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The Impact Of Weight Status On The Adoption Of Self-Care Behaviors Among Heart Failure Patients, Bern'nadette Knight Jan 2013

The Impact Of Weight Status On The Adoption Of Self-Care Behaviors Among Heart Failure Patients, Bern'nadette Knight

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Self-care is a major component of heart failure management. Excess weight is a disease that may negatively affect a patient's ability to effectively practice self-care. The project aimed to assess 1) the relationship between weight status and heart failure self-care behaviors and 2) the modification of the relationship between social support and heart failure self-care by weight status. This cross sectional study utilized baseline data from a cohort of African-American and Caucasian participants diagnosed with heart failure. The heart failure cohort was formed from three larger studies (n=690) designed to assess the relationships among social support, self-care behaviors and hospital …

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Virus-Induced Inflammation And Central Nervous System Development, Kate Kosmac Jan 2013

Virus-Induced Inflammation And Central Nervous System Development, Kate Kosmac

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Congenital human cytomegalovirus (HCMV) infection is a complex cause of central nervous system (CNS) disease. Infection with HCMV during pregnancy results in virus transmission across the placenta and infection of the fetus. With a seroconversion rate in pregnant women between 1% and 4%, HCMV is the most frequently transmitted virus from mother to developing child. Each year between 2,000 and 4,000 infants will suffer from long-term neurologic deficits as a result of congenital infection. The well documented CNS sequelae resulting from congenital HCMV infection have described a wide range of damage without a specific set of pathologic markers for disease. …

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Characterization Of Legal Highs And Their Pyrolysis Products, Emily Denise Bouso Jan 2013

Characterization Of Legal Highs And Their Pyrolysis Products, Emily Denise Bouso

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Legal highs are any mind-altering substance produced and sold in a manner to avoid the legal consequences of illicit substances. They have been advertised and sold as Spice, Bath Salts, plant food, and research chemicals. Not only are these drugs presenting major problems to law enforcement, but also to health care providers. The exact composition for many of these substances is not known. Therefore, treatment for patients who have taken these drugs is limited to symptomatic care. Harmful exposure to these substances is not limited to the primary components within the drugs, but can include potentially toxic by-products that result …

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The Influence Of Socioeconomic Status And System Design On Child Passenger Safety, Donald Scott Burke Jan 2013

The Influence Of Socioeconomic Status And System Design On Child Passenger Safety, Donald Scott Burke

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Motor vehicle collisions remain the number one cause of death for children in the United States, despite decades of prevention efforts led by safety experts and numerous private and government organizations. The overarching purpose of this research was to examine and compare the system safety factors that influence child passenger safety (CPS) with a particular focus on children living in poverty. The NASS-CDS and U.S. Census national databases were utilized to determine the effect of socioeconomic status on child occupant morbidity and mortality. The results of this analysis revealed for the first time, the disproportionate vulnerability of poor children in …

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Impact Of Quality Performance On Financial Risk And Cost Of Capital In Hospitals, James D. Byrd Jan 2013

Impact Of Quality Performance On Financial Risk And Cost Of Capital In Hospitals, James D. Byrd

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This study evaluated the relationship of hospital quality of care as measured by mortality scores to hospital cost of capital as represented by average cost of debt. A composite mortality score (weighted average of Hospital Compare's risk adjusted mortality rate for each hospital) was regressed against the hospitals' average cost of debt using OLS and the Stata 11 robust clustering function to adjust for repeated occurrences of hospitals across years. The data base consisted of acute care hospitals with interest expense observed over the three year period 2008 - 2010 (n=3420). Control variables included a number of hospital characteristic (e.g., …

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O-Linked Beta-N-Acetylglucosamine (O-Glcnac) And The Mitochondrion, Christopher Calderon Jan 2013

O-Linked Beta-N-Acetylglucosamine (O-Glcnac) And The Mitochondrion, Christopher Calderon

