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Articles 451 - 480 of 1601
Full-Text Articles in Entire DC Network
Necrotizing Granulomas In A Young Immunocompetent Patient, Dhivya Velu, Farrah Ibrahim, Ali Hassoun
Necrotizing Granulomas In A Young Immunocompetent Patient, Dhivya Velu, Farrah Ibrahim, Ali Hassoun
UAB Huntsville Research Day - All Presentations
2020 clinical vignette poster
Disseminated Nocardiosis In An Immunocompetent Patient While On Daptomycin Therapy, Dhivya Velu, Swetha Bheemanathni, Ali Hassoun
Disseminated Nocardiosis In An Immunocompetent Patient While On Daptomycin Therapy, Dhivya Velu, Swetha Bheemanathni, Ali Hassoun
UAB Huntsville Research Day - All Presentations
2020 clinical vignette poster
Effect Of Patient-Level Characteristics On Fluoroquinolone Susceptibility, Jeffrey Alan Franks
Effect Of Patient-Level Characteristics On Fluoroquinolone Susceptibility, Jeffrey Alan Franks
All ETDs from UAB
Antimicrobial stewardship programs are becoming more widespread to combat antibiotic resistance. This study aimed to evaluate the influence of patient-level characteristics on fluoroquinolone susceptibly among five gram-negative isolates to help better their implementation. We performed a retrospective analysis of patients over the age of 18 for five gram-negative isolates (Acinetobacter species, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa). We utilized Cox proportional hazards to determine the risk of patient-level characteristics, for both hospital and community-acquired infections, on fluoroquinolone resistance between 2016 and 2019. The population sample consisted of 8,285 patients receiving fluoroquinolones for at least one of the …
Impact Of Different Human Coronaviruses (Hcovs) On Pediatric Patients At A Tertiary Pediatric Hospital – Retrospective Study, Abdulsalam Alsulami
Impact Of Different Human Coronaviruses (Hcovs) On Pediatric Patients At A Tertiary Pediatric Hospital – Retrospective Study, Abdulsalam Alsulami
All ETDs from UAB
Background: Human Coronaviruses (HCoV) are important pathogens associated with respiratory disease in humans and animals. The majority of HCoVs are emerging human pathogens with 7 known types causing human disease and 5 being identified in the last 2 decades. Methods: We performed a retrospective review of all encounters with known HCoV at a tertiary pediatric hospital from January 2015 until January 2018. Electronic medical records (EMRs) were reviewed for demographic data, HCoV type, viral copathogens, time to testing, admission, need for increased intensity of care (HLC), requirement for supplemental oxygen, radiographic findings suggestive lower respiratory tract disease (LRT) when available …
Cd8 T-Cell Responses To A Diverse Virus: Adaptation And Cross-Reactivity In Hiv Vaccination, Sushma Boppana
Cd8 T-Cell Responses To A Diverse Virus: Adaptation And Cross-Reactivity In Hiv Vaccination, Sushma Boppana
All ETDs from UAB
In the four decades since human immunodeficiency virus (HIV) was discovered, significant progress has been made in treating HIV infection and in understanding the viral and immune dynamics underlying disease pathogenesis. However, in spite of scientific advances, HIV remains a significant global health issue, and an effective preventative vaccine has yet to be created. Many groups have demonstrated the importance of CD8 T cells in viral control during natural HIV infection and believe that CD8 T cells could contribute to vaccine efficacy by alleviating disease course in individuals who became infected despite vaccination. One major obstacle to inducing potent CD8 …
Early Childhood Quality Of Education And Late-Life Cognitive Function In A Population-Based Sample From Puerto Rico, Cheyanne Celine Barba
Early Childhood Quality Of Education And Late-Life Cognitive Function In A Population-Based Sample From Puerto Rico, Cheyanne Celine Barba
All ETDs from UAB
In general, greater years of education is associated with reduced risk of cognitive impairment in older adulthood, but the strength of this association has been found to differ by study population. Additionally, quality of education is understudied, despite evidence that quality of education and, in turn, literacy, may be additional indicators of cognitive reserve. This thesis examined years of education, literacy, and childhood quality of education indicators in relation to late-life cognitive outcomes in an older Puerto Rican population. We hypothesized that greater years of education, literacy, and quality of childhood education would be positively associated with each other, as …
Toxin Secretion By Mycobacterium Tuberculosis, Uday Tak
Toxin Secretion By Mycobacterium Tuberculosis, Uday Tak
All ETDs from UAB
