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Role Of Gtp Cyclohydrolase I In Glioblastoma, Kaysaw C. Tuy Jan 2023

Role Of Gtp Cyclohydrolase I In Glioblastoma, Kaysaw C. Tuy

All ETDs from UAB

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with a median survival of 15 months. Poor patient survival is, in part, caused by a stem-like and therapy-resistant population of brain tumor initiating cells (BTICs). BTICs are plastic, with the capacity to overcome oxidative damage. Guanosine triphosphate cyclohydrolase I (GCH1), a rate limiting enzyme in the de novo synthesis of the redox cofactor, tetrahydrobiopterin (BH4), was previously identified as a significant regulator of oxidative stress in BTICs. Reducing oxidative damage in the form of lipid peroxidation is imperative for GBM growth: lipid metabolism is required for the …


Senior Executive Experience And The Performance Of Healthcare Organizations, John Patrick Walsh Jan 2023

Senior Executive Experience And The Performance Of Healthcare Organizations, John Patrick Walsh

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SENIOR EXECUTIVE EXPERIENCE AND THE PERFORMANCE OF HEALTHCARE ORGANIZATIONS JOHN P. WALSH HEALTH SERVICES ADMINISTRATION ABSTRACT The healthcare industry has become increasingly complex over the past two decades causing concern for stakeholders of hospitals and health systems regarding the future viability. Given the tumultuous times, understanding who is best suited to lead these organizations is essential. While some work has been done studying certain characteristics of the Senior Leaders of these organizations, none have looked at the relationship between the Senior Leader’s work experience comparing those with for-profit experience and those without and performance. Using Upper Echelon’s Theory as a …


The Influence Of Economic Disadvantage On The Health And Well-Being Of Youth Transitioning To Adulthood, Shanquela Williams Jan 2023

The Influence Of Economic Disadvantage On The Health And Well-Being Of Youth Transitioning To Adulthood, Shanquela Williams

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Young adults transitioning to adulthood from economically disadvantaged backgrounds may experience physical, cognitive, and socio-emotional challenges. Resources and opportunities available during this transition can significantly impact their ability to integrate into society. The impact of economic disadvantage on the well-being of youth transitioning to adulthood remains understudied. The purpose of this study was to understand how economic disadvantage influenced the well-being of youth transitioning into adulthood. This project used longitudinal data from the Panel Study of Income Dynamics (PSID) and its supplements: the Child Development Supplement (CDS) and the Transition into Adulthood Supplement (TAS). Hypothesis one results revealed that young …


Cognition, Self-Awareness, And Driving After Moderate-To-Severe Traumatic Brain Injury, Christina A. Diblasio Jan 2023

Cognition, Self-Awareness, And Driving After Moderate-To-Severe Traumatic Brain Injury, Christina A. Diblasio

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Moderate-to-severe traumatic brain injury (TBI) often results in cognitive deficits in learning/memory, executive functions, and self-awareness. Cognitive impairments and unawareness of those impairments hinder driving capacity, yet a large proportion of survivors return to driving after injury. Given that many survivors are driving, it is essential to understand how cognition and self-awareness impact driving practices. To date, studies in this area are limited. This dissertation aimed to (1) create a normative sample for the Brief Test of Adult Cognition by Telephone (BTACT), a short cognitive battery adapted for telephone administration and validated for the TBI population; (2) examine the relationship …


Restoring Justice On Their Terms: The Path To Healing For Tulsa And Birmingham, Kameryn Thigpen Jan 2023

Restoring Justice On Their Terms: The Path To Healing For Tulsa And Birmingham, Kameryn Thigpen

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This thesis is a comparative case study examining the impact of the Tulsa Race Massacre in 1921 and the Birmingham Sixteenth Street Church Bombing in 1963. The comparative case study method aims to study how both communities educated the public about racial violence through the nonprofit sector. This research explores the racial structures that were in place during the time. This thesis argues for the role of the government in providing diversity, equity, accessibility, and inclusion training for federal employees. This research also discusses the government's contribution to advancing social equity.


