Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

University of Alabama at Birmingham

Discipline
Keyword
Publication Year
Publication
Publication Type

Articles 10921 - 10950 of 14457

Full-Text Articles in Entire DC Network

Fracture Strength Of All-Ceramic Restorations After Fatigue Loading, Balasudha Baladhandayutham Jan 2011

Fracture Strength Of All-Ceramic Restorations After Fatigue Loading, Balasudha Baladhandayutham

All ETDs from UAB

Fracture strength of monolithic and bilayered LAVA and e. max lower molar crowns after load cycling was measured and compared. The study included three groups (n = 8) from LAVA zirconia and three groups from e. max lithium disilicate to compare influences of different layers, thicknesses and manufacturing techniques. Prefabricated anatomically designed crowns were cemented to dies made from Z 100 composite resin using Rely X Luting Plus resin modified glass ionomer cement. Cemented crowns were stored at 37° C for 24 hours then cyclic loaded to test fatigue properties. The crowns were loaded to 200,000 cycles at 25N at …

Go to article

Antimicrobial Effectiveness Of Silver-Releasing Elastomeric Ligature Ties, Matthew Christopher O'Dell Jan 2011

Antimicrobial Effectiveness Of Silver-Releasing Elastomeric Ligature Ties, Matthew Christopher O'Dell

All ETDs from UAB

Introduction: Fixed appliances make satisfactory oral hygiene a greater challenge for the orthodontic patient. Improper oral hygiene during orthodontic treatment can cause enamel demineralization resulting in unesthetic white spot lesions. A new approach to providing protection against demineralization during treatment has been to incorporate antimicrobial agents into elastomeric ligature ties. A recent elastomeric ligature tie uses the antimicrobial characteristic of silver to help prevent formation of white spot lesions. The purpose of this in vitro study is to determine the antimicrobial effectiveness of a silver-releasing elastomeric ligature tie (OrthoShield Safe-T-Tie) against Streptococcus mutans and compare its results with a selenium-containing …

Go to article

Role Of The Cystine/Glutamate Exchanger In Glioma Cell Biology, Toyin Adeyemi Ogunrinu Jan 2011

Role Of The Cystine/Glutamate Exchanger In Glioma Cell Biology, Toyin Adeyemi Ogunrinu

All ETDs from UAB

Changes in the glioma microenvironment including oxygen (O2) levels, supply of amino acid such as L-glutamate and L-cystine and glutathione (GSH) concentrations play a critical role in glioma biology. Previous data from our laboratory and others have implicated the L-cystine/L-glutamate exchanger, system xc- in the invasion and proliferation of cancers including glioma. The central aim of this dissertation was to characterize the contribution of L-cystine uptake, GSH synthesis and L-glutamate release to migration and proliferation of glioma cells. In my first study, I examined the role of system xc- mediated L-glutamate release on glioma migration. I show that activation of …

Go to article

Fenofibrate And Insulin Resistance, Corrie E. Paeglow Jan 2011

Fenofibrate And Insulin Resistance, Corrie E. Paeglow

All ETDs from UAB

Both animal and human models suggest that fenofibrate, a medication widely prescribed to decrease triglycerides, also decreases insulin resistance. In the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) cohort, which included 780 individual who took 160 mg of micronized fenofibrate daily for three weeks, fenofibrate was found to decrease HOMA-IR by -0.24 units, (95% CI: -0.32, -0.14), insulin by -0.65 uU/mL (95% CI: -0.97, -0.34) and glucose by 2.46 mg/dL (95% CI: -2.51, -2.42). In a meta-analysis of 19 studies that included 1,297 individuals without diabetes and 196 individuals with diabetes treated with fenofibrate for three weeks or …

Go to article

Impact Of Site Development Techniques In The Soft Tissue Height On Single Implant Supported Prosthesis In The Anterior Maxilla, Juan Francisco Pardo Jan 2011

