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Targeting The Frataxin Transcriptional Defect As A Therapeutic Approach For Friedreich's Ataxia, Anna Maria Schreiber Jan 2022

Targeting The Frataxin Transcriptional Defect As A Therapeutic Approach For Friedreich's Ataxia, Anna Maria Schreiber

All ETDs from UAB

Friedreich’s ataxia (FRDA) is the most common inherited ataxia worldwide. This autosomal recessive neurodegenerative disorder manifests in the central and peripheral nervous system but also affects the cardiovascular and endocrine systems. No effective treatment is available. FRDA is caused by expansion of GAA repeat tracts in intron 1 of the frataxin (FXN) gene on both alleles. An inverse correlation between FXN levels and GAA repeat length exists. Frataxin is a mitochondrial protein participating in iron-sulfur (Fe-S) cluster formation. Frataxin deficiency results in reduced activity of Fe-S-containing enzymes involved in critical biological processes, such as cellular respiration and DNA repair. Expansion …

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Cognition And The Brain Of The Healthy Oldest-Old, Sara A. Sims Jan 2022

Cognition And The Brain Of The Healthy Oldest-Old, Sara A. Sims

All ETDs from UAB

There is an increasing number of people aged 65 and older, particularly in the oldest old cohort (aged 85 and older). Aging is characterized by significant changes in the brain including disruptions to white matter and functional connectivity. While cognition is impacted in many age related diseases, like Alzheimer’s Disease or Parkinson’s Disease, an understanding of the healthy aging brain is important for informing research on successful aging. My dissertation consists of three aims: (1) For the first aim, my overall objective was to determine the validity of the NIH toolbox in the oldest old cohort. I used other standard …

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Embedding A Mixed Methods Process Evaluation In A Web-Based Diet And Exercise Program For Older Cancer Survivors, Jami Lee Anderson Jan 2022

Embedding A Mixed Methods Process Evaluation In A Web-Based Diet And Exercise Program For Older Cancer Survivors, Jami Lee Anderson

All ETDs from UAB

The purpose of this dissertation is to describe critical steps in designing a usercentered mixed methods process evaluation and implement the process evaluation within an existing program. Three objectives of this dissertation include: 1) develop a conceptual framework for conducting user-centered process evaluations of web-based diet and exercise programs for middle-aged and older cancer survivors; 2) inform the design of a user-centered process evaluation by leveraging insights from “think aloud” interviews collected during the beta-testing phase of the AMPLIFY program (a webbased diet and exercise program designed to support healthy lifestyle needs of older cancer survivors); and 3) present results …

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The Role Of The Bone Marrow Microenvironment In Flt3-Itd Acute Myeloid Leukemia Stem Cell Resistance To Flt3 Inhibition, Nicholas R. Anderson Jan 2022

The Role Of The Bone Marrow Microenvironment In Flt3-Itd Acute Myeloid Leukemia Stem Cell Resistance To Flt3 Inhibition, Nicholas R. Anderson

All ETDs from UAB

Acute myeloid leukemia (AML) is an aggressive, complex hematological malignancy. AML cases with constitutively-activating internal tandem duplications in the Flt3 receptor (Flt3-ITD) represent a distinct subtype of disease with poor prognosis, but unique opportunities for targeted therapy. Flt3-specific tyrosine kinase inhibitors (TKI) have entered clinical practice due to their ability to induce remissions in a large proportion of Flt3-mutant AML patients, but their long-term efficacy remains limited due to the persistence of leukemia stem cells (LSC) in the bone marrow (BM). Herein, we outline the importance of the bone marrow microenvironment (BMM) in harboring LSC through AML development and drug …

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A Hybrid Data And Hypothesis-Driven Model For Software Development In Support Of The Machine-Learning Paradigm, Anthony D. Bowman Jan 2022

A Hybrid Data And Hypothesis-Driven Model For Software Development In Support Of The Machine-Learning Paradigm, Anthony D. Bowman

