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In Vivo Trafficking Of Endogenous Opioid Receptors, Yulin Wang, Elisabeth J. Van Bockstaele, Lee-Yuan Liu-Chen

Department of Neurosurgery Faculty Papers

Studies on trafficking of endogenous opioid receptors in vivo are subject of the present review. In many of the in vivo studies, the use of semi-quantitative immuno-electron microscopy is the approach of choice. Endogenous opioid receptors display differential subcellular distributions with μ opioid receptor (MOPR) being mostly present on the plasma membrane and δ- and κ-opioid receptors (DOPR and KOPR, respectively) having a significant intracellular pool. Etorphine and DAMGO cause endocytosis of the MOPR, but morphine does not, except in some dendrites. Interestingly, chronic inflammatory pain and morphine treatment promote trafficking of intracellular DOPR to the cell surface which may …

Download The Pdf Of The Entire Issue: Jefferson Surgical Solutions Vol. 3, Issue 2, Fall 2008

Jefferson Surgical Solutions

No abstract provided.

Jss Editorial Board & Credits

Jefferson Surgical Solutions

No abstract provided.

News In Brief

Jefferson Surgical Solutions

No abstract provided.

The Nicoletti Family Professorship In Transplantation Surgery

Jefferson Surgical Solutions

No abstract provided.

On The Job

Jefferson Surgical Solutions

No abstract provided.

Surgical Residents And Phd Candidate Make Significant Contributions To Ongoing Adult Stem Cell Research

Jefferson Surgical Solutions

No abstract provided.

Meet Our Surgical Interns

Jefferson Surgical Solutions

No abstract provided.

Jefferson Pancreas Tumor Registry Opens For Enrollment

Jefferson Surgical Solutions

No abstract provided.

Overview From The Chairman

Jefferson Surgical Solutions

No abstract provided.

Caveolin-1, Tgf-Β Receptor Internalization, And The Pathogenesis Of Systemic Sclerosis, Francesco Del Galdo, Michael P. Lisanti, Sergio A. Jimenez

Jefferson Institute of Molecular Medicine Papers and Presentations

PURPOSE OF REVIEW: To review the scientific literature supporting the participation of caveolin-1 in the pathogenesis of tissue fibrosis and the notion that modulation of the caveolin-1 pathway may represent a novel treatment for systemic sclerosis and other fibrotic diseases.

RECENT FINDINGS: Caveolin-1 plays an important role in the regulation of transforming growth factor-beta (TGF-beta) signaling owing to its participation in TGF-beta receptor internalization. TGF-beta receptor internalized through caveolin-1 lipid rafts undergoes rapid degradation, effectively decreasing TGF-beta signaling. Studies have shown that caveolin-1 knockdown in vitro markedly increased collagen gene expression in normal human lung fibroblasts. Caveolin-1 was reduced in …

Angioedema After Local Trauma In A Patient On Angiotensin-Converting Enzyme Inhibitor Therapy, B. B. Simmons, Michelle A. Folsom, L.Eslie A. Bryden, James Studdiford

Department of Family & Community Medicine Faculty Papers

Angioedema is a side effect that is often associated with use of angiotensin converting enzyme inhibitor medications. These medications result in increased levels of circulating bradykinins. This case illustrates the result of a local traumatic event to the upper lip, presumably causing marked bradykinin release in a patient who was taking an ACE-inhibitor. The local release of bradykinin from trauma, in addition to decreased bradykinin catabolism secondary to ACE-inhibitor therapy resulted in angioedema predominantly in the upper lip. The angioedema resolved with discontinuation of the ACE-inhibitor.

Young Woman With Chronic Conversion Disorder With Dramatic Improvement In Upper Motor Neuron Type Syndromes Through The Use Of Electromyography (Emg) Triggered Biofeedback, Bruce H. Hsu, Md, Nethra S. Ankam, Md, Ralph J. Marino

Department of Rehabilitation Medicine Faculty Papers

Patient: 31 year old woman chronic flexion contracture of hand, prior history seizure disorder, chronic conversion disorder.

