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Redneck Revolutionaries: The Young Patriots And The Rainbow Coalition, Emily Ann Wilson

Vulcan Historical Review

pp. 22-32

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3 - Uab Arts, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

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Uab Magazine - Spring/Summer 2022, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

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Mevisit: Value-Based Approach To Primary Care Delivery By Mtelemedicine Utilization Applied Through Lean Principles, Neil Coyer Thornbury

All ETDs from UAB

Background: Significant issues of inconsistent patient services in the U.S. health system impact health outcomes and create high cost. Limitations of immobility, inefficiency, and accessibility sacrifice patient treatment, delay recovery, and escalate health risks from the lack of primary care physicians. The primary purpose of this study was to examine meVisit, a connective mobile technology, as a feasible primary care solution to address escalating health costs by reducing emergency room (ER) visits and inpatient admissions (IA). Methods: The feasibility study applied descriptive and inferential statistics to secondary data (n=4,024) and compared the two independent patient groups from the same large …

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Access To The Kidney Transplant Waitlist For People Living With Hiv, Brittany A. Shelton

All ETDs from UAB

People living with HIV (PLWH) have experienced substantial increases in life expectancy, largely attributable to improvements in care such as antiretroviral therapy. As a result, there has been a concurrent increase in the development of aging-related comorbidities such as end-stage organ disease. One such comorbidity is kidney disease. Concerningly, PLWH are at disproportionately higher risk of chronic kidney disease and end-stage kidney disease (ESKD) as compared to HIV-negative counterparts. Kidney transplantation is the ideal therapy for ESKD as it is both cost-effective and provides a significant survival benefit and yet, despite excellent transplant outcomes among PLWH, access to transplantation among …

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Examining Sex And Race Difference In Obesity Risk Factors In Older Americans Using Genetic And Lifestyle Data In Regards, Hairui Yu

All ETDs from UAB

Obesity is a prevalent chronic condition determined by social, psychological, behavioral, and biological factors. The prevalence of obesity remains a major public health issue and has continued to rise in the United States and around the world. People who are obese face a higher risk of cardiovascular and metabolic diseases. The fat mass and obesityassociated gene (FTO) is one of the most commonly identified genes in obesity-related research. This three-paper dissertation is aimed at improving understanding of sex and race differences in obesity risk factors in older Americans from genetic (FTO SNPs) and lifestyle (diet and physical activity) perspectives, using …

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Targeting The Frataxin Transcriptional Defect As A Therapeutic Approach For Friedreich's Ataxia, Anna Maria Schreiber

All ETDs from UAB

Friedreich’s ataxia (FRDA) is the most common inherited ataxia worldwide. This autosomal recessive neurodegenerative disorder manifests in the central and peripheral nervous system but also affects the cardiovascular and endocrine systems. No effective treatment is available. FRDA is caused by expansion of GAA repeat tracts in intron 1 of the frataxin (FXN) gene on both alleles. An inverse correlation between FXN levels and GAA repeat length exists. Frataxin is a mitochondrial protein participating in iron-sulfur (Fe-S) cluster formation. Frataxin deficiency results in reduced activity of Fe-S-containing enzymes involved in critical biological processes, such as cellular respiration and DNA repair. Expansion …

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Cognition And The Brain Of The Healthy Oldest-Old, Sara A. Sims

All ETDs from UAB

There is an increasing number of people aged 65 and older, particularly in the oldest old cohort (aged 85 and older). Aging is characterized by significant changes in the brain including disruptions to white matter and functional connectivity. While cognition is impacted in many age related diseases, like Alzheimer’s Disease or Parkinson’s Disease, an understanding of the healthy aging brain is important for informing research on successful aging. My dissertation consists of three aims: (1) For the first aim, my overall objective was to determine the validity of the NIH toolbox in the oldest old cohort. I used other standard …

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Embedding A Mixed Methods Process Evaluation In A Web-Based Diet And Exercise Program For Older Cancer Survivors, Jami Lee Anderson

