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Articles 901 - 930 of 1601
Full-Text Articles in Entire DC Network
Dna Testing Of Blood Sample Not Effective For Identifying Cmv In Newborns, Says Uab Research, Staff
Dna Testing Of Blood Sample Not Effective For Identifying Cmv In Newborns, Says Uab Research, Staff
Browse All News
No abstract provided.
Uab Flu Expert: Southeast Should Be On Guard Because Of Continued H1n1 Flu Spread This Spring, Staff
Uab Flu Expert: Southeast Should Be On Guard Because Of Continued H1n1 Flu Spread This Spring, Staff
Browse All News
No abstract provided.
March 22, 2010 Reporter, University Of Alabama At Birmingham
March 22, 2010 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
February 22, 2010 Reporter, University Of Alabama At Birmingham
February 22, 2010 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
February 8, 2010 Reporter, University Of Alabama At Birmingham
February 8, 2010 Reporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
Targeted Prevention Measures Stopped Spread Of H1n1 Flu At Alabama Boys Camp, Uab Doctor Says, Staff
Targeted Prevention Measures Stopped Spread Of H1n1 Flu At Alabama Boys Camp, Uab Doctor Says, Staff
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No abstract provided.
Discussion Book Gives Uab Students Insight Into Haiti Tragedy, Staff
Discussion Book Gives Uab Students Insight Into Haiti Tragedy, Staff
Browse All News
No abstract provided.
January 13, 2010 Greenmail, University Of Alabama At Birmingham
January 13, 2010 Greenmail, University Of Alabama At Birmingham
GreenMail (student newsletter through 2024)
No abstract provided.
Still Time To Get H1n1 Flu Vaccine, Urges Uab's Whitley, Leader Of Infectious Diseases Society, Staff
Still Time To Get H1n1 Flu Vaccine, Urges Uab's Whitley, Leader Of Infectious Diseases Society, Staff
Browse All News
No abstract provided.
Childhood Vaccine Schedule Updated; Uab Infectious Disease Doctor On Panel, Staff
Childhood Vaccine Schedule Updated; Uab Infectious Disease Doctor On Panel, Staff
Browse All News
No abstract provided.
Uab Magazine - Fall 2010, University Of Alabama At Birmingham
Uab Magazine - Fall 2010, University Of Alabama At Birmingham
UAB Magazine
No abstract provided.
Inquiro 4 (Complete Issue), Inquiro Staff
Inquiro 4 (Complete Issue), Inquiro Staff
Inquiro (undergraduate research journal)
No abstract provided.
"We Came, We Saw, But I Am Not Sure We Conquered": The Effects Of New Vaccines And Emerging Virus Strains, Ashruta Patel
"We Came, We Saw, But I Am Not Sure We Conquered": The Effects Of New Vaccines And Emerging Virus Strains, Ashruta Patel
Inquiro (undergraduate research journal)
pp. 12-13
Developing A Screen To Identify Small Molecule Inhibitors That Disrupt Protein-Protein Interactions In Mycobacteria, Deborah Mai
Developing A Screen To Identify Small Molecule Inhibitors That Disrupt Protein-Protein Interactions In Mycobacteria, Deborah Mai
All ETDs from UAB
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB) and infects nearly one-third of the world's population. The same TB chemotherapeutic regimen has been administered for more than 50 years, and can be improved by developing innovative methods to discover new anti-TB drugs. This work describes a newly established high-throughput screen (HTS) platform technology based on Mycobacterial-Protein Fragment Complementation (M-PFC) to identify small molecule inhibitors of protein-protein interactions in mycobacteria. M-PFC HTS employs both whole cell and target-based approaches, and offers flexibility in selecting an appropriate protein interaction target for HTS. Selectable drug targets can include interactions of essential …
Identification And Validation Of Biodosimetry Markers In Multiple Models Of Radiation Exposure, Ashley Nicole Filiano
Identification And Validation Of Biodosimetry Markers In Multiple Models Of Radiation Exposure, Ashley Nicole Filiano
All ETDs from UAB
