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I Can Hear You, But Do I See You?, Jewel Pereira, Joe Williams, Meredith Lewis Jan 2024

I Can Hear You, But Do I See You?, Jewel Pereira, Joe Williams, Meredith Lewis

UAB Huntsville Research Day - All Presentations

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Palm Reading: Subtle Pain And Paresthesias Of The Hand As A Harbinger Of Synovial Sarcoma, Michael Pettit, Nathan Lee, Roger D. Smalligan Jan 2024

Palm Reading: Subtle Pain And Paresthesias Of The Hand As A Harbinger Of Synovial Sarcoma, Michael Pettit, Nathan Lee, Roger D. Smalligan

UAB Huntsville Research Day - All Presentations

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That Sodium Is Low, But Why Though?, Hinal Rathi, Christian Motley, Pranayraj Kondapally, Nessy Abraham Phillip Jan 2024

That Sodium Is Low, But Why Though?, Hinal Rathi, Christian Motley, Pranayraj Kondapally, Nessy Abraham Phillip

UAB Huntsville Research Day - All Presentations

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Who Let The Cat Out: A Rare Case Of Bartonella Henslae Cat Scratch Disease Causing Culture Negative Prosthetic Valve Endocarditis, Hinal Rathi, Aesha Patel, Ali Hassoun Jan 2024

Who Let The Cat Out: A Rare Case Of Bartonella Henslae Cat Scratch Disease Causing Culture Negative Prosthetic Valve Endocarditis, Hinal Rathi, Aesha Patel, Ali Hassoun

UAB Huntsville Research Day - All Presentations

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A Rare Case Of Statin-Induced Immune-Mediated Necrotizing Myopathy (Imnm), Hinal Rathi, Jordan Mcgill, Jitesh Kar Jan 2024

A Rare Case Of Statin-Induced Immune-Mediated Necrotizing Myopathy (Imnm), Hinal Rathi, Jordan Mcgill, Jitesh Kar

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When A Uti Becomes More Trouble Than Usual: A Complex Case Of Urosepsis And Fournier's Gangrene, Hinal Rathi, Timothy Pham, Pranayraj Kondapally, Nessy Abraham Phillip Jan 2024

When A Uti Becomes More Trouble Than Usual: A Complex Case Of Urosepsis And Fournier's Gangrene, Hinal Rathi, Timothy Pham, Pranayraj Kondapally, Nessy Abraham Phillip

UAB Huntsville Research Day - All Presentations

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Double Trouble: The Intersection Of Primary Prostate And Colon Cancers, Bradley Thigpen, Christian Motley, Roger Smalligan Jan 2024

Double Trouble: The Intersection Of Primary Prostate And Colon Cancers, Bradley Thigpen, Christian Motley, Roger Smalligan

UAB Huntsville Research Day - All Presentations

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Isaac Syndrome - A Critical Diagnosis For Neuromuscular Enigmas, Bradley Thigpen, Michael Pettit, Parekha Yedla Jan 2024

Isaac Syndrome - A Critical Diagnosis For Neuromuscular Enigmas, Bradley Thigpen, Michael Pettit, Parekha Yedla

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A Unique Cause Of Nstemi: Embolization Of The Right Coronary Artery From A Left Ventricular Thrombus, Lauren Usrey, Soumyadeep Bag, Emory Johnson, Nessy Abraham-Phillip Jan 2024

A Unique Cause Of Nstemi: Embolization Of The Right Coronary Artery From A Left Ventricular Thrombus, Lauren Usrey, Soumyadeep Bag, Emory Johnson, Nessy Abraham-Phillip

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Battle In The Bloodstream: A Case Of Pediatric Autoimmune Neutropenia, Abigail Zane, Elijah Fox Jan 2024

Battle In The Bloodstream: A Case Of Pediatric Autoimmune Neutropenia, Abigail Zane, Elijah Fox

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Hypertension Management At Equal Access Birmingham, A Student-Run Free Clinic At University Of Alabama Birmingham School Of Medicine, Peter Abdelmessih, Katherine Smith, Nick Van Wagoner Jan 2024