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O-linked beta-N-acetylglucosamine (O-GlcNAc) is a dynamic and ubiquitous posttranslational modification of serine and threonine residues on nuclear and cytoplasmic proteins. O-GlcNAc has emerged as an important regulator of cellular processes such as cell signaling, transcription, translation, apoptosis, and cell cycle regulation, among others. O-GlcNAc is thought to be a contributor to pathologies such as hyperglycemia and insulin resistance. O-GlcNAc has been viewed as an indicator of cellular energy levels and is associated with diabetic complications under nutrient excess. Other studies have shown that a variety of stress stimuli increase the levels of protein O-GlcNAc in mammalian cells, and this increase …

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Adolescent Mothers: Factors Affecting Social And Sexual Decision-Making, Donna M. Campbell Jan 2013

Adolescent Mothers: Factors Affecting Social And Sexual Decision-Making, Donna M. Campbell

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Adolescent pregnancy remains a public health concern despite decades of attempts to prevent it. The United States continues to have the highest adolescent pregnancy rates of any industrialized country (Kost, Henshaw, & Carlin, 2010). While adolescents of all ages (10-21 years) can become pregnant, pregnancy rates are highest among adolescents who are 15 to 19 years of age. Multiple factors have been identified that increase the likelihood of adolescent pregnancy and repeat pregnancy. Often times, adolescent pregnancy is the result of sexual risk-taking, which has been attributed to the changes that occur neurologically, physically, and emotionally (Reyna & Farley, 2006). …

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Reckless Reevaluated: Containment Theory And Its Ability To Explain Desistance Among Serious Adolescent Offenders, Stephanie Michelle Cardwell Jan 2013

Reckless Reevaluated: Containment Theory And Its Ability To Explain Desistance Among Serious Adolescent Offenders, Stephanie Michelle Cardwell

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Social control theorists posit that crime and delinquency occur among members in society because an individuals' behavior is not well regulated. Recent control theories have emphasized the importance of high self-control and strong bonds to society in deterring criminal behavior. However, one of the original theories of self-control has been largely ignored among scholars. Developed by Walter Reckless in the 1960s, containment theory suggests that individuals are pushed and pulled into crime. Pushes are elements that pressure individuals to engage in delinquency while pulls draw individuals away from accepted forms of behavior. The theory states that pushes and pulls are …

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The Flow Of The Social: Developing A Constructal Systemic Approach To The Study Of Health Inequalities, William A. Anderson Jan 2013

The Flow Of The Social: Developing A Constructal Systemic Approach To The Study Of Health Inequalities, William A. Anderson

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Society is a dynamic, living system. People, groups, institutions, and cultures are intricately interconnected. Changes in one area of society create changes in other areas. Causes and results may be closely linked or separated by time and space. Sociologists readily acknowledge this dynamic reality. However, our mainstream theories and methods often fail to account for it. Even after decades of research into social inequalities in health, medical sociology still seems far away from being able to offer any definitive ideas about why such inequalities exist and persist despite efforts to alleviate them. Medical sociology (and sociology in general) is centered …

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Energy Performance Evaluation Of Aac, Hulya Aybek Jan 2013

Energy Performance Evaluation Of Aac, Hulya Aybek

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The U.S. building industry constitutes the largest consumer of energy (i.e., electricity, natural gas, petroleum) in the world. The building sector uses almost 41percent of the primary energy and approximately 72percent of the available electricity in the United States. As global energy-generating resources are being depleted at exponential rates, the amount of energy consumed and wasted cannot be ignored. Professionals concerned about the environment have placed a high priority on finding solutions that reduce energy consumption while maintaining occupant comfort. Sustainable design and the judicious combination of building materials comprise one solution to this problem. A future including sustainable energy …

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The Molecular Mechanisms Underlying Cardiac Hypertrophy Due To Volume Overload., Justin Andrew Barnes Jan 2013

The Molecular Mechanisms Underlying Cardiac Hypertrophy Due To Volume Overload., Justin Andrew Barnes

