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Development And Validation Of A Palliative Care Needs Assessment Instrument-English/Arabic Versions (Pcna-Eav), For Use With Patients With Advanced Cancer, Susan Edith Volker Jan 2010

Development And Validation Of A Palliative Care Needs Assessment Instrument-English/Arabic Versions (Pcna-Eav), For Use With Patients With Advanced Cancer, Susan Edith Volker

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The aim of this study was to develop and translate a psychometrically valid and reliable, population-based, needs assessment instrument, the PCNA-EAV, to measure the health care and support needs of patients with advanced cancer. The cross-sectional study design combined qualitative and quantitative methods, to test instrument reliability and validity, and to examine the association between sample characteristics and health care and support needs. The 116-item, PCNA-EAV, comprised 10 domains of need: physical/functional; social; psychological/emotional; information; communication; helpful resources; financial; religious/spiritual; priority of need; and preference for care The target population was all cancer patients in the department of oncology at …

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Usp14: A Link Between The Proteasome And Synaptic Function, Brandon John Walters Jan 2010

Usp14: A Link Between The Proteasome And Synaptic Function, Brandon John Walters

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The ubiquitin proteasome system (UPS) is a coordinated process by which the cell can control protein distribution and abundance. Proteins are marked for turnover by the construction of a polyubiquitin chain on the protein substrate. Once engaged by the proteasome, the ubiquitin side-chain is disassembled by proteasomal deubiquitinating enzymes (DUBs), preventing entry of ubiquitin into the proteasome and recycling it for use in future reactions. One of the DUBs that resides on the proteasome is Ubiquitin Specific Protease 14 (Usp14), which is mutated in the ataxia (axJ) mice. This mutation results in pronounced physical deficits and, unexpectedly, a deficit in …

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Place-Based Approaches To Rural Economic Revitalization: A Public Funding Analysis And Implications For The Alabama Black Belt, David Sheldon Williams Jan 2010

Place-Based Approaches To Rural Economic Revitalization: A Public Funding Analysis And Implications For The Alabama Black Belt, David Sheldon Williams

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Many rural areas in Alabama are underdeveloped and economically depressed. The Black Belt Counties are a subset within Alabama that tend to lag behind other counties and nationwide indicators for social and economic well-being. Targeted place-based policies for economic development and community improvement have resurfaced on the federal policy agenda under the Obama Administration. Place-based policies have the potential to change the condition of places like the Black Belt by adding the place-based approaches to rural development policy. The purpose of this research is to analyze the specific rural needs and policies utilized in the state of Alabama by understanding …

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Contributions Of The Atrial Natriuretic Peptide Gene System To The Relationship Between Pediatric Body Fat, Free Fatty Acids, And Blood Pressure, Amanda Willig Jan 2010

Contributions Of The Atrial Natriuretic Peptide Gene System To The Relationship Between Pediatric Body Fat, Free Fatty Acids, And Blood Pressure, Amanda Willig

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Elevated blood pressure and nonesterified fatty acids (NEFA) in children can lead to increased chronic disease risk during adulthood. The atrial natriuretic peptide precursor A (NPPA) and natiuretic peptide receptor A (NPR1) genes encode for atrial natriuretic peptide (ANP) and its cell receptor, respectively, and may influence levels of blood pressure and NEFA. Additionally, it is unclear how body composition, physical activity, physical fitness, and racial genetic ancestry influence pediatric NEFA and blood pressure. In order to understand the associations among these factors, five investigations were performed. For experimental aim 1, the association between blood pressure and body composition measures …

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Development And Validation Of A Scale To Measure Fear Of Physical Response To Exercise Among Overweight And Obese Adults, Brooks Cotton Wingo Jan 2010

Development And Validation Of A Scale To Measure Fear Of Physical Response To Exercise Among Overweight And Obese Adults, Brooks Cotton Wingo

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specified and alteration of both Type I and Type II error rates occurs. We examine

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Small Molecule Inhibitors Of Acid Sensing Ion Channel-1, Yawar J. Qadri Jan 2010

