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Physiological And Neuroimmune Effects Of Manual Therapy, Murdi S. Alanazi Jan 2026

Physiological And Neuroimmune Effects Of Manual Therapy, Murdi S. Alanazi

ETDs from 2020-2029

Manual therapy (MT) is widely used across healthcare disciplines for the management of musculoskeletal conditions. Emerging evidence indicates that MT may also influence broader physiological systems such as the nervous and the immune systems. However, the mechanisms underlying these effects are still not well understood, and limited evidence exists regarding the neuroimmune effect of MT in neurologically impaired populations such as multiple sclerosis (MS). The overall aim of this dissertation was to investigate the physiological effects of MT, synthesizing current evidence across mechanistic domains, and generating pilot data to inform future research. This dissertation was structured around four manuscripts. The …


Clinical Decision Support Using Medical Imaging Artificial Intelligence, Yun-Chi Lin Jan 2026

Clinical Decision Support Using Medical Imaging Artificial Intelligence, Yun-Chi Lin

ETDs from 2020-2029

Medical imaging plays a central role in modern clinical decision-making, yet its effective integration with artificial intelligence (AI) remains challenged by real-world clinical constraints. This dissertation investigates how medical imaging-based AI frameworks can be strategically designed to support clinical decision-making for two distinct but clinically critical scenarios: acute pandemic care and chronic neurodegenerative disease management. In acute pandemic settings, such as the COVID-19 crisis, healthcare systems face an urgent need for rapid risk stratification under conditions of data scarcity and operational stress including surges in patient volume and limited medical resources. This work explores strategies for developing deep learning models …


Does Market Penetration Of Medicare Advantage Plans Impact The Financial Performance Of Texas Critical Access Hospitals?, Charles Anthony Brocato Jan 2026

Does Market Penetration Of Medicare Advantage Plans Impact The Financial Performance Of Texas Critical Access Hospitals?, Charles Anthony Brocato

ETDs from 2020-2029

ABSTRACT This study investigated the impact of increasing market penetration of Medicare Advantage plans on the financial performance of Critical Access Hospitals (CAHs) in Texas, specifically focusing on days cash on hand (DCOH) and operating margin (OM). With over 20% of Americans relying on CAHs for healthcare, the financial viability of these hospitals is crucial for rural community health. The study analyzed longitudinal data from 72 CAHs in Texas between 2018 to 2023, a period marked by significant changes in the healthcare landscape due to the COVID-19 pandemic. Despite increased enrollment in Medicare Advantage plans rising from 26% to 40%, …


The Efficacy Of Computerized Visual Scanning Training Tools In Vision Rehabilitation Following Acquired Brain Injury, Lulwah Almulhim Jan 2026

The Efficacy Of Computerized Visual Scanning Training Tools In Vision Rehabilitation Following Acquired Brain Injury, Lulwah Almulhim

ETDs from 2020-2029

Various neurological conditions, including acquired brain injuries, can cause visual scanning deficits, which disrupt the ability to gather and interpret visual information. Computerized training tools, such as light boards, are utilized to enhance functional vision and occupational performance. The Dynavision (D2) is a well-established visuomotor training tool primarily utilized to address visual field and visual scanning deficits. The Bioness Integrated Therapy System (BITS) is a touchscreen-based rehabilitation tool designed to assess and enhance vision, motor skills, cognition, and balance. To our knowledge, normative data for BITS visual scanning programs have not been established. We conducted a scoping review to identify …


Investigating Stromal Cell-Mediated Biomechanics For Angiogenesis And Reperfusion In A 3d Microfluidic Model For Ischemic Vascular Disease, Vaishali Bala Jan 2026

Investigating Stromal Cell-Mediated Biomechanics For Angiogenesis And Reperfusion In A 3d Microfluidic Model For Ischemic Vascular Disease, Vaishali Bala

ETDs from 2020-2029

Peripheral artery disease (PAD) affects millions worldwide, causing tissue ischemia and impaired healing due to insufficient blood flow. Current therapeutic strategies to promote revascularization remain limited, largely because the mechanical regulation of angiogenesis is poorly understood. While biochemical growth factors like VEGF have been extensively studied, the role of mechanical forces generated by stromal cells in the perivascular matrix remains underexplored. This dissertation investigated how stromal cell contractility drives vascular growth through mechanotransduction pathways and modulation of endothelial cell-cell junctions. Using 3D fibrin or fibrin-collagen-I-based microtissues and compartmentalized microfluidic devices, we characterized the mechanical phenotypes of multiple fibroblast populations and …


Optimizing Practice Facilitation: A Comprehensive Study On Implementation Fidelity And Its Determinants, Demetria Marie Hubbard Jan 2026