Following a radiological or nuclear disaster, radiation dose assessment is imperative to minimize morbidity and mortality through rationally directed medical intervention. Current methods of retrospective dosimetry are not amenable to mass exposure scenarios and remain limited to monitoring of clinical symptoms (nausea/vomiting and lymphocyte depletion) and cytogenetic analysis. The goal of this study was to identify radiation biomarkers capable of qualitative (non-irradiated/irradiated) and quantitative (dose) assessment of radiation exposure. Initial analyses revealed 17 radiation-responsive cytokine/chemokine genes in blood samples from 6 pediatric cancer patients undergoing fractionated total body irradiation (TBI). These 17 genes were combined with 29 additional IR-inducible genes …
Prevalence And Susceptibility Of Cryptococcus Neoformans To Fluconazole In Hiv Patients In Kenya, Rennatus Magina Mdodo
Prevalence And Susceptibility Of Cryptococcus Neoformans To Fluconazole In Hiv Patients In Kenya, Rennatus Magina Mdodo
All ETDs from UAB
In an applied analysis, examining the association between log transformed C-reactive
The Development Of Humoral And Cellular Responses To Plasmodium Falciparum Malaria In The Hypoendemic Peruvian Amazon And Potential Clinical Protection, Eva Helen Clark
The Development Of Humoral And Cellular Responses To Plasmodium Falciparum Malaria In The Hypoendemic Peruvian Amazon And Potential Clinical Protection, Eva Helen Clark
All ETDs from UAB
Each year 300-500 million cases of Plasmodium falciparum malaria occur, leading to more than 1 million deaths. In high malaria transmission regions, development of immunity from severe infection requires 2-10 years of persistent parasitemia. This delay has been attributed to difficulties in the development of protective humoral responses. Indeed, anti-malarial antibody responses tend to be short-lived, and immunologic memory seems to be dysfunctional in high-transmission regions. In contrast, in the low-transmission Peruvian Amazon >60% of infections are asymptomatic, suggesting that clinical immunity occurs despite low parasite exposure. To analyze more precisely the naturally-acquired humoral responses to malarial antigens and their …
Association Between Birth Outcomes And Aflatoxin B1-Biomarker Levels Among Pregnant Women In Kumasi, Ghana, Faisal Mohammed Barbas Shuaib
Association Between Birth Outcomes And Aflatoxin B1-Biomarker Levels Among Pregnant Women In Kumasi, Ghana, Faisal Mohammed Barbas Shuaib
All ETDs from UAB
Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Although studies have linked these toxins to adverse health outcomes, few studies have investigated the association between birth outcomes and aflatoxin B1-lysine adduct levels among pregnant women. The objective of this dissertation was to investigate the association between birth outcomes and aflatoxin B1- lysine adduct levels among pregnant women in Kumasi, Ghana. In a cross-sectional study of 755 pregnant women, Aflatoxin B1-lysine adduct (AF-ALB) levels were determined by High Performance Liquid Chromatography. AF-ALB associations were assessed as both continuous and categorical values. Analysis of variance (ANOVA) was …
Hypothesis Testing Based On Pool Screening With Unequal Pool Sizes, Hongjiang Gao
Hypothesis Testing Based On Pool Screening With Unequal Pool Sizes, Hongjiang Gao
All ETDs from UAB
Pool screening is a widely applied technique to estimate the prevalence of a rare event. This focus of this research is on developing statistical test of hypothesis procedures under the assumption that pool sizes are unequal but known. One of the proposed test procedures is , an exact test based on the number of positive pools (denoted by T). Another set of proposed test procedures is a modification of the likelihood ratio, Wald's and Score tests which are commonly-used likelihood-based tests. In paper 1, we derive the distribution of T which will be the basis of the exact test. Other …
Project-Induced Displacement, Secondary Stressors, And Health, Yue Cao
Project-Induced Displacement, Secondary Stressors, And Health, Yue Cao