Impact Of Site Development Techniques In The Soft Tissue Height On Single Implant Supported Prosthesis In The Anterior Maxilla, Juan Francisco Pardo

All ETDs from UAB

Background: Implant placement should be based on a restoration-oriented treatment plan with correct three-dimensional positioning to allow optimal support and stability of surrounding hard and soft tissues. After tooth extraction the alveolus remodels producing changes in the soft tissues contours. This may translate into the inability to place the implant or in a non-esthetic restoration. In contemporary esthetic implant dentistry, the main objective is to maintain the socket dimensions and soft tissue contours to allow ideal implant placement and to provide a harmonious restoration. Objective: To evaluate if socket grafting with FDBA with or without PRP or rhPDGF in site …

Go to article

The Effects Of Apolipoprotein Mimetic Peptides On Inflammation And Oxidative Stress, Toral Rohit Patel Jan 2011

The Effects Of Apolipoprotein Mimetic Peptides On Inflammation And Oxidative Stress, Toral Rohit Patel

All ETDs from UAB

Coronary Artery Disease (CAD) is the leading cause of deaths worldwide, including the United States. Atherosclerosis remains the primary cause of CAD, and is a leading target for drug treatments. Despite advances in treatments, many questions remain unanswered pertaining to the mechanisms of the treatments on inflammation and oxidative stress. We hypothesize that peptides 4F and Ac-hE18A-NH2 act as anti-inflammatory factors and reduce oxidative stress. We also hypothesize that these peptides require apolipoprotein A-I (apoA-I) to increase paraoxonase-1 (PON-1) activity. The effects of administering peptides 4F and Ac-hE18A-NH2 on oxidative stress were evaluated through the analysis of plasma from apoA-I-null …

Go to article

Homelessness In Birmingham, Al: An Analysis Using The Local Homeless Management Information System And Surveys From Local Supportive Housing Programs, Adrian Kendall Smith Jan 2011

Homelessness In Birmingham, Al: An Analysis Using The Local Homeless Management Information System And Surveys From Local Supportive Housing Programs, Adrian Kendall Smith

All ETDs from UAB

A homeless management information system (HMIS) records and stores a client's demographic information and his/her service utilization history while allowing for case management opportunities between the client and service provider. HMISs are changing the way communities serve their homeless populations and how agencies serving the homeless interact with their clients and other agencies. With a focus on the city of Birmingham, its local HMIS, and the local agencies using HMIS this research seeks to answer the following questions: How can the homeless management information system help us to better understand the homeless population in Birmingham? What are the different approaches …

Go to article

Associations Among Measures Of Engagement With Kp.Org And Clinical Outcomes, Heather J. Sobko Jan 2011

Associations Among Measures Of Engagement With Kp.Org And Clinical Outcomes, Heather J. Sobko

All ETDs from UAB

USING MEASURES OF ENGAGEMENT WITH KP.ORG TO DETERMINE ASSOCIATIONS WITH SELECTED CLINICAL OUTCOMES HEATHER J. SOBKO SCHOOL OF NURSING ABSTRACT Introduction The purpose of this retrospective cohort study was to examine patterns of use of an electronic personal health record among adults diagnosed with diabetes, hypertension or hyperlipidemia. Intermediate behavioral measures (medication possession ratios) and physiological measures of metabolic control for diabetes (hemoglobinA1c), hypertension (blood pressure) and hyperlipidemia (low density lipoprotein) were examined. Methods Administrative data from Kaiser Permanente Georgia were analyzed. Adult members of with selected chronic diseases of diabetes, hypertension or hyperlipidemia who used the Kaiser Permanente electronic …

Go to article

Ultrasound Elasticity Measurements As A Predictor For Arteriovenous Fistula Maturation, Anna Sorace Jan 2011

Ultrasound Elasticity Measurements As A Predictor For Arteriovenous Fistula Maturation, Anna Sorace

