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Articles 931 - 960 of 1601
Full-Text Articles in Entire DC Network
Genotyping Of Streptococcus Mutans Using Multilocus Sequence Typing, Stephanie Momeni
Genotyping Of Streptococcus Mutans Using Multilocus Sequence Typing, Stephanie Momeni
All ETDs from UAB
ABSTRACT The role of Streptococcus mutans has been extensively studied using a variety of genotyping techniques. Repetitive extragenic palindromic polymerase chain reaction (rep-PCR) is an effective tool for screening large-scale epidemiological studies with high discriminatory power and reproducibility. For this study, multilocus sequence typing (MLST) analysis is used to evaluate genotypes previously identified as unique using rep-PCR. Twenty-two unique S. mutans rep- PCR genotypes were selected from a longitudinal study. Four additional isolates were selected from each genotype group of the 6 most commonly occurring genotypes (n=30) for further analysis. Real-time PCR was performed using eight housekeeping S. mutans gene …
Uab's Whitley Installed As President Of Infectious Diseases Society, Staff
Uab's Whitley Installed As President Of Infectious Diseases Society, Staff
Browse All News
No abstract provided.
November 23, 2009 Reporter, University Of Alabama At Birmingham
November 23, 2009 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
November 9, 2009 Reporter, University Of Alabama At Birmingham
November 9, 2009 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
September 7, 2009 Reporter, University Of Alabama At Birmingham
September 7, 2009 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
August 26, 2009 Greenmail, University Of Alabama At Birmingham
August 26, 2009 Greenmail, University Of Alabama At Birmingham
GreenMail (student newsletter through 2024)
No abstract provided.
Uab Aids Research Center Earns $7.5 Million Grant Renewal, Staff
Uab Aids Research Center Earns $7.5 Million Grant Renewal, Staff
Browse All News
No abstract provided.
June 1, 2009 Reporter, University Of Alabama At Birmingham
June 1, 2009 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
May 4, 2009 Reporter, University Of Alabama At Birmingham
May 4, 2009 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
February 23, 2009 Reporter, University Of Alabama At Birmingham
February 23, 2009 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
Richard Whitley Appointed Distinguished Professor, Staff
Richard Whitley Appointed Distinguished Professor, Staff
Browse All News
No abstract provided.
Pfizer Visiting Professor In Infectious Diseases To Speak Jan. 26, Reporter Staff
Pfizer Visiting Professor In Infectious Diseases To Speak Jan. 26, Reporter Staff
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No abstract provided.
The Medical And Social Impact Of Cholera In The 19th Century And Beyond, Heather Guy
The Medical And Social Impact Of Cholera In The 19th Century And Beyond, Heather Guy
Vulcan Historical Review
pp. 71-84
Uab Magazine - Fall 2009, University Of Alabama At Birmingham
Uab Magazine - Fall 2009, University Of Alabama At Birmingham
UAB Magazine
No abstract provided.
