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University of Alabama at Birmingham

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The 340b Drug Pricing Program: Are 340b Covered Entities Providing More Services And More Uncompensated Care?, Isabell M. Pacheco Jan 2021

The 340b Drug Pricing Program: Are 340b Covered Entities Providing More Services And More Uncompensated Care?, Isabell M. Pacheco

All ETDs from UAB

The 340B Drug Pricing Program enacted in 1992 requires pharmaceutical manufacturers participating in the Medicaid program to provide statutorily defined discounts on "covered outpatient drugs" purchased by government-supported facilities, known as covered entities, that are expected to serve the nation's most vulnerable patient populations. The Program has been under copious scrutiny by industry stakeholders and Presidential Executive Orders that threaten its macrocosm. While previous research suggests that health systems with a mix of 340B participating and non-participating locations are not associated with expanded access to care, additional research is needed to determine if entities participating in the 340B Drug Pricing …

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The Relationship Of Debt Ratio And Financial Performance For Large Nfp Health Systems, Mark Lombardi Jan 2021

The Relationship Of Debt Ratio And Financial Performance For Large Nfp Health Systems, Mark Lombardi

All ETDs from UAB

This dissertation was a quasi-experimental research study exploring the relationship between long-term to debt capitalization ratio and financial performance in an environment where interest rates remained historically low and stable, while investment returns in the U.S. equity markets increased year over year. The study reviewed 142 not for profit health systems and examined total and non-operating margins along with long-term debt to capitalization ratio to determine if margins increased as long-term debt increased. Researchers have discussed the opportunity that not for profit health systems have to utilize low cost, tax-exempt debt to maintain or grow their endowments and in turn …

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Production And Purification Of Titanium-45 For Imaging Of Psma+ Prostate Cancer, Ivis Francis Chaple Jan 2021

Production And Purification Of Titanium-45 For Imaging Of Psma+ Prostate Cancer, Ivis Francis Chaple

All ETDs from UAB

Positron Emission Tomography (PET) has revolutionized the world of molecular imaging, increasing the potential for improved diagnosis and characterization of various disease states, including cancer. Molecular biology has afforded the knowledge that each type of cancer cell is different, and these differences can be leveraged to develop methods for targeting these cells for imaging or therapy, as well as understanding of other characteristics. Due to the increased diversity in available targets, there has been an equal need to develop new agents used to image these receptors. Radioisotopes with varying halflives, chemical and nuclear properties have been studied in recent years …

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Fqhcs, Health Center Controlled Network Affiliation And Performance, Armika Jessica Berkley Jan 2021

Fqhcs, Health Center Controlled Network Affiliation And Performance, Armika Jessica Berkley

All ETDs from UAB

Since the mid-1960s, Federally Qualified Health Centers (FQHCs) have been funded by the U.S. federal government to provide access to preventative and primary care for medically underserved communities. The federal government’s involvement in the funding of FQHCs was a response to extreme poverty, economic instability, and civil unrest related to the Civil Rights movement. Adoption of value-based care delivery practices to improve clinical and financial performances among FQHCs has been slow. This slow adoption has been attributable to cost, lack of expertise, and support. Since August 1994, the Department of Health Resources and Services Administration (HRSA), the funding source for …

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Self-Efficacy And Sexual And Reproductive Health In Women With Cystic Fibrosis: A Mixed Methods Study, Janet L. Brown Jan 2021

Self-Efficacy And Sexual And Reproductive Health In Women With Cystic Fibrosis: A Mixed Methods Study, Janet L. Brown

All ETDs from UAB

SELF-EFFICACY AND SEXUAL AND REPRODUCTIVE HEALTH IN WOMEN WITH CYSTIC FIBROSIS: A MIXED METHODS STUDY JANET BROWN DOCTOR OF PHILOSOPHY IN NURSING ABSTRACT BACKGROUND: Cystic fibrosis (CF) is the most common life-limiting genetic disorder among Caucasians. There are approximately 30,000 individuals with CF in the United States and over 70,000 worldwide, with approximately 1,000 new cases diagnosed globally each year. In other chronic diseases, a positive relationship between self-efficacy and behavior has been identified. Self-efficacy may be a factor related to behaviors, including underutilization of sexual and reproductive health (SRH) care services for women with CF.METHODS: Self-efficacy and utilization of …

