Risk Factors For New Persistent Post-Surgical Opioid Use, Gia Marie Pittet Jan 2021

Disrupting The Perioperative Opioid Gateway: Identification Of Risk Factors For New Persistent Post-Surgical Opioid Use, Gia Marie Pittet

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A large portion of the American Opioid Crisis is due to opioid naïve patients who become new persistent post-surgical opioid users, although the risk factors for the development of this addiction are not well studied. The objective of this study was to analyze multiple layers of pre-operative and procedural risk factors using an ecological perspective theoretical framework in adult patients undergoing invasive surgery. We performed a retrospective analysis of 13,970 opioid naïve adults in a mixed surgical cohort with data available at the University of California Los Angeles that was merged with narcotics data for the State of California (IRB#19-000625). …

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Beautiful Hunt, Dena Leonard Pruett Jan 2021

Beautiful Hunt, Dena Leonard Pruett

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Beautiful Hunt explores the moment when you realize what is now never will be again no matter how hard you might try to go back. This work also explores developing selfhood – the tension between who we are, who we want to become, how we see ourselves, and how others see us. How is our story told, and who gets to tell it? In January 1998, Alice Landry arrives in the small town of Sans Souci, the boot of the boot of Louisiana. Her father, Sans Souci born and raised, moved away when he married Alice’s mom, a New York …

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Development And Evaluation Of A Functional Human Cardiac Tissue Equivalent Fabricated From Multi-Lineage Human Induced Pluripotent Stem Cell Derived Cells, Danielle Pretorius Jan 2021

Development And Evaluation Of A Functional Human Cardiac Tissue Equivalent Fabricated From Multi-Lineage Human Induced Pluripotent Stem Cell Derived Cells, Danielle Pretorius

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The human heart is an exceptionally complex muscular organ that is vital for survival. Electrical impulses signal activation of mechanical contractions, pumping blood through the entire body and allowing for oxygen-exchange to occur. Unfortunately, certain disease states or traumatic injuries such as myocardial infarctions hamper the heart’s efficiency and function by damaging its structure. Ideal treatment would allow for the replacement or regeneration of the damaged tissue with cells and material harvested from the patient, thus avoiding the potential for immune rejection. Engineered cardiac tissues fabricated from human induced pluripotent stem cells have shown great promise for restoring function in …

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Inflammation, Executive Function, And Adiposity In Children With Or At Risk For Obesity, Kathryn L. Prendergast Jan 2021

Inflammation, Executive Function, And Adiposity In Children With Or At Risk For Obesity, Kathryn L. Prendergast

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Obesity is associated with executive function (EF) deficits across the lifespan. Higher body mass index (BMI), greater severity of obesity, and poorer adherence and weight outcomes in obesity treatment have all been associated with EF deficits. Adult literature has begun to emphasize neuroinflammation in obesity as a possible pathway to later cognitive impairment. However, the pediatric obesity literature has yet to even establish associations between peripheral inflammation and EF. Thus, the present study aimed to examine associations and variability in inflammatory biomarkers, EF, and adiposity in children with or at risk for obesity. Additionally, inflammation was examined as a mechanism …

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Biomarker And Target Discovery In Cancer, Alyncia Dominique Robinson Jan 2021

Biomarker And Target Discovery In Cancer, Alyncia Dominique Robinson

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Cancer is a complex disease characterized by uncontrolled growth of transformed cells that can arise in many tissue types throughout the body (e.g., breast, lung, prostate, pancreas, lymph nodes) and is a major cause of death worldwide. Cancer progression resulting in aggressive or metastatic disease accounts for one of the leading causes of death worldwide, second only to heart disease in the US. Incidentally, cancer-related mortality has been on a steady decline, dropping 25% over the last 25 years [1]. This could be attributed to improved and earlier diagnoses and better treatment options being developed over the past few decades. …

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