Inquiro 3 (End Matter), Inquiro Staff
Inquiro 3 (End Matter), Inquiro Staff
Inquiro (undergraduate research journal)
pp. 98-102
Uab's 2009 Goldwater Representatives, Shweta Patel
Uab's 2009 Goldwater Representatives, Shweta Patel
Inquiro (undergraduate research journal)
p. 97
Examination Of The Capacity Of The Cathelicidins To Control Bacillus Anthracis Pathogenesis, Mark W. Lisanby
Examination Of The Capacity Of The Cathelicidins To Control Bacillus Anthracis Pathogenesis, Mark W. Lisanby
All ETDs from UAB
cillus anthracis is a gram-positive, spore forming bacterium that causes infection through three routes: cutaneous, gastrointestinal and pulmonary. Historically, anthrax pathogenesis was thought to be initiated via the uptake of spores by resident macrophages, which then transited to the regional lymph nodes. While en-route, the spores germinated and developed into bacilli within the phagolysosome, escaped into the cytoplasm, killed the cell and eventually the host. Following the recent use of B. anthracis as a biological weapon, researchers began to reevaluate anthrax pathogenesis in order to develop novel treatments. One aspect of anthrax pathogenesis that saw renewed interest was the intracellular …
Immunotherapy Of Cancer Employing Γδ-T Cells: A Study Examining Their Utility And Feasibility, Benjamin Hester Beck
Immunotherapy Of Cancer Employing Γδ-T Cells: A Study Examining Their Utility And Feasibility, Benjamin Hester Beck
All ETDs from UAB
Unlike antigen-specific alpha beta-T cells, gamma delta-T cells can recognize and lyse cancerous cells rapidly upon encounter in a manner that does not require the recognition of tumor-specific antigens. Given the well-documented capacity of gamma delta-T cells to innately kill malignant cells, efforts are now underway to exploit the antitumor properties of gamma delta-T cells for clinical purposes. Here, we present for the first time preclinical in vivo mouse models of gamma delta-T cell-based immunotherapy directed against breast cancer. These studies were explicitly designed to approximate clinical situations in which adoptively-transferred gamma delta-T cells would be employed therapeutically against breast …
The Significance Of Heavy Chain Cdr3 Diversity In The Antibody Response To Polysaccharides, Tamer Mahmoud
The Significance Of Heavy Chain Cdr3 Diversity In The Antibody Response To Polysaccharides, Tamer Mahmoud
All ETDs from UAB
An understanding of the molecular mechanisms involved in the generation of protective antibody responses to polysaccharides associated with pathogenic microorganisms is of importance for improving vaccine design. The heavy chain third complementarity-determining region (HCDR3) of an antibody molecule is at the center of its antigen-binding site and plays a determinative role in antigen recognition. The goal of this dissertation was to investigate the role of HCDR3 diversity and composition on the antibody response to the polysaccharide α 1→3 Dextran (DEX). In the first study, we investigated the role of TdT, a DNA polymerase that plays a major role in generating …
Analysis Of The Malaria Vaccine Potential Of Plasmodium Falciparum Merozoite Surface Protein-3, Stephen James Jordan
Analysis Of The Malaria Vaccine Potential Of Plasmodium Falciparum Merozoite Surface Protein-3, Stephen James Jordan
All ETDs from UAB
Malaria causes an estimated 1-3 million deaths each year, with the majority of deaths being a result of infection with Plasmodium falciparum. No commercially available vaccine currently exists, but multiple subunit-based vaccines are in development including one based on the promising vaccine candidate P. falciparum Merozoite Surface Protein-3 (PfMSP3). PfMSP3 varies in sequence between P. falciparum isolates, but all variation is restricted to the N-terminal domain. This observation has lead to the development of a PfMSP3-based vaccine comprised solely of the highly conserved, yet poorly immunogenic, C-terminal domain. The rationale for supporting the C-terminal domain relies entirely on its conserved …
The Cultural Worldview Of Allopthic And Naturopathic Physicians, Cullen Clark
The Cultural Worldview Of Allopthic And Naturopathic Physicians, Cullen Clark
All ETDs from UAB
Worldview is the socio-cultural compass with which we navigate the existential mysteries of life. It is our way of seeing – and being in – the world. As such it influences every aspect of culture from art to medicine. This exploratory study uses a sequential design combining quantitative and qualitative methodology to explore the worldview of allopathic and naturopathic physicians. Using survey research, the study identifies five basic components of competing worldviews among allopathic (n = 550) and naturopathic physicians (n = 399). It measures agreement among the two groups with these components and explores their influence upon support for …
Protein Trafficking And 4.1r Relocalization In Plamodium Falciparum-Infected Erythrocytes, Lindsay A. Parish