Optimizing Practice Facilitation: A Comprehensive Study On Implementation Fidelity And Its Determinants, Demetria Marie Hubbard

ETDs from 2020-2029

Intervention outcomes cannot be fully understood without examining how implementation strategies are delivered. While implementation fidelity to interventions is well recognized as a determinant of effectiveness, the fidelity of implementation strategies—the methods used to support intervention adoption—remains under-documented and under-assessed. Without this information, it is difficult to contextualize why interventions succeed or fail across diverse settings. This three-paper dissertation focuses on practice facilitation (PF), a widely used strategy in primary care quality improvement, as implemented in the Heart Health Improvement Project (HHIP) in Alabama. HHIP, led by the Alabama Cardiovascular Cooperative and funded by the Agency for Healthcare Research and …


Integrated Proteomics To Understand The Role Of Neuritin-1 (Nrn1) As A Molecular Mediator Of Synaptic Resilience In Alzheimer’S Disease, Derian Pugh Jan 2026

Integrated Proteomics To Understand The Role Of Neuritin-1 (Nrn1) As A Molecular Mediator Of Synaptic Resilience In Alzheimer’S Disease, Derian Pugh

ETDs from 2020-2029

Alzheimer’s disease (AD) is the leading cause of dementia in adults over the age of 65, and currently affects approximately 6.9 million people in the United States. By 2060, the number of people age 65 and older with AD is projected to reach 13.8 million, barring the development of disease-altering therapies to prevent, slow or cure AD. Thus, there is a need for progress in the understanding of AD pathophysiology, as well as in the development of diagnostic and therapeutic interventions. Approximately one-third of individuals without dementia at the time of death are found to harbor high levels of amyloid-beta …


Cbct Evaluation Of Planned Vs. Achieved Expansion And Buccal Bone Thickness In Phase I Orthodontic Cases Treated With Clear Aligners, Jared Teeples Jan 2026

Cbct Evaluation Of Planned Vs. Achieved Expansion And Buccal Bone Thickness In Phase I Orthodontic Cases Treated With Clear Aligners, Jared Teeples

ETDs from 2020-2029

Introduction: Within orthodontics, CBCT technology has been used to analyze tooth movement with both fixed appliances and clear aligners. However, little research has evaluated alveolar bone remodeling outcomes in growing patients treated with clear aligner expansion. Methods: This study compared pre-treatment (T0) and post-treatment (T1) CBCTs of Phase I patients treated with clear aligners who had expansion planned in the Invisalign® ClinCheck. CBCTs were collected and analyzed, including 27 maxillary and 22 mandibular arches. The aims were (1) to compare planned vs. actual expansion and (2) to evaluate the arch width (AW) and alveolar bone changes before and after treatment. …


Building An Empire-The Life And Legacy Of Dr. A.G. Gaston, Solymar Ortiz Jan 2026

Building An Empire-The Life And Legacy Of Dr. A.G. Gaston, Solymar Ortiz

ETDs from 2020-2029

The life, work, and legacy of Dr. A.G. Gaston demonstrate the significance of commemorating key civil rights activists through the establishment of historical institutions. Gaston was a pivotal leader in Birmingham’s Civil Rights Movement, and as the first Black millionaire in Alabama, he dedicated his life to generating wealth and uplifting his community. Stemming from humble beginnings, he was raised by formerly enslaved grandparents in a former plantation town. His rough upbringing encompassed a fight against racial injustice, an intense work ethic, and a passion for entrepreneurship. That passion allowed him to build his businesses from the ground up and …


Cysteine Protease Activity In Allergen Recognition And Initiation Of Th2 Allergic Responses, Audrey Rae Meloun Jan 2026

Cysteine Protease Activity In Allergen Recognition And Initiation Of Th2 Allergic Responses, Audrey Rae Meloun

ETDs from 2020-2029

Allergens are non-infectious environmental proteins that can trigger T helper 2 (Th2) cell-mediated inflammation in atopic individuals. Allergens are structurally diverse and typically lack pathogen-associated molecules patterns (PAMPs), which are recognized by pathogen recognition receptors (PRRs). PRRs are the canonical sensors of the innate immune system that typically detect PAMPs in microbes, initiating signaling pathways that drive pathogen clearance. Because allergens generally do not activate PRRs in the same way as infectious agents, alternative detection mechanisms are likely responsible for their recognition and the subsequent initiation of Th2 cell-mediated inflammation. House Dust Mite (HDM), a major indoor allergen, and other …


Exercise Testing And Training For Individuals With Cystic Fibrosis, Najlaa Zayed Alotaibi Jan 2026

Exercise Testing And Training For Individuals With Cystic Fibrosis, Najlaa Zayed Alotaibi