Hypertension Management At Equal Access Birmingham, A Student-Run Free Clinic At University Of Alabama Birmingham School Of Medicine, Peter Abdelmessih, Katherine Smith, Nick Van Wagoner

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Impact Of Donor And Recipient Age On Systemic Stem Cell Therapy, Brenton T. Bicknell, Carolina Francelin, Xiaoping Qi, Juliana Godoy, Maria B. Grant, Michael E. Boulton Jan 2024

Impact Of Donor And Recipient Age On Systemic Stem Cell Therapy, Brenton T. Bicknell, Carolina Francelin, Xiaoping Qi, Juliana Godoy, Maria B. Grant, Michael E. Boulton

UAB Huntsville Research Day - All Presentations

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Identifying And Promoting Alabama’S Rural Areas To Increase Physician Workforce, Heather Crow, Kyle Siegrist, Caleb Lenox Jan 2024

Identifying And Promoting Alabama’S Rural Areas To Increase Physician Workforce, Heather Crow, Kyle Siegrist, Caleb Lenox

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Predictors Of Pain Relief After Stereotactic Radiosurgery For Trigeminal Neuralgia, Evan Gross, James Mooney, Addison Stewart, Markus Bredel, Nicole Bentley, Marshall Holland Jan 2024

Predictors Of Pain Relief After Stereotactic Radiosurgery For Trigeminal Neuralgia, Evan Gross, James Mooney, Addison Stewart, Markus Bredel, Nicole Bentley, Marshall Holland

UAB Huntsville Research Day - All Presentations

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Immunotherapy For Pediatric Brain And Spine Tumors: Current State And Future Directions, Dagoberto Estevez-Ordonez, Samuel E. Gary, Travis J. Atchley, Pedram D. Maleknia, Jordan A. George, Nicolas M B Laskay, Rishi K. Devulapali, James M. Johnston Jan 2024

Immunotherapy For Pediatric Brain And Spine Tumors: Current State And Future Directions, Dagoberto Estevez-Ordonez, Samuel E. Gary, Travis J. Atchley, Pedram D. Maleknia, Jordan A. George, Nicolas M B Laskay, Rishi K. Devulapali, James M. Johnston

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Health Insurance And Differences In Infant Mortality Rates In The Us, Desalyn L. Johnson, Waldemar A. Carlo, A K M Rahman, Rachel Tindal, Sarah G. Trulove, Mykaela J. Watt Jan 2024

Health Insurance And Differences In Infant Mortality Rates In The Us, Desalyn L. Johnson, Waldemar A. Carlo, A K M Rahman, Rachel Tindal, Sarah G. Trulove, Mykaela J. Watt

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The Impact Of Socioeconomic Status On Cervical Spondylotic Myelopathy Presentation, Evan Gross, Yifei Sun, Nicholas Laskay, Mohammad Hamo, Sasha Howell, James Mooney Jan 2024

The Impact Of Socioeconomic Status On Cervical Spondylotic Myelopathy Presentation, Evan Gross, Yifei Sun, Nicholas Laskay, Mohammad Hamo, Sasha Howell, James Mooney

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Establishing Collaborations In Global Neurosurgery: The Role Of Intersurgeon, Pedram Maleknia, Nathan A. Shlobin, James M. Johnston, Gail Rousseau Jan 2024

Establishing Collaborations In Global Neurosurgery: The Role Of Intersurgeon, Pedram Maleknia, Nathan A. Shlobin, James M. Johnston, Gail Rousseau

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Predictors Of Neutropenia Secondary To Ganciclovir Exposure During Treatment Of Congenital Cytomegalovirus Disease, Javier K. Nishikawa, Immaculada Aban, Edward Acosta, Pablo J. Sanchez, David W. Kimberlin Jan 2024

Predictors Of Neutropenia Secondary To Ganciclovir Exposure During Treatment Of Congenital Cytomegalovirus Disease, Javier K. Nishikawa, Immaculada Aban, Edward Acosta, Pablo J. Sanchez, David W. Kimberlin

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The Role Of Altered Cell-Cell Communication Between Glia And Neurons In Alzheimer’S Disease, Tabea Marga Soelter Jan 2024