All ETDs from UAB

istorically, research has often been conducted in a hypothesis-driven manner with software development methodologies created to support those efforts. However, in recent years data-driven approaches to research have seen a dramatic rise in prominence. While software development methodologies such as agile development, extreme programming, and the waterfall model have allowed developers to tackle increasingly complex problems, they were not designed to efficiently support data-driven approaches such as the machine learning paradigm. To address the need to support the different programmatic requirements of both classical, hypothesis-driven as well as data-driven development, novel development strategies are warranted. In this research, we adapted …

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Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas Jan 2022

Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas

All ETDs from UAB

of ALL survivors are at risk for reduced functional outcomes, and these outcomes may be more strongly related to executive functioning than neighborhood-specific variables or IEP support. Long-term goals include translating findings into practice to remediate adaptive or academic difficulties in ALL survivors.

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Heart Rate Variability And Stress In The Intensive Care Unit Nursing Workplace, Paula Miller Levi Jan 2022

Heart Rate Variability And Stress In The Intensive Care Unit Nursing Workplace, Paula Miller Levi

All ETDs from UAB

Intensive care unit (ICU) nurses work in a demanding environment, facing repeated encounters with trauma and ethical issues when caring for patients. Psychological stressors can include death of patients, violent acts by patients or their families, caring for suffering patients, and moral distress from performing futile care. These factors place ICU nurses at increased risk of developing post-traumatic stress disorder (PTSD). Suffering from chronic PTSD symptoms can negatively impact nurses’ psychological and physical health. There are also consequences for patients and hospitals, including increased risk for substandard care, decreased government reimbursements from poor patient satisfaction scores, and retention issues. Few …

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Monoclonal Antibody-Mediated Cancer Treatment: Development, Manufacturing And Evaluation, Yingnan Si Jan 2022

Monoclonal Antibody-Mediated Cancer Treatment: Development, Manufacturing And Evaluation, Yingnan Si

All ETDs from UAB

Malignant cancer is one of the greatest threats to human health globally. Conventional (non-targeted) treatments such as chemo-drugs and radiation therapy remain the major choices for cancer patients while always accompanied by severe systemic toxicity/side effects. Monoclonal antibody (mAb) is one of the most successful biomolecules discovered and well investigated as a targeted therapy to treat human disease. This dissertation research was aimed to develop monoclonal antibody-based targeted drugs for cancer treatment, which include antibody-drug conjugates (ADCs), liposomal drug and exosome-based drug delivery. Novel targets were discovered, screened and confirmed by proteomics, western blotting and flow cytometry analysis. Cancer cells …

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Oral Language In The Prewriting Stage In Early Childhood: A Mixed Methods Study, Rebekah Lee Reach Jan 2022

Oral Language In The Prewriting Stage In Early Childhood: A Mixed Methods Study, Rebekah Lee Reach

All ETDs from UAB

The purpose of this study was to investigate the difference oral language experiences during the prewriting stage of writing make in a student’s quality of writing, enjoyment of writing, and writing behaviors in kindergarten, first, and second grades. Convergent mixed methods design was used for this study. Triangulation of data was completed using three data collection methods: observations, student interviews, and writing samples produced by four kindergarten students, four first grade students, and four second grade students. Each participant engaged in a pretest and posttest for four weeks. The writing samples were scored, and repeated measure design was implemented using …

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Preventing Unintentional Childhood Injuries In Rural Uganda: Caregiver Perceptions And Promotion Of Personal Safety Skills Through Classroom-Based Instruction, Marissa H. Swanson Jan 2022

Preventing Unintentional Childhood Injuries In Rural Uganda: Caregiver Perceptions And Promotion Of Personal Safety Skills Through Classroom-Based Instruction, Marissa H. Swanson

