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Membrane Capacitance Derived From Bioimpedance Spectroscopy Is Associated With Insulin Resistance In Relatively Healthy U.S. Women, But Not Men, Valene Garr Barry
Membrane Capacitance Derived From Bioimpedance Spectroscopy Is Associated With Insulin Resistance In Relatively Healthy U.S. Women, But Not Men, Valene Garr Barry
All ETDs from UAB
Current screening methods have failed to detect more than 50% of the 120 million U.S. adults with insulin resistance and/or metabolic syndrome, conditions that substantially increase one’s risk for cardiometabolic disease (CMD).1 Evidence exists that metabolic health is associated with cell membrane composition, which is reflected in the electrical properties of the body cell mass. The objective of this study was to determine whether bioimpedance spectroscopy can identify insulin resistance and/or metabolic syndrome by evaluating membrane capacitance (CM). We hypothesized that CM would be higher in individuals with insulin resistance and/or metabolic syndrome when compared to healthy individuals. This cross-sectional …
Religiosity And Spirituality As Predictors Of Substance Use In Patients With Cystic Fibrosis, Benjamin Edwin Burgess
Religiosity And Spirituality As Predictors Of Substance Use In Patients With Cystic Fibrosis, Benjamin Edwin Burgess
All ETDs from UAB
Cystic fibrosis (CF) is a degenerative chronic illness that results in pulmonary and gastrointestinal impairment. Because health-related behaviors, such as substance use, impact health outcomes in this population, it is important to understand factors that predict substance use in patients with CF. Thus, this study aimed to examine the unique roles of spirituality and religiosity in alcohol, tobacco, and marijuana use. Higher religiosity was expected to predict lower substance use directly, reflecting a direct regulation of health behavior. Higher spirituality was expected to predict less substance use through lower depression, reflecting an indirect regulation of health behavior through emotion regulation. …
How School District Secession Impacts The District Left Behind, Christopher Tyler Burks
How School District Secession Impacts The District Left Behind, Christopher Tyler Burks
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This is the first national analysis of school district secessions that predicts which kind of school districts are likely to have a secession attempt and measures the impact of secession on the per-pupil revenue of the district left behind. Data on school district secessions was limited prior to EdBuild’s 2017 report, Fractured. This thesis combines data from the National Center for Education Statistics with EdBuild’s data on secessions. Using a linear probability model, I find that larger districts in urban areas with more disadvantaged students receiving free and reduced-price lunch are more likely to experience a secession attempt. I then …
Adiposity And Health In Zoo African And Asian Elephants, Daniella Chusyd
Adiposity And Health In Zoo African And Asian Elephants, Daniella Chusyd
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African (Loxodonta africana) and Asian (Elephas maximus) elephant populations are rapidly declining due to poaching, and habitat fragmentation and loss. Due to the precarious situation elephants are facing worldwide, captive elephant populations are being viewed as an insurance policy against extinction. Unfortunately, captive elephant populations are not self-sustaining, in part because of reproductive and health issues. One hypothesis for the observed reproductive and health issues is zoo elephants are obese. The current method of assessing obesity in elephants is based on a qualitative visual tool, the body condition score, which does not quantify fat mass. The purpose of this dissertation …
Functional Analysis Of Cdc45 In The Replication Fork And In Response To Replicative Stress, Amanda Debrot
Functional Analysis Of Cdc45 In The Replication Fork And In Response To Replicative Stress, Amanda Debrot
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DNA replication is a highly conserved and tightly regulated process, with a variety of factors acting to ensure faithful duplication and stability of chromosomal DNA. During replication, positive supercoils form ahead of the advancing replication fork. DNA topoisomerase 1 (Top1) acts to prevent DNA damage by relieving the torsional strain created by these supercoils. The camptothecin (CPT) class of chemotherapeutics target Top1, creating a long-lived DNA-Top1-CPT covalent complex, which leads to S-phase specific DNA lesions and cellular death. Our lab previously performed a genetic screen to isolate mutant proteins that enhance cell sensitivity to Top1-mediated DNA damage. One of the …
The Influence Of Perceived Stress And Sleep Disturbance On Fatigue And Blood Pressure As Mediated By Cortisol In Children With Sickle Cell Disease, Heather Carol Soistmann
The Influence Of Perceived Stress And Sleep Disturbance On Fatigue And Blood Pressure As Mediated By Cortisol In Children With Sickle Cell Disease, Heather Carol Soistmann
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ABSTRACT Introduction: Life expectancy is improving for those with sickle cell disease (SCD); however, with this improvement come increasing risks for long-term health complications. Early identification of health concerns could lead to improved long-term health outcomes. Two health concerns in school-age children with SCD are fatigue and blood pressure (BP). Previous research with other populations indicates perceived stress and sleep disturbance may influence outcomes of fatigue and BP. Further, cortisol, a stress hormone, may mediate the proposed relationships. Therefore, the purpose of the study was to determine effect sizes of relationships between fatigue, BP, perceived stress, and sleep disturbance in …