All ETDs from UAB

The purpose of this dissertation is to describe critical steps in designing a usercentered mixed methods process evaluation and implement the process evaluation within an existing program. Three objectives of this dissertation include: 1) develop a conceptual framework for conducting user-centered process evaluations of web-based diet and exercise programs for middle-aged and older cancer survivors; 2) inform the design of a user-centered process evaluation by leveraging insights from “think aloud” interviews collected during the beta-testing phase of the AMPLIFY program (a webbased diet and exercise program designed to support healthy lifestyle needs of older cancer survivors); and 3) present results …

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The Role Of The Bone Marrow Microenvironment In Flt3-Itd Acute Myeloid Leukemia Stem Cell Resistance To Flt3 Inhibition, Nicholas R. Anderson

All ETDs from UAB

Acute myeloid leukemia (AML) is an aggressive, complex hematological malignancy. AML cases with constitutively-activating internal tandem duplications in the Flt3 receptor (Flt3-ITD) represent a distinct subtype of disease with poor prognosis, but unique opportunities for targeted therapy. Flt3-specific tyrosine kinase inhibitors (TKI) have entered clinical practice due to their ability to induce remissions in a large proportion of Flt3-mutant AML patients, but their long-term efficacy remains limited due to the persistence of leukemia stem cells (LSC) in the bone marrow (BM). Herein, we outline the importance of the bone marrow microenvironment (BMM) in harboring LSC through AML development and drug …

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A Hybrid Data And Hypothesis-Driven Model For Software Development In Support Of The Machine-Learning Paradigm, Anthony D. Bowman

All ETDs from UAB

istorically, research has often been conducted in a hypothesis-driven manner with software development methodologies created to support those efforts. However, in recent years data-driven approaches to research have seen a dramatic rise in prominence. While software development methodologies such as agile development, extreme programming, and the waterfall model have allowed developers to tackle increasingly complex problems, they were not designed to efficiently support data-driven approaches such as the machine learning paradigm. To address the need to support the different programmatic requirements of both classical, hypothesis-driven as well as data-driven development, novel development strategies are warranted. In this research, we adapted …

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Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas

All ETDs from UAB

of ALL survivors are at risk for reduced functional outcomes, and these outcomes may be more strongly related to executive functioning than neighborhood-specific variables or IEP support. Long-term goals include translating findings into practice to remediate adaptive or academic difficulties in ALL survivors.

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Heart Rate Variability And Stress In The Intensive Care Unit Nursing Workplace, Paula Miller Levi

All ETDs from UAB

Intensive care unit (ICU) nurses work in a demanding environment, facing repeated encounters with trauma and ethical issues when caring for patients. Psychological stressors can include death of patients, violent acts by patients or their families, caring for suffering patients, and moral distress from performing futile care. These factors place ICU nurses at increased risk of developing post-traumatic stress disorder (PTSD). Suffering from chronic PTSD symptoms can negatively impact nurses’ psychological and physical health. There are also consequences for patients and hospitals, including increased risk for substandard care, decreased government reimbursements from poor patient satisfaction scores, and retention issues. Few …

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Monoclonal Antibody-Mediated Cancer Treatment: Development, Manufacturing And Evaluation, Yingnan Si

All ETDs from UAB

Malignant cancer is one of the greatest threats to human health globally. Conventional (non-targeted) treatments such as chemo-drugs and radiation therapy remain the major choices for cancer patients while always accompanied by severe systemic toxicity/side effects. Monoclonal antibody (mAb) is one of the most successful biomolecules discovered and well investigated as a targeted therapy to treat human disease. This dissertation research was aimed to develop monoclonal antibody-based targeted drugs for cancer treatment, which include antibody-drug conjugates (ADCs), liposomal drug and exosome-based drug delivery. Novel targets were discovered, screened and confirmed by proteomics, western blotting and flow cytometry analysis. Cancer cells …

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Preventing Unintentional Childhood Injuries In Rural Uganda: Caregiver Perceptions And Promotion Of Personal Safety Skills Through Classroom-Based Instruction, Marissa H. Swanson

All ETDs from UAB

Objective: Unintentional childhood injuries present a substantial public health burden in low- and middle-income countries (LMIC) including Uganda. Interventions to reduce this risk should be responsive to children’s unique developmental, environmental, and sociocultural context. This project had three primary objectives: 1) Analyzing caregiver reports of child injury events in rural Uganda to identify perceived causal and preventative factors; 2) Identifying Ugandan first and sixth graders’ developmental safety needs by comparing hazard recognition and past-year injuries among these students; and 3) Evaluating the impact of the Careful Cubs intervention on Ugandan first graders’ personal safety knowledge, skills, and beliefs. Methods: 1) …