All ETDs from UAB

Objective: Unintentional childhood injuries present a substantial public health burden in low- and middle-income countries (LMIC) including Uganda. Interventions to reduce this risk should be responsive to children’s unique developmental, environmental, and sociocultural context. This project had three primary objectives: 1) Analyzing caregiver reports of child injury events in rural Uganda to identify perceived causal and preventative factors; 2) Identifying Ugandan first and sixth graders’ developmental safety needs by comparing hazard recognition and past-year injuries among these students; and 3) Evaluating the impact of the Careful Cubs intervention on Ugandan first graders’ personal safety knowledge, skills, and beliefs. Methods: 1) …

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Neural Outcomes Of Adolescent Substance Use, Juliann B. Purcell Jan 2022

Neural Outcomes Of Adolescent Substance Use, Juliann B. Purcell

All ETDs from UAB

Adolescent substance use is common and may disrupt structural and functional brain development given that adolescence is a period of substantial neural maturation. Neurodevelopmental disruptions may be most pronounced within brain regions that undergo substantial development during adolescence (e.g., prefrontal cortex [PFC]) and regions that are integral to reward networks (e.g., nucleus accumbens [NAcc]). This project used latent growth curve models (LGCM) coupled with neuroimaging techniques to investigate relationships between adolescent substance use and young adult brain structure and functional connectivity. Substance use was assessed at 4 timepoints (ages 11, 13, 16, 19) in 1,594 participants. A subset of participants …

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Understanding The Protumorigenic Functions Of St6gal1 In Glioblastoma Stemness And Metabolism, Sajina Gc Jan 2022

Understanding The Protumorigenic Functions Of St6gal1 In Glioblastoma Stemness And Metabolism, Sajina Gc

All ETDs from UAB

Glioblastoma (GBM) is a rare but deadly cancer with median survival of just 15 months despite of aggressive treatment. Advancement in novel treatment modalities is hindered by its heterogeneous nature, which includes subsets of neural stem cell-like brain tumor initiating cells (BTICs) that are highly tumorigenic and therapy-resistant. bgalactoside a-2,6-sialyltransferase 1 (ST6Gal1) is elevated in most tumors including in normal and neoplastic stem cells. ST6Gal1 imparts oncogenic phenotypes such as invasion, apoptosis evasion, therapy resistance, TIC maintenance among others via sialylation of critical receptors like, Fas, TNFR1, EGFR and more. Yet ST6Gal1 led regulation of BTIC specific cell surface proteins …

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The Evolutionary Ecology Of The Antarctic Red Macroalga Plocamium Sp. In Relation To Its Defensive Secondary Metabolite Diversity, Sabrina Heiser Jan 2022

The Evolutionary Ecology Of The Antarctic Red Macroalga Plocamium Sp. In Relation To Its Defensive Secondary Metabolite Diversity, Sabrina Heiser

All ETDs from UAB

Organisms produce chemical defenses to gain a competitive advantage, and to protect themselves from pathogens and predators. There is high inter- and, sometimes, intraspecific diversity in the types and quantities of defensive secondary metabolites. Yet, we do not know much about the mechanisms driving the diversity and its distribution. Macroalgae are important members of ecosystems since they provide living space and are primary producers. To prevent predation, macroalgae make structural or chemical defenses. Chemical defenses in the Antarctic red macroalga Plocamium sp. have extensively been studied. It is widespread along the western Antarctic Peninsula and abundant at sites where it …

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Characterization Of Exercise-Associated Skeletal Muscle Secreted Factors Through Aging, Dalton Chase Patterson Jan 2022

Characterization Of Exercise-Associated Skeletal Muscle Secreted Factors Through Aging, Dalton Chase Patterson

All ETDs from UAB

Exercise is a powerful behavioral intervention against Central Nervous System (CNS) aging1–3 and plays an essential role in maintaining healthy neurocognitive function and immune metabolism in the aging brain3. We have developed a new transgenic mouse model that moderately over-expresses transcription factor master regulator of proteostasis, Transcription Factor E-B (TFEB), in skeletal muscle (cTFEB;HSACre mice). Despite living sedentary lifestyles, our model of enhanced skeletal muscle proteostasis shows significantly ameliorated proteotoxicity, increased BDNF levels and neurogenesis while improving neurocognitive function and decreasing neuroinflammation in the aging CNS4,5. These neuroprotective effects are markedly reminiscent of those observed in the aging CNS post-exercise6,7, …

