Digital Commons Network^™

Sequencing Of Cdna From 50 Unrelated Patients Reveals That Mutations In The Triple-Helical Domain Of Type Iii Procollagen Are An Infrequent Cause Of Aortic Aneurysms., Gerard Tromp, Yuli Wu, Darwin J. Prockop, Swarna L. Madhatheri, Caren Kleinert, James J. Earley, Jiapiao Zhuang, Orjan Norrgård, R. Clement Darling, William M. Abbott, C. William Cole, Pekka Jaakkola, Markku Ryynanen, William H. Pearce, James S.T. Yao, Kari Majamaa, Stanton N. Smullens, Zoran Gatalica, Robert E. Ferrell, Sergio A. Jimenez, Charles E. Jackson, Virginia V. Michels, Michael Kaye, Helena Kuivaniemi

Department of Biochemistry and Molecular Biology Faculty Papers

Detailed DNA sequencing of the triple-helical domain of type III procollagen was carried out on cDNA prepared from 54 patients with aortic aneurysms. The 43 male and 11 female patients originated from 50 different families and five different nationalities. 43 patients had at least one additional blood relative who had aneurysms. Five overlapping asymmetric PCR products, covering all the coding sequences of the triple-helical domain of type III procollagen, were sequenced with 28 specific sequencing primers. Analysis of the sequencing gels revealed only two nucleotide changes that altered the structure of the protein. One was a substitution of threonine for …

Regulation Of Human Lung Fibroblast Alpha 1(I) Procollagen Gene Expression By Tumor Necrosis Factor Alpha, Interleukin-1 Beta, And Prostaglandin E2., Arturo Diaz, Elena Munoz, Rosemary Johnston, Joseph H. Korn, Sergio A. Jimenez

Department of Medicine Faculty Papers

We investigated the participation of prostaglandin (PG) E2 in the regulation of the alpha 1(I) procollagen gene expression by tumor necrosis factor alpha (TNF alpha), and interleukin-1 beta (IL-1 beta) in normal adult human lung fibroblasts. TNF alpha (100 units/ml) and IL-1 beta (100 units/ml) stimulated the production of PGE2 and caused a dose-dependent inhibition of up to 54 and 66%, respectively, of the production of type I procollagen. Preincubation of cultures with indomethacin partially reversed the inhibition of procollagen production induced by the cytokines. Cytokine-stimulated endogenous fibroblast PG accounted for 35 and 68% of the inhibition induced by TNF …

Jefferson Alumni Bulletin – Volume Xlii, Number 3, Spring 1993

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLII, Number 3, Spring 1993

Genetic factors behind behavioral disorder are at the center of department research, page 2

Baldwin L. Keyes, ’17: A career through many countries, battles, and specialties, page 5

Baldwin L. Keyes, ’17: A chairman who taught by personal example, page 7

Committee provides guidance on ethical issues that underlie clinical cases, page 9

John E. Deitrick, M.D.: Early appraiser of medical education, page 12

Scientists link nitric oxide to brain damage in neurologic viral diseases, page 14

Study shows Jefferson succeeds in training rural physicians, page 15

Students help organize …

The Tight Skin Mouse: Demonstration Of Mutant Fibrillin-1 Production And Assembly Into Abnormal Microfibrils, Cay M. Kielty, Michael Raghunath, Linda D. Siracusa, Michael J. Sherratt, Reiner Peters, C. Adrian Shuttleworth, Sergio A. Jimenez

Selected Works of Sergio Jiménez, MD, MACR

Mice carrying the Tight skin (Tsk) mutation harbor a genomic duplication within the fibrillin-1 (Fbn 1) gene that results in a larger than normal in-frame Fbn 1 transcript. In this study, the consequences of the Tsk mutation for fibrillin-containing microfibrils have been examined. Dermal fibroblasts from Tsk/+ mice synthesized and secreted both normal fibrillin (approximately 330 kD) and the mutant oversized Tsk fibrillin-1 (approximately 450 kD) in comparable amounts, and Tsk fibrillin-1 was stably incorporated into cell layers. Immunohistochemical and ultrastructural analyses of normal and Tsk/+ mouse skin highlighted differences in the gross organization and distribution of microfibrillar arrays. Rotary …