Small Molecule Inhibitors Of Acid Sensing Ion Channel-1, Yawar J. Qadri

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Acid Sensing Ion Channel 1 is one of the many proteins in the Epithelial Sodium Channel/Degenerin family. The proteins in this family interact to form cation channels with unique biophysical properties and can all be inhibited by the small molecule amiloride. Their expression in many different cell types underlies their involvement in a large variety of physiological and pathophysiological processes. ASIC-1 containing channels, specifically, are an important therapeutic target for ischemic stroke, nociception, the invasiveness of glioblastoma cells, and many other processes including anxiety and memory formation. Of the members of the ENaC/Deg family, chicken ASIC-1 is the only protein …

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Overexpression Of Garp2 Increases Phototransduction Gain., Shanta Sarfare Jan 2010

Overexpression Of Garp2 Increases Phototransduction Gain., Shanta Sarfare

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The cGMP-gated cation channel (CNG) in the rod photoreceptors is an essential component of phototransduction, and may have a role in maintaining structural integrity of the rod outer segment (ROS). The ß-subunit of the CNG channel (CNGB1) in the rod photoreceptors is comprised of an N-terminal glutamic acid-rich region (GARP') and a C-terminal channel-like region. Additionally, two soluble proteins GARP1 and GARP2 are alternatively spliced from the CNGB1 gene. Although GARPs are known to interact with other proteins in the rod photoreceptors, their role is currently unknown. To determine the role of GARP2 in the rod photoreceptors, we generated transgenic …

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Parental Separation Anxiety And Shared Responsibility For Diabetes-Related Tasks In Adolescents Diagnosed With Type 1 Diabetes Mellitus, Kathryn Anne Sheppard Jan 2010

Parental Separation Anxiety And Shared Responsibility For Diabetes-Related Tasks In Adolescents Diagnosed With Type 1 Diabetes Mellitus, Kathryn Anne Sheppard

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Type 1 diabetes mellitus (T1D) is most commonly diagnosed in children and young adults, and complications may be life-long as well as life threatening. Management of T1D has proven to be very challenging during adolescence, and parental involvement in diabetes management has been shown to improve adherence and glycemic control in children and adolescents. Middle adolescents should become increasingly responsible for diabetes-related tasks under the supervision and guidance of parents (shared management). However, adolescents spend less time with their family as they get older, resulting in parents' being unable to validate effective self-management; this inability may lead to anxiety about …

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Association Between Birth Outcomes And Aflatoxin B1-Biomarker Levels Among Pregnant Women In Kumasi, Ghana, Faisal Mohammed Barbas Shuaib Jan 2010

Association Between Birth Outcomes And Aflatoxin B1-Biomarker Levels Among Pregnant Women In Kumasi, Ghana, Faisal Mohammed Barbas Shuaib

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Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Although studies have linked these toxins to adverse health outcomes, few studies have investigated the association between birth outcomes and aflatoxin B1-lysine adduct levels among pregnant women. The objective of this dissertation was to investigate the association between birth outcomes and aflatoxin B1- lysine adduct levels among pregnant women in Kumasi, Ghana. In a cross-sectional study of 755 pregnant women, Aflatoxin B1-lysine adduct (AF-ALB) levels were determined by High Performance Liquid Chromatography. AF-ALB associations were assessed as both continuous and categorical values. Analysis of variance (ANOVA) was …

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Assessment Of Water Samples From The Cahaba River And Buck Creek For The Presence Of Estrogenic Compounds, Patricia Jackson Jan 2010

Assessment Of Water Samples From The Cahaba River And Buck Creek For The Presence Of Estrogenic Compounds, Patricia Jackson

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No abstract provided.

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Assessment Of Clinical And In Vitro Wear Of A Nano -Hybrid Composite Resin By Non-Contact Profilometry, Courtney Michelson Jan 2010

Assessment Of Clinical And In Vitro Wear Of A Nano -Hybrid Composite Resin By Non-Contact Profilometry, Courtney Michelson

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No abstract provided.

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Retention Characteristics Of A Crown On A Prefabricated Abutment Or A Custom Fabricated Implant Abutment, Ruben A. Sauceda Jan 2010

Retention Characteristics Of A Crown On A Prefabricated Abutment Or A Custom Fabricated Implant Abutment, Ruben A. Sauceda

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No abstract provided.