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Labor Union Membership Tenure And Midlife Health: A Gendered Perspective, Clifford Ross Jan 2022

Labor Union Membership Tenure And Midlife Health: A Gendered Perspective, Clifford Ross

All ETDs from UAB

The benefits of labor unions have not gone unstudied. Individuals in labor unions have better access to lower cost/more substantial health insurance plans, higher quality pension plans, and better wages leading to increased lifetime earnings. Even though many of these benefits create important pathways that could lead to better health, unions have been paid little attention in health literature. Additionally, in the modern workplace Mothers are offered lower starting salaries, are perceived as less competent, and face a penalty regarding hiring, promotion, and workplace educational opportunities. Compared to men, women with children see an income gap 20 cents wider than …

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The Role Ofbiomechanics In Vascular Endothelial Growth Factor Receptor-2 Signaling, Bronte Miller Jan 2022

The Role Ofbiomechanics In Vascular Endothelial Growth Factor Receptor-2 Signaling, Bronte Miller

All ETDs from UAB

Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. When a tumor is small, diffusion is sufficient to receive essential nutrients; however, as the tumor grows a vascular supply is needed to deliver oxygen and nutrients into the increasing mass. Several anti-angiogenic cancer therapies target VEGF and its receptor VEGFR-2, which are major promoters of blood vessel development. Unfortunately, many of these cancer treatments fail to completely stop angiogenesis in the tumor microenvironment (TME). Since these therapies focus on the biochemical activation of VEGFR-2 via VEGF ligand binding, we …

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The Shifting Nature Of Empire: Vandalia And Other Plans For New Colonies West Of The Allegheny Mountains Before The American Revolution, Michael Davis Jan 2022

The Shifting Nature Of Empire: Vandalia And Other Plans For New Colonies West Of The Allegheny Mountains Before The American Revolution, Michael Davis

All ETDs from UAB

North American westward expansion following the end of the Seven Years’ War is a subject that has been dealt with by many historians from both sides of the Atlantic. The American push west of the Allegheny Mountains facilitated political divisions and divergent visions that would advance the push for independence from the British Empire and contribute to the creation of a new authority and a new kind of empire. This paper focuses on one aspect of this significant area of late-colonial and early republican American history. New western colonial schemes emerged from the ashes of the global war with France …

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Low-Dose Dextromethorphan For The Treatment Of Pain In Fibromyalgia: A Single-Blind Placebo-Controlled Crossover Trial, Stephanie Christina Mueller Jan 2022

Low-Dose Dextromethorphan For The Treatment Of Pain In Fibromyalgia: A Single-Blind Placebo-Controlled Crossover Trial, Stephanie Christina Mueller

All ETDs from UAB

Fibromyalgia (FM) is a debilitating chronic pain condition. Its pathophysiology is largely unknown, which has hindered the development of effective treatments. Central sensitization and neuroinflammation have been forwarded as models of FM pathophysiology, both of which indicate the antitussive drug dextromethorphan (DXM) as a potentially effective treatment. DXM is an N-Methyl-D-aspartic acid (NMDA)-receptor antagonist and microglial modulator with anti-neuroinflammatory properties at low doses. It is currently available for clinical use, but has not been tested as a treatment for FM at low dosages. The current study evaluated the effectiveness of DXM in treating FM-associated symptoms of pain, fatigue, cognitive problems, …

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The Difference In Fracture Strength Of Translucent Zirconia (5y-Z) Using Different Cements And Surface Treatments, Esra Elamin Jan 2022

The Difference In Fracture Strength Of Translucent Zirconia (5y-Z) Using Different Cements And Surface Treatments, Esra Elamin