The Influence Of A Low Glycemic Load Diet On Appetite In Women With Pcos, Sarah Et Hoover Jan 2023

The Influence Of A Low Glycemic Load Diet On Appetite In Women With Pcos, Sarah Et Hoover

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Dysregulated appetite may contribute to weight gain and high prevalence of comorbid obesity in women with polycystic ovary syndrome (PCOS), yet dietary recommendations to promote satiety and facilitate weight maintenance in this population remain scarce. The objective of this dissertation was to determine if women with PCOS have alterations in appetite-regulating hormones that can be manipulated by low glycemic load diet habituation to improve satiety. This was tested by secondary analyses of two randomized controlled dietary intervention trials in women with and without PCOS. First, we explored differences in women with and without PCOS during a standardized liquid meal test …


Production, Purification And Radiochemistry Development Of Manganese-52 Fir Characterization Of Pet/Mr Imaging Agents, Jennifer Marie Pyles Jan 2023

Production, Purification And Radiochemistry Development Of Manganese-52 Fir Characterization Of Pet/Mr Imaging Agents, Jennifer Marie Pyles

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Manganese (Mn) has the potential to be an important element in biomedical research as different isotopes of Mn have the characteristics to be used for both positron emission tomography (PET) and magnetic resonance imaging (MRI). Manganese(II) (55Mn) is paramagnetic which makes it useful as a contrast agent in T1-weighted magnetic resonance imaging (MRI). Mn as a radiotracer provides excellent sensitivity for studying 55Mn, but only Manganese-52 (52Mn) met the criteria for this research. 52Mn has a half-life (t1/2 = 5.591 days) that was long enough to optimize purification, chemistry and examine timepoints over several days. 52Mn decays by positron emission …


Molecular Mechanisms Of Amphetamine Abuse, Samuel James Mabry Jan 2023

Molecular Mechanisms Of Amphetamine Abuse, Samuel James Mabry

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Amphetamine (AMPH), a psychostimulant commonly prescribed for the treatment of neuropsychiatric and neurological disorders, has a high liability for abuse. The stimulant properties of AMPH are primarily associated with its ability to increase dopamine (DA) neurotransmission. This increase is mediated by non-vesicular DA release (DA efflux). This DA efflux is the result of the reversal of the DA transporter (DAT), which is promoted by AMPH. Syntaxin 1 (Stx1), a SNARE protein, interacts with the DAT N-terminus. Stx1 is phosphorylated at Ser14 by casein kinase II (CK2). This phosphorylation site contributes to the DAT/Stx1 interaction and is critical for allowing DAT …


Patient-Driven Payment Model And The Covid-19 Pandemic External Environment Impact On Nursing Home Industry In The Last 5 Years, Gregory N. Orewa Jan 2023

Patient-Driven Payment Model And The Covid-19 Pandemic External Environment Impact On Nursing Home Industry In The Last 5 Years, Gregory N. Orewa

All ETDs from UAB

Nursing homes face an ever-changing environment and must adapt to achieve organizational success. Recent events such as the COVID-19 pandemic and the implementation of the Patient-Driven Payment Model (PDPM) reimbursement policy have disrupted nursing homes. PDPM put pressure on nursing homes to change their operations and billing practices. The reimbursement policy changed from Resource Utilization Group (RUG) under the Prospective Payment Model (PPS), to PDPM. PDPM, which encourages more value in skilled nursing facility (SNF) spending, has been explored by various studies with respect to nursing home’s reaction in reducing therapy staffing. Three studies follow that examine PDPM and COVID-19 …


Understanding The Impact Of Hospital Price Transparency Initiatives On Consumer Decision-Making To Purchase Healthcare Services, Neel Pathak Jan 2023

Understanding The Impact Of Hospital Price Transparency Initiatives On Consumer Decision-Making To Purchase Healthcare Services, Neel Pathak

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This study examined the influence of hospital list price information on individuals' decision-making to purchase healthcare services. The study collected quantitative data from 550 individuals by administering a hospital price transparency survey. Findings indicate that awareness of hospital list prices and quality outcomes metrics was high, but utilization rates were relatively low among survey participants. Demographic variations were explored with respect to the awareness and utilization of hospital list prices. Quality outcomes and recommendations from friends, family, and physicians emerged as the most important attributes influencing decision-making to purchase healthcare services whereas hospital list prices and social media had a …


Navigating Missed Visits In Hiv Primary Care: Exploring Risk Factors Associated With Missed Visits, Jiaying Hao Jan 2023

Navigating Missed Visits In Hiv Primary Care: Exploring Risk Factors Associated With Missed Visits, Jiaying Hao

