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Effects Of Stress On Growth Hormone Receptor Signaling, Ryan Marshall Corrick
Effects Of Stress On Growth Hormone Receptor Signaling, Ryan Marshall Corrick
All ETDs from UAB
Growth hormone (GH) regulates body composition via stimulation of protein synthesis and catabolism of adipose tissue, generally promoting maintenance of lean body mass. Following severe injury, GH resistance contributes to muscle protein wasting, adversely impacting morbidity and mortality. In this dissertation research, we sought to determine the mechanisms of GH resistance following injury. To accomplish this, we evaluated GH signaling in a mouse model of severe injury. In the first section of this thesis, we demonstrate severe impairments in hepatic GH signaling occurring in association with an apparent, hemorrhage-dependent cleavage of the GH receptor (GHR). In the second section, we …
How Older Adults With Age-Related Macular Degeneration Living In A Southeastern Metropolitan Area Develop Physical Activity Self-Efficacy, A Grounded Theory Study, Elizabeth Anne Barstow
How Older Adults With Age-Related Macular Degeneration Living In A Southeastern Metropolitan Area Develop Physical Activity Self-Efficacy, A Grounded Theory Study, Elizabeth Anne Barstow
All ETDs from UAB
HOW OLDER ADULTS WITH AGE-RELATED MACULAR DEGENERATION LIVING IN A SOUTHEASTERN METROPOLITAN AREA DEVELOP PHYSICAL ACTIVITY SELF-EFFICACY, A GROUNDED THEORY STUDY ABSTRACT This qualitative grounded theory study explored the process of Physical Activity Self-Efficacy development among older adults with age-related macular degeneration in a southeastern metropolitan area. According to the United States Administration on Aging, the population of individuals over 65 will be 88.5 million by the year 2050, doubling its 2010 estimates. As our population ages, so does the prevalence of chronic conditions. One of these chronic conditions, age-related macular degeneration, is the leading cause of vision loss in …
Evaluation Of The Association Of Low-Level Prenatal Blood Lead Exposure And Auditory Brainstem Response Among Infants, Timothy A. Dignam
Evaluation Of The Association Of Low-Level Prenatal Blood Lead Exposure And Auditory Brainstem Response Among Infants, Timothy A. Dignam
All ETDs from UAB
Hearing loss is one of the most common major abnormalities present among infants. Two to four infants per 1,000 are born in the United States with severe-to-profound newborn hearing loss (Chu 2003). Undetected, hearing loss delays speech, language, and cognitive development. Numerous studies have shown that prenatal lead exposure is associated with a variety of neurobehavioral and electrophysiological abnormalities (Abbate 1995, Bellinger 2004, Koller 2004). Studies focusing on hearing have primarily described pediatric cases or occupationally exposed adults where blood lead levels (BLLs) are much higher than currently seen in the United States (Otto 1985; Bleecker 2003; Schwartz 1987). Hearing …
The Impact Of The State Children's Health Insurance Program's Unborn Child Ruling On Foreign-Born Latina Prenatal Care Utilization And Birth Outcomes, 2000-2007, Jonathan Hawthorne Drewry
The Impact Of The State Children's Health Insurance Program's Unborn Child Ruling On Foreign-Born Latina Prenatal Care Utilization And Birth Outcomes, 2000-2007, Jonathan Hawthorne Drewry
All ETDs from UAB
In 2002 the State Children's Health Insurance Program (SCHIP) "unborn child ruling" was established to provide prenatal care (PNC) to low income women otherwise without health insurance. The majority of foreign-born (FB) Latinas otherwise ineligible for PNC should have benefited most from the ruling. In late 2003 six states incorporated the UCR into their state plan amendments, providing a natural experiment for policy analysis. This study used cross-sectional pooled natality data from 2000-2007 to estimate the effect of the UCR on prenatal care utilization (PNCU) and birth outcomes. A differences-in-differences econometrics model was employed using policy enacting and non-enacting states, …
Soy And Breast Cancer, Mandeep K. Virk-Baker
Soy And Breast Cancer, Mandeep K. Virk-Baker
All ETDs from UAB
The incidence of breast cancer is lower in Asia as compared to Western countries. However, the breast cancer risk among Asian immigrants living in Western countries reaches nearly as high as the Western country, suggesting environmental factors (e.g. diet and lifestyle) may be important for this geographical disparity. One dietary change of Asian immigrants is a reduction in soy consumption. Soy is rich in isoflavones, which compete with estrogen for receptor (ER) binding, and may protect against breast cancer. S-(-)equol, a metabolite of the soy isoflavone daidzein (DZ) has a higher bioavailability and greater affinity for ER than DZ. The …
