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Articles 11611 - 11640 of 14457
Full-Text Articles in Entire DC Network
Cancer Vaccinations, Ashruta Patel
The Incision Into The Realm Of Science, Chase Taylor, Jason Neeley
The Incision Into The Realm Of Science, Chase Taylor, Jason Neeley
Inquiro (undergraduate research journal)
pp. 12-14
Environmental Tobacco Smoke: Role In Progression Of Diabetic Nephropathy, David M. Obert, Ping Hua, Meagan E. Pilkerton, Wenguang Feng, Edgar A. Jaimes
Environmental Tobacco Smoke: Role In Progression Of Diabetic Nephropathy, David M. Obert, Ping Hua, Meagan E. Pilkerton, Wenguang Feng, Edgar A. Jaimes
Inquiro (undergraduate research journal)
pp. 46-49
Spatial Analysis Of Environmental Factors Related To Lyme Disease In Alabama Using Nasa Earth Observation Systems, Nathan Renneboog, Emily G. Capilouto, Stephen L. Firsing Iii, Kyle Levy, Marilyn Mcallister, Kathryn Roa, Shveta Setia, Lili Xie, Jeff Luvall, Donna Burnett
Spatial Analysis Of Environmental Factors Related To Lyme Disease In Alabama Using Nasa Earth Observation Systems, Nathan Renneboog, Emily G. Capilouto, Stephen L. Firsing Iii, Kyle Levy, Marilyn Mcallister, Kathryn Roa, Shveta Setia, Lili Xie, Jeff Luvall, Donna Burnett
Inquiro (undergraduate research journal)
pp. 57-69
Obese Women With Greater Impulsivity Show Reduced Executive Function Brain Activation During Delay Discounting, Felix Kishinevsky, Rosalyn Weller
Obese Women With Greater Impulsivity Show Reduced Executive Function Brain Activation During Delay Discounting, Felix Kishinevsky, Rosalyn Weller
Inquiro (undergraduate research journal)
pp. 85-95
Inquiro 3 (End Matter), Inquiro Staff
Inquiro 3 (End Matter), Inquiro Staff
Inquiro (undergraduate research journal)
pp. 98-102
Multidisciplinary Approach To Research: An Interview With Dr. Bradley Newcomer, Toral Patel
Multidisciplinary Approach To Research: An Interview With Dr. Bradley Newcomer, Toral Patel
Inquiro (undergraduate research journal)
pp. 96-97
Bone Properties Surrounding Ha-Coated Custom Osseous Integrated Dental Implants, Maribel Ibañez Baker
Bone Properties Surrounding Ha-Coated Custom Osseous Integrated Dental Implants, Maribel Ibañez Baker
All ETDs from UAB
No abstract provided.
Russia In A European Coat: The Paradoxes Of Peter Chaadaev, Kristina Brandon
Russia In A European Coat: The Paradoxes Of Peter Chaadaev, Kristina Brandon
All ETDs from UAB
No abstract provided.