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The HIV care continuum is a public health model that outlines the steps or stages people with HIV go through from diagnosis to achieving and maintaining viral suppression. Retention in care, a key component of the HIV care continuum, is critical in achieving good health outcomes for people with HIV (PWH) and preventing HIV transmission. Consistent HIV care is essential for the health of PWH as a part of retention in care. De-spite no standard measure for retention in care to PWH, the missed (no-show) vis-its/appointments is one of the most commonly used methods for evaluating retention in HIV care. …


An Exploration Of The Mental Health Experiences Of Young Women With Diminished Ovarian Reserve, Brittany M. Woods Jan 2023

An Exploration Of The Mental Health Experiences Of Young Women With Diminished Ovarian Reserve, Brittany M. Woods

All ETDs from UAB

Infertility is a reproductive disease resulting in the inability to conceive. One in six individuals will experience infertility in their lifetime. Diminished ovarian reserve (DOR) reduces the quantity and/or quality of a female's oocyte pool and is a known cause of infertility. Although this occurs during normal ovarian aging in the late 30s and early 40s, DOR can also impact younger women, increasing their risk for psychological distress from an unexpected diagnosis. The purpose of this dissertation is to develop a deeper understanding of the mental health experiences of young women with DOR through the generation of three manuscripts. Manuscript …


Regulating Cancer Cell Metabolism During Hypoxia-Reoxygenation: Examing The Interplay Of Gasotransmitters And Glutaminolysis, Dianna L. Xing Jan 2023

Regulating Cancer Cell Metabolism During Hypoxia-Reoxygenation: Examing The Interplay Of Gasotransmitters And Glutaminolysis, Dianna L. Xing

All ETDs from UAB

Oxidative phosphorylation is an oxygen-dependent metabolic process that provides the majority of ATP used to support essential cellular functions. However, in cancer, limitations in oxygen availability occur during the development and metastasis of tumors. To compensate for the demands of rapidly proliferating cells, many cancers exhibit an increased demand for glycolysis, the TCA cycle, and glutaminolysis. In this thesis, extracellular flux technology and metabolomics were applied in a hypoxia-reoxygenation model to investigate the metabolic adaptations that occur in dynamic changes in oxygen and nutrient availability in cancer cells. We show the significance of glutaminolysis and its substrates in regulating cancer …


Effects Of Dietary R, S-1, 3-Butanediol Diacetoacetate On Components Of Energy Balance And Hepatic Health, Kelsey A. Rushing Jan 2023

Effects Of Dietary R, S-1, 3-Butanediol Diacetoacetate On Components Of Energy Balance And Hepatic Health, Kelsey A. Rushing

All ETDs from UAB

Objective: Exogenous ketone administration presents a possible treatment strategy for obesity and obesity-related diseases. The exogenous ketone ester, R,S-1,3-butanediol diacetoacetate (BD-AcAc2) decreases adiposity and hepatic steatosis in high-fat dietinduced obese mice. In our previous work, carbohydrate energy was removed and replaced with the ketone ester to produce isocaloric diets. The current investigation aimed to determine whether BD-AcAc2 decreases markers of hepatic steatosis and inflammation in lean mice on a high-fat, high-sugar (HFHS) diet without removing carbohydrate energy. Methods: Sixteen 11-week-old male C57BL/6J mice were randomized to one of two groups for 9 weeks (n = 8 per group): 1) Control …


Understanding The Dual Role Of The Oncolytic Viruses And Natural Killer Cells In Targeting Neuroblastoma, Colin Harrington Quinn Jan 2023

Understanding The Dual Role Of The Oncolytic Viruses And Natural Killer Cells In Targeting Neuroblastoma, Colin Harrington Quinn

All ETDs from UAB

Pediatric cancer is the leading cause of death by disease in children, and neuroblastoma accounts for roughly 15% of pediatric cancer related deaths. Neuroblastoma is a malignancy of neural crest origin and develops in the ganglia of the peripheral nervous system, most commonly arising in the adrenal glands. Advancements in therapy have significantly improved outcomes for children with low-risk neuroblastoma but for those with high-risk refractory, or relapsed disease, survival outcomes remain dismal and intervention with toxic chemotherapeutics often result in long term morbidities. The need for improved therapies for this patient population is dire. Immunotherapies offer a novel approach …