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Likelihood Based Inferential Methods To Analyze Trials Incorporating Patient's Treatment Choice, Rouba A. Chahine Jan 2021

Likelihood Based Inferential Methods To Analyze Trials Incorporating Patient's Treatment Choice, Rouba A. Chahine

All ETDs from UAB

Randomized clinical trials (RCT) are the gold standards for clinical trials as they reduce bias and minimize variability between different arms of a study. One of the drawbacks of these designs is their lack of flexibility to incorporate patient’s preference, which may reduce recruitment rates and/or reduce patient’s tolerance if they receive a non-preferred treatment. Designs incorporating choice allow a subset of participants to choose a preferred treatment. Some of these designs are Zelen’s (1979), Brewin’s (1989), and Rucker’s (Two-Stage RCT, 1989). Current methods to analyze two-stage RCT are based on an analysis of variance (ANOVA) approach that do not …

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The Function Of Tgfβr3 (Betaglycan) In The Differentiation And Proliferation Of T Cells, Samuel Duesman Jan 2021

The Function Of Tgfβr3 (Betaglycan) In The Differentiation And Proliferation Of T Cells, Samuel Duesman

All ETDs from UAB

TGFβR3 is a membrane bound co-receptor to many members of the TGFβ superfamily of ligands and is broadly expressed in the human body. TGFβR3 is known to modulate immune system function, but its exact role is at this time poorly understood. Work by Aleman-Muench et al., (2012) suggests that TGFβR3 regulates T cell development in the thymus. In order to further investigate the role of TGFβR3 in the immune system our lab developed a mouse which lacks TGFβR3 selectively in mature T cells. The contribution of TGFβR3 on in vivo activation and differentiation of T cells was investigated by utilizing …

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Mental Health And Chronic Disease Management: Examining The Association Between Depression And Multiple Sclerosis (Ms) Outcomes, Christina J. Glenn Jan 2021

Mental Health And Chronic Disease Management: Examining The Association Between Depression And Multiple Sclerosis (Ms) Outcomes, Christina J. Glenn

All ETDs from UAB

The aim of this dissertation is to determine whether depression is associated with clinical (relapses and disability worsening) and MRI outcomes in multiple sclerosis (MS) by conducting a secondary data analysis of the CombiRx clinical trial. Psychiatric comorbidities, including depression are common in people living with MS (PwMS), often underreported, and contribute to reduced quality of life and mortality associated with the disease. Most clinical studies that have examined the relationship between depression, depression medication usage, and MS outcomes have been small, excluded participants with relapsing-remitting subtypes and severe depressive symptoms, and had relatively short study periods—all shortcomings this thesis …

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Religion, Spirituality, Faith, Centeredness And Wellbeing: An Exploration Of How These Elements Impact Individual Wellbeing, Carol Griggs Jan 2021

Religion, Spirituality, Faith, Centeredness And Wellbeing: An Exploration Of How These Elements Impact Individual Wellbeing, Carol Griggs

All ETDs from UAB

Wellness and wellbeing have been a national priority in the United States of American for many years. Since 1961, wellbeing models have been created and reconstructed to define our understanding of what wellbeing is as well as what it should or could potentially be. These endeavors have contributed to a body of research that serve as a foundation for this study. The aim of this study was to review current theory and design a qualitative study to determine if current theory could be expanded upon utilizing religion, spirituality, faith and centeredness as central grounding principles for the model. This was …

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Stress, Inflammation, And Mood: A Role For Leptin?, Kathleen Hodgin Jan 2021

Stress, Inflammation, And Mood: A Role For Leptin?, Kathleen Hodgin

All ETDs from UAB

Prior research has suggested a possible role for the proinflammatory adipokine leptin in depression. Leptin has also been associated with stress, a known predictor of depression. The purpose of this project was to investigate associations between stress, leptin, and depressed mood. We used data from a larger observational study that collected daily levels of plasma leptin and self-reported stress and depressed mood from 55 women over 25 days. Women with and without chronic fatigue syndrome (CFS) were included. We hypothesized the following: increased stress would be associated with both worsened mood and higher leptin, and that leptin would be positively …

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Laser Spectroscopy, Amplification, And Laser Properties Of Fe:Znse Mid-Ir Gain Media Under Er:Yag Laser Excitation, Krishna Karki Jan 2021