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The Effect Of Autopolymerizing Acrylic Resin Thickness On The Bond Strength Of A Repaired Denture Tooth, Wendy A. Auclair Jan 2010

The Effect Of Autopolymerizing Acrylic Resin Thickness On The Bond Strength Of A Repaired Denture Tooth, Wendy A. Auclair

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No abstract provided.

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Icon Caries Infiltrant Resin And Mi Paste Plus For The Treatment Of White Spot Lesions, Allison S. Bergdoll Jan 2010

Icon Caries Infiltrant Resin And Mi Paste Plus For The Treatment Of White Spot Lesions, Allison S. Bergdoll

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No abstract provided.

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Expansion And Differentiation Of Human Mesenchymal Stem Cells In A Perfusion And Surface Shear Stress Biore Actor For Engineered Tissue Cartilage, Carlos A. Carmona-Moran Jan 2010

Expansion And Differentiation Of Human Mesenchymal Stem Cells In A Perfusion And Surface Shear Stress Biore Actor For Engineered Tissue Cartilage, Carlos A. Carmona-Moran

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No abstract provided.

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Assesment Of Motorcycle Safety In Alabama, Santosh Chitikesi Jan 2010

Assesment Of Motorcycle Safety In Alabama, Santosh Chitikesi

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No abstract provided.

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Characterization Of Btbd9 Knockout Mice: A Potential Model Of Restless Legs Syndrome, Mark P. Deandrade Jan 2010

Characterization Of Btbd9 Knockout Mice: A Potential Model Of Restless Legs Syndrome, Mark P. Deandrade

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No abstract provided.

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A Dual Protease Inhibitor/Receptor Antagonist With Therapeutic Implications For Chronic Inflammatory Lung Diseases, Matthew Thomas Hardison Jan 2010

A Dual Protease Inhibitor/Receptor Antagonist With Therapeutic Implications For Chronic Inflammatory Lung Diseases, Matthew Thomas Hardison

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protein (CRP) and smoking, controlling for waist circumference (WC) and race, we find

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Investigation Of Residues Of The Vesicular Stomatitis Virus Nucleocapsid Protein That Affect Transcription And Rna Replication, Djamila Harouaka Jan 2010

Investigation Of Residues Of The Vesicular Stomatitis Virus Nucleocapsid Protein That Affect Transcription And Rna Replication, Djamila Harouaka

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The template for transcription and RNA replication for vesicular stomatitis virus (VSV) and other negative-strand RNA viruses is a ribonucleoprotein (RNP) complex consisting of the viral RNA genome and associated nucleocapsid (N) protein. The structure of the RNP-like complex of VSV showed that the RNA is sequestered between two lobes of the N protein, and adjacent N monomers are linked by an extensive network of interactions. Long-range interactions mediated by the N-terminal arm and C-terminal loop of the N protein stabilize the side-to-side contacts between adjacent N monomers, and are required for RNA encapsidation. It is unclear how the polymerase …

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The Social Network: An Analysis Of The Use Of Facebook By Nonprofit Organizations In The South, Meghan Ann Hauswirth Jan 2010

The Social Network: An Analysis Of The Use Of Facebook By Nonprofit Organizations In The South, Meghan Ann Hauswirth

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Facebook has become a social networking phenomenon. Investigation into the specific features that Facebook offers nonprofits is vital to determining whether the benefits of having a Facebook presence outweigh the costs. Given the current economic climate and the fact that nonprofits are always looking for ways to expand their client base in the most efficient and cost effective ways possible, alternate ways to interact with constituents and reach new ones should be considered This descriptive analysis seeks to build upon the total body of work by examining nonprofit organizations knowledge, attitudes and behaviors regarding Facebook. A sam-ple of 400 nonprofit …

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O-Glcnac Transferase Modulates Jnk1 And Foxo4 Transcription Factor To Resist Acute Oxidative Stress, Shiuh-Rong Ho Jan 2010