Prenatal And Postnatal Factors Regulate Food Intake And Body Composition, Minsung Kang
Prenatal And Postnatal Factors Regulate Food Intake And Body Composition, Minsung Kang
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This research sought to identify the effects of prenatal and postnatal factors on systemic metabolism and the regulation of food intake, weight, and body composition. It was found that the manipulation of maternal diets influenced the systemic metabolism of offspring. The offspring of dams fed an isocaloric, low protein diet were significantly smaller and consumed less food than offspring from dams fed a control diet. In the case of the offspring from dams fed a western diet, they were significantly heavier and consumed more food than offspring from dams fed a control diet. In addition, the offspring showed altered glucose …
Metagenomic Analysis Of Microbial Community Compositions And Functions In Perennially Ice-Covered Lake Ecosystems In East Antarctica, Hyunmin Koo
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The perennially ice-covered lakes of the Antarctic continent are considered to be the ideal extreme ecosystems to study growth, sustenance, and evolution of microbial mats without any direct influence by higher organisms and other external environmental factors. This dissertation research utilized Next Generation Sequencing (NGS) technology and bioinformatics tools to study the microbial composition and metabolic potential of the microbial mats in permanently ice-covered freshwater Lake Untersee, Lake Obersee and their surrounding ecosystems in East Antarctica. Overall, the microbial communities in the microbial mats of Lake Untersee were distinct in regard to their compositions, shared taxa and metabolic potential as …
Apoe E4 Carrier Status And Prestroke Cognitive Function In A Case/Cohort Sample Of Incident Stroke From The Reasons For Geographic And Racial Differences In Stroke (Regards) Study, Caroline Lassen-Greene
Apoe E4 Carrier Status And Prestroke Cognitive Function In A Case/Cohort Sample Of Incident Stroke From The Reasons For Geographic And Racial Differences In Stroke (Regards) Study, Caroline Lassen-Greene
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This study explores the role of ApoE e4 in cognitive function and incident stroke to better understand the risk of cognitive decline associated with both normal aging and dementia. ApoE e4 is a genetic risk factor for mild cognitive impairment and dementia, and may have detrimental effects on cerebrovascular integrity by increasing the risk of acquiring cerebrovascular abnormalities such as white matter lesions (WMLs), infarcts, and cerebral microbleeds. Subtle cognitive impairments may reflect these clinically undetected brain vascular pathologies that also are associated with increased likelihood of incident stroke. Results of the study revealed that ApoE e4 was associated with …
Lick My Battery, Sasha Mitchell
Lick My Battery, Sasha Mitchell
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An insecure cyborg named Grit defects to a tech-atheist society. Her neuro-disorder-addicted sister, Siri, follows her with a licentious government drone, one officer Rah Tetra of the Austere Sapien Services (A.S.S. for short). Sex, anthropology, family dysfunction, and social rigidity are tackled beneath the influences of Radiohead, Billy Wilder, and Jonathan Swift.
The Influence Of Treatment Expectation On Transcranial Direct Current Stimulation (Tdcs)-Induced Suppression Of Craving And Eating, Mary Katherine Osborn Ray
The Influence Of Treatment Expectation On Transcranial Direct Current Stimulation (Tdcs)-Induced Suppression Of Craving And Eating, Mary Katherine Osborn Ray
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Transcranial direct current stimulation (tDCS) is a neuromodulation technique with promise to improve numerous diseases, but results are inconsistent. Possible explanations for the conflicting evidence include: 1) expectation effects arising from discernable real vs. sham tDCS conditions, and 2) uncontrolled individual differences related to the outcome variables. Therefore, we conducted a study that systematically assessed the putative action of tDCS to suppress food craving and eating while controlling for expectation effects and baseline individual differences. N=74 adults were randomized to one of four groups: Told Fake/Got Fake (participants were told they were receiving fake and received fake tDCS), Told Fake/Got …
Novel Anti-Cancer Therapy Development Using Omics Guided Rational Cell Process Engineering, Ningning Xu
Novel Anti-Cancer Therapy Development Using Omics Guided Rational Cell Process Engineering, Ningning Xu
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Cancer is one of the leading causes of mortality globally, and multiple anti-cancer therapies have been developed and applied over last few decades. Antibody-based cancer therapies have been on one of the most exciting and promising therapeutic strategies. Monoclonal antibodies (mAbs) can control the progression of cancers via targeted binding to the specific antigen of tumors to trigger an immune response, target and block the signaling pathway involved in cancer progression, or deliver cytotoxic agents into tumors. Two chimeric/humanized monoclonal antibodies (anti-HER2 mAb and anti-CD 20 mAb) with higher efficacy were successfully expressed in engineered Chinese Hamster Ovary Cells (CHO). …