Mycobacterium tuberculosis (Mtb) is a highly infectious airborne bacterial pathogen, and the causative agent of human tuberculosis. Mtb infects approximately one-third of the human population, and is responsible for more deaths than any other infectious disease in the history of mankind. Mtb is an intracellular pathogen and primarily infects myeloid cells, such as macrophages in the human lung. In macrophages, Mtb establishes a replication niche within membrane-bound vacuoles named phagosomes, while subverting immunity. The intracellular survival of Mtb depends on manipulation of host cellular processes through secreted effector proteins. Ultimately, this intracellular vacuole is ruptured by the type VII secretion …
Understanding The Impact Of Diet And Obesity On Anti-Tumor Immunity And Therapeutic Efficacy In Kidney Cancer, Rachael Miller Orlandella
Understanding The Impact Of Diet And Obesity On Anti-Tumor Immunity And Therapeutic Efficacy In Kidney Cancer, Rachael Miller Orlandella
All ETDs from UAB
Obesity is regarded as a major risk factor for developing renal cell carcinoma (RCC). Advanced-stage RCC exhibits chemotherapeutic resistance, but is responsive to immunotherapies such as the immune checkpoint inhibitor anti-programmed cell death-1 (anti-PD-1). Despite some clinical successes, response rates remain low for anti-PD-1 monotherapy (20-30%). Preclinical evaluations of immunotherapeutic strategies typically use lean mice and do not account for patient comorbidities. This may explain the underwhelming success rates following clinical translation of new cancer treatments. Recent studies found that obesity was associated with favorable outcomes and responses to immunotherapy in melanoma. However, the effects of obesity on anti-tumor immunity …
Novel Hiv Adaptation Strategy Against Host Cd8 T Cell Immunity, Kai Qin
Novel Hiv Adaptation Strategy Against Host Cd8 T Cell Immunity, Kai Qin
All ETDs from UAB
Since the 1980s, HIV infection has caused millions of death and tremendous economic losses worldwide. Despite great scientific advances, the only effective therapy to date, antiretroviral therapy (ART), merely delays disease progression yet cannot eradicate viral infection. Therefore, an effective HIV vaccine that can prevent the acquisition of infection would be a desirable alternative. The critical role of CD8 T-cell immunity in HIV infection has been well documented and therefore not surprisingly a great deal of effort has been focused on developing an effective CD8 T-cell based HIV vaccine. However, by far, such CD8 T-cell based HIV vaccine trials have …
Protective Host Responses During Acute And Chronic Lung Exposure To Aspergillus Fumigatus, Joseph Mackel
Protective Host Responses During Acute And Chronic Lung Exposure To Aspergillus Fumigatus, Joseph Mackel
All ETDs from UAB
Aspergillus fumigatus is an environmental airborne fungus that acts as both an opportunistic pathogen and an allergen. In immunocompromised hosts, A. fumigatus can germinate in the lung, cause tissue damage and pneumonia, and disseminate to other organs, causing a disease termed invasive aspergillosis (IA). In severe asthma, sensitization to fungi such as A. fumigatus is associated with more severe disease. Determination of host and fungal factors that drive immunoprotection versus immunopathogenesis in both of these settings will ultimately enable therapeutic modulation of immune responses to improve disease outcomes. In this body of work, we build on recent findings that implicate …
Copper Dependent Inhibitors Subvert Common Resistance Mechanisms In Staphylococcus Aureus And Inhibit Crucial Metabolic Pathways, Cameron Crawford
Copper Dependent Inhibitors Subvert Common Resistance Mechanisms In Staphylococcus Aureus And Inhibit Crucial Metabolic Pathways, Cameron Crawford
All ETDs from UAB
The effective antibiotic pool is shrinking with antibiotic resistance a constant problem that threatens to make our current therapies obsolete. To combat this, new drug screening methodologies are required since the traditional drug screens are offering limited results or only improvements upon current treatments. This work expands upon the idea that transition metal toxicity can be preferentially targeted towards bacteria. Specifically, the focus is on copper dependent inhibitors that quickly work to eliminate Staphylococcus aureus. S. aureus is a particularly threatening bacteria with high strain variability, a litany of survival and virulence factors, and multiple drug resistance mechanisms that are …
Anantharamaiah Named To National Academy Of Inventors, Alicia Rohan
Anantharamaiah Named To National Academy Of Inventors, Alicia Rohan
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No abstract provided.
