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Articles 25591 - 25620 of 38141
Full-Text Articles in Entire DC Network
Pai Dui, Forrest Mcsweeney
Migration And The Transformation Of The Southern Workplace Since 1945, Rebecca Dobrinski
Migration And The Transformation Of The Southern Workplace Since 1945, Rebecca Dobrinski
Vulcan Historical Review
pp. 274-276
Ficus, Gregory Fraser
Future Site, Julie Funderburk
Repurposing Old Buildings Is No Laughing Matter, Lesley Jenike
Repurposing Old Buildings Is No Laughing Matter, Lesley Jenike
Birmingham Poetry Review
p. 34
Iguanas Fall From Trees, Erica Dawson
Silent, Gregory Fraser
The Spy's Egg, Julie Funderburk
Lyric #3, Ryo Yamaguchi
Noir Poem, Medbh Mcguckian
The Contents Of The Cupboard, Medbh Mcguckian
Psa On The Dangers Of Fire, Saara Myrene Raappana
At The Carnival With Faye Howard, Rawdon Tomlinson
Shotwell Mill Lane, Rothwell, Northamptonshire, 1905, 2005, Will Wells
Shotwell Mill Lane, Rothwell, Northamptonshire, 1905, 2005, Will Wells
Birmingham Poetry Review
pp. 88-89
Lyric #2, Ryo Yamaguchi
Uab Magazine - Spring/Summer 2011, University Of Alabama At Birmingham
Uab Magazine - Spring/Summer 2011, University Of Alabama At Birmingham
UAB Magazine
No abstract provided.
Uab Magazine - Fall/Winter 2011, University Of Alabama At Birmingham
Uab Magazine - Fall/Winter 2011, University Of Alabama At Birmingham
UAB Magazine
No abstract provided.
A Recombinant Myeloid-Binding Adenovirus For Targeted Pulmonary Gene Therapy, Michael O. Alberti
A Recombinant Myeloid-Binding Adenovirus For Targeted Pulmonary Gene Therapy, Michael O. Alberti
All ETDs from UAB
Inflammation and airway destruction are hallmarks of many debilitating lung diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), acute lung injury (ALI), and cancer. Gene-based therapeutic interventions that modulate this pathologic inflammatory response are likely to reduce the progressive destruction to lung airways. In this regard, a number of strategies have been evaluated for targeting the pul-monary vasculature; particularly those based on serotype 5 Adenovirus (Ad5). The ad-vantages of Ad over other vector systems include: in vivo stability, low oncogenic poten-tial, and large packaging capacity. Yet, specific and efficient gene delivery to the lung has been hampered …
Significance And Regulation Of Cd68 Expression In The Osteoclast, Jason Waid Ashley
Significance And Regulation Of Cd68 Expression In The Osteoclast, Jason Waid Ashley
All ETDs from UAB
The mucin-like Lysosome Associated Membrane Protein (LAMP) family member CD68 is a primarily myeloid lineage restricted transmembrane protein that is expressed in macrophages and osteoclasts. While the existence and expression pattern of human CD68 and mouse CD68 (sometimes called macrosialin) are well-known, and these molecules are routinely used as histological markers of tissue macrophages, the functional signific-ance of CD68 expression remains an unanswered question. Our overall goal is to deter-mine the significance and characterize the function of CD68 in osteoclasts and explore the effects of Receptor Activator of Nuclear Factor κB (RANK) signaling on CD68 post-translational modification. To achieve this …
Intracellular Distribution Of Glycogen Synthase Kinase-3beta In The Brain, Johanna C. Gandy
Intracellular Distribution Of Glycogen Synthase Kinase-3beta In The Brain, Johanna C. Gandy
All ETDs from UAB
The widely distributed serine/threonine kinase glycogen synthase kinase 3beta is well known for its multiple functions in the health brain tissue, which include cell fate, neuronal growth and remodeling, synaptic plasticity, and neuroinflammation. However much of GSK3beta focuses on its abnormal functions in neurological disorders like Alzheimer's Disease and psychiatric disorders. To maintain normal GSK3beta function in the brain, this constitutively active kinase must be strictly regulated. Many factors within the cell work together to influence GSK3beta activity. Two ways to regulate GSK3beta activity are through phosphorylation by upstream kinases or the formation of protein complexes that block substrate binding. …
An Evaluation Of Dietary Lipids On Growth Performance In The Sea Urchin, Lytechinus Variegatus (Echinodermata: Echinoidea), Victoria K. Gibbs
An Evaluation Of Dietary Lipids On Growth Performance In The Sea Urchin, Lytechinus Variegatus (Echinodermata: Echinoidea), Victoria K. Gibbs
All ETDs from UAB