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Mitral regurgitation (MR) is a common form of heart disease, but there are no approved medical therapies for MR or other cardiovascular conditions associated with hemodynamic volume overload (VO) and eccentric remodeling. We have previously shown that a standard heart failure treatment, ß-adrenergic system blockade (ß-RB), improves function in animal models of VO and in MR patients without attenuating the adverse eccentric hypertrophy that occurs in conjunction with VO. This paradox highlights how poorly we understand eccentric remodeling of the heart, and a better understanding of the molecular mechanisms at work in VO must be obtained before we can develop …

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The Interactional Effects Of Incentive Value And Task Difficulty: A Partial Explanation For Gender Differences In Cardiovascular Response To A Performance Challange., Patricia Barreto Jan 2013

The Interactional Effects Of Incentive Value And Task Difficulty: A Partial Explanation For Gender Differences In Cardiovascular Response To A Performance Challange., Patricia Barreto

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Participants were presented an impossible or moderately difficult mental addition task; half of them were led to believe that they could win a traditionally masculine incentive by meeting a certain performance standard and half of them were led to believe that they could win a traditionally feminine incentive if they met the same performance standard. In the feminine incentive group, Systolic Blood Pressure (SBP) during the work period was stronger under difficult than impossible conditions among women, but low under both difficulty conditions among men. In the masculine incentive group, blood pressure measures (SBP, diastolic blood pressure, and mean arterial …

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Adapter Based Strategies For Adenovirus Vector Retargeting To T Lymphocytes, Matthew S. Beatty Jan 2013

Adapter Based Strategies For Adenovirus Vector Retargeting To T Lymphocytes, Matthew S. Beatty

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Adenoviruses are the most commonly used gene therapy vector for cancer therapy clinical trials. While adenovirus has shown a great track record in a variety of cancer therapeutics it has not progressed as a vector system for the modification of T lymphocytes. One of the major roadblocks towards utilizing adenovirus for T cell therapy is the lack of coxsackie virus and adenovirus receptor on the cell surface of T cell lineages. Exploitation of alternative receptors has allowed adenovirus vectors to be utilized in a variety of cell types that native adenovirus type 5 cannot infect. Thus, retargeting adenovirus to an …

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In-Vivo Characterization Of Cone Photoreceptor Packing Density With Adaptive Optics Scanning Laser Ophthalmoscopy In Different Racial Groups, Ernesto Blanco Rivero Jan 2013

In-Vivo Characterization Of Cone Photoreceptor Packing Density With Adaptive Optics Scanning Laser Ophthalmoscopy In Different Racial Groups, Ernesto Blanco Rivero

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Cone photoreceptors are one of the two types of essential light sensitive cells that initiate the visual process in the human retina. A normal database of the cone density of healthy eyes may provide an important measure for diagnosing retinal diseases that cause photoreceptor loss, for monitoring disease progression, and for evaluating treatment out-come. Recent studies revealed that the foveal pit morphology, retina thickness, retinal nerve fiber layer (RNFL) thickness, and optic nerve head structure significantly correlated with racial background. We hypothesize that the cone density may be also modified by racial background. To test this hypothesis, I used a …

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A Prospective Study Of Bone Augmentation With Growth Factors In Extraction Sockets, Athanasios Ntounis Jan 2013

A Prospective Study Of Bone Augmentation With Growth Factors In Extraction Sockets, Athanasios Ntounis

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Ridge preservation protocols reduce crestal remodeling after tooth extraction. Limited evidence supports the potential of different grafting materials to preserve the alveolar ridge. There is limited evidence to indicate advantage of bone replacement grafting in combination with platelet rich plasma (PRP), compared to grafting alone. A combination of recombinant human platelet derived growth factor (rhPDGF-BB) with beta tricalcium phosphate (ß-TCP) has recently been approved to aid wound healing. Aim: To evaluate early healing of grafted and non-grafted extraction sockets in the es-thetic zone, with or without PRP and rhPDGF-BB. Materials and Methods: Population consisted of 41 healthy adult patients whose …

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Uptake Of Antenatal Care Services And Pregnancy Outcome In Kumasi, Ghana, Asundep Ntui Jan 2013

Uptake Of Antenatal Care Services And Pregnancy Outcome In Kumasi, Ghana, Asundep Ntui