All ETDs from UAB

This research thesis examines the applicability of using ultrasound imaging to quantify arterial elasticity and assess potential of arteriovenous fistula maturation in chronic kidney disease (CKD) patients. Tissue-specific abnormalities have proven useful for identifying disease states within oncology, cardiovascular and musculoskeletal system. Using ultrasound-based imaging to evaluate arterial elasticity is a noninvasive and novel technique. It has the potential to contribute further insight into chronic kidney disease fistula failure and become a noninvasive prognostic indicator. Reliable vascular access is critical for delivery of adequate hemodialysis treatment to CKD patients and to maintain long-term connections for dialysis. An arteriovenous fistula is …

Go to article

Molecular Piracy In The Mobilization Of Staphylococcus Aureus Pathogenicity Island 1, Michael Spilman Jan 2011

Molecular Piracy In The Mobilization Of Staphylococcus Aureus Pathogenicity Island 1, Michael Spilman

All ETDs from UAB

Staphylococcus aureus bacteriophage 80α is a temperate, double-stranded DNA phage that serves as a "helper" phage for the mobilization of several S. aureus pathogenicity islands (SaPIs), including SaPI1. When mobilized by 80α, SaPI1 genomes are packaged into smaller phage-like transducing particles composed of 80α capsid (gp47), scaffolding (gp46) and portal (gp42) proteins. In this dissertation, I utilize electron microscopy and biochemistry to tease apart the structural and genetic controls and consequences of SaPI1 as a molecular pirate. More specifically, I show that two SaPI1 proteins shift assembly from 63-nm, T = 7 icosahedral capsids to 47-nm, T = 4 capsids, …

Go to article

"The Role Of Health Promotion In Physical Therapy Survey" Reliability And Validity Testing", Jaca Stephens Jan 2011

"The Role Of Health Promotion In Physical Therapy Survey" Reliability And Validity Testing", Jaca Stephens

All ETDs from UAB

ABSTRACT Purpose: Physical therapists (PTs) have a unique opportunity to play a meaningful role in educating patients on health and wellness to prevent chronic conditions, such as cardiac disease, cerebrovascular disease, pulmonary disease, cancer, diabetes, and obesity. No instrument has been validated to measure physical therapists' views on health promotion and their practices. The purpose of this study was to evaluate the validity and reliability of a health promotion survey designed for physical therapists. Method: An expert panel of 9 physical therapists assessed the content validity of "The Role of Health Promotion in Physical Therapy Survey." as developed by Rea …

Go to article

Calcium Dynamics Of Glial Cells And Genetic Influences On Behavior Of The Nematode Caenorhabditis Elegans, Randy Franklin Stout Jan 2011

Calcium Dynamics Of Glial Cells And Genetic Influences On Behavior Of The Nematode Caenorhabditis Elegans, Randy Franklin Stout

All ETDs from UAB

A major challenge in neuroscience is understanding how the different neural cell types work together to process information and produce a behavioral output. Glial cells of the human brain have long been thought to act as support for the fundamental cell to cell communication at the core of cognition: neuronal synaptic communication. Research over the past several decades measuring glial activity and experimentally controlling glial cells in rodent model systems has shown that the two macroglia sub-types of glial cells (astrocytes and oligodendrocytes) have active roles in establishment, maintenance, and modulation of synaptic communication in the mammalian brain. Much of …

Go to article

Protective Factors Against Relapse For Practicing Nurse Anesthetists In Recovery From Anesthetic Opiates, Elizabeth Laura Wright Jan 2011

Protective Factors Against Relapse For Practicing Nurse Anesthetists In Recovery From Anesthetic Opiates, Elizabeth Laura Wright