Siderophore-Mediated Iron Acquisition In Mycobacterium Tuberculosis, Ryan Wells
Siderophore-Mediated Iron Acquisition In Mycobacterium Tuberculosis, Ryan Wells
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Mycobacterium tuberculosis is a dangerous human pathogen that has the capacity to adapt to and survive within the harsh phagosomal environment of macrophages. One obstacle that must be overcome by pathogens is to acquire iron, an essential component and cofactor of proteins required for vital cellular processes. M. tuberculosis meets its iron demands in the face of an array of sequestration strategies of the host by synthesizing and secreting two siderophores called mycobactin and carboxymycobactin. Siderophores are low molecular weight high affinity iron binding compounds that steal iron away from host stores and have been shown to be important for …
Retinoids And Abnormal Alveolar Development, Masheika L. James
Retinoids And Abnormal Alveolar Development, Masheika L. James
All ETDs from UAB
Extremely preterm infants are at high risk for a form of chronic lung disease called bronchopulmonary dysplasia (BPD), which is characterized by impaired alveolar development. Exposure to hyperoxia and deficiency of vitamin A (VA) contribute to the development of BPD in preterm infants. Randomized controlled trials indicate VA supplementation decreases BPD and/or death. However, 25% of preterm infants continue to remain VA deficient despite supplementation, probably due to impairment in VA transport, VA is stored in the liver as retinyl esters which are transported to the lung and irreversibly metabolized into all-trans-retinoic acid (ATRA), the active metabolite. A combination of …
Forensic Facial Reconstruction Using Computational Approach, Wenzhen Jia
Forensic Facial Reconstruction Using Computational Approach, Wenzhen Jia
All ETDs from UAB
Forensic facial reconstruction is an application of forensic anthropology. It is a process of recreating the face of a human being based on skull remains. The process of recreating faces can be used to identify otherwise unknown individuals or to reconstruct faces of historical figures, such as the famous effort of reconstructing King Tut in 2005. There are many approaches to perform facial reconstruction in both two-dimensional (2-D) and three-dimensional (3-D). In 2-D cases, an artist works from photos of the skull and sketches the facial features based on his or her scientific training and artistic intuition. In 3-D cases, …
The Role Of Endoplasmic Reticulum Stress Response In Glioma Cell Death, Guyla G. Johnson
The Role Of Endoplasmic Reticulum Stress Response In Glioma Cell Death, Guyla G. Johnson
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Malignant gliomas, including glioblastomas, are the main primary adult brain tumor. Even with current therapies, the median survival time for patients diagnosed with glioblastomas is only about 12 months. Therefore, it is imperative to identify pathways that can induce glioma cell death. This dissertation provides evidence defining how Endoplasmic Reticulum Stress Response (ERSR) induction promotes cell death selectively in malignant glioma cells (MGCs). I present data showing a correlation between ER Ca2+ storage abnormalities, ER ribosome-translocon expression and activity, ERSR intensity and cell death in MGCs. These data show ERSR induction with thapsigargin (THAP) results in a larger loss of …
Application Of The Social Cognitive Theory To A Web-Based Physical Activity Intervention For Overweight African American Female College Students, Rodney Joseph
All ETDs from UAB
Background.African American women report low levels of physical activity and share a disproportionate burden of many health conditions associated with being insufficiently active, indicating the need for innovative approaches to promote physical activity in this population. The purpose of the current study was to evaluate changes in physical activity and associated Social Cognitive Theory constructs of outcome expectations, enjoyment, self-regulation, and social support following the completion of a six month, culturally-adapted, Social Cognitive Theory-based website-delivered weight loss and physical activity intervention for young African-American women. Methods.A secondary data analysis was performed on African-American female college students (N=34) enrolled in a …
The Effects Of Psychological Stress, Depressive Symptoms, And Cortisol On Body Mass And Central Adiposity In 10-To12-Year-Old Children, Hong-Thuy Lam