O-Glcnac Transferase Modulates Jnk1 And Foxo4 Transcription Factor To Resist Acute Oxidative Stress, Shiuh-Rong Ho

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O-GlcNAcylation is an abundant and dynamic post-translational modification on serine and threonine residues of nuclear and cytoplasmic proteins. O-GlcNAc Transferase (OGT) and Nuclear Cytoplasmic O-GlcNAcase and Acetyltransferase (NCOAT) are the only two enzymes and major regulators in this process. In the past two decades, many studies have demonstrated its important modulation roles in nutrient sensing, protein turnover, cell cycle progression, transcription, translation as well as stress resistance. Among these biological functions, the understanding of O-GlcNAcylation dependent oxidative stress is relatively unknown. This study aims to examine the effects of O-GlcNAcylation on JNK1 and FOXO4 transcription factors under acute oxidative stress …

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Cardiometabolic Risk And Risk Perception Among Oklahoma American Indian Women With Previous Gestational Diabetes, Emily Jean Jones Jan 2010

Cardiometabolic Risk And Risk Perception Among Oklahoma American Indian Women With Previous Gestational Diabetes, Emily Jean Jones

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Introduction: Cardiovascular disease (CVD) is the number one killer of women in the United States (US). Increasing rates of CVD have been associated with the epidemic rates of type 2 diabetes mellitus (T2DM) in the US. Minority women, particularly American Indian women, experience a greater burden of health risk factors and significant disparities in health status related to CVD and T2DM. Furthermore, women who have had gestational diabetes mellitus (GDM) during pregnancy are at greater risk for these diseases than women who have not had GDM. However, these women often do not perceive themselves to be at risk, or, if …

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Building Occupancy And Energy Conservation In Institutional Buildings Of The University Of Alabama At Birmingham, Atul Nandkumar Kajale Jan 2010

Building Occupancy And Energy Conservation In Institutional Buildings Of The University Of Alabama At Birmingham, Atul Nandkumar Kajale

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Building occupancy and lighting surveys were conducted in various campus buildings of the University of Alabama at Birmingham (UAB) in 2007 (summer and fall semesters) and 2008 (spring and summer semesters) to investigate their energy performance. The details of the occupancy, lighting, and utility bills of the Business Engineering Complex, Humanities Building, Hill University Center, Ryals School of Public Health, and Sterne Library are discussed in this thesis. The after-hour occupancy was very low in most of the buildings surveyed and, at the same time, there were several unoccupied and fully lit rooms. In order to reduce energy waste, the …

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Role Of Epithelial Sodium Channel And Acid Sensing Ion Channel In Glioblastoma Multiforme, Niren Kapoor Jan 2010

Role Of Epithelial Sodium Channel And Acid Sensing Ion Channel In Glioblastoma Multiforme, Niren Kapoor

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Glioblastoma Multifrome is the most common and aggressive of the primary brain tumors. These tumors express multiple members of the Epithelial Sodium Channel (ENaC)/Degenerin (Deg) family, associated with a basally active amiloride sensitive cation current. We hypothesize that this glioma current is mediated by a hybrid channel composed of a mixture of Epithelial Sodium Channel (ENaC) and Acid Sensing Ion Channel (ASIC) subunits. To test this hypothesis we made dominant negative cDNAs for ASIC1, αENaC, and γENaC. D54-MG glioma cells transfected with the dominant negative constructs for ASIC1, αENaC, or γENaC showed reduced protein expression for each of the specific …

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Characteristics Of Fundraising For Nonprofit Hospital Organizations, Cathleen Owens Erwin Jan 2010

Characteristics Of Fundraising For Nonprofit Hospital Organizations, Cathleen Owens Erwin

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This study addresses a gap that has been noted in the charitable fundraising literature, which is a scarcity of theoretically-based studies of fundraising by nonprofit organizations and the need to study fundraising within sub-sectors of organizations rather than the full nonprofit sector. The study uses institutional theory and strategic management constructs to examine the characteristics of the fundraising operations of nonprofit organizations. A categorization scheme is created based on nonprofit organizational effectiveness and performance characteristics to analyze fundraising by nonprofit hospital organizations as an organizational field. The categorization scheme identifies distinct clusters of organizations that are then investigated to determine …