Study Aims To Discover If Hookworm, Related Intestinal Parasites Are Present In Alabama Black Belt, Alicia Rohan
Study Aims To Discover If Hookworm, Related Intestinal Parasites Are Present In Alabama Black Belt, Alicia Rohan
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No abstract provided.
Uab's 1917 Clinic To Find New Home In Lakeview, Alicia Rohan
Uab's 1917 Clinic To Find New Home In Lakeview, Alicia Rohan
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No abstract provided.
Impaired Tumor-Necrosis-Factor-Alpha-Driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection From Allergic Inflammation In Infants, Brit Blalock
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No abstract provided.
Nih Study To Explore Vaccine For Gonorrhea Prevention, Staff
Nih Study To Explore Vaccine For Gonorrhea Prevention, Staff
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No abstract provided.
Uab Website Aims To Educate Public About The Flu, Prevention And Treatment, Staff
Uab Website Aims To Educate Public About The Flu, Prevention And Treatment, Staff
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No abstract provided.
Uab Researchers Receive U54 Grant, Join Rare Diseases Consortium, Alicia Rohan
Uab Researchers Receive U54 Grant, Join Rare Diseases Consortium, Alicia Rohan
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No abstract provided.
Six Ways To Reduce Hidden Hazards Of Tailgating, Staff
Six Ways To Reduce Hidden Hazards Of Tailgating, Staff
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No abstract provided.
Uab Cfar Researchers Awarded Contracts To Aid The Ending The Hiv Epidemic Plan, Alicia Rohan
Uab Cfar Researchers Awarded Contracts To Aid The Ending The Hiv Epidemic Plan, Alicia Rohan
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No abstract provided.
How Il-6 Allows The Immune Response To Develop For A Key Cell, The T Follicular Helper, Jeff Hansen
How Il-6 Allows The Immune Response To Develop For A Key Cell, The T Follicular Helper, Jeff Hansen
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No abstract provided.
3 Honored As Emeritus Faculty, Haley Herfurth
Uab Receives Grant From Merck Foundation To Address Hiv Disparities In The Southeast, Alicia Rohan
Uab Receives Grant From Merck Foundation To Address Hiv Disparities In The Southeast, Alicia Rohan
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No abstract provided.
6 Ways To Reduce Hidden Hazards Of Tailgating, Haley Herfurth
6 Ways To Reduce Hidden Hazards Of Tailgating, Haley Herfurth
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No abstract provided.
Pence's Bioethics Career Explores 'People Making Choices And Learning From Their Mistakes', Haley Herfurth
Pence's Bioethics Career Explores 'People Making Choices And Learning From Their Mistakes', Haley Herfurth
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No abstract provided.
This Game Helps Young Scientists Avoid Playing The Fool - And It's Catching On, Matt Windsor
This Game Helps Young Scientists Avoid Playing The Fool - And It's Catching On, Matt Windsor
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No abstract provided.
Researchers Awarded $10 Million To Study Acute Flaccid Myelitis, Staff
Researchers Awarded $10 Million To Study Acute Flaccid Myelitis, Staff
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No abstract provided.
Lee Named Uab Medicine Healthcare Epidemiologist, Alicia Rohan
Lee Named Uab Medicine Healthcare Epidemiologist, Alicia Rohan
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No abstract provided.
Uab Center For Aids Research Receives $7.5 Million Grant Renewal, Alicia Rohan
Uab Center For Aids Research Receives $7.5 Million Grant Renewal, Alicia Rohan
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No abstract provided.
Dine With The Docs Connects Students With Faculty Mentors, Uab Heersink School Of Medicine News
Dine With The Docs Connects Students With Faculty Mentors, Uab Heersink School Of Medicine News
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No abstract provided.