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Understanding The Protumorigenic Functions Of St6gal1 In Glioblastoma Stemness And Metabolism, Sajina Gc

All ETDs from UAB

Glioblastoma (GBM) is a rare but deadly cancer with median survival of just 15 months despite of aggressive treatment. Advancement in novel treatment modalities is hindered by its heterogeneous nature, which includes subsets of neural stem cell-like brain tumor initiating cells (BTICs) that are highly tumorigenic and therapy-resistant. bgalactoside a-2,6-sialyltransferase 1 (ST6Gal1) is elevated in most tumors including in normal and neoplastic stem cells. ST6Gal1 imparts oncogenic phenotypes such as invasion, apoptosis evasion, therapy resistance, TIC maintenance among others via sialylation of critical receptors like, Fas, TNFR1, EGFR and more. Yet ST6Gal1 led regulation of BTIC specific cell surface proteins …

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Characterization Of Exercise-Associated Skeletal Muscle Secreted Factors Through Aging, Dalton Chase Patterson

All ETDs from UAB

Exercise is a powerful behavioral intervention against Central Nervous System (CNS) aging1–3 and plays an essential role in maintaining healthy neurocognitive function and immune metabolism in the aging brain3. We have developed a new transgenic mouse model that moderately over-expresses transcription factor master regulator of proteostasis, Transcription Factor E-B (TFEB), in skeletal muscle (cTFEB;HSACre mice). Despite living sedentary lifestyles, our model of enhanced skeletal muscle proteostasis shows significantly ameliorated proteotoxicity, increased BDNF levels and neurogenesis while improving neurocognitive function and decreasing neuroinflammation in the aging CNS4,5. These neuroprotective effects are markedly reminiscent of those observed in the aging CNS post-exercise6,7, …

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Labor Union Membership Tenure And Midlife Health: A Gendered Perspective, Clifford Ross

All ETDs from UAB

The benefits of labor unions have not gone unstudied. Individuals in labor unions have better access to lower cost/more substantial health insurance plans, higher quality pension plans, and better wages leading to increased lifetime earnings. Even though many of these benefits create important pathways that could lead to better health, unions have been paid little attention in health literature. Additionally, in the modern workplace Mothers are offered lower starting salaries, are perceived as less competent, and face a penalty regarding hiring, promotion, and workplace educational opportunities. Compared to men, women with children see an income gap 20 cents wider than …

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Low-Dose Dextromethorphan For The Treatment Of Pain In Fibromyalgia: A Single-Blind Placebo-Controlled Crossover Trial, Stephanie Christina Mueller

All ETDs from UAB

Fibromyalgia (FM) is a debilitating chronic pain condition. Its pathophysiology is largely unknown, which has hindered the development of effective treatments. Central sensitization and neuroinflammation have been forwarded as models of FM pathophysiology, both of which indicate the antitussive drug dextromethorphan (DXM) as a potentially effective treatment. DXM is an N-Methyl-D-aspartic acid (NMDA)-receptor antagonist and microglial modulator with anti-neuroinflammatory properties at low doses. It is currently available for clinical use, but has not been tested as a treatment for FM at low dosages. The current study evaluated the effectiveness of DXM in treating FM-associated symptoms of pain, fatigue, cognitive problems, …

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The Difference In Fracture Strength Of Translucent Zirconia (5y-Z) Using Different Cements And Surface Treatments, Esra Elamin

All ETDs from UAB

Statement of Problem: With the recent advent of translucent and ultra-translucent zirconia, it is unknown if this type of high-strength ceramic restoration requires adhesive cementation to enhance retention as well as the effect of surface treatment thus its clinical applicability requires further investigation. Purpose: To investigate the difference in fracture strength of translucent zirconia (5Y-Z) using different crown thickness, different cements under different surface treatment conditions. Materials and Methods: The experimental design consisted of five groups of 30 specimens each. Two different cements were utilized under different surface treatment conditions. Copings of (1.0 mm) uniform thickness were milled of 3Y-zirconia …