Sea urchin fisheries are declining across the world, and sea urchin aquaculture will be an important alternative to wild-caught fisheries. A significant aspect of a successful sea urchin culture operation is the formulation of nutritionally-complete diets with the potential to support optimal growth and health to sea urchins at different life stages. Due to the ecological variety of sea urchin species, the inclusion level and source of the various macronutrients and micronutrients needed for a complete diet must be carefully considered for each sea urchin species. Lytechinus variegatus is an echinoid species commonly found in the northern Gulf of Mexico, …
Violating The Code: Inmates' Justifications For Failing To Uphold The Code, Anastasia Gwyn Brown
Violating The Code: Inmates' Justifications For Failing To Uphold The Code, Anastasia Gwyn Brown
All ETDs from UAB
Many theories have been created in hope of explaining why people deviate from societal norms to commit crimes. However, Elijah Anderson's Code of the Streets has recently grown in popularity as an explanation for street crime that construes criminal behavior more adequately than previous theories. Recent empirical evidence of researchers such as Anderson suggests the existence of an insidious street culture whose members identify themselves not with conventional norms, but instead with the standards of the street culture. To violate this street code would be to jeopardize self esteem and risk ostracism, further victimization, and often physical safety. However, people …
Differential Contributions Of C-Kit Activating Mutations To Promotion Of Aml1-Eto Associated Neoplasia, Heidi Jean Nick
Differential Contributions Of C-Kit Activating Mutations To Promotion Of Aml1-Eto Associated Neoplasia, Heidi Jean Nick
All ETDs from UAB
The t(8;21) translocation, which generates an AML1-ETO fusion protein (also known as RUNX1-ETO), is one of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML). Murine studies have demonstrated that AML1-ETO promotes the accumulation of myeloid progenitor cells with self-renewal capability and impaired differentiation capacity. However, AML1-ETO+ mice do not progress to AML in the absence of additional mutations, suggesting that expression of the translocation is insufficient for leukemogenesis. This hypothesis is supported by studies demonstrating the persistence of AML1-ETO-expressing hematopoietic progenitors obtained from patients in long-term clinical remission. Mutations affecting receptor tyrosine kinases, particularly c-KIT, are commonly detected …
Investigation Of Numerical Approaches To Analyze Flapping Wings, Nitin Bhagat
Investigation Of Numerical Approaches To Analyze Flapping Wings, Nitin Bhagat
All ETDs from UAB
For centuries, the agility and maneuverability of flying insects have been an inspiration to fluid dynamists. A large number of research activities have been conducted within the biological, aerodynamics, and computational science communities to understand the complex flow fields around flapping insects and their capability for rapid maneuvers. However, the understanding of these natural phenomena is still in its infancy. Recent experimental flow visualizations have shown the complex vortical structures around flapping wings and vortex interactions. Even with the advent of faster and better computer processors and improved numerical algorithms, computational fluid dynamics (CFD) techniques to accurately predict flow features …
Hierarchical And Bayesian Approaches For Estimating Prevalence Based On Pool Screening, Thomas Birkner
Hierarchical And Bayesian Approaches For Estimating Prevalence Based On Pool Screening, Thomas Birkner
All ETDs from UAB
Pool screening is a method that combines individual items into pools. Each pool will either test positive (at least one of the items is positive) or negative (all items are negative). Pool screening is commonly applied to the study of tropical diseases where pools consist of vectors (e.g. black flies) that can transmit the disease. The goal is to estimate the proportion of infected vectors. In paper 1, we present a frequentist Bernoulli-Beta hierarchical model to relax the constant prevalence assumption underlying the traditional frequentist prevalence estimation approach. This assumption is called into question when sampling from a large geographic …
Low And High Let Irradiation Of Human Aortic Endothelial Cells Induces Dose And Time Dependent Adhesion Of Monocytes Which Is Mediated By Chemokines Expressed By The Irradiated Endothelium., Saman Fatima Khaled