Understanding Attitudes, Subjective Norms, And Intent Of Covid-19 Vaccine Hesitancy And Refusal Among African Americans In The United States Using The Theory Of Reasoned Action, Deandrea Lashay Martinez Jan 2023

Understanding Attitudes, Subjective Norms, And Intent Of Covid-19 Vaccine Hesitancy And Refusal Among African Americans In The United States Using The Theory Of Reasoned Action, Deandrea Lashay Martinez

All ETDs from UAB

COVID-19 vaccine hesitancy and vaccine refusal contributed to many African Americans not receiving the COVID-19 vaccine. The reasons for vaccine hesitancy and vaccine refusal were unclear by sociodemographic factors (income, gender, education, and age) among African Americans. This research explored attitudes, subjective norms, and intent of COVID-19 vaccine hesitancy and vaccine refusal among African Americans in the United States using the Theory of Reasoned Action. The two research questions were (1) Among African Americans, do age, income, gender, and education factors remain stable across three study cohorts in differentiating subjects who are COVID-19 vaccine hesitant versus refusal from 2020–2022? (2) …


The Costly Performance Of Strength: An Exploration Of Mental Health Treatment Utilization Among Black Women In The Deep South, Amber N. Martin Jan 2023

The Costly Performance Of Strength: An Exploration Of Mental Health Treatment Utilization Among Black Women In The Deep South, Amber N. Martin

All ETDs from UAB

Introduction: Strength is indoctrinated into the cultural tapestry of Black women, dating back to slavery, and passed down through intergenerational socialization. The incessant need for Black women to be strong diminishes their psychological health leading to poorer quality of life. Further, historical injustices and unethical practices in mental healthcare continue to perpetuate the need for Black women to perform in strength. The performance of strength is one explanation for the grave mental health disparities among Black women offering an opportunity to better understand their mental health needs. This project aims to center Black women within the cultural contextualization of the …


Converging Crises: The Spanish Flu And Wwi's Influence Within Egon Schiele's Oeuvre, Mclean Boone Jan 2023

Converging Crises: The Spanish Flu And Wwi's Influence Within Egon Schiele's Oeuvre, Mclean Boone

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This thesis investigates the effect of the converging crises of WWI and the Spanish Flu in on the last artworks of Egon Schiele, and argues that these two events precipitated a shift in the artist’s theme, aesthetic, and technique in these 1918 artworks. Before his death from the Spanish Flu in late October, 1918, Schiele managed to produce nearly thirty paintings in the last two years of his career. While many scholars have discussed Schiele’s art in the context of personal maturation, I argue instead that Schiele’s aesthetic shift towards naturalism symbolized new modes of exploring ideas of life and …


Impact Of Covid-19 On A Smoking Cessation Intervention: A Look At Recruitment And Retention, Elizabeth S. Hawes Jan 2023

Impact Of Covid-19 On A Smoking Cessation Intervention: A Look At Recruitment And Retention, Elizabeth S. Hawes

All ETDs from UAB

While smoking prevalence rates have declined in the general population over the past 50 years, persons in the criminal legal population have disproportionally high rates of smoking. Previous research suggests that smoking cessation interventions and campaigns have missed targeting this population. Due to the COVD-19 pandemic, many ongoing clinical trials had to rapidly shift to using remote trials, including our smoking cessation trial with the criminal legal population. The purpose of this secondary analysis was to compare recruitment rate, study adherence, retention, NRT adherence, and quit attempts for participants who completed the study as planned (In Person), after implementation of …


Correlates Of Life Space Mobility, Driving Frequency And Exposure Amon Older Blacks/African Americans And Whites With Diabetes, Henrietta Armah Jan 2023

Correlates Of Life Space Mobility, Driving Frequency And Exposure Amon Older Blacks/African Americans And Whites With Diabetes, Henrietta Armah

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Diabetes mellitus is one of the most common chronic diseases among older adults, affecting all aspects of daily living including restricted life space mobility, driving and building relationships outside of the home. The aim of this study was to investigate the covariate-adjusted associations of cognitive functioning, depressive symptoms, amount of support received and satisfaction with support with life space mobility, driving frequency and driving exposure among Blacks/African Americans and Whites with diabetes. The study used a representative sample of 247 older adults aged 65 and above from the University of Alabama at Birmingham (UAB) Diabetes and Aging Study of Health …


Plasticity Characteristics Of Cxcr5+ Cd4+ T Memory Cells And Cxcr5- Non-Tfh Memory Cells, Ching-En Lee Jan 2023