ETDs from 2020-2029

Cystic fibrosis (CF) is a progressive genetic disease that impacts multiple systems (e.g., respiratory system). Hence, routine cardiopulmonary exercise testing (CPET) is recommended to track the disease progression in people with CF. Besides the benefits of exercise testing, exercise training is also beneficial for long-term wellness. It is recommended that people with CF engage in at least 30–60 minutes of aerobic exercise 3 days a week. However, despite the significance of exercise testing and training for people with CF, CPET and exercise training are underutilized in international CF centers. According to the literature, the majority of international CF centers use …


Analysis Of Activated Carbon Fiber (Acf) As Particulate Filtration And Volatile Organic Compound (Voc) Media For The Development Of A Dual-Air Purifying Facepiece Respirator, Brie Mcmahan Jan 2026

Analysis Of Activated Carbon Fiber (Acf) As Particulate Filtration And Volatile Organic Compound (Voc) Media For The Development Of A Dual-Air Purifying Facepiece Respirator, Brie Mcmahan

ETDs from 2020-2029

Exposure to particulate matter (PM) and volatile organic compounds (VOCs) in occupational or public settings poses adverse health outcomes such as respiratory, cardiovascular, reproductive, neurological, carcinogenic morbidity and mortality. Many occupational settings expose workers to PM and VOC concurrently, yet most commercially available respirators are designed to address either particulates or vapors alone. This includes air-purifying respirators (APRs), powered air-purifying respirators (PAPRs), and filtering facepiece respirators (FFRs) with nuisance-level vapor protection, often limited by bulk, discomfort, high pressure drop, and misuse. We identified a need for alternative dual-exposure media and a respiratory protection device that is lighter, and more comfortable …


Understanding Mobility Limitations And Public Transportation Accessibility For People With Disabilities, Jada Meria Stringer Jan 2026

Understanding Mobility Limitations And Public Transportation Accessibility For People With Disabilities, Jada Meria Stringer

ETDs from 2020-2029

Mobility for people with disabilities (PWDs) depends on both the availability of transportation and public services and the accessibility of these systems. The presence of public transportation systems does not ensure usability. Vehicles, infrastructure, and the built environment must be designed to accommodate diverse physical, sensory, cognitive, and other needs. PWDs must also be able to navigate public buildings and surrounding spaces safely and comfortably. This thesis examines mobility limitations for PWDs in India and the United States, focusing on accessibility along the full mobility chain. A review of existing literature provides context on accessibility policies, design standards, and the …


Development Of Human Trophoblast Cell Surface Antigen-2 (Trop-2) Specific Radiopharmaceutical Tracers, Arnav Vipulkumar Patel Jan 2026

Development Of Human Trophoblast Cell Surface Antigen-2 (Trop-2) Specific Radiopharmaceutical Tracers, Arnav Vipulkumar Patel

ETDs from 2020-2029

Trophoblast cell surface antigen 2 (Trop2) is closely related to the development and progression of triple-negative breast cancers (TNBC) and is also being investigated as a pan-cancer biomarker. Trop-2 tumorigenesis is mediated by the calcium ion signaling pathways. By accurately predicting and targeting Trop-2 for immunotherapy, precision therapy is crucial. Trop-2 is overexpressed in tumor tissues compared to normal tissues, which makes it a promising molecular target for cancer-targeted therapy. This thesis reports the development and preclinical evaluation of two novel Trop-2-specific radiopharmaceutical tracers derived from the clinically approved antibody-drug conjugate Sacituzumab Govitecan (SG): a full antibody drug conjugate-based tracer …


January 21, 2026 Blazer Weekly, University Of Alabama At Birmingham Jan 2026

January 21, 2026 Blazer Weekly, University Of Alabama At Birmingham

Blazer Weekly (student newsletter)

No abstract provided.


January 16, 2026 Ereporter, University Of Alabama At Birmingham Jan 2026

January 16, 2026 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


January 14, 2026 Blazer Weekly, University Of Alabama At Birmingham Jan 2026

January 14, 2026 Blazer Weekly, University Of Alabama At Birmingham

Blazer Weekly (student newsletter)

No abstract provided.