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Mechanisms Of Major Outer Membrane Protein (Momp)-Vaccine Induced Protective Immunity Against Chlamydia Muridarum Genital Infection, Christina M. Farris Jan 2010

Mechanisms Of Major Outer Membrane Protein (Momp)-Vaccine Induced Protective Immunity Against Chlamydia Muridarum Genital Infection, Christina M. Farris

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Urogenital infection with Chlamydia trachomatis is the most common bacterial sexually transmit-ted disease with an estimated 90 million new infections occurring each year worldwide. In women infection with C. trachomatis can result in serious complications including ectopic pregnancy, pelvic inflammatory disease and tubal factor infertility. Despite very effective antimicrobial chemotherapy, control of the infection will likely require an effective vaccine. We have assessed the protective effect of an outer membrane based vaccine using a murine model of chlamydial genital tract infection. Female mice were vaccinated with C. muridarum major outer membrane protein (MOMP) plus the immunostimulatory adjuvants CpG-1826 and Montanide …

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Computerized Cognitive Testing Among Older Adults: Exploring The Effect Of Computer Experience, Anxiety, And Attitudes On Performance, Pariya L. Fazeli Jan 2010

Computerized Cognitive Testing Among Older Adults: Exploring The Effect Of Computer Experience, Anxiety, And Attitudes On Performance, Pariya L. Fazeli

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While computerized cognitive testing among older adults has become more common, such tests have not replaced traditional paper and pencil measures due to potential barriers to implementation. One potential barrier of concern is that prior computer attitudes, anxiety, and experience may affect performance. The purpose of the current study was to examine the relationship of prior computer attitudes, anxiety, and experience on the performance of three computerized cognitive tests: the Useful Field of View (UFOV®) test, the Road Sign Test (RST), and the Stroop Task. Specifically, one objective was to compare the differential effects of these computer variables on the …

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An Investigation Of The Molecular Mechanisms Involved In The Generation Of Breast Cancer, Joseph Tyson Deangelis Jan 2010

An Investigation Of The Molecular Mechanisms Involved In The Generation Of Breast Cancer, Joseph Tyson Deangelis

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Cell culture models of oncogenesis that use cellular reprogramming to generate a neoplastic cell from a normal cell provide one of the few opportunities to study the early stages of breast cancer development. Human mammary epithelial cells (HMECs) were induced to undergo a neoplastic transformation using defined genetic elements to generate transformed HMECs (THMECs). We conducted proteomic and transcriptomic analysis of three points in the neoplastic progression of breast cancer. First we monitored alterations in the proteome that revealed a progressive trend towards a metastatic state. Next, we identified a set of genes from transcriptomic analysis that displayed this same …

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A Framework For Composite Service Development: Process-As-A-Concept, Varadraj Prabhu Gurupur Jan 2010

A Framework For Composite Service Development: Process-As-A-Concept, Varadraj Prabhu Gurupur

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This dissertation addresses the problem of bridging the gap that exists between user requirements and the implemented software solution. This gap between the user needs and the actual implementation is usually termed the semantic gap problem. In this dissertation, the software solution is viewed as a composite of available software services and seeking semantically motivated approaches for the composition of a final solution. Representing user needs by capturing the semantic components of these needs and using this representation to build a composite service solution are therefore critical in reducing the aforementioned semantic gap. Although scientists have presented solutions that contribute …

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Hypothesis Testing Based On Pool Screening With Unequal Pool Sizes, Hongjiang Gao Jan 2010

Hypothesis Testing Based On Pool Screening With Unequal Pool Sizes, Hongjiang Gao

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Pool screening is a widely applied technique to estimate the prevalence of a rare event. This focus of this research is on developing statistical test of hypothesis procedures under the assumption that pool sizes are unequal but known. One of the proposed test procedures is , an exact test based on the number of positive pools (denoted by T). Another set of proposed test procedures is a modification of the likelihood ratio, Wald's and Score tests which are commonly-used likelihood-based tests. In paper 1, we derive the distribution of T which will be the basis of the exact test. Other …

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