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Racial Differences In The Association Of Insulin Resistance With Risk Of Incident Heart Failure In Participants Of Regards, Nirav Patel

All ETDs from UAB

Background: Insulin resistance is linked to the development of heart failure (HF). However, there is limited understanding of the racial differences in the association of insulin resistance with the risk of incident HF among individuals without diabetes. Objectives: In a US national cohort of Black and White participants, we sought to evaluate: 1) the relationship between insulin resistance with incident HF participants, and 2) whether there are racial differences in the association of insulin resistance with HF. Methods: We examined >16,000 participants without HF and diabetes at baseline from the REGARDS cohort. Cox regression modeling was used to assess the …

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Assessing The Impact Of The Covid-19 Pandemic On Metastatic Lung Cancer Time To Treatment Initiation, Health Care Resource Utilization, And Costs In The United States, Teresa M. Zyczynski

All ETDs from UAB

The COVID-19 pandemic has derailed normal operations in the health care delivery systems in the United States (US) and globally, providing prioritized care to patients seeking acute management of the novel coronavirus and its complications. Simultaneously, cancer screening tests have decreased, resulting in decreased rates of cancer diagnoses and referrals to oncologists. The purpose of this study was to assess time to treatment initiation (TTI) with systemic cancer therapy in patients with newly diagnosed metastatic lung cancer, metastatic lung cancer-related and total healthcare resource utilization (HCRU) and costs during the pandemic/post-pandemic period compared with the pre-pandemic period. The retrospective claims …

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A Few More Things I Should Have Learned From Vallejo, Christopher Buckley

Birmingham Poetry Review

pp. 63-66

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Anti-Abortion Activism And Advances: A Historography, Haley Wells

Vulcan Historical Review

pp. 75-85

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No Ordinary Poet: Nicole Sealey As Master Of Form And Agent Of Social Justice, Teri Elam

Birmingham Poetry Review

pp. 4-16

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Shying Away From The Shot: A Qualitative Analysis On Vaccine Hesitancy At Uab Huntsville Family Medicine Clinic, Nadia Anabtawi, Roger D. Smalligan, Gayatri Venkatraman

UAB Huntsville Research Day - All Presentations

2022 oral presentation

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Balance In The Force: The Fine Line Of Immunosuppression In Hospitalized Patients With Covid-19 Infection And Common Variable Immunodeficiency, Jeremy Brozyna, Holman Li, Ali Hassoun, Farrah Ibrahim

UAB Huntsville Research Day - All Presentations

2022 oral presentation

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A Rare Case Of Late-Presenting Congenital Diaphragmatic Hernia (Cdh) Complicated By Postoperative Renal Infarction, Andrew Canto, Adam Bonner, Zaria Murrell

UAB Huntsville Research Day - All Presentations

2022 oral presentation

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Persistent Abdominal Pain Reveals Recurrent Intussusception With An Enclosed Lymphoma, Aubriana Smith

UAB Huntsville Research Day - All Presentations

2022 oral presentation

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The Utility Of Thrombophilia Panels Prior To Microvascular Surgery, S Drummond, O Olaleye, E Soto, R J. Fix, J May, P Patcha

UAB Huntsville Research Day - All Presentations

2022 research poster

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Full-Text Articles in Entire DC Network

Redneck Revolutionaries: The Young Patriots And The Rainbow Coalition, Emily Ann Wilson

Vulcan Historical Review

3 - Uab Arts, University Of Alabama At Birmingham

UAB Magazine

Uab Magazine - Spring/Summer 2022, University Of Alabama At Birmingham

UAB Magazine

Mevisit: Value-Based Approach To Primary Care Delivery By Mtelemedicine Utilization Applied Through Lean Principles, Neil Coyer Thornbury

All ETDs from UAB

Access To The Kidney Transplant Waitlist For People Living With Hiv, Brittany A. Shelton

All ETDs from UAB

Examining Sex And Race Difference In Obesity Risk Factors In Older Americans Using Genetic And Lifestyle Data In Regards, Hairui Yu