All ETDs from UAB

Statement of Problem: With the recent advent of translucent and ultra-translucent zirconia, it is unknown if this type of high-strength ceramic restoration requires adhesive cementation to enhance retention as well as the effect of surface treatment thus its clinical applicability requires further investigation. Purpose: To investigate the difference in fracture strength of translucent zirconia (5Y-Z) using different crown thickness, different cements under different surface treatment conditions. Materials and Methods: The experimental design consisted of five groups of 30 specimens each. Two different cements were utilized under different surface treatment conditions. Copings of (1.0 mm) uniform thickness were milled of 3Y-zirconia …

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Racial Differences In The Association Of Insulin Resistance With Risk Of Incident Heart Failure In Participants Of Regards, Nirav Patel Jan 2022

Racial Differences In The Association Of Insulin Resistance With Risk Of Incident Heart Failure In Participants Of Regards, Nirav Patel

All ETDs from UAB

Background: Insulin resistance is linked to the development of heart failure (HF). However, there is limited understanding of the racial differences in the association of insulin resistance with the risk of incident HF among individuals without diabetes. Objectives: In a US national cohort of Black and White participants, we sought to evaluate: 1) the relationship between insulin resistance with incident HF participants, and 2) whether there are racial differences in the association of insulin resistance with HF. Methods: We examined >16,000 participants without HF and diabetes at baseline from the REGARDS cohort. Cox regression modeling was used to assess the …

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Assessing The Impact Of The Covid-19 Pandemic On Metastatic Lung Cancer Time To Treatment Initiation, Health Care Resource Utilization, And Costs In The United States, Teresa M. Zyczynski Jan 2022

Assessing The Impact Of The Covid-19 Pandemic On Metastatic Lung Cancer Time To Treatment Initiation, Health Care Resource Utilization, And Costs In The United States, Teresa M. Zyczynski

All ETDs from UAB

The COVID-19 pandemic has derailed normal operations in the health care delivery systems in the United States (US) and globally, providing prioritized care to patients seeking acute management of the novel coronavirus and its complications. Simultaneously, cancer screening tests have decreased, resulting in decreased rates of cancer diagnoses and referrals to oncologists. The purpose of this study was to assess time to treatment initiation (TTI) with systemic cancer therapy in patients with newly diagnosed metastatic lung cancer, metastatic lung cancer-related and total healthcare resource utilization (HCRU) and costs during the pandemic/post-pandemic period compared with the pre-pandemic period. The retrospective claims …

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Inventing The African America, Kamau Bamidele Jan 2022

Inventing The African America, Kamau Bamidele

Vulcan Historical Review

pp. 8-14

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Throwing The Snake, Michael Chitwood Jan 2022

Throwing The Snake, Michael Chitwood

Birmingham Poetry Review

pp. 71-72

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Interview With Nicole Sealey, Jeffrey Peterson Jan 2022

Interview With Nicole Sealey, Jeffrey Peterson

Birmingham Poetry Review

pp. 36-43

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Reprise, Amy Wright Jan 2022

Reprise, Amy Wright

Birmingham Poetry Review

pp. 157-158

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What Reading Thomas Merton Will Do, Laura Van Prooyen Jan 2022

What Reading Thomas Merton Will Do, Laura Van Prooyen

Birmingham Poetry Review

p. 148

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Cuttings, Hannah Dow Jan 2022

Cuttings, Hannah Dow

Nelle (literary magazine)

p. 18

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Things That Collapse, Raye Hendrix Jan 2022

Things That Collapse, Raye Hendrix

Nelle (literary magazine)

pp. 48-49

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Different Birds Maybe 1, Shira Dentz Jan 2022

Different Birds Maybe 1, Shira Dentz

Nelle (literary magazine)

p. 82

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Vulcan Historical Review 26 (End Matter), Vulcan Historical Review Staff Jan 2022

Vulcan Historical Review 26 (End Matter), Vulcan Historical Review Staff

Vulcan Historical Review

No abstract provided.

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