The Effects Of Psychological Stress, Depressive Symptoms, And Cortisol On Body Mass And Central Adiposity In 10-To12-Year-Old Children, Hong-Thuy Lam
All ETDs from UAB
The percentage of children with elevated body mass and central adiposity has tripled in the U.S. over the past thirty years. While physical factors, such as decreased physical activity and poor nutrition, have been noted to influence elevated body mass and central adiposity in school-aged children, less is known about psychological factors, such as psychological stress and depressive symptoms, especially in 10-to12-year-old children. Further, it has been suggested that cortisol, a biomarker of psychological stress, plays a role in the underlying mechanism that links psychological stress and depressive symptoms to increased body mass and central adiposity, but this has not …
Mechanism Of Nfi-C Functionin During Tooth Root Formation, Ejvis Lamani
Mechanism Of Nfi-C Functionin During Tooth Root Formation, Ejvis Lamani
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Currently, very little is known regarding tissue-specific gene regulation during the later stages of tooth development, especially those associated with root formation. Re-cent studies have identified nuclear factor I-C (NFI-C) as a critical factor for root for-mation in mammals. NFI-C functions as a cellular transcription factor and adenovirus DNA replication factor. Its role in root formation first became evident when Nfi-c null mice were shown to lack molar roots. A similar phenotype of incomplete or absent root formation is observed in patients with the autosomal dominant disease Radicular Dentin Dysplasia (RDD; MIM125400) also known as Rootless Teeth or Dentin Dysplasia …
Regulation Of Alpha-Synuclein Accumulation By The Autophagy-Lysosome Pathway In A Preclinical Model Of Parkinson Disease, Leandra Rosa Mangieri
Regulation Of Alpha-Synuclein Accumulation By The Autophagy-Lysosome Pathway In A Preclinical Model Of Parkinson Disease, Leandra Rosa Mangieri
All ETDs from UAB
Finding novel therapeutics that delay or halt the progression of Parkinson Disease (PD) is key to providing symptomatic relief of debilitating symptoms. A defining pathological feature of PD is characterized by the formation of Lewy bodies, intraneuronal inclusions comprised mainly of α-synuclein (ASYN) (4). Vacuolar ATPase (V-ATPase), an enzyme complex comprised of two multi-subunit-containing domains, critically regulates the acidification of vesicles such as lysosomes and thus proper function of the autophagy-lysosome pathway (ALP), which is critical for the degradation of ASYN. Compromises to V-ATPase have been shown to negatively affect lysosome function and its ability to clear toxic forms of …
Socioeconomic Patterning Of Obesity Among African American Women In The Jackson Heart Study, Tonya Moore
Socioeconomic Patterning Of Obesity Among African American Women In The Jackson Heart Study, Tonya Moore
All ETDs from UAB
Objectives: The purpose of this study was to expand upon what has been observed in literature about obesity and its ties to socioeconomic status (SES) among African American Women (AAW) participants of the Jackson Heart Study (JHS). Methods: This secondary analysis was a sub-study of the JHS and focused on four SES variables: education, income, occupation and wealth; and five outcome variables: body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT). Two analytic samples were created in order to examine data collected during Exam 1 (2000-2004) and Exam 2 (2005-2008). …
A Repeated Measures Quantitative Prospective Inquiry Into The Change In Medical Student Self-Reported Empathy In Clinical Rotations, Kristina T C Panizzi Woodley
A Repeated Measures Quantitative Prospective Inquiry Into The Change In Medical Student Self-Reported Empathy In Clinical Rotations, Kristina T C Panizzi Woodley
All ETDs from UAB
This dissertation study examined whether or not there were quantitative changes in medical student self-reported empathy scores over time and across gender within third- and fourth-year cohorts enrolled in an integrated curriculum at a Southeastern U.S. medical school. The dependent variable was quantitative empathy scores at time 1 and time 2 using the Jefferson Scale of Empathy (JSE, medical student S-Version). Primary independent variables were cohort year and gender. Variables of clinical campus site, rotation orientation category, and specialty interest orientation category were also explored. The study found that empathy increased for the third-year complete cohort but decreased for the …
Factors Associated With Participant Retention In A Behavioral Weight Loss Study, Cathy C. Roche
Factors Associated With Participant Retention In A Behavioral Weight Loss Study, Cathy C. Roche