All ETDs from UAB

Introduction: Addiction to anesthetic opiates is an occupational hazard for anesthesia providers, which includes nurse anesthetists. Several factors influence this hazard risk, including, genetic make-up, personality traits, and job stress. Also of great concern is the risk of relapse if an anesthesia provider returns to work, which can be as high as 40%. However, there are nurse anesthetists who have successfully returned to the practice of anesthesia while in recovery from addiction to anesthetic opiates. These nurse anesthetists have first-hand experience with the challenges of recovery when faced with continual access to opiates, and their experience can help others in …

Go to article

Role Of Vdr In Host Immune Response To Porphyromonas Gingivalis Infection, Gulam Yezdani Jan 2011

Role Of Vdr In Host Immune Response To Porphyromonas Gingivalis Infection, Gulam Yezdani

All ETDs from UAB

Porphyromonas gingivalis is one of the etiologic factors of periodontal disease, a chronic inflammatory disorder characterized by the destruction of periodontal connective tissue and the subsequent loss of alveolar bone. Epidemiological and genetic studies have indicated an association between periodontal disease and the vitamin D system. However, little is known regarding how vitamin D signaling regulates the inflammatory immune process of this disease. The purpose of the study was to understand the role of the vitamin D receptor (VDR) in regulating the host response to P. gingivalis infection by using a dual chamber mouse model. These chambers served both as …

Go to article

Assessment Of Mitochondrial Stressors On Cellular Bioenergetics, Blake Reid Zelickson Jan 2011

Assessment Of Mitochondrial Stressors On Cellular Bioenergetics, Blake Reid Zelickson

All ETDs from UAB

The mitochondrion plays a central role in the maintenance of bioenergetic function through the production of ATP and essential metabolites. The development of mitochondrial bioenergetic defects is a hallmark of important pathologies such as cardiovascular and liver diseases. It is well established that a decrease in mitochondrial function, typically of 20-40%, is associated with the progression of these pathologies. Causal relationships have been more difficult to establish because of the challenge of assessing mitochondrial function in a cellular setting. Specifically, it is known that mitochondria function at less than their maximal respiratory capacity and the remainder, known as reserve or …

Go to article

In Vivo Interactions Between Virus Genomes And Host Proteins For Members Of The Order Picornavirales, Erik Michael Lenarcic Jan 2011

In Vivo Interactions Between Virus Genomes And Host Proteins For Members Of The Order Picornavirales, Erik Michael Lenarcic

All ETDs from UAB

A significant number of pathogens of economical and medical importance are positive sense RNA viruses. Their genomes enter host cells and subvert them to support virus growth. These large-scale changes involve the co-opting of cellular proteins through interactions with viral RNA and proteins. Characterizing these interactions leads to a better understanding of viral life cycles and the identification of new antiviral therapies. The order Picornavirales contains viruses that infect a wide array of eukaryotes. Their genomes serve as a messenger RNA (mRNA) that is translated by host ribosomes cap-independently through an internal ribosome entry site (IRES). Most members of the …

Go to article

The Intestinal Extracellular Matix As An Innate Regulator Of Effector T-Cell Responses, Kayci Renee Huff Jan 2011

The Intestinal Extracellular Matix As An Innate Regulator Of Effector T-Cell Responses, Kayci Renee Huff

All ETDs from UAB

Extracellular matrix (stroma) regulation of mucosal T-cell function is incompletely understood. Here we uncovered a role for intestinal stromal products in the innate regulation of effector T-cells. Stroma-conditioned media (S-CM) derived from normal human intestinal stroma (TGF-&betahi/IL-6lo/IL-1ßlo) significantly down-regulated T-cell proliferation and IFN-&gamma production compared to S-CM derived from inflamed Crohn's mucosa (TGF-&betahi/IL-6hi/IL-1&betahi). Antibody neutralization studies showed that TGF-&beta in normal S-CM inhibited T-cell proliferation and IFN-&gamma production, whereas IL-6 plus IL-1&beta in Crohn's S-CM promoted T-cell proliferation, and the IL-1&beta alone promoted IFN-γ and IL-17 release. Importantly, stromal cells in normal tissue produce TGF-&beta and contribute to mucosal homeostasis …