Examination Of The Capacity Of The Cathelicidins To Control Bacillus Anthracis Pathogenesis, Mark W. Lisanby
Examination Of The Capacity Of The Cathelicidins To Control Bacillus Anthracis Pathogenesis, Mark W. Lisanby
All ETDs from UAB
cillus anthracis is a gram-positive, spore forming bacterium that causes infection through three routes: cutaneous, gastrointestinal and pulmonary. Historically, anthrax pathogenesis was thought to be initiated via the uptake of spores by resident macrophages, which then transited to the regional lymph nodes. While en-route, the spores germinated and developed into bacilli within the phagolysosome, escaped into the cytoplasm, killed the cell and eventually the host. Following the recent use of B. anthracis as a biological weapon, researchers began to reevaluate anthrax pathogenesis in order to develop novel treatments. One aspect of anthrax pathogenesis that saw renewed interest was the intracellular …
Klf4 And Retinoid Receptor Signaling In Cancer, Wen Jiang
Klf4 And Retinoid Receptor Signaling In Cancer, Wen Jiang
All ETDs from UAB
The fight against cancer has generated wide interest in understanding the genetic mechanisms behind the disease. One group of oncogenes – transcription factors – offers many opportunities for treatment or prevention. Among these transcription factors is KLF4, which functions in post-mitotic epithelial cells to promote differentiation. KLF4 has tumorigenic activity in both in vitro and in vivo models. In analyzing transcripts that were induced by KLF4, we noted the induction of multiple nuclear receptors, including retinoid receptors. Retinoids are well-established as chemopreventive agents, but the mechanisms by which they act to prevent cancer remain unclear. Previous studies have shown that …
Regulation Of Neural Precursor Cell Apoptosis And Proliferation By Glycogen Synthase Kinase-3, Tae-Yeon Eom
Regulation Of Neural Precursor Cell Apoptosis And Proliferation By Glycogen Synthase Kinase-3, Tae-Yeon Eom
All ETDs from UAB
Neurogenesis is a crucial process for development, plasticity, and regenerative capacity of the developing and adult brain. Impairment of neurogenesis has been implicated in the etiology of psychiatric disorders. Although substantial studies have shown that therapeutic interventions enhance neurogenesis, much less is known about what factors impair neurogenesis. Thus, the present work examined if glycogen synthase kinase-3 (GSK3) has a role in impaired neurogenesis, focusing on apoptosis and proliferation of neural precursor cells (NPCs). This investigation found that GSK3 promotes apoptotic signaling in cultured NPCs subjected to two insults, trophic factor withdrawal and genotoxic stress. Both stimuli activated GSK3, Bax, …
Pathological Modification Of Tau Induce Toxicity And Facilitate Cell Death, Tori A. Matthews
Pathological Modification Of Tau Induce Toxicity And Facilitate Cell Death, Tori A. Matthews
All ETDs from UAB
eimer’s disease (AD) is a progressive neurodegenerative disorder characterized by two major pathophysiological hallmarks, beta-amyloid (A��) plaques and tau tangles. In AD and other tau associated neurodegenerative disorders, termed tauopathies, a critical role in promoting neuronal degeneration has been demonstrated for hyperphosphorylated forms of tau. Recent findings suggest that cleavage of tau in the carboxyl-terminal region (Asp421) may also promote deleterious effects of tau on neuronal health. In the first half of my study, the relationship between Asp421 cleaved tau and a common AD associated stressor (endoplasmic reticulum [ER] stress) was investigated using an inducible cortical neuronal model. Cells expressing …
Mechanisms And Countermeasures Of Microgravity Induced Bone Loss: In Vitro And In Vivo Model Systems, Ritu Saxena
Mechanisms And Countermeasures Of Microgravity Induced Bone Loss: In Vitro And In Vivo Model Systems, Ritu Saxena
All ETDs from UAB
Rapid bone loss occurs during prolonged periods of weightlessness experienced by astronauts during spaceflights which leads to osteopenia and increased fracture risk upon return to earth. Spaceflight studies have shown that the bone loss occurs as a result of both a decrease in bone formation and an increase in bone resorption, however, the molecular mechanisms still need to be elucidated. Previous studies from our laboratory and other groups have indicated that modeled microgravity leads to inhibition of osteoblastogenesis and a stimulation of adipogenesis of human mesenchymal stem cells in osteogenic medium which is most likely mediated by a decrease in …
Non-Shared Familial Environment As A Determinant Of Discordant Patterns Of Disordered Eating Behaviors Among Sibling Pairs In A Family, Suparna Bagchi
Non-Shared Familial Environment As A Determinant Of Discordant Patterns Of Disordered Eating Behaviors Among Sibling Pairs In A Family, Suparna Bagchi
All ETDs from UAB