The Role Of Altered Cell-Cell Communication Between Glia And Neurons In Alzheimer’S Disease, Tabea Marga Soelter

All ETDs from UAB

Alzheimer’s disease is the most prevalent neurodegenerative disease and is characterized by progressive memory loss and cognitive decline, affecting behavior, speech, and motor abilities. The neuropathology includes the formation of extracellular amyloid-β plaques and intracellular neurofibrillary tangles of phosphorylated tau. Additionally, neurons become functionally impaired before degenerating and dying. While neuronal loss is a disease hallmark, glia maintain neuronal health and homeostasis through cell-cell communication with neurons. Cellular crosstalk is mediated through the release of chemical intermediates (i.e., ligands), which are taken up by cell surface membrane receptors. Previous studies have shown dysregulation of global cell-cell communication patterns and communication …


Growing Need For A Standardized Response To Radiopharmaceutical Extravasations, Michael Richard Drelich Jan 2024

Growing Need For A Standardized Response To Radiopharmaceutical Extravasations, Michael Richard Drelich

All ETDs from UAB

Extravasations are medical occurrences where an injected or infused pharmaceutical is unintentionally deposited into the soft tissue near the injection site, rather than into the bloodstream. With radiopharmaceuticals, extravasations can result in potentially large radiation doses to skin and tissue. The current rate of extravasations in clinical settings is estimated to be between 3-23%. In the interest of patient safety, a clearer understanding of the dosimetry and differences in extravasation scenarios to simplify dose estimation is needed. Similarly, the NRC is considering modifying regulations to include extravasations as reportable medical events rather than to continue considering them as patient interventions. …


Towards A Biobehavioral And Social-Structural Model Of Inflammation And Executive Function In Pediatric Obesity: A Pilot Longitudinal Study, Kathryn P. King Jan 2024

Towards A Biobehavioral And Social-Structural Model Of Inflammation And Executive Function In Pediatric Obesity: A Pilot Longitudinal Study, Kathryn P. King

All ETDs from UAB

Pediatric chronic health conditions (CHCs) prevalence has increased post-COVID- 19, and CHCs affect children’s psychosocial development while representing significant family and societal financial burden. Interventions addressing CHC outcomes and psychosocial sequelae would benefit from examining and targeting biobehavioral and social-structural influences on such outcomes. Chronic inflammation and executive function (EF) deficits represent cross-cutting biobehavioral processes, promising novel targets, are vulnerable to social-structural influences, and common across CHC populations. Pediatric obesity represents a model CHC to examine, given its strong ties to chronic inflammation, EF deficits, health behavior, and SES, in addition to its increased prevalence in the wake of COVID-19. …


Education Attainment And Health: Outside The Gender Binary, Brianna Patterson Jan 2024

Education Attainment And Health: Outside The Gender Binary, Brianna Patterson

All ETDs from UAB

Transgender and gender nonbinary individuals, hereafter referred to as trans, report worse health outcomes than trans individuals whose gender identity matches their sex assigned at birth, hereafter referred to as cisgender (Bauer, Hammond, Travers et al. 2009, Cicero, Reisner, Merwin et al. 2020). Past research has indicated that social determinants of health, such as education attainment, may be responsible for these inequities (Low 2006, The Lancet Public 2020). Education’s influence on health is well known from previous research, but the association is not distributed equally. In the United States (US) educational system, state and local governments have control, not the …


Environmental Influences On The Physiology Of Cnidarians And Their Symbionts, Shelby Gantt Jan 2024

Environmental Influences On The Physiology Of Cnidarians And Their Symbionts, Shelby Gantt

All ETDs from UAB

Corals and other cnidarians maintain complex symbioses that include photosynthetic endosymbiotic dinoflagellates (Symbiodiniaceae), protozoans, fungi, bacteria, archaea, and other metazoans, collectively known as the holobiont. The stability of these associations is crucial for holobiont resilience and adaptation to environmental conditions and are the results of long-term ecological and evolutionary processes. Environmental factors such as light availability, seasonal environmental fluctuations, and warmer, more acidic conditions can disrupt these symbiotic associations and alter holobiont functioning. To understand the influence of different environments on cnidarian host and symbiont physiology, two framework coral species (Acropora palmata and Orbicella faveolata) from nursery-raised and wild populations …