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A prior study reported a 44.6% prevalence of adverse pregnancy outcomes in Kumasi, Ghana. This study investigated factors that may influence antenatal care (ANC) utilization and their association with adverse pregnancy outcomes; defined as low birth weight, stillbirth, preterm delivery or small for gestational age among pregnant women in Kumasi. A quantitative cross sectional study of 643 women, age 19-48 years who presented for delivery at select public hospitals and private traditional birth attendants from July through November 2011 was conducted. Information on socio-demographic characteristics and other factors associated with ANC attendance was collected using a structured questionnaire. Medical and …

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Epigenetic Regulation Of Kir4.1 In Normal And Pathological States: A Focus On Spinal Cord Injury, Sinifunanya Elvee Nwaobi Jan 2013

Epigenetic Regulation Of Kir4.1 In Normal And Pathological States: A Focus On Spinal Cord Injury, Sinifunanya Elvee Nwaobi

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Astrocytes are the most numerous cells in the brain and play a critical role in maintaining homeostatic extracellular potassium ([K+]e). This process is mediated, in part, by a glial-specific, inwardly rectifying potassium channel, Kir4.1. Pharmacological inhibition, knock down, or complete knock out of this channel results in astrocytes with increased membrane resistance, depolarized resting membrane potential, and altered extracellular potassium dynamics. Subsequent to the dysregulation of [K+]e, Kir4.1 knockout (KO) animals suffer from ataxia, seizures, and early postnatal death. Interestingly, Kir4.1 has long been characterized as a seizure susceptibility gene. The importance of Kir4.1 is further underscored by recent studies …

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New Mouse Models To Aid Studies Of The Role Of Primary Cilia In Limb Patterning And Bone Development, Amber Kathleen O'Connor Jan 2013

New Mouse Models To Aid Studies Of The Role Of Primary Cilia In Limb Patterning And Bone Development, Amber Kathleen O'Connor

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Hedgehog (Hh) signaling is required for many developmental processes, and causes several diseases and cancers. Described in chapter one below, vertebrate Hh sig-naling is dependent on the primary cilium (PC), a small organelle that extends from the surface of most mammalian cell types. A better understanding of how the PC modulates Hh signaling is important, as defects in the structure or function of PC result in severe human disorders termed the ciliopathies. For example, patients with Meckel-Gruber Syndrome have extra digits and neural tube defects, which are Hh both related pheno-types. In chapter two we sought to further understand the …

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Obesity, Prediabetes, And Perceived Stress In Municipal Workers, Louise Camilleri O'Keefe Jan 2013

Obesity, Prediabetes, And Perceived Stress In Municipal Workers, Louise Camilleri O'Keefe

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Obesity and diabetes are major contributors to morbidity and mortality in the United States. According to the American Public Health Association and Partnership for Prevention, obesity is growing faster than any other public health problem in the United States. The prevalence of diabetes has also increased significantly with an estimated 79 million Americans aged 20 years or older suffering from prediabetes. Few studies have examined the influence of perceived stress on obesity and prediabetes among working adults. Investigations are needed to examine factors that can contribute to higher health care costs for both employees and employers. The aims of this …

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The Comparison Of Dental Arch Forms Obtained From Teeth, Alveolar Bone, And The Overlying Soft Tissue, Patrick O'Neil Jan 2013

The Comparison Of Dental Arch Forms Obtained From Teeth, Alveolar Bone, And The Overlying Soft Tissue, Patrick O'Neil

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THE COMPARISON OF DENTAL ARCH FORMS OBTAINED FROM TEETH, ALVEOLAR BONE, AND THE OVERLYING SOFT TISSUE Patrick D. O'Neil, DMD UAB DEPARTMENT OF ORTHODONTICS: DENTISTRY ABSTRACT Objective: The objective of this study was to determine if a difference existed between arch forms created from tooth surfaces, alveolar bone, and overlying soft tissue. Materials and Methods: The sampling population for this study was 18 individuals with a Class I malocclusion, mild crowding, and a CBCT image of good diagnostic quality. The Facial-axis point was chosen to create the arch form from teeth, the Bowman-Kau point was used to establish the arch …