Go to article

Exhaustion Renders Cd8 T Cells Unresponsive To Antigen-Independent Activation And Is Characterized By Il-18 Receptor Downregulation, Jennifer T. Ingram Jan 2011

Exhaustion Renders Cd8 T Cells Unresponsive To Antigen-Independent Activation And Is Characterized By Il-18 Receptor Downregulation, Jennifer T. Ingram

All ETDs from UAB

During many chronic infections virus-specific CD8 T cells succumb to exhaustion as they lose their ability to respond to antigenic activation. Combinations of interleukin (IL)-12, IL-18, and IL-21 have been shown to induce the antigen-independent production of IFN-γ by effector and memory CD8 T cells. In this study we investigated whether exhausted CD8 T cells are sensitive to activation by these cytokines. We show that effector and memory, but not exhausted, CD8 T cells produce interferon-gamma (IFN-γ) and upregulate CD25 following exposure to certain combinations of IL-12, IL-18, and IL-21. This unresponsiveness was associated with downregulation of the IL-18 receptor …

Go to article

Substance-Dependent Tasc Offenders Taking Psychotropic Pharmacotherapy--Associated Factors, Substance Use Outcomes, And Criminal Diversion Outcomes, Dorothy Octavia Jackson Jan 2011

Substance-Dependent Tasc Offenders Taking Psychotropic Pharmacotherapy--Associated Factors, Substance Use Outcomes, And Criminal Diversion Outcomes, Dorothy Octavia Jackson

All ETDs from UAB

Current evidence suggests that persons with co-occurring disorders (COD) are at risk for poorer treatment outcomes in terms of substance use and recidivism. Studies have examined this trend in incarcerated individuals, but few have examined COD offenders under community supervision. The purpose of this study was to develop a predictive model to identify offenders under community corrections supervision with substance use diagnoses who were actively taking psychotropic medications (SUPM) as an index of COD and to compare demographics, social histories, and sexual risk behaviors for SUPM offenders to offenders with a substance use disorder (SUD) only and those who met …

Go to article

Teaching Breast Health To Adolescent Females In High School: Comparing Interactive Teaching With Traditional Didactic Methods, Jacqueline Anita Horton Jan 2011

Teaching Breast Health To Adolescent Females In High School: Comparing Interactive Teaching With Traditional Didactic Methods, Jacqueline Anita Horton

All ETDs from UAB

Breast Health Knowledge Breat Health Beliefs

Go to article

Effects Of Growth Factor Induced Pathways On Differentiation Of The Human Neuronal Cell Line Sh-Sy-5y., Ashish D. Dwary Jan 2011

Effects Of Growth Factor Induced Pathways On Differentiation Of The Human Neuronal Cell Line Sh-Sy-5y., Ashish D. Dwary

All ETDs from UAB

Background: The VSNL1 gene product, Visinin-like-protein-1 (VILIP-1), is a member of the neuronal EF-hand Ca2+-sensor protein family. Previously, VILIP-1 mRNA and protein expression were shown to be altered in animal models and in schizophrenia patients. VILIP-1 influences cytosolic cAMP levels, cell migration, exocytotic processes and differentiation in the periphery. This raises the question, whether similar to other potential schizophrenia susceptibility genes, such as Disc1, PDE4B and Akt, VILIP-1 may be associated with schizophrenia-related measures, and if it could mechanistically affect cAMP signaling and neurite outgrowth in neurons. Methods: 627 people with schizophrenia and 541 control subjects were ascertained and the …

Go to article

A Recombinant Myeloid-Binding Adenovirus For Targeted Pulmonary Gene Therapy, Michael O. Alberti Jan 2011

A Recombinant Myeloid-Binding Adenovirus For Targeted Pulmonary Gene Therapy, Michael O. Alberti