Worldwide 15-40% of adolescents practice Disordered Eating Behavior (DEB). This study examined DEB development and the role of 1) shared familial factors among sibling pairs; and 2) non-shared familial experiences among discordant sibling pairs adjusted for individual and shared familial factors. The "National Longitudinal Study of Adolescent Health" data on 3274 adolescents were analyzed. The sample contained: twins (n=952), full siblings (n=1434), half siblings (n=418), and biologically not-related siblings (n=470). Multivariable regression analysis examined familial factors associated with DEB in the overall sample and sibling pair types. Adolescents engaging in DEB (~16%) were more likely to be white females with …
Immunotherapy Of Cancer Employing Γδ-T Cells: A Study Examining Their Utility And Feasibility, Benjamin Hester Beck
Immunotherapy Of Cancer Employing Γδ-T Cells: A Study Examining Their Utility And Feasibility, Benjamin Hester Beck
All ETDs from UAB
Unlike antigen-specific alpha beta-T cells, gamma delta-T cells can recognize and lyse cancerous cells rapidly upon encounter in a manner that does not require the recognition of tumor-specific antigens. Given the well-documented capacity of gamma delta-T cells to innately kill malignant cells, efforts are now underway to exploit the antitumor properties of gamma delta-T cells for clinical purposes. Here, we present for the first time preclinical in vivo mouse models of gamma delta-T cell-based immunotherapy directed against breast cancer. These studies were explicitly designed to approximate clinical situations in which adoptively-transferred gamma delta-T cells would be employed therapeutically against breast …
Identification Of New Strategies For The Treatment Of Glioblastoma Multiforme Utilizing A Pharmacogenomic Approach: Genetic Profiles Associated With Patient Prognosis And Outcome To Capecitabine Treatment, Jessica Marie Grunda
All ETDs from UAB
Glioblastoma multiforme (GBM) is the most lethal form of primary brain neoplasm with average patient survival between 9 and 15 months even with the most aggressive treatment modalities. Unfortunately, this poor outcome has not appreciably changed in the past 50 years emphasizing the lack of traditional `trial and error' methods in identifying an efficacious treatment for GBM. Pharmacogenomics is greatly impacting cancer research through the development of personalized medicine and rationally designed treatment paradigms for the development of more efficacious and less toxic treatment modalities. The main objective of this research was to utilize a pharmacogenomic approach to identify new …
An Analysis Of Mechanisms Designed To Reduce Crowd -Out Among State Children's Health Insurance Programs And Their Implications For Public Service, James Lee Laughridge
An Analysis Of Mechanisms Designed To Reduce Crowd -Out Among State Children's Health Insurance Programs And Their Implications For Public Service, James Lee Laughridge
All ETDs from UAB
No abstract provided.
Identification Of The Function Of Rv0194 In Mycobacterium Tuberculosis, Rachel Philpott
Identification Of The Function Of Rv0194 In Mycobacterium Tuberculosis, Rachel Philpott
All ETDs from UAB
No abstract provided.
Factors Associated With Sleep Disruption Among Community-Dwelling Older Adults In The Health And Retirement Study, Laura L. Williams
Factors Associated With Sleep Disruption Among Community-Dwelling Older Adults In The Health And Retirement Study, Laura L. Williams
All ETDs from UAB
Introduction: The purpose of this study was to examine behavioral outcomes and sleep disruption in aging adults using data from the 2004 wave of the longitudinal Health and Retirement Study (HRS). It was hypothesized that sleep disruption is associated with behavioral outcomes and sociodemographic variables in a population-based sample. Methods: The 2004 HRS data (N=20,129) represents a cross-sectional analysis of community dwelling aging adults born in the US at or before 1923 through 1953. Data are stratified by date of birth to provide five cohorts of aging elderly. The HRS Psychosocial Leave-Behind Participant Lifestyle Questionnaire (PLBQ) was given to a …
The Role Of The Ss2-Integrin Family On T Cell Subsets, Jillian E. Wohler
The Role Of The Ss2-Integrin Family On T Cell Subsets, Jillian E. Wohler
All ETDs from UAB
Members of the ß2-integrin family of adhesion molecules, CD11a, CD11b, and CD11c, have all been shown to play a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). CD11d had yet to be studied in demyelinating disease and its functions remained unclear. We report here that CD11d is the only member of the ß2-integrin family of adhesion molecules that fails to protect against the development of EAE. Surprisingly, the EAE studies suggested that CD11a, CD11b, and CD11c were all contributing to T cell activity during disease development by mechanisms beyond the migration of these cells into the CNS. However, the …
Monosodium L-Glutamate Exposure Adversely Affects Early Development In The Sea Urchin Lytechinus Variegatus, Dorothy B. Moseley
Monosodium L-Glutamate Exposure Adversely Affects Early Development In The Sea Urchin Lytechinus Variegatus, Dorothy B. Moseley
All ETDs from UAB
No abstract provided.