All ETDs from UAB
It is estimated that 15 million migrants displaced by development projects every year in the world. However, research on health impacts of project-induced displacement is insufficient. The existing literature concerning the causal effect of migration on health is inconclusive due to the selective nature of migration and other methodological problems. This study employs the stress process model as the major theoretical framework, components from Cernea's IRR model as well as Scudder and Colson's framework are also incorporated to examine the short-term health impact of the displacement resulting from China's Three Gorges Dam Project. I also explore whether the displacement's effect …
Determinants Of Self-Efficacy To Seek Care For Tuberculosis And Complete Tuberculosis Treatment Among Hiv-Positive Patients Attending Government Hiv/Aids Clincis In Honduras, Mayra Silvana Arias
Determinants Of Self-Efficacy To Seek Care For Tuberculosis And Complete Tuberculosis Treatment Among Hiv-Positive Patients Attending Government Hiv/Aids Clincis In Honduras, Mayra Silvana Arias
All ETDs from UAB
control
Development Of A Mucosal Vaccine Protective Against Francisella Tularensis Infection, Amit R. Ashtekar
Development Of A Mucosal Vaccine Protective Against Francisella Tularensis Infection, Amit R. Ashtekar
All ETDs from UAB
Francisella tularensis, a facultative intracellular, gram-negative coccobacillus, is the causative agent of tularemia and has been classified as a category A biological agent. Since there currently is no licensed vaccine available, in this study, we assessed the potential of a bivalent subunit vaccine comprising of DnaK and Tul4 to protect against respiratory tularemia. Intranasal immunization of C57BL/6 mice with DnaK, Tul4, and the adjuvant GPI-0100 resulted in mucosal and systemic antibody responses to DnaK and Tul4. In addition to antibody responses, this immunization regimen also induced both Th1 and Th2 cell-mediated immune responses specific for DnaK and Tul4. Finally, more …
Host Preference Profile In An Area Of Eastern Equine Encephalitis (Eee) Virus Transmission In Alabama, Ana Lucia Oliveira
Host Preference Profile In An Area Of Eastern Equine Encephalitis (Eee) Virus Transmission In Alabama, Ana Lucia Oliveira
All ETDs from UAB
osteoporosis susceptibility, perceived osteoporosis severity, perceived barriers to
Pneumococcal Vaccine Response And Aging In Human, Saeyoung Park
Pneumococcal Vaccine Response And Aging In Human, Saeyoung Park
All ETDs from UAB
Streptococcus pneumoniae is a major human pathogen, especially for young children and older adults. To protect from pneumococcal diseases, 23-valent pneumococcal polysaccharide vaccine (PPV23) has been used clinically since 1983. However, PPV23 is not so effective among old adults with its protective efficacy diminishing with age. We confirmed that young and old adults, who were immunized with PPV23, have comparable pneumococcal polysaccharide (PS) specific IgG levels. Interestingly, we found that old adults had lower IgA and IgM antibody levels than young adults for three serotypes (serotype 14, 18C and 23F). Consistent with the previous results, opsonic capacities of immune sera …
The Role Of Socioeconomic Factors In Racial And Ethnic Disparities Among Child And Adult Tuberculosis Cases, Spatial And Non-Spatial Analysis: Alabama 1993-2007, Sharada Adolph
All ETDs from UAB
This study aimed to evaluate the role of individual and community/population level socioeconomic factors on racial/ethnic disparities among children and adults with TB, and used area-based socioeconomic measures (ABSMs) for the identification of high-risk geographic areas for populations-at-risk. Joinpoint, multivariable and Poisson regression, and spatial methods were used to determine the trends and risks of disease in a low TB incidence state. General disease trends declined significantly by factors of -0.044838 from 1993-1998, and -0.061821 from 2001-2007; but, were disparate and increased for the foreign-born, African Americans (AA) and Latinos, and in long-term care settings. The average annual percentage change …