All ETDs from UAB

Targeting The Frataxin Transcriptional Defect As A Therapeutic Approach For Friedreich's Ataxia, Anna Maria Schreiber

All ETDs from UAB

Cognition And The Brain Of The Healthy Oldest-Old, Sara A. Sims

All ETDs from UAB

Embedding A Mixed Methods Process Evaluation In A Web-Based Diet And Exercise Program For Older Cancer Survivors, Jami Lee Anderson

All ETDs from UAB

The Role Of The Bone Marrow Microenvironment In Flt3-Itd Acute Myeloid Leukemia Stem Cell Resistance To Flt3 Inhibition, Nicholas R. Anderson

All ETDs from UAB

A Hybrid Data And Hypothesis-Driven Model For Software Development In Support Of The Machine-Learning Paradigm, Anthony D. Bowman

All ETDs from UAB

Defining Genetic Underpinnings Of Cellular Diversity And Vulnerability In The Context Of Parkinson's Disease, Stephanie M. Boas

All ETDs from UAB

Heart Rate Variability And Stress In The Intensive Care Unit Nursing Workplace, Paula Miller Levi

All ETDs from UAB

Monoclonal Antibody-Mediated Cancer Treatment: Development, Manufacturing And Evaluation, Yingnan Si

All ETDs from UAB

Preventing Unintentional Childhood Injuries In Rural Uganda: Caregiver Perceptions And Promotion Of Personal Safety Skills Through Classroom-Based Instruction, Marissa H. Swanson

All ETDs from UAB

Understanding The Protumorigenic Functions Of St6gal1 In Glioblastoma Stemness And Metabolism, Sajina Gc

All ETDs from UAB

Characterization Of Exercise-Associated Skeletal Muscle Secreted Factors Through Aging, Dalton Chase Patterson

All ETDs from UAB

Labor Union Membership Tenure And Midlife Health: A Gendered Perspective, Clifford Ross

All ETDs from UAB

Low-Dose Dextromethorphan For The Treatment Of Pain In Fibromyalgia: A Single-Blind Placebo-Controlled Crossover Trial, Stephanie Christina Mueller

All ETDs from UAB

The Difference In Fracture Strength Of Translucent Zirconia (5y-Z) Using Different Cements And Surface Treatments, Esra Elamin

All ETDs from UAB

Racial Differences In The Association Of Insulin Resistance With Risk Of Incident Heart Failure In Participants Of Regards, Nirav Patel

All ETDs from UAB

Assessing The Impact Of The Covid-19 Pandemic On Metastatic Lung Cancer Time To Treatment Initiation, Health Care Resource Utilization, And Costs In The United States, Teresa M. Zyczynski

All ETDs from UAB

A Few More Things I Should Have Learned From Vallejo, Christopher Buckley

Birmingham Poetry Review

Anti-Abortion Activism And Advances: A Historography, Haley Wells

Vulcan Historical Review

No Ordinary Poet: Nicole Sealey As Master Of Form And Agent Of Social Justice, Teri Elam

Birmingham Poetry Review

Shying Away From The Shot: A Qualitative Analysis On Vaccine Hesitancy At Uab Huntsville Family Medicine Clinic, Nadia Anabtawi, Roger D. Smalligan, Gayatri Venkatraman

UAB Huntsville Research Day - All Presentations

Balance In The Force: The Fine Line Of Immunosuppression In Hospitalized Patients With Covid-19 Infection And Common Variable Immunodeficiency, Jeremy Brozyna, Holman Li, Ali Hassoun, Farrah Ibrahim

UAB Huntsville Research Day - All Presentations

A Rare Case Of Late-Presenting Congenital Diaphragmatic Hernia (Cdh) Complicated By Postoperative Renal Infarction, Andrew Canto, Adam Bonner, Zaria Murrell

UAB Huntsville Research Day - All Presentations

Persistent Abdominal Pain Reveals Recurrent Intussusception With An Enclosed Lymphoma, Aubriana Smith

UAB Huntsville Research Day - All Presentations

The Utility Of Thrombophilia Panels Prior To Microvascular Surgery, S Drummond, O Olaleye, E Soto, R J. Fix, J May, P Patcha

UAB Huntsville Research Day - All Presentations