Hitler's Baby Farms: The Lebensborn Project, John C. Faulkner
Hitler's Baby Farms: The Lebensborn Project, John C. Faulkner
Vulcan Historical Review
pp. 28-52
A Comparison Of Two Soft Tissue Gingivectomy Techniques, James R. Durham
A Comparison Of Two Soft Tissue Gingivectomy Techniques, James R. Durham
All ETDs from UAB
No abstract provided.
A Detailed Look At The Familial, Social, And Clinical Contexts For Children After The Identification Of Maltreatment, Lindsay M. Duty
A Detailed Look At The Familial, Social, And Clinical Contexts For Children After The Identification Of Maltreatment, Lindsay M. Duty
All ETDs from UAB
No abstract provided.
“Voyeurizing The Voyeurs”: An Analysis Of The Gaze Of The Nonhuman Other In Chris Marker's Film Sans Soleil, Michele Forman
“Voyeurizing The Voyeurs”: An Analysis Of The Gaze Of The Nonhuman Other In Chris Marker's Film Sans Soleil, Michele Forman
All ETDs from UAB
No abstract provided.
State Building Energy Efficiency Determination Using Energy Audits, Vance Scott Gibbs
State Building Energy Efficiency Determination Using Energy Audits, Vance Scott Gibbs
All ETDs from UAB
No abstract provided.
Development And Application Of A Technique To Measure Soft Tissue Changes Following Noncarious Cervical Lesion Restorations, Prabhavathi Jampani
Development And Application Of A Technique To Measure Soft Tissue Changes Following Noncarious Cervical Lesion Restorations, Prabhavathi Jampani
All ETDs from UAB
No abstract provided.
Effects Of Cyclic Strain On Tgf-Ss1 Activation And Phenotype Modulation The Aortic Valve Interstitial Cells, Michael P. Nilo
Effects Of Cyclic Strain On Tgf-Ss1 Activation And Phenotype Modulation The Aortic Valve Interstitial Cells, Michael P. Nilo
All ETDs from UAB
No abstract provided.
Development And Implementation Of Knock-In And Bac-In Il-2 Reporter Mouse Models To Characterize Il2 Gene Regulation In Cd4 T Cells, Rita Jeanne Luther
Development And Implementation Of Knock-In And Bac-In Il-2 Reporter Mouse Models To Characterize Il2 Gene Regulation In Cd4 T Cells, Rita Jeanne Luther
All ETDs from UAB
Maintenance of immune homeostasis involves a balance between T cell effector responses to antigen stimulus and reciprocal downregulation of this response through peripheral tolerance mechanisms. Upon exposure to pathogen, cytokine production and signaling serve to tightly coordinate cell-mediated clearance of antigen followed by contraction of the immune response. Interkeukin-2 (IL-2) is a type I family cytokine critical for expansion of activated T cells in vitro and enhancement of T cell memory responses in vivo. Deficiency of IL-2 in vivo also revealed a critical role for IL-2 in immune tolerance through the maintenance of T regulatory cell populations (Treg) in peripheral …