A Model To Promote Activity Competence In Elders., Ruth E. Levine, Laura N. Gitlin

Department of Occupational Therapy Faculty Papers

This paper describes an occupational therapy home-based intervention in which purposeful activities were used to promote adaptation and competence in older adults with chronic disabilities. Seven home care therapists visited 17 randomly selected, community-living elders who were chronically disabled and who volunteered to participate in the program. The number of visits ranged from 3 to 10 and occurred over a 3-month period according to clients' needs and wishes. Therapists enhanced their ability to enter the client's social and cultural system by using participant-observation techniques and collaboratively identified activities. Therapists documented each home visit with a structured fieldnote form. An analysis …

Jefferson Alumni Bulletin – Volume Xlil, Number 2, Winter 1993

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLIL, Number 2, Winter 1993 New technology, new faculty, and new productivity Mark Jefferson Radiology, page 2 An early contract for medical care, page 10 Jefferson meets the challenges of geriatric medicine, page 11 Students establish a community outreach initiative, page 14 What does a Jefferson medical college diploma mean to me? Page 16 Jefferson discoveries May help show how to keep AIDS dormant, page 18 Genetic cause of common leukemia is found here, page 19 Alcohol research center receives $8 million grant to continue basic investigations, page 20 Use of decoy peptides to block …

1993 Clinic Yearbook, Kimberly T. Jones, Mark J. Syms

Sidney Kimmel Medical College Yearbooks

The Clinic is the yearbook of the Sidney Kimmel Medical College (formerly Jefferson Medical College) at Thomas Jefferson University.

Gender Differences In Dementia Management Plans Of Spousal Caregivers: Implications For Occupational Therapy., Mary A. Corcoran

Department of Occupational Therapy Faculty Papers

Occupational therapists treating older people with Alzheimer disease know that they must also consider the others who are affected by the disease, the informal caregivers. Intervention is most effective when it enables both the impaired person and the primary caregiver to manage the secondary symptoms of dementia. Unfortunately, little is understood about how caregivers approach and carry out their tasks and about why male and female caregivers respond differently to their caregiving role in terms of depression, burden, stress, and substance abuse. This paper discusses the effects of gender on dementia management plans of spousal caregivers. Husbands and wives have …

Jefferson Alumni Bulletin – Volume Xlii, Number 1, Fall 1992

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLII, Number 1, Fall 1992

New challenges are met successfully, page 2

The longitudinal study, page 4

Changes strengthen curriculum, page 6

Applications reach all-time high, page 7

The critical link between clinical practice and basic science, page 8

Drive to raise $200 million is in high gear, page 12

Hamilton professors are named, page 13

New Rorer professor, page 14

Endocrinology director appointed, page 14

Bequest from dubbs, ’31 establishes fellowships, page 15

New associate Dean, page 15

$5 million grant made to Jefferson cancer institute, page 16

President Brucker is welcomed in Washington, …

Childhood Typhoid Fever Diagnosed In An Urban U.S. Setting., Surinder K. Sodhi, Stephen C. Eppes, Joel D. Klein

Department of Pediatrics Faculty Papers

The majority of cases of childhood typhoid fever diagnosed in the United States occur in persons recently returned from travel abroad. We report two childhood cases of typhoid fever acquired in Mexico and India and diagnosed in an urban United States setting. This report describes these cases and provides insights into the pitfalls in recognizing this condition in a nonendemic setting as well as information concerning differential diagnosis and treatment.

Dementia Management: An Occupational Therapy Home-Based Intervention For Caregivers., Mary A. Corcoran, Laura N. Gitlin

Department of Occupational Therapy Faculty Papers

This paper describes an occupational therapy intervention designed for family caregivers of persons with dementia. The intervention, based on the framework of a competence-environmental press model and the principle of collaboration, was implemented during 5 home visits. Each visit was designed to build caregiving skills through collaboration in identifying problem areas, developing and implementing environmental strategies, and modifying management approaches. A case vignette illustrates the therapeutic process and outcomes. The theoretical rationale and structure of the intervention and innovative documentation for evaluation of the theoretic process are also presented.

