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The Effects Of P-Glycoprotein Deficiency On Intestinal Integrity And Homeostasis, Elizabeth Marie Staley Jan 2009

The Effects Of P-Glycoprotein Deficiency On Intestinal Integrity And Homeostasis, Elizabeth Marie Staley

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THE EFFECTS OF P-GLYCOPROTEIN DEFICIENCY ON INTESTINAL INTEGRITY AND HOMEOSTASIS ELIZABETH M. STALEY MICROBIOLOGY ABSTRACT P-glycoprotein (P-gp) is an ATP-binding transmembrane pump associated with substrate extrusion in cells of epithelial and hematopoietic lineage. Polymorphisms in multidrug resistance genes (MDR), which encode this protein, are associated with development of inflammatory bowel disease in patient subsets. Furthermore, FVB/N animals deficient in P-gp expression develop spontaneous colitis. Disease in FVB.mdr1a-/- animals is reported to be the result of P-gp deficiencies in intestinal epithelial cells. We developed a neonatal model of bone marrow reconstitution to accurately evaluate the contribution of P-gp deficiencies in either …

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Perceptions Of Four Principals Of Southeastern Award-Winning Urban Schools On School, Family, And Community Involvement, Eleanor Victoria Stokes Jan 2009

Perceptions Of Four Principals Of Southeastern Award-Winning Urban Schools On School, Family, And Community Involvement, Eleanor Victoria Stokes

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PERCEPTIONS OF FOUR PRINCIPALS OF SOUTHEASTERN AWARD-WINNING URBAN SCHOOLS ON SCHOOL, FAMILY, AND COMMUNITY INVOLVEMENT ELEANOR V. STOKES EDUCATIONAL LEADERSHIP ABSTRACT The purpose of this qualitative case study was to gain insight through examining the experiences of four urban award-winning schools' principals with regard to school, family, and community involvement, and the perceived effects of such participation on student achievement as reflected in the schools' Adequate Yearly Progress Report. This qualitative study examined the ways in which four elementary and middle school principals perceived family and community involvement in their school. Major themes that emerged from the study were relationships, …

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Genetic Complexity And Population Diversity Of Plasmodium Falciparum In The Peruvian Amazon, Patrick Lee Sutton Jan 2009

Genetic Complexity And Population Diversity Of Plasmodium Falciparum In The Peruvian Amazon, Patrick Lee Sutton

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GENETIC COMPLEXITY AND POPULATION DIVERSITY OF PLASMODIUM FALCIPARUM IN THE PERUVIAN AMAZON PATRICK LEE SUTTON MICROBIOLOGY GRADUATE PROGRAM ABSTRACT Characterizing the genetic complexity of immunologically relevant proteins, expressed during the life cycle of P. falciparum, is essential for identifying and advancing potential vaccine candidates. The current malaria immunity paradigm is rooted in high transmission studies which have investigated the impact of high genetic diversity on the development of humoral responses. Given the dynamic nature of malaria parasites, especially their ability to acclimate to change, it is likely that regions of low transmission do not share the same malaria immunity paradigm …

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Regulation Of Tissue Remodeling Through The Calreticulin Binding Domain Of Thrombospondin-1, Mariya Ts'ana Sweetwyne Jan 2009

Regulation Of Tissue Remodeling Through The Calreticulin Binding Domain Of Thrombospondin-1, Mariya Ts'ana Sweetwyne

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Thrombospondin-1 (TSP1) is a multifunctional matricellular protein released by platelets in response to injury and secreted by cells under stress. TSP1 is cleaved into functional N- and C-terminal domain fragments, which have paradoxical actions with respect to angiogenesis, cell survival, and cell adhesion. Wound healing studies by others demonstrated that TSP1 knockout mice have delayed rates of wound closure, which was attributed to actions of the C-terminal domain. We wished to investigate the specific role of the N-terminal domain in tissue remodeling. Previously, we established that a sequence (aa 17-35) in the N-terminal domain of TSP1 induces focal adhesion disassembly, …

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Characterization Of The Induction And Regulation Of Early B Cell Development, Melissa Ann Thal Jan 2009

Characterization Of The Induction And Regulation Of Early B Cell Development, Melissa Ann Thal

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Hematopoiesis is a highly regulated process directed by the microenvironment or niche in the bone marrow and the transcription factors those signals activate. Gene knockout experiments have identified critical cytokine signals and transcription factors required for promoting the differentiation of a hematopoietic stem cell to a B cell, but the regulatory mechanisms have yet to be fully elucidated. In early B cell development, a transcriptional hierarchy exists wherein E2A proteins activate early B-cell factor (Ebf1), which in turn activates expression of the B cell commitment factor, Pax5. In our studies, we use IL-7 receptor alpha chain (IL-7Rα) knockout animals that …