Plasticity Characteristics Of Cxcr5+ Cd4+ T Memory Cells And Cxcr5- Non-Tfh Memory Cells, Ching-En Lee

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iv ability to differentiate into CXCR5- and CXCR5+ effector cells between the CCR7- and CCR7+ CXCR5+ CD4+ T memory cells, between WT and μMT CXCR5+ CD4+ T memory cells, as well as between Bcl6- and Bcl6+ CXCR5- non-Tfh memory cells. This finding did not support the hypothesis that the heterogeneous characteristics within CXCR5- non-Tfh memory cells and CXCR5+ CD4+ T memory cells significantly affect their abilities to differentiate into CXCR5- and CXCR5+ effector cells during recall responses.


Relative Efficacy Of Innovative Endodontic Antimicrobial Agents, Ziqi Sally Liu Jan 2023

Relative Efficacy Of Innovative Endodontic Antimicrobial Agents, Ziqi Sally Liu

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Purpose: Novel endodontic antimicrobial agents would potentially improve outcomes of endodontic treatment, including regenerative endodontic therapy. The aim of this study was to determine the efficacy of a novel experimental compound, analogue #66, compared to tigecycline and other controls in an ex-vivo model. Materials and Methods: MIC determination with tigecycline and analogue #66 was done for Streptococcus mutans and Streptococcus intermedius. Forty single rooted extracted teeth were inoculated weekly for three weeks with S. intermedius to create a biofilm. All teeth were instrumented to 40/06 to working length and irrigated with 5% NaOCl. Teeth were randomly divided into 4 groups …


An In Vitro Assessment Of The Antibacterial Activity, Biocompatibility, And Mineralization Inducing Potential Of Biodentine®Xp, Chandani Arjun Mantri Jan 2023

An In Vitro Assessment Of The Antibacterial Activity, Biocompatibility, And Mineralization Inducing Potential Of Biodentine®Xp, Chandani Arjun Mantri

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Purpose: The purpose of this study was to assess the in-vitro antibacterial activity, biocompatibility, and mineralization-inducing potential of Biodentine® XP. Methods: Four contemporary pulp capping materials, namely Dycal®, a calcium hydroxide, Theracal® LC, a resin calcium silicate and, tricalcium silicates namely Biodentine®, and Biodentine® XP were compared in the study. The antibacterial activity of the pulp capping materials included in the study was evaluated against Streptococcus mutans UA159 and Enterococcus faecalis ATCC 29212 and were determined by the direct culture test. The biocompatibility of these materials in preodontoblastic 17IIA11 cells were compared by the MTT assay and mineralization-inducing potential in …


Genetic And Epigenetic Risk Scores For Chronic Kidney Disease In African Americans, Alana C. Jones Jan 2023

Genetic And Epigenetic Risk Scores For Chronic Kidney Disease In African Americans, Alana C. Jones

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Kidney disease is the tenth-leading cause of death in the United States (US). There are significant racial disparities within kidney disease: African Americans (AAs) have the highest rates of CKD and carry a four-fold higher risk of developing end-stage renal disease (ESRD). They are also less likely to undergo kidney transplants, and among those who do, are more likely to experience graft rejection. Additionally, until 2021, kidney function equations were shown to underestimate the severity of kidney disease in AA due to the use of race coefficients. Among all populations, genetic and epigenetic factors contribute to kidney disease. However, AAs …


Optimization Of Progranulin Gene Therapy, A Potential Treatment For Frontotemporal Dementia, Shreya Natesh Kashyap Jan 2023

Optimization Of Progranulin Gene Therapy, A Potential Treatment For Frontotemporal Dementia, Shreya Natesh Kashyap

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Heterozygous loss of function mutations in the progranulin gene cause frontotemporal dementia, characterized by deficits in social behavior, language comprehension and motor function. Almost every frontotemporal dementia-related progranulin mutation is loss of function and results in progranulin haploinsufficiency. For this reason, progranulin replacement is a conceptually straightforward therapeutic strategy for patients with frontotemporal dementia caused by progranulin mutations. Here, we outline progranulin biology, progranulin deficient mouse models of frontotemporal dementia and preclinical interventions centered around increasing brain progranulin levels. We have demonstrated that blocking the progranulin C-terminus, which harbors the sortilin binding site, improves the cross-correctional capacity of neurotropic progranulin …