Antibodies Against Epstein-Barr Nuclear Antigen (Ebna) In Multiple Sclerosis Csf, And Two Pentapeptide Sequence Identities Between Ebna And Myelin Basic Protein., Patrick F. Bray, J Luka, Paul F. Bray, K W. Culp, J P. Schlight

Cardeza Foundation for Hematologic Research

The Epstein-Barr virus (EBV) causes infectious mononucleosis and is linked to several disparate malignancies. Prior studies on patients with multiple sclerosis (MS) showed that 100% are EBV-seropositive and that their blood contains higher antibody titers than those of controls to both transformation and lytic cycle antigens. We performed three different assays for antibodies in CSF to three major EBV antigens from patients with MS and controls. Among 93 patients with MS, 79 (85%) had CSF that reacted with a 70 kD protein, shown to be the nuclear antigen, EBNA-1, whereas only 11 (13%) of 81 EBV-seropositive controls reacted, p less …

Jefferson Alumni Bulletin – Volume Xli, Number 4, Summer 1992

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLI, Number 4, Summer 1992

Malignant bone tumors developing at sites of benign preexisting bone disease, page 13

An experience with a small rural hospital, page 15

The prevention of Turista and the enjoyment of foreign travel, page 16

The Nemours children’s clinic, page 17

The shoulder revisited, page 19

Jeff’s trauma program, page 20

The biochemical basis for diabetic nephropathy, page 21

Dealing with the media, page 23

Space motion sickness, page 24

Total joint replacement, page 25

Decision making and the doctor-patient relationship, 26

New endowed chair, page 30

Inaugural grandon lecture, page …

Department Of Radiology-Annual Report-July 1, 1991 To June 30, 1992, David C. Levin

Department of Radiology Administrative Documents and Reports

Department of Radiology Annual Report, July 1, 1991 to June 30, 1992. Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States. 72 pages.

1992 Commencement For Jefferson Medical College And College Of Graduate Studies

Jefferson College of Biomedical Sciences Commencement

No abstract provided.

1992 Commencement For Jefferson Medical College And College Of Graduate Studies

Sidney Kimmel Medical College Commencements

No abstract provided.

Insulin Receptor And Epidermal Growth Factor Receptor Dephosphorylation By Three Major Rat Liver Protein-Tyrosine Phosphatases Expressed In A Recombinant Bacterial System, Naotake Hashimoto, Wei-Ren Zhang, Barry J. Goldstein

Department of Medicine Faculty Papers

Protein-tyrosine phosphatases (PTPases) play an essential role in the regulation of signal transduction mediated by reversible protein-tyrosine phosphorylation. In order to characterize individual rat hepatic PTPases that might have specificity for autophosphorylated receptor tyrosine kinases, we isolated cDNA segments encoding three PTPases (PTPase 1B, LAR and LRP) that are expressed in insulin-sensitive liver and skeletal muscle tissue, and evaluated their catalytic activity in vitro. The intrinsic PTPase activities of the full-length PTPase 1B protein and the cytoplasmic domains of LAR and LRP were studied by expression of recombinant cDNA constructs in the inducible bacterial vector pKK233-2 using extracts of …

Alternative Splicing Of Human Prostaglandin G/H Synthase Mrna And Evidence Of Differential Regulation Of The Resulting Transcripts By Transforming Growth Factor Beta 1, Interleukin 1 Beta, And Tumor Necrosis Factor Alpha., Arturo Diaz, Anthony M. Reginato, Sergio A. Jimenez