Effects Of Dietary R,S-1,3 Butanediol Diacetoacetate On Components Of Energy Balance, Rachel A H Davis
Effects Of Dietary R,S-1,3 Butanediol Diacetoacetate On Components Of Energy Balance, Rachel A H Davis
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Ketogenic diet (KD) has been used to attenuate the decline in energy expenditure occurring from calorie restriction-induced weight loss, but long-term adherence can be difficult due to the strict nature of the diet. The growing body of evidence supporting KD-treatment of neurologic and metabolic diseases, as well as obesity, has prompted interest in the ability to increase circulating ketones via exogenous delivery. Ketone esters (KE) can raise blood ketone concentrations similarly to fasting and appear to reduce food intake acutely, but studies assessing effects on energy balance are limited and provide a potentially promising direction for weight control. Previous investigations …
Evaluation Of The Factors Influencing Feed Intake And Satiety Of The Variegated Sea Urchin, Lytechinus Variegatus, Marlee Hayes
Evaluation Of The Factors Influencing Feed Intake And Satiety Of The Variegated Sea Urchin, Lytechinus Variegatus, Marlee Hayes
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Feed intake is the primary determinant of nutrient and energy acquisition for most metazoans. Satiety regulates feed intake and may have cascading effects on nutrient acquisition and health. Satiety of many higher organisms involves complex processes and a variety of signaling molecules that are responsive to many factors associated with nutrient intake. However, the ability to sate is observed in many simpler animals with less complex physiological processes. Sea urchins, with relatively simple digestive and nervous systems, provide an ideal model for the study of fundamental drivers of feed intake. Understanding the process of satiety in this primitive deuterostome can …
Pastoral Care Spreads Compassion Across Uab And Community, Haley Herfurth
Pastoral Care Spreads Compassion Across Uab And Community, Haley Herfurth
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No abstract provided.
Improving Sleep Quality For Breast Cancer Survivors, Staff
Improving Sleep Quality For Breast Cancer Survivors, Staff
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No abstract provided.
Fobian Elected Councilor For Obesity Society In Pediatrics, Staff
Fobian Elected Councilor For Obesity Society In Pediatrics, Staff
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No abstract provided.
Blazer Innovation Challenge Student Winners Announced In "Shark Tank"-Style Competition, Justin Marden
Blazer Innovation Challenge Student Winners Announced In "Shark Tank"-Style Competition, Justin Marden
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No abstract provided.
Uab Establishes Obesity Health Disparities Research Center, Staff
Uab Establishes Obesity Health Disparities Research Center, Staff
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No abstract provided.
Nutrition Program Aims To Decrease Chronic Disease In Those Living With Hiv, Alicia Rohan
Nutrition Program Aims To Decrease Chronic Disease In Those Living With Hiv, Alicia Rohan
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No abstract provided.
Addiction Program Focuses On Caring For Women With Substance Use Disorders While Pregnant, Staff
Addiction Program Focuses On Caring For Women With Substance Use Disorders While Pregnant, Staff
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No abstract provided.
Mona Fouad Elected To National Academy Of Medicine, Kendra Carter
Mona Fouad Elected To National Academy Of Medicine, Kendra Carter
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No abstract provided.
Mona Fouad Elected To National Academy Of Medicine, Staff
Mona Fouad Elected To National Academy Of Medicine, Staff
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No abstract provided.
Uab Hospital Named Among Top Breast Centers In The U.S., Staff
Uab Hospital Named Among Top Breast Centers In The U.S., Staff
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No abstract provided.
Graduate Student Continues Breast Cancer Research With New Grant, Staff
Graduate Student Continues Breast Cancer Research With New Grant, Staff
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No abstract provided.
National Alumni Society Presents Leadership Awards To Five, Shannon Thomason
National Alumni Society Presents Leadership Awards To Five, Shannon Thomason
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No abstract provided.
Two Faculty Honored For Innovation In Online Education, Haley Herfurth
Two Faculty Honored For Innovation In Online Education, Haley Herfurth
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No abstract provided.
Senior Adult Food Insecurities Being Addressed In Clinic With Two Simple Elements Of Home Life, Alicia Rohan
Senior Adult Food Insecurities Being Addressed In Clinic With Two Simple Elements Of Home Life, Alicia Rohan
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No abstract provided.
Uab Hosts National Meeting Of Society Of Asian Academic Surgeons, Staff
Uab Hosts National Meeting Of Society Of Asian Academic Surgeons, Staff
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No abstract provided.
An Opening For Early Detection: What Your Mouth Says About Your Health, Staff
An Opening For Early Detection: What Your Mouth Says About Your Health, Staff
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No abstract provided.