Spilling The Tea, Memoir Of A Future's Past: A Scholarly Personal Narrative, Dominique Jerome Hector Jan 2023

Spilling The Tea, Memoir Of A Future's Past: A Scholarly Personal Narrative, Dominique Jerome Hector

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Lesbian, Gay, Bisexual, Transgender, and Questioning (LGBTQ) individuals and topics have been at the precipice of media coverage and policy decisions for decades. With the passage of same sex marriage by the Supreme Court in 2015, this ushered in a new era of unearthing narratives that are unique to LGBTQ+ identities. Although this is a huge advancement for this population here within the United States, scholars have posited how these identities intersecting with other social constructs such as race, gender, socioeconomic status, and social justice have reimaged how LGBTQ+ identities are viewed and treated in the country. Although there is …


Molecular Influences Of Racial Disparities In Pancreatic Neuroendocrine Tumors, Brendon Herring Jan 2023

Molecular Influences Of Racial Disparities In Pancreatic Neuroendocrine Tumors, Brendon Herring

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Pancreatic Neuroendocrine Tumors (PNETs) are highly heterogeneous neoplasms arising from the hormone-secreting cells of the endocrine pancreas. PNETs are broadly categorized as functional and non-functional based on the presence of symptoms associated with hormone secretion, which occurs in approximately 30% of cases. While functional tumors are all considered for resection because of these symptoms and their associated sequelae, non-functional tumors > 2cm are currently resected based on increased risk of developing metastatic disease. However, this criterion is based on data from predominantly White patients. Recent studies have shown that Black patients have much higher rates of lymph node metastatic disease at …


Spatial/Temporal Zonation, Diversification, And Evolutionary Conservation Of Kidney Resident Macrophage Subpopulations In Mice And Humans After Kidney Injury, Elise Nicole Erman Jan 2023

Spatial/Temporal Zonation, Diversification, And Evolutionary Conservation Of Kidney Resident Macrophage Subpopulations In Mice And Humans After Kidney Injury, Elise Nicole Erman

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In the United States, acute kidney injury (AKI) affects nearly 20% of all intensive care unit patients. Additionally, over a third of Americans aged 50 or older suffer from stage 3 chronic kidney disease (CKD) or higher. AKI and CKD are encompassing terms for many etiologies and pathological processes that affect different regions of the kidney but converge at tissue inflammation and fibrosis. Macrophages perform vital homeostatic functions and can initiate or ameliorate inflammation and fibrosis. As the largest component of the kidney immune system, kidney resident macrophages (KRMs) have been implicated in both disease propagation and mitigation, yet the …


Investigating Scientific Self-Concept In The General Chemistry Laboratory While Performing Course-Based Undergraduate Research Throughout A Pandemic, Josh Forakis Jan 2023

Investigating Scientific Self-Concept In The General Chemistry Laboratory While Performing Course-Based Undergraduate Research Throughout A Pandemic, Josh Forakis

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Climate change, waste management crises, and global pandemics emphasize the need for a thriving science, technology, engineering, and mathematics (STEM) workforce, and one of the jobs of STEM educators is to provide meaningful educational experiences that engage STEM students in scientific practices, broaden their worldview, and prepare them for a future career in the scientific field. Undergraduate research experiences have been shown to benefit STEM students, but few students can participate, especially at early stages in their undergraduate studies. To broaden participation in undergraduate research, an honors general chemistry laboratory course was converted into a course-based undergraduate research experience (CURE) …


Inkjet-Printed Reseroir Computing Network For In Situ Sensor Predictions, Steven D. Gardner Jan 2023

Inkjet-Printed Reseroir Computing Network For In Situ Sensor Predictions, Steven D. Gardner

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The technological achievements made with silicon-based transistors have led to nearly all the computing seen today, complete with benefits such as maximized operating speeds, parallel/tensor processing, minimized power overhead, etc. The silicon electronics industry is foundational to scientific progression with its profound impact on modeling, simulations, and fast/reliable computing. However, silicon-based transistors have evolved to meet their physical limitations and have saturated fields of innovation. New fields in computing outside of silicon-based methods have emerged as exotic materials enter the research domain. The suite of super-performing materials like Graphene, Carbon Nanotubes, and Molybdenum Disulfide have chaotic, non-linear behaviors that make …