Department of Medicine Faculty Papers

Prostaglandin G/H synthase (PGG/HS) is the rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins and thromboxanes. We screened a human lung fibroblast cDNA library with an ovine PGG/HS cDNA and isolated a 2.3-kilobase clone (HCO-T9). Sequence analysis of this clone showed that (a) it contained the entire translated region of PGG/HS and (b) it displayed an in-frame splicing of the last 111 base pairs encoded by exon 9, which resulted in the elimination of the N-glycosylation site at residue 409. Polymerase chain reaction amplification with specific oligonucleotides of reverse-transcribed mRNA from diverse human tissues and cultured cells yielded …

Jefferson Alumni Bulletin – Volume Xli, Number 3, Spring 1992

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Jefferson Alumni Bulletin – Volume XLI, Number 3, Spring 1992

State of the division 1992, page 2

Interviews with two distinguished faculty members, page 5

Programs link Alumni and students, page 9

Robert Gallo, ’63 and the human element, page 10

On campus, page 14

Drawing on his medical knowledge, page 17

American psychiatric association chooses Joseph T. English, ’58 as president, page 19

Class notes, page 24

Part I: Jefferson Medical College 1982 To 1988 (Pages 597-628)

Thomas Jefferson University - A chronological history and alumni directory, 1824 - 1990, edited by Frederick B. Wagner, Jr., MD, and J. Woodrow Savacool, MD, 1992.

No abstract provided.

Part Iv: College Of Graduate Studies 1980-1990, With Index (Pages 949-972)

Thomas Jefferson University - A chronological history and alumni directory, 1824 - 1990, edited by Frederick B. Wagner, Jr., MD, and J. Woodrow Savacool, MD, 1992.

No abstract provided.

1992 Clinic Yearbook, Jim Mckeith

Sidney Kimmel Medical College Yearbooks

The Clinic is the yearbook of the Sidney Kimmel Medical College (formerly Jefferson Medical College) at Thomas Jefferson University.

Part I: Jefferson Medical College 1934 To 1942 (Pages 373-404)

Thomas Jefferson University - A chronological history and alumni directory, 1824 - 1990, edited by Frederick B. Wagner, Jr., MD, and J. Woodrow Savacool, MD, 1992.

No abstract provided.

Part I: Jefferson Medical College 1846 To 1854 (Pages 55-88)

Thomas Jefferson University - A chronological history and alumni directory, 1824 - 1990, edited by Frederick B. Wagner, Jr., MD, and J. Woodrow Savacool, MD, 1992.

No abstract provided.

Part I: Jefferson Medical College 1906 To 1914 (Pages 265-298)

Thomas Jefferson University - A chronological history and alumni directory, 1824 - 1990, edited by Frederick B. Wagner, Jr., MD, and J. Woodrow Savacool, MD, 1992.

No abstract provided.

Part V: The School Of Nursing 1961-1980 (Pages 1091-1126)

Thomas Jefferson University - A chronological history and alumni directory, 1824 - 1990, edited by Frederick B. Wagner, Jr., MD, and J. Woodrow Savacool, MD, 1992.

No abstract provided.

Part I: Jefferson Medical College 1915 To 1925 (Pages 299-340)

Thomas Jefferson University - A chronological history and alumni directory, 1824 - 1990, edited by Frederick B. Wagner, Jr., MD, and J. Woodrow Savacool, MD, 1992.

No abstract provided.

Part Iv: College Of Graduate Studies 1914-1964 (Pages 897-918)

Thomas Jefferson University - A chronological history and alumni directory, 1824 - 1990, edited by Frederick B. Wagner, Jr., MD, and J. Woodrow Savacool, MD, 1992.

No abstract provided.

Part I: Jefferson Medical College 1957 To 1966 (Pages 475-518)

Thomas Jefferson University - A chronological history and alumni directory, 1824 - 1990, edited by Frederick B. Wagner, Jr., MD, and J. Woodrow Savacool, MD, 1992.

No abstract provided.

Part V: The School Of Nursing 1941-1960 (Pages 1053-1090)

Thomas Jefferson University - A chronological history and alumni directory, 1824 - 1990, edited by Frederick B. Wagner, Jr., MD, and J. Woodrow Savacool, MD, 1992.

No abstract provided.