Protein Trafficking And 4.1r Relocalization In Plamodium Falciparum-Infected Erythrocytes, Lindsay A. Parish
All ETDs from UAB
Malaria is a mosquito-borne infectious disease that is caused by parasites in the genus Plasmodium. There are four species of malaria that routinely infect humans, but it is P. falciparum that is responsible for the majority of the severe and fatal cases of malaria. P. falciparum has a complex life cycle involving a mosquito vector and intracellular stages in both hepatocytes and erythrocytes; however, it is only the intraerythrocytic stages that are the cause of the pathology associated with malaria. This pathology is largely due to the ability of infected erythrocytes to cytoadhere to host microvasculature. After invasion, the parasite …
Late Development Plasticity In The T Helper 17 Lineage, Yun Kyung Lee
Late Development Plasticity In The T Helper 17 Lineage, Yun Kyung Lee
All ETDs from UAB
CD4 T cells are a principal component of the adaptive immune system that is required for the efficient elimination of foreign antigens, but dysregulated CD4 T cells responses may result in autoimmune and chronic inflammatory diseases. The differentiation of effector CD4 T cells is directed by cytokines elicited by pathogendriven innate immune responses. Therefore the coordinated innate and adaptive immune responses provide an efficient system for host protection. Our understanding of distinct differentiated CD4 T cells has recently expanded with the discovery of the Th17 lineage, a new subset of effector CD4 T cells that has been implicated in chronic …
Living With Stress: Neighborhood Disadvantage, Social Capital, And Depression, John Porter Lillis
Living With Stress: Neighborhood Disadvantage, Social Capital, And Depression, John Porter Lillis
All ETDs from UAB
This study's objective was to determine the effects of personal and neighborhood stressors on depressive symptomology for community dwelling adults aged 65 and over. The psychosocial resource model was employed as social capital is hypothesized to be a resource and play a mediating role in the effect of both types of stressors on depressive symptomology. Individual level data utilized came from the UAB Study of Aging (N = 919) and the neighborhood level data came from the 2000 Decennial Census. Logistic regression analysis determined that neighborhood stressors had no direct or indirect effect on depressive symptomology. This analysis did show …
Protective Mechanisms Of Apoa-I Mimetic Peptide Action In Sepsis-Induced Tissue Injury, Zhenghao Zhang
Protective Mechanisms Of Apoa-I Mimetic Peptide Action In Sepsis-Induced Tissue Injury, Zhenghao Zhang
All ETDs from UAB
Sepsis is among the top ten causes of death in the US, and it is associated with severe inflammatory tissue damage and organ dysfunction. Reduced plasma high density lipoprotein (HDL) is associated with increased mortality in septic patients. Since raising plasma apolipoprotein (apo) A-I and HDL may reduce sepsis complications, we tested the hypothesis that the apoA-I mimetic peptide 4F confers similar protective effects in two animal models of sepsis, and explored the possible mechanisms. In endotoxemic rats, inflammatory mediators were significantly induced while blood pressure was significantly reduced by 6hr. The impaired arterial response to vasoconstrictors was related to …
Genetic Complexity And Population Diversity Of Plasmodium Falciparum In The Peruvian Amazon, Patrick Lee Sutton
Genetic Complexity And Population Diversity Of Plasmodium Falciparum In The Peruvian Amazon, Patrick Lee Sutton
All ETDs from UAB
GENETIC COMPLEXITY AND POPULATION DIVERSITY OF PLASMODIUM FALCIPARUM IN THE PERUVIAN AMAZON PATRICK LEE SUTTON MICROBIOLOGY GRADUATE PROGRAM ABSTRACT Characterizing the genetic complexity of immunologically relevant proteins, expressed during the life cycle of P. falciparum, is essential for identifying and advancing potential vaccine candidates. The current malaria immunity paradigm is rooted in high transmission studies which have investigated the impact of high genetic diversity on the development of humoral responses. Given the dynamic nature of malaria parasites, especially their ability to acclimate to change, it is likely that regions of low transmission do not share the same malaria immunity paradigm …
December 22, 2008 Reporter, University Of Alabama At Birmingham
December 22, 2008 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
December 8, 2008 Reporter, University Of Alabama At Birmingham
December 8, 2008 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
November 24, 2008 Reporter, University Of Alabama At Birmingham
November 24, 2008 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
Whitley Chosen To Advise U.S. Infectious Disease Agency, Staff
Whitley Chosen To Advise U.S. Infectious Disease Agency, Staff
Browse All News
No abstract provided.