Low And High Let Irradiation Of Human Aortic Endothelial Cells Induces Dose And Time Dependent Adhesion Of Monocytes Which Is Mediated By Chemokines Expressed By The Irradiated Endothelium., Saman Fatima Khaled
All ETDs from UAB
Exposure to radiation from a variety of sources is associated with increased risk of heart disease and stroke. Since radiation also induces inflammation, a possible mechanism is a change in the adhesiveness of vascular endothelial cells, triggering pro-atherogenic accumulation of leukocytes. To investigate this mechanism at the cellular level, the effect of xrays, iron (Fe56) ions, and protons on adhesiveness of cultured human aortic endothelial cells (HAECs) was determined. HAECs were grown as monolayers and exposed to 0 to 30 Gy X-rays, 0, 2, and 5 Gy Fe56 ions, and 0, 0.5, and 2 Gy protons followed by measurement of …
Elucidation Of The Elongated Fibrillar Structure Of Streptococcus Mutans Antigen I/Ii, Matthew Rodney Larson
Elucidation Of The Elongated Fibrillar Structure Of Streptococcus Mutans Antigen I/Ii, Matthew Rodney Larson
All ETDs from UAB
Streptococcus mutans (S. mutans) is the causative agent behind dental caries, an infectious disease also known as tooth decay or dental cavities. S. mutans has a cell wall-attached protein known as Antigen I/II (AgI/II) utilized for bacterial adhesion to the tooth surface. Here we have solved the structures of both amino- and carboxy-terminal regions of the AgI/II molecule using X-ray crystallography. Using this structural information we have now built a tertiary model for AgI/II as a fibrillar protein. Further, we have functionally characterized AgI/II and determined minimal regions of AgI/II that are implicated in its adherence to the salivary agglutinin …
Bayesian Hierarchical Generalized Linear Models For Detecting (Rare) Haplotype-Haplotype And Haplotype-Environment Interactions In Genetic Association Analysis, Jun Li
All ETDs from UAB
This dissertation research focuses on genetic association analysis based on haplotypes in the context of both population-based and family-based studies. Haplotype-based association analysis is powerful in the discovery and characterization of the genetic basis of complex human diseases. However, statistical models that fit haplotype-haplotype and haplotype-environment interactions have not yet been fully developed. Furthermore, statistical methods for detecting the association between rare haplotypes and disease have not kept pace with their counterpart of common haplotypes. For both population-based and family-based association analyses, we herein propose two efficient and robust methods to separately tackle these problems based on Bayesian hierarchical generalized …
Erythropoiesis In The Absence Of Adult Hemoglobin, Shanrun Liu
Erythropoiesis In The Absence Of Adult Hemoglobin, Shanrun Liu
All ETDs from UAB
The mammalian erythrocyte is a highly specialized blood cell that differentiates via an orderly series of committed progenitors in the bone marrow in a process termed erythropoiesis. During erythroid development, hemoglobin synthesis increases from early erythroid progenitors to mature enucleated red blood cells (RBCs). Although hemoglobin is the most extensively studied protein in history, the role, if any, that hemoglobin plays in erythroid development remains obscure. In this study, I ask the question what happens during erythropoiesis in the absence of hemoglobin. I demonstrate that my original hypothesis that excess free heme would accumulate in the absence of globin chain …
Near-Infrared Spectroscopy Of Ices Under Conditions Relevant To Interstellar And Planetary Environments, Christina Rae Richey
Near-Infrared Spectroscopy Of Ices Under Conditions Relevant To Interstellar And Planetary Environments, Christina Rae Richey
All ETDs from UAB
The abundances of ices in planetary environments are obtained through measurements of near-infrared absorption features (&nu=10,000-4,000 cm-1, &lambda=1-2.5 &mum), and near-IR measurements of materials present in the interstellar medium are increasingly common. In the studies presented here, the near-IR band strengths for molecules are determined through correlations to their better-known mid-IR characteristics. These strengths are used to determine the column densities of molecules in the interstellar dense cloud or other environments from observed data. The first set of experiments is focused on the near-IR features of molecules relevant to the study of interstellar icy grain mantles and planetary bodies: CO, …