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Urban Kindergarten Teachers' Perceptions Of Former Head Start Students And Their Readiness For School, Stephanie Hardy Parker Jan 2013

Urban Kindergarten Teachers' Perceptions Of Former Head Start Students And Their Readiness For School, Stephanie Hardy Parker

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The purpose of this qualitative multiple case study was to explore the experiences and instruction of kindergarten teachers in an urban school district who are teaching students who were previously enrolled in a Head Start program. Eleven kindergarten teachers who taught in an urban school district in the southeastern United States participated in this study. Data sources collected for this multiple case study included: (a) semi-structured interviews, (b) observations, and (c) curriculum documents. Results from the study revealed mixed experiences teaching former Head Start students. While some teachers expressed positive experiences teaching former Head Start students, others indicated teaching former …

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Phospho-Erk And Amyloid Beta: Targets Of Estrogen In The Brain, Thomas Reed Peavy Jan 2013

Phospho-Erk And Amyloid Beta: Targets Of Estrogen In The Brain, Thomas Reed Peavy

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Estrogen replacement therapy (ERT) has been shown to improve memory function in menopausal women, but increases hormone sensitive cancers, prompting a more targeted investigation of estrogen's action in learning and memory to develop more targeted therapeutics. Estrogen improves performance on the novel object recognition task by increasing phosphorylation of extracellular signal-regulated kinase (pERK) within minutes in the hippocampus. Dr. Lori McMahon's lab showed that the improvement in novel object recognition can be seen 24 hours after subcutaneous injection of proestrous levels of estrogen (referred to as E24). Whether a corresponding increase in pERK occurs at the E24 time point had …

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Engaging First Graders In Transformational Early Childhood Emergent Learning Themes, Amanda Daniel Pendergrass Jan 2013

Engaging First Graders In Transformational Early Childhood Emergent Learning Themes, Amanda Daniel Pendergrass

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The purpose of this qualitative case study was to encourage learners to care for others and make a difference in the world through Reggio Emilia-inspired teaching and learning practice that promoted transformational education. Students were anticipated to take an active role in helping to develop the transformational educational curriculum. Students recommended ways of making a difference in their school, neighborhood, and community while investigating a learning theme of their interest and choice. A total of 15 first grade students and nine parents participated in this study. Limited literature exists on the topic of Reggio Emilia-inspired early childhood classrooms and recycling …

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Characterization Of The Retina In The Alpha 7 Nicotinic Acetylcholine Receptor Knockout Mouse, Marci Lynn Smith Jan 2013

Characterization Of The Retina In The Alpha 7 Nicotinic Acetylcholine Receptor Knockout Mouse, Marci Lynn Smith

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Acetylcholine receptors (AChRs) are involved in visual processing and are expressed by inner retinal neurons in all species studied to date (Keyser et al., 2000; Dmitrieva et al., 2007; Liu et al., 2009), but their distribution in the mouse retina remains unknown. Reductions in alpha 7 nicotinic AChRs (nAChRs) are thought to contribute to memory and visual deficits observed in Alzheimer's and schizophrenia (Coyle et al., 1983; Nordberg et al., 1999; Leonard et al., 2006). However, the alpha 7 nAChR knockout (KO) mouse has a mild phenotype (Paylor et al., 1998; Fernandes et al., 2006; Young et al., 2007; Origlia …

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Oral Language Development In Title I Preschools In Central Alabama: A Multi-Case Study, Suzanne O'Rear Snow Jan 2013

Oral Language Development In Title I Preschools In Central Alabama: A Multi-Case Study, Suzanne O'Rear Snow

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Among risk factors associated with reading difficulties, underdeveloped oral language skills can be detrimental to students' reading success. Many educators are teaching early reading skills without prior knowledge of scaffolding methods and developmentally appropriate developmentally appropriate factors from research (Kirkland & Patterson, 2005). This multi-case study examined aspects of how five preschool personnel developed oral language development in two Titles I preschool by answering the following questions: How do preschool teachers and paraprofessionals describe the ways in which oral language development is developed in a preschool setting? The research sub-questions included were: Two Title I schools were purposefully chosen for …