All ETDs from UAB
Participant retention in longitudinal research is gaining increasing attention. By identifying factors associated with participant retention, programs can be better designed to promote effective weight loss. This study examines factors associated with participant retention. The Anderson Behavioral Model provided the conceptual framework for the study. The sample consisted of secondary data abstracted from the research records of 316 participants in the University of Alabama at Birmingham cohort of the Look Action for Health in Diabetes (AHEAD) trial. The Look AHEAD trial is a randomized controlled trial designed to investigate the long-term effects of interventions aimed at producing weight loss in …
High-Risk Human Papillomavirus And Cervical Intraepithelial Neoplasia Among Foreign-Born Latinas At Colposcopy, Bertha Hidalgo
High-Risk Human Papillomavirus And Cervical Intraepithelial Neoplasia Among Foreign-Born Latinas At Colposcopy, Bertha Hidalgo
All ETDs from UAB
Although the literature is quite extensive with regard to the human papillomavirus (HPV) among many racial/ethnic populations, there continues to be a paucity of information regarding the prevalence of HPV types as well as of cervical intraepithelial neoplasia (CIN among Latinas, specifically foreign-born Latinas. Some studies have reported prevalence of HPV among Latinas, but very few have differentiated between US- and foreign-born Latinas. This nuance is essential to understanding the true effect contributed by each group to HPV and CIN incidence and prevalence rates. Therefore, this dissertation aimed to assess differences in the prevalence of high- and low-risk types and …
Effect Of Childhood Obesity On Risk Of Pelvic Bone Fracture In Simulated Sideways Fall, Min-Heng Hsieh
Effect Of Childhood Obesity On Risk Of Pelvic Bone Fracture In Simulated Sideways Fall, Min-Heng Hsieh
All ETDs from UAB
Since the number of obese children in the U.S. has been increasing, the question arises whether obese children could be at higher or lower risk compared to nonobese children. The objective of this research was to investigate the risk of pediatric pelvic bone fracture in sideways falls using computational modeling and simulation considering various levels of obesity. Two sets of models were developed and tested. The first set was body component models. Several 10-year-old pelvis-femur complex models were developed. The models included biological soft tissue layers to reflect various levels of obesity, and they were validated against published experimental data. …
Five Changes Could Make This Your Last Unhealthy Bowl Season, Jim Bakken
Five Changes Could Make This Your Last Unhealthy Bowl Season, Jim Bakken
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No abstract provided.
December 12, 2011 Reporter, University Of Alabama At Birmingham
December 12, 2011 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
Resolutions Are A Waste If You Don't Plan To Achieve Them, Jim Bakken
Resolutions Are A Waste If You Don't Plan To Achieve Them, Jim Bakken
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No abstract provided.
Low-Carbohydrate Diet Good For Overweight Girls?, Alicia Rohan
Low-Carbohydrate Diet Good For Overweight Girls?, Alicia Rohan
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No abstract provided.
Holiday Eating By The Numbers; Good Choices Equal Less Weight Gain, Jim Bakken
Holiday Eating By The Numbers; Good Choices Equal Less Weight Gain, Jim Bakken
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No abstract provided.
Low-Income Seniors More Likely To Develop Heart Failure, Alicia Rohan
Low-Income Seniors More Likely To Develop Heart Failure, Alicia Rohan
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No abstract provided.
Accelerate For A Cancer Cure, Staff
Uab Studying Effectiveness Of New Weight-Loss Drug, Jim Bakken
Uab Studying Effectiveness Of New Weight-Loss Drug, Jim Bakken
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No abstract provided.
October 17, 2011 Reporter, University Of Alabama At Birmingham
October 17, 2011 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
Whitt Building Bridges To Healthy Uab Workforce, Tyler Greer
Whitt Building Bridges To Healthy Uab Workforce, Tyler Greer
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No abstract provided.
Get Prepped For The First Uab Blazer Fun Run, Tyler Greer
Get Prepped For The First Uab Blazer Fun Run, Tyler Greer
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No abstract provided.
October 3, 2011 Reporter, University Of Alabama At Birmingham
October 3, 2011 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.