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Calreticulin And Its Role In Collagen Regulation, Lauren Van Duyn Jan 2009

Calreticulin And Its Role In Collagen Regulation, Lauren Van Duyn

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Calreticulin (CRT), classically known for its chaperone functions in the endoplasmic reticulum and as a calcium regulator, also is found on the cell surface and in the extracellular matrix. It is involved in many cellular processes including signaling, adhesion, migration, apoptotic cell clearance, gene regulation, and production of a fibronectin matrix. CRT has been suggested to play a role in wound healing and fibrosis. Therefore, these studies investigated the role of CRT in collagen production, an important extracellular matrix molecule in wounding and fibrosis. We demonstrated that CRT regulates collagen through transcription, secretion, and processing. We also investigated the role …

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Marginal Zone B-Cell Precursors As Cellular Agents For Type I Ifn Promoted Antigen Transport, John Hsien Wang Jan 2009

Marginal Zone B-Cell Precursors As Cellular Agents For Type I Ifn Promoted Antigen Transport, John Hsien Wang

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Type I IFN is a known pro-inflammatory cytokine that is associated with the development of systemic lupus erythematosus (SLE). At the level of B-cell regulation, current literature primarily attributes the formation of autoantibodies at the post-germinal center stage when type I IFN is known to promote plasmablast differentiation. However, our findings here point to a type I IFN effect at the pre-germinal stage. Type I IFN promotes T-dependent antibody response, activation-induced cytidine deaminase (AID) expression, germinal center formation, all of which are processes before the onset of plasmablast differentiation. We have determined a subset of splenic transitional B-cells, that is …

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A Novel & Efficient Method To Produce High Titers Of Infectious Hpv In Organotypic Cultures Of Primary Human Keratinocytes, Hsu-Kun Wang Jan 2009

A Novel & Efficient Method To Produce High Titers Of Infectious Hpv In Organotypic Cultures Of Primary Human Keratinocytes, Hsu-Kun Wang

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Infections by the high-risk human papillomavirus type 18 (HPV-18) or type 16 (HPV-16) can lead to cancers of the anogenital tract. Because the propagation of HPVs is restricted to differentiated human squamous epithelia, experimental studies of the productive program are conducted in organotypic cultures. The current methods are of low efficiency and time consuming and have relied on immortalized epithelial cell lines that do not support efficient viral DNA amplification or virion production, compromising HPV genetic analyses and obscuring normal virus-host cell interactions. I used Cre-loxP site-specific recombination to develop a relatively simple, fast and highly efficient system to produce …

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Factors Affecting Young Adults' Opinions About Hospice And Home Death, Nicole Marie Webb Jan 2009

Factors Affecting Young Adults' Opinions About Hospice And Home Death, Nicole Marie Webb

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An aging population and increased prevalence of chronic illness will demand greater in-volvement by young adults with respect to end-of-life care decisions, and little research has examined opinions about end-of-life care among this population. Exploration of fac-tors influencing opinions about hospice and home death is necessary in order to address potential barriers to available care options and, thus, to improved quality of care at the end of life. The present study first examined a sample of 1035 Caucasian or African American introductory psychology students in order to explore factors affecting opinions about hospice and home death. A subsample of 250 …

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Nowhere To Put A Heart, Alicia Claire Bolton Jan 2009

Nowhere To Put A Heart, Alicia Claire Bolton

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No abstract provided.

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The Black Male Nude: A Study Of John Singer Sargent's Thomas Mckeller Nude Within The Context Of Nineteenth-Century Art And Culture, Jennifer Lynn Blount Jan 2009

The Black Male Nude: A Study Of John Singer Sargent's Thomas Mckeller Nude Within The Context Of Nineteenth-Century Art And Culture, Jennifer Lynn Blount

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No abstract provided.

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Erg Assessment Of Scotopic And Photopic Critical Flicker Frequency In Older And Younger Human Subjects, Kristen Bowles Jan 2009

Erg Assessment Of Scotopic And Photopic Critical Flicker Frequency In Older And Younger Human Subjects, Kristen Bowles

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No abstract provided.

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The Dual Role Of A Non -Tenured Teacher As A Mentor And Mentee In A Public Secondary High School In Alabama: A Case Study, Barry Lee Wilson Jan 2009

The Dual Role Of A Non -Tenured Teacher As A Mentor And Mentee In A Public Secondary High School In Alabama: A Case Study, Barry Lee Wilson

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No abstract provided.

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African American Soft Tissue Analysis, Lisa Jones Wilborn Jan 2009

African American Soft Tissue Analysis, Lisa Jones Wilborn

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No abstract provided.