All ETDs from UAB

Inflammation and airway destruction are hallmarks of many debilitating lung diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), acute lung injury (ALI), and cancer. Gene-based therapeutic interventions that modulate this pathologic inflammatory response are likely to reduce the progressive destruction to lung airways. In this regard, a number of strategies have been evaluated for targeting the pul-monary vasculature; particularly those based on serotype 5 Adenovirus (Ad5). The ad-vantages of Ad over other vector systems include: in vivo stability, low oncogenic poten-tial, and large packaging capacity. Yet, specific and efficient gene delivery to the lung has been hampered …

Go to article

Vitamin D And Insulin Sensitivity Among African American And European American Adolescents And Adults, Jessica Alejandra Alvarez Jan 2011

Vitamin D And Insulin Sensitivity Among African American And European American Adolescents And Adults, Jessica Alejandra Alvarez

All ETDs from UAB

Adequate vitamin D status is associated with a reduced risk for type 2 diabetes (T2DM); the relationship may be mediated by insulin sensitizing effects of vitamin D. African Americans (AA) are at a greater risk for T2DM and insulin resistance, as well as vitamin D deficiency, compared to European Americans (EA). The primary objective of this dissertation was to investigate the independent relationships of vitamin D with various measures of insulin sensitivity. Investigations were performed in a series of studies involving adolescent and adult female cohorts. The intravenous glucose tolerance test-derived insulin sensitivity index (SI) or the oral glucose tolerance …

Go to article

Biometic Self-Assembled Nanomatrix For Bone Tissue Regeneration, Joel Matthew Anderson Jan 2011

Biometic Self-Assembled Nanomatrix For Bone Tissue Regeneration, Joel Matthew Anderson

All ETDs from UAB

Formation of the native bone extracellular matrix (ECM) provides an attractive template for bone tissue engineering. At the cellular level, structural support and biological complexity of bone ECM are provided within a composite microenvironment that consists of an organic fibrous network reinforced by inorganic hydroxyapatite (HA) nanostructured crystals. To synthetically recreate this biphasic assembly, a bone ECM analogous scaffold comprised of self-assembling peptide amphiphile (PA) nanofibers and interspersed HA nanoparticles was investigated. The PAs have been endowed with biomolecular ligand signaling using synthetically inscribed peptide sequences (i.e. RGDS, DGEA) derived from the native bone ECM and integrated with HA nanoparticles …

Go to article

Post-Translational Modifications, Structure And Function Of Human Lens Crystallins, Chinwe Asomugha Jan 2011

Post-Translational Modifications, Structure And Function Of Human Lens Crystallins, Chinwe Asomugha

All ETDs from UAB

Cataract is an opacification of the lens causing reduction in vision over time. It is one of the leading causes of vision loss among adults age 55 and older. The lens is a transparent structure that focuses incoming light onto the retina for visual perception. It has a high protein content, attributed mainly to water-soluble proteins known as crystallins. With age, crystallins undergo post-translational modifications (PTMs) that alter their structural and/or functional properties and, in turn, lead to cataract formation. The purpose of this research was to take a top-down approach in understanding changes in lens proteins with age, starting …

Go to article

The Effect Of Sulfasalazine On Functional Recovery And Neuropathic Pain Following Spinal Cord Injury, Kelly Dunham Atkins Jan 2011

The Effect Of Sulfasalazine On Functional Recovery And Neuropathic Pain Following Spinal Cord Injury, Kelly Dunham Atkins

All ETDs from UAB

Spinal cord injury (SCI) is a devastating condition resulting in loss of motor function as well as sensory abnormalities. Insight into the pathophysiology of SCI progression has been gained through use of pre-clinical animal models, however these have not been successful in yielding pharmacological interventions for clinical management of SCI. One proposed reason for this discrepancy may be the use of SCI models which are not fully clinically relevant and do not assess the contribution of gray matter pathology to SCI functional outcomes. Post-SCI inflammation is well-documented and may lead to downstream loss of motor function. Additionally, inflammation is thought …