The Role Of Toll-Like Receptors 2 And 4 In Helicobacter Felis Infections And Asthma, Carolyn Durham
The Role Of Toll-Like Receptors 2 And 4 In Helicobacter Felis Infections And Asthma, Carolyn Durham
All ETDs from UAB
The inverse correlation between the industrialization and disease prevalence is termed the "hygiene hypothesis." Supporting this, immunological studies show Th1 cytokines modulate Th2 immune responses. Because the mucosa is essential in antigenic exposure, understanding bacterial sensing here is critical to addressing three foundations of this hypothesis: the role of bacterial exposure, relevance of noninvasive bacterial exposure, and influence of these exposures on immune responses. Key components of antigen sensing in the mucosa are toll-like receptors (TLRs) 2 and 4, which have been implicated in disease. The hypothesis of this thesis is, by globally knocking out one or both of these …
An Assessment Of The Factors That Affect The Self-Care Behaviors Of Diabetics, Gregory Ellis
An Assessment Of The Factors That Affect The Self-Care Behaviors Of Diabetics, Gregory Ellis
All ETDs from UAB
various heteroskedastic analysis of covariance (ANCOVA) models with orthogonal
Cellular Mechanisms Involved In Host Responses To Porphyromonas Gingivalis And Its Virulence Factor Hemagglutinin B, Dalia Emil Gaddis
Cellular Mechanisms Involved In Host Responses To Porphyromonas Gingivalis And Its Virulence Factor Hemagglutinin B, Dalia Emil Gaddis
All ETDs from UAB
Porphyromonas gingivalis is a main causative agent for adult chronic periodontitis and immunization with its virulence factor Hemagglutinin B (HagB) provides protection against infection. Toll-like receptors (TLRs) recognize various microbial products and are crucial in eliciting and regulating the innate and adaptive immune responses to infections. The objective of this dissertation was to investigate the cellular mechanisms that influence the innate and adaptive immune response to HagB and P. gingivalis, focusing on the role of TLR signaling in the response. We started with investigating the ability of HagB to activate dendritic cells (DC), the most efficient antigen-presenting cell in priming …
Characterization Of The Oligosaccharides Of B. Anthracis Exosporium, Shengli Dong
Characterization Of The Oligosaccharides Of B. Anthracis Exosporium, Shengli Dong
All ETDs from UAB
Fatal systemic anthrax is caused by exposure to spores of Bacillus anthracis. The outermost layer of the B. anthracis spore is called the exosporium. It consists of a paracrystalline basal layer and an external hair-like nap. The filaments of the hair-like nap are primarily composed of the glycoprotein BclA. Our previous studies showed that a 715-Da tetrasaccharide and a 324-Da disaccharide are attached to BclA through GalNAc. We named the novel nonreducing terminal sugar of the 715-Da tetrasaccharide anthrose. We subsequently proposed a plausible anthrose biosynthetic pathway and identified a gene cluster of four continuous genes that appeared to encode …
Exosomal Curcumin: Its Bioavailability And Potential Anti-Inflammation Activity, Dongmei Sun
Exosomal Curcumin: Its Bioavailability And Potential Anti-Inflammation Activity, Dongmei Sun
All ETDs from UAB
Curcumin, a pleiotropic polyphenol derived from turmeric plants Curcuma Longa with rhizome, exhibits strong evidence as an anti-inflammation, anti-oxidant and anti-cancer reagent both in vitro and in vivo. Due to its low stability and systemic bioavailability, a large amount of curcumin has to be administrated to achieve therapeutic effects both in animal and in human. The major effort to overcome this barrier is making by encapsulation of curcumin into nanoparticles such as polymers and liposomes; some promising data have demonstrated the effectiveness of such method. Exosomes are vesicle-like nanoparticles secreted by living cells. Exosomes contain both cell surface molecules and …