Laser Spectroscopy, Amplification, And Laser Properties Of Fe:Znse Mid-Ir Gain Media Under Er:Yag Laser Excitation, Krishna Karki

All ETDs from UAB

Many organic molecules exhibit strong and narrow absorption in the middle infrared (mid-IR) 2-8 μm and long-wavelength-infrared (LWIR) 8-20 μm spectral ranges. Hence, this infrared laser radiation is of interest for spectroscopy, remote sensing of atmospheric constituents, oil prospecting, as well as the number of applications such as free-space optical communication, laser surgical and dental treatment, and many defense-related applications. Transition metal (TM) doped II-VI semiconductors exhibit highly favorable spectroscopic properties for many mid-IR laser applications. Among these materials the most significant results have been obtained with the use of Fe:ZnSe crystals because of their unique properties such as broad …

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Portrait Of Brother As A Tractor At The Equipment Sale, Samatha Leigh Futhey Jan 2021

Portrait Of Brother As A Tractor At The Equipment Sale, Samatha Leigh Futhey

Birmingham Poetry Review

pp. 67-68

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Seneca Falls: Halloween Weekend 2016, Before The Election, Nancy Mccabe Jan 2021

Seneca Falls: Halloween Weekend 2016, Before The Election, Nancy Mccabe

Nelle (literary magazine)

p. 5

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Early Cretaceous Swims Up To The Bar, Lesley Wheeler Jan 2021

Early Cretaceous Swims Up To The Bar, Lesley Wheeler

Nelle (literary magazine)

p. 123

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Hungry America And The African Solution: How Hippopotami Nearly Fed America, Tyler Dennis Jan 2021

Hungry America And The African Solution: How Hippopotami Nearly Fed America, Tyler Dennis

Vulcan Historical Review

pp. 39-46

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Justice For Breonna Taylor, Alan Atkins Jan 2021

Justice For Breonna Taylor, Alan Atkins

Vulcan Historical Review

p. 59

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White Knight, Derrick Harriell Jan 2021

White Knight, Derrick Harriell

Birmingham Poetry Review

p. 72

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"I Don’T Want To Be A Priest. I’D Rather Be A God": An Interview With David Kirby, Alex Quinlan Jan 2021

"I Don’T Want To Be A Priest. I’D Rather Be A God": An Interview With David Kirby, Alex Quinlan

Birmingham Poetry Review

pp. 30-49

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Cloud Cover, Laurie Rachkus Uttich Jan 2021

Cloud Cover, Laurie Rachkus Uttich

Nelle (literary magazine)

pp. 48-49

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I'Ll Tell You What Helped, Melissa Crowe Jan 2021

I'Ll Tell You What Helped, Melissa Crowe

Nelle (literary magazine)

pp. 86-87

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Physical, Jennifer Davis Michael Jan 2021

Physical, Jennifer Davis Michael

Nelle (literary magazine)

p. 110

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It Came From Beyond The Snow, L M. Davenport Jan 2021

It Came From Beyond The Snow, L M. Davenport

Nelle (literary magazine)

pp. 51-68

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Nelle 4 (Complete Issue), Nelle Staff Jan 2021

Nelle 4 (Complete Issue), Nelle Staff

Nelle (literary magazine)

No abstract provided.

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American Crow, Caroline Myers Jan 2021

American Crow, Caroline Myers

Vulcan Historical Review

p. 11

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From A Cold Location To A Cold War: The 8147th Army Unit’S Mountaineering Instructors, Kallee Knox Jan 2021

From A Cold Location To A Cold War: The 8147th Army Unit’S Mountaineering Instructors, Kallee Knox

Vulcan Historical Review

pp. 17-23

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Pawpaw Fruit, Caroline Myers Jan 2021

Pawpaw Fruit, Caroline Myers

Vulcan Historical Review

p. 97

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Decomposition, Claude Blair Jan 2021

Decomposition, Claude Blair

Vulcan Historical Review

p. 96

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"Annie, Annie Are You Okay?", David Moolten Jan 2021

"Annie, Annie Are You Okay?", David Moolten

Birmingham Poetry Review

p. 126

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Collision, Shelby Knauss Jan 2021

Collision, Shelby Knauss

Birmingham Poetry Review

p. 95

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My Father Should Die In Winter, Barry Marks Jan 2021

My Father Should Die In Winter, Barry Marks

Birmingham Poetry Review

pp. 106-107

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