Go to article

Significance And Regulation Of Cd68 Expression In The Osteoclast, Jason Waid Ashley Jan 2011

Significance And Regulation Of Cd68 Expression In The Osteoclast, Jason Waid Ashley

All ETDs from UAB

The mucin-like Lysosome Associated Membrane Protein (LAMP) family member CD68 is a primarily myeloid lineage restricted transmembrane protein that is expressed in macrophages and osteoclasts. While the existence and expression pattern of human CD68 and mouse CD68 (sometimes called macrosialin) are well-known, and these molecules are routinely used as histological markers of tissue macrophages, the functional signific-ance of CD68 expression remains an unanswered question. Our overall goal is to deter-mine the significance and characterize the function of CD68 in osteoclasts and explore the effects of Receptor Activator of Nuclear Factor κB (RANK) signaling on CD68 post-translational modification. To achieve this …

Go to article

Role Of The Cardiomyocyte Circadian Clock In Modulating Myocardial Physiology And Pathophysiology, David Joseph Durgan Jan 2011

Role Of The Cardiomyocyte Circadian Clock In Modulating Myocardial Physiology And Pathophysiology, David Joseph Durgan

All ETDs from UAB

It is well established that multiple parameters of cardiovascular physiology and pathophysiology exhibit diurnal variations. For example, human heart rate and blood pressure peak during the morning and trough in the evening. Similarly, there is a morning prevalence for the onset of multiple adverse cardiovascular events, including myocardial ischemia, arrhythmias, and sudden cardiac death. Traditionally these rhythms have been attributed to rhythms in neurohumoral stimulation. However recent identification of the circadian clock mechanism in cardiovascular relevant cell types, including the cardiomyocyte, has prompted investigation into its role in modulating myocardial physiology and pathophysiology over the course of the day. Preliminary …

Go to article

Characteristics Of Juveniles Charged With Domestic Violence In The Jefferson County Family Court And The Effect Of Prior Domestic Violence Conviction On Case Disposition., Omobolanle Atinuke Ene-Korubo Jan 2011

Characteristics Of Juveniles Charged With Domestic Violence In The Jefferson County Family Court And The Effect Of Prior Domestic Violence Conviction On Case Disposition., Omobolanle Atinuke Ene-Korubo

All ETDs from UAB

Juvenile violence has received considerable attention both in criminological literature and policy circles, but this attention has largely ignored juvenile domestic violence offending, which is a growing problem in the Jefferson County Family Court. This study identifies the characteristics of juvenile domestic offenders in the Jefferson County Family Court, and examines the effect of prior domestic violence conviction on case disposition. Results indicate that these juveniles are black, males, inschool and the most likely victim of the violence is the juveniles mother. Prior domestic violence offending has no statistically significant effect on case disposition.

Go to article

The Role Of The Classical Nf-Kb Pathway In Hsc Self-Renewal And Acute Myeloid Leukemia, Robert Jason Flynn Jan 2011

The Role Of The Classical Nf-Kb Pathway In Hsc Self-Renewal And Acute Myeloid Leukemia, Robert Jason Flynn

All ETDs from UAB

Acute myeloid leukemia (AML) comprises approximately 25% of newly diagnosed cases of leukemia each year. The constitutive activation of the classical NF-κB signaling pathway has been observed in up to 70% of AML cases, and could be due to mutations upstream involving the PI3K-Akt cascade, which is also constitutively active in a majority of cases. In mice, constitutive activation of Akt either through deletion of the negative regulator of PI3K-Akt, PTEN, or by expression of Myr-Akt induces rapid stem cell loss along with a lethal, transplantable myeloproliferative disorder and AML. These studies show that constitutive Akt and NF-κB signaling distinguish …

Go to article

First Prev Next Last