Exploring The Associations Between Cognitive Training, Social Determinants Of Health, And Driving Behaviors: A Longitudinal Analysis Of The Active Study, Katie Wheeler Jan 2024

Exploring The Associations Between Cognitive Training, Social Determinants Of Health, And Driving Behaviors: A Longitudinal Analysis Of The Active Study, Katie Wheeler

All ETDs from UAB

As the average lifespan increases, older adults are remaining independent into older ages than before. The ability to drive a vehicle is an essential part of daily living that helps older adults maintain independence. Cognitive training, specifically speed of processing training (SOPT), is an intervention that has consistently shown to benefit older adult’s driving abilities and driving behaviors. This dissertation examined the longitudinal association between cognitive training and primary driving location on crash risk across 20 years (Paper 1), investigated the effects of cognitive training and dosage on driving mobility across 10 years (Paper 2), and explored social determinants of …


Identification Of The Synthetic Cannabinoids Bzo-Poxizid And Mda-19 Using Gas Chromatography- Mass Spectrometry, Samantha Way Jan 2024

Identification Of The Synthetic Cannabinoids Bzo-Poxizid And Mda-19 Using Gas Chromatography- Mass Spectrometry, Samantha Way

All ETDs from UAB

Synthetic cannabinoids are synthetic compounds created to mimic the effects of naturally derived cannabis. They are up to 100 times more potent than natural cannabis, and due to their cannabinoid-like activity, they are considered schedule one drugs in Alabama. They are also the most common new psychoactive substance in the state of Alabama. The possible threat to public health and their schedule one status makes it necessary to develop a method for the detection of these substances. BZO-POXIZID and MDA-19 are two synthetic cannabinoids of recent interest. This study was conducted to validate a method for the detection of these …


The Modification Of Single Domain Antibody Framework And Variable Regions To Impart Novel Pharmacodynamic And Pharmacokinetic Properties, Lucinda Ann Hall Jan 2024

The Modification Of Single Domain Antibody Framework And Variable Regions To Impart Novel Pharmacodynamic And Pharmacokinetic Properties, Lucinda Ann Hall

All ETDs from UAB

In recent years, nanobodies have become important theranostic molecules, and research has focused on improving their pharmacokinetics and binding for novel targets. Nanobodies are characterized by their high kidney uptake, leading to potentially unsafe exposure of the kidneys when delivering cytotoxic payloads. Researchers hypothesize that positively charged amino acids contribute to this kidney uptake. To address this, we assessed the impact of substituting lysine residues within the 2Rs15d HER2 nanobody scaffold to alanine on its in vivo pharmacokinetics using positron emission tomography (PET) imaging. We found that nanobodies bearing lysine-to-alanine substitutions maintained their affinity for HER2. Characterization of the K88A …


A Case Of Amyloidosis Presenting With Nephrotic Syndrome And Acute Renal Failure, Ahmed Ali, Ahmed Abdelhaleem, Farrah Ibrahim, Ali Hachem Jan 2024

A Case Of Amyloidosis Presenting With Nephrotic Syndrome And Acute Renal Failure, Ahmed Ali, Ahmed Abdelhaleem, Farrah Ibrahim, Ali Hachem

UAB Huntsville Research Day - All Presentations

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Psyched For Surgery — Preoperative Evaluation Of A Patient With Extensive Psychiatric History, Ashely Archer, Fizza Mahmood, Tarak Vasavada Jan 2024

Psyched For Surgery — Preoperative Evaluation Of A Patient With Extensive Psychiatric History, Ashely Archer, Fizza Mahmood, Tarak Vasavada

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Id: Identifying Best Practices For Patients With Intellectual Disabilities, Jacqueline Beard, Nikki Ahuja, Yesenia Lopez, Meredith Lewis Jan 2024

Id: Identifying Best Practices For Patients With Intellectual Disabilities, Jacqueline Beard, Nikki Ahuja, Yesenia Lopez, Meredith Lewis

UAB Huntsville Research Day - All Presentations

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