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Host Genetic Factors Associated With Cervical Human Papillomavirus Clearance, Staci Lynn Sudenga Jan 2013

Host Genetic Factors Associated With Cervical Human Papillomavirus Clearance, Staci Lynn Sudenga

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This dissertation research focuses on how variants in various host genes are associated with clearance of HPV in three longitudinal cohorts from the United States. I first examined the definition of the intermediate phenotype to cervical cancer, HPV persistence and then I incorporated this phenotype in all my three aims by examining variations in xenobiotic metabolism genes in HIV-1 negative and immune-related genes in HIV-1 positive females and how these contribute to HPV infection outcomes. Several significant variants were associated with HPV clearance for the three aims. For the first aim, in ALTS assessing functional variants within xenobiotic metabolism genes …

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Biocomposite Material Evaluation And Processing For Automotive Interior Components, Theresa Lee Sullins Jan 2013

Biocomposite Material Evaluation And Processing For Automotive Interior Components, Theresa Lee Sullins

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There is growing demand for materials that are environmentally friendly and sustainable. One of the areas of focus right now is the transportation/automotive field where more energy efficient vehicles are needed to meet growing government regulations and to reduce the negative impacts on global air quality, human health and global climate. Several researchers are focusing on bio-based composites with natural fibers being the prime choice for fiber reinforced composites. The processing and characterization of 30 wt. % industrial hemp fiber reinforced PP composites for automotive interior components are discussed. The material was compounded by a twin screw and then processed …

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The Effect Of Incentive Strategy On Health Behaviors And Outcomes In The Workplace, Lindsay M. Sutton Jan 2013

The Effect Of Incentive Strategy On Health Behaviors And Outcomes In The Workplace, Lindsay M. Sutton

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This study examined participation, engagement, and achievement of health-related targets under two sequentially administered wellness programs for approximately 2,000 full-time city personnel of a Southern municipal government. Program A utilized paper fliers and community posters as the primary communication strategy and incented employees for achieving 3 health outcomes only by a lump-sum, one-time monetary reward distributed at the end of the year. Program B subsequently utilized a web-based site where employees logged into individualized accounts and received points that accrued for both completing behaviors and achieving health outcomes. Both electronic and paper communication strategies were utilized to as primary mediums …

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Three-Dimensional Photography Of Facial Morphology Of Adult African-Americans Compared To Various Population Sets, Leslie Talbert Jan 2013

Three-Dimensional Photography Of Facial Morphology Of Adult African-Americans Compared To Various Population Sets, Leslie Talbert

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The purpose of this study is to compare the facial morphologies of an adult African-American population to an adult Caucasian-American population using three-dimensional surface imaging. Materials and Methods: Three-dimensional facial images were captured via a stereo-photogrammetric camera system (3dMDfaceTM system). One hundred images of each population (African-American and Caucasian-American) were taken. Subjects were between 19-30 years of age, normal BMI, and no gross craniofacial anomalies. All facial images were aligned and combined using Rapidform 2006 Plus Pack 2 software to produce a male and female facial average for each population. The facial averages were then superimposed for comparison and the …

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Effects Of Light Spectra And Uv Radiation In Relation To Dietary Carotenoids On The Sea Urchin Lytechinus Variegatus, James Christopher Taylor Jan 2013

Effects Of Light Spectra And Uv Radiation In Relation To Dietary Carotenoids On The Sea Urchin Lytechinus Variegatus, James Christopher Taylor

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An important factor in the marketability of sea urchin gonad is color. A marketable color is suggested to be dependent upon the in vivo accumulation of red and yellow carotenoid pigments within the gonad. Carotenoids obtained through the diet can be modified in sea urchins, but the function of these carotenoids is unknown. We hypothesize that differential light exposure can affect carotenoid deposition and, as a consequence, gonad color in sea urchins. We performed two experiments to determine if light spectra affect gonad color of Lytechinus variegatus. In the first experiment, urchins were fed a formulated feed supplemented with or …

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