Neighborhood-Level Social Vulnerability And Cognitive Outcomes In Older Adults With Solid Tumors, Ahmed Qaedi, Ariann Nassel, Mackenzie Fowler, Elizabeth Baker, Smith Giri, Gabriela Oates, Grant Williams, Noha Sharafeldin Jan 2026

Neighborhood-Level Social Vulnerability And Cognitive Outcomes In Older Adults With Solid Tumors, Ahmed Qaedi, Ariann Nassel, Mackenzie Fowler, Elizabeth Baker, Smith Giri, Gabriela Oates, Grant Williams, Noha Sharafeldin

UAB Huntsville Research Day - All Presentations

2026 research poster


Small Vessels, Big Consequences: It’S Not Always Lupus Nephritis, Hinal Rathi, Carlo Castillo, John Fanning Jan 2026

Small Vessels, Big Consequences: It’S Not Always Lupus Nephritis, Hinal Rathi, Carlo Castillo, John Fanning

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster


The Silent Epidemic: Deadly Outcomes Of Undiagnosed Hiv/Aids In Young People, Raksha Ramdas Jan 2026

The Silent Epidemic: Deadly Outcomes Of Undiagnosed Hiv/Aids In Young People, Raksha Ramdas

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster


When Therapy Becomes The Trigger: An Antibiotic With A Twist, Hinal Rathi, Roshini Raghu, Parekha Yedla Jan 2026

When Therapy Becomes The Trigger: An Antibiotic With A Twist, Hinal Rathi, Roshini Raghu, Parekha Yedla

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster


Uncovering Recurrent Oral And Genital Lipschütz Ulcers As An Initial Manifestation Of Immunodeficiency In A Sexually Inactive Adolescent, Raksha Ramdas Jan 2026

Uncovering Recurrent Oral And Genital Lipschütz Ulcers As An Initial Manifestation Of Immunodeficiency In A Sexually Inactive Adolescent, Raksha Ramdas

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster


Misleading Edema: When Pancreas Was To Blame; A Case Of Ectopic Cushing Syndrome, Soumit Sharma, Vasudha Reddy, Jesse Faulk, Madan Gowda Jan 2026

Misleading Edema: When Pancreas Was To Blame; A Case Of Ectopic Cushing Syndrome, Soumit Sharma, Vasudha Reddy, Jesse Faulk, Madan Gowda

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster


A Rare Case Of Paraneoplastic Neuromyelitis Optica Secondary To Colonic Adenocarcinoma Responding To Folfiri Chemotherapy, Soumit Sharma, Ahmed Qaedi, Kelsey Ivey Jan 2026

A Rare Case Of Paraneoplastic Neuromyelitis Optica Secondary To Colonic Adenocarcinoma Responding To Folfiri Chemotherapy, Soumit Sharma, Ahmed Qaedi, Kelsey Ivey

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster


Hypopituitarism Secondary To Hiv-Associated Pituitary Toxicity Despite Viral Suppression: A Rare Presentation Of Adrenal Crisis, Soumit Sharma, Allison C. Estep, Pierce Elliot, Farrah Ibrahim Jan 2026

Hypopituitarism Secondary To Hiv-Associated Pituitary Toxicity Despite Viral Suppression: A Rare Presentation Of Adrenal Crisis, Soumit Sharma, Allison C. Estep, Pierce Elliot, Farrah Ibrahim

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster


When Edema Means More: Membranous Nephropathy Complicated By Fatal Hemorrhage, Rye Shiver, Luke Stone, Taylor Addison, Shivana Malhotra Jan 2026

When Edema Means More: Membranous Nephropathy Complicated By Fatal Hemorrhage, Rye Shiver, Luke Stone, Taylor Addison, Shivana Malhotra

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster


From Skin To Skull: Basal Cell Carcinoma Complicated By Calvarial Osteomyelitis, Laci Turner, Ahmed Qaedi, Anna Cash, Eesha Chitneni, Farrah Ibrahim Jan 2026

From Skin To Skull: Basal Cell Carcinoma Complicated By Calvarial Osteomyelitis, Laci Turner, Ahmed Qaedi, Anna Cash, Eesha Chitneni, Farrah Ibrahim

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster


Necrotizing Autoimmune Myopathy With Overlap Connective Tissue Features: Treatment With Intravenous Immunoglobulin Therapy, Soumit Sharma, Ashley Kimbel, Farrah Ibrahim Jan 2026

Necrotizing Autoimmune Myopathy With Overlap Connective Tissue Features: Treatment With Intravenous Immunoglobulin Therapy, Soumit Sharma, Ashley Kimbel, Farrah Ibrahim

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster


More Than A Fall: A Minor Injury Unmasking Disseminated Mssa Infection, Claudia Warden, Anna Cash, Ross Hardin, Kelsey Ivey Jan 2026

More Than A Fall: A Minor Injury Unmasking Disseminated Mssa Infection, Claudia Warden, Anna Cash, Ross Hardin, Kelsey Ivey

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster


Delayed Bladder Cancer Diagnosis In An Adult With Spina Bifida: Gaps In Transition Of Care, Lillian Royston, Joseph Pettus Jan 2026

Delayed Bladder Cancer Diagnosis In An Adult With Spina Bifida: Gaps In Transition Of Care, Lillian Royston, Joseph Pettus

UAB Huntsville Research Day - All Presentations

2026 clinical vignette poster