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The Effects Of The Renewable Portfolio Standard In The State Of Alabama, Candace Watson Jan 2009

The Effects Of The Renewable Portfolio Standard In The State Of Alabama, Candace Watson

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No abstract provided.

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Leg Press Stretch -Shortening Potentiation In Male Long Distance Runners, David Samuel Wood Jan 2009

Leg Press Stretch -Shortening Potentiation In Male Long Distance Runners, David Samuel Wood

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No abstract provided.

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Structural Basis For Thrombospondin-1 - Calreticulin Interactions Underlying Calreticulin - Induced Focal Adhesion Disassembly, Qi Yan Jan 2009

Structural Basis For Thrombospondin-1 - Calreticulin Interactions Underlying Calreticulin - Induced Focal Adhesion Disassembly, Qi Yan

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No abstract provided.

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Maximum Likelihood Estimators For Circular Structural Model, Maria Zaeva Jan 2009

Maximum Likelihood Estimators For Circular Structural Model, Maria Zaeva

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No abstract provided.

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The Archeology Of Rain, Alicia K. Clavell Jan 2009

The Archeology Of Rain, Alicia K. Clavell

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No abstract provided.

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Protective Art Of Indonesia Balinese Kris Holders From The Collection Of The Berman Museum Of World History, Cynthia Castillo Jan 2009

Protective Art Of Indonesia Balinese Kris Holders From The Collection Of The Berman Museum Of World History, Cynthia Castillo

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No abstract provided.

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A Study Of Exergy Destruction And Methods Of Improving Second Law Efficiency In Common Production Engines Using A Thorough Analysis Of Engine Simulation Results, Nolan A W Carpenter Jan 2009

A Study Of Exergy Destruction And Methods Of Improving Second Law Efficiency In Common Production Engines Using A Thorough Analysis Of Engine Simulation Results, Nolan A W Carpenter

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No abstract provided.

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“The Web Of The World”: Untenable Binaries Of Chaos And Control In The Novels Of Vladimir Nabokov, Sally Culpepper Jan 2009

“The Web Of The World”: Untenable Binaries Of Chaos And Control In The Novels Of Vladimir Nabokov, Sally Culpepper

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No abstract provided.

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Clinical Comparison Of Two Indirect Bonding Systems On Retention Rates Of Orthodontic Brackets: Chemical Cured Custom Base Vs. Light-Cured Non-Custom Base, Alexander Davis Cranford Jan 2009

Clinical Comparison Of Two Indirect Bonding Systems On Retention Rates Of Orthodontic Brackets: Chemical Cured Custom Base Vs. Light-Cured Non-Custom Base, Alexander Davis Cranford

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No abstract provided.

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The Mother In Seventeenth-Century Dutch Art, Christina Sorrell Dick Jan 2009

The Mother In Seventeenth-Century Dutch Art, Christina Sorrell Dick

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No abstract provided.

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A Detailed Look At The Familial, Social, And Clinical Contexts For Children After The Identification Of Maltreatment, Lindsay M. Duty Jan 2009

A Detailed Look At The Familial, Social, And Clinical Contexts For Children After The Identification Of Maltreatment, Lindsay M. Duty

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No abstract provided.

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Effects Of Locus Coeruleus Lesion On Α-Adrenoceptor Mediated Long-Term Depression At Ca3-Ca1 Synapses In Rat Hippocampus, Katie Lynn Dyer Jan 2009

Effects Of Locus Coeruleus Lesion On Α-Adrenoceptor Mediated Long-Term Depression At Ca3-Ca1 Synapses In Rat Hippocampus, Katie Lynn Dyer

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No abstract provided.

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Active Traffic Management Strategies In The U.S. - Implementing Shoulder Lanes, Germin Essam Fadel Jan 2009

Active Traffic Management Strategies In The U.S. - Implementing Shoulder Lanes, Germin Essam Fadel

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No abstract provided.

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“Voyeurizing The Voyeurs”: An Analysis Of The Gaze Of The Nonhuman Other In Chris Marker's Film Sans Soleil, Michele Forman Jan 2009

“Voyeurizing The Voyeurs”: An Analysis Of The Gaze Of The Nonhuman Other In Chris Marker's Film Sans Soleil, Michele Forman

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No abstract provided.

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State Building Energy Efficiency Determination Using Energy Audits, Vance Scott Gibbs Jan 2009

State Building Energy Efficiency Determination Using Energy Audits, Vance Scott Gibbs

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No abstract provided.

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Levels Of 23 Cytokines In Nonstimulated And Stimulated Tears Of Normal Human Subjects, Kayla Snipes Vickers Jan 2009

Levels Of 23 Cytokines In Nonstimulated And Stimulated Tears Of Normal Human Subjects, Kayla Snipes Vickers

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No abstract provided.

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