Program Description: Patient presented initially to neurology service with chronic right hand flexion contracture in the context of 3 days of weakness and numbness in lower extremities after exertion. MRI/MRA Brain, Head CT, CT of entire spine were all unrevealing. Patient was transferred to the rehabilitation unit 8 days after initial admission. On rehabilitation admission patient exam was noted to have right hand markedly flexed with pain to passive ranging out of extreme flexion, chronic in nature. Patient initially had her hand ranged …

The Value Of Intraoperative Examination Of Axillary Sentinel Nodes In Carcinoma Of The Breast., Gordon F. Schwartz, Lauren S. Krill, Juan P. Palazzo, Abhijit Dasgupta

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Abstract Axillary sentinel lymph node biopsy (SLNB) has become the standard of care for T1-2, N-0, M-0 carcinoma of the breast. However, the accuracy of frozen section in the intra-operative examination of sentinel nodes (SN) remains controversial. The senior author has championed the use of the intraoperative examination of SN by frozen section ex-amination from the inception of its use, and we present our experience with frozen section examination of SN, confirming that this technique is both practical and highly accurate. Materials & Methods: Between 2000 and 2007, 236 SLNB procedures were performed that were read as “fro-zen section negative.” …

Simulation Session: The Power Of Simulation In Teaching Health Care Professionals In The 21st Century, Thomas Loveless, Msn, Crnp, Rn, Kevin Dysart, Md, Brian Glynn, Ksenia Zukowsky, Crnp, Phd, Dale Berg, Md, Katherine Berg, Md, Ann Barr, Pt, Dpt, Phd, Robert Hargraves, E. Adel Herge, Ms, Otr/L, Donna Williams, Md, Audrey Zapletal, Ms, Otr/L

InterProfessional Care for the 21st Century: Redefining Education 2008

Objectives:

1. Demonstrate the utility and power of simulation and simulation scenarios in teaching and evaluation.

2. Discuss the development and implementation of selected interprofessional curricula.

Workshop #3: Interprofessional Education Knowledge And Skills Development, Stephen Kern, Phd, Otr/L, Faota, Molly A. Rose, Phd, Crnp, Rn, Cynthia Sanoski, Bs, Pharmd, Fccp, Bcps

InterProfessional Care for the 21st Century: Redefining Education 2008

Objectives:

1. Categorize the elements of successful interprofessional curricular design.

2. Produce an interprofessional action plan for existing courses.

Workshop #2: Incorporating Communication Skills Training Into Health Professions Curricula, Lauren Collins, Md, Janice Burke, Otr/L Phd, Faota

InterProfessional Care for the 21st Century: Redefining Education 2008

Objectives:

1. Discuss the role of verbal and nonverbal communication skills in the patient encounter.

2. Adopt new tools for teaching and assessing communication skills with health professions students.

3. Devise an action plan for one strategy to promote training of culturally and linguistically competent healthcare professionals.

Workshop #1: Chronic Disease Management - Chronic Illness Geriatric Education Center (Gec) Curriculum Examples, Christine Hsieh, Md, Emily Hajjar, Pharmd, Bcps, Cgp, Cecilia Borden, Edd, Msn, Rn

InterProfessional Care for the 21st Century: Redefining Education 2008

Objectives:

1. Outline elements of a curriculum in chronic illness prevention model.

2. Formulate an action plan to incorporate chronic illness education into individual professional programs.

Implementing Campus-Wide Interprofessional Education: The Jefferson Health Mentors Program, Christine Arenson, Md

InterProfessional Care for the 21st Century: Redefining Education 2008

Objectives:

1. Describe an example of a longitudinal interprofessional education curriculum.

2. Identify strategies to evaluate outcomes of interprofessional education curricula.

3. Distinguish barriers and facilitators of an interprofessional education program.

Keeping Patients Safe: The Role Of Interprofessional Education And Practice, Mary L. Manning, Phd, Crnp, Rn

InterProfessional Care for the 21st Century: Redefining Education 2008

Objectives:

1. Explain the complexity of healthcare and the impact on patient safety.

2. Describe the relationship between patient safety and an interprofessional approach to health care.

3. Identify elements of successful interprofessional patient safety programs.

Improving Quality Of Care: Emerging Core Principles, Laura Gitlin, Phd

InterProfessional Care for the 21st Century: Redefining Education 2008

Objectives:

1. Describe the health care needs of older adults and family caregivers.

2. Describe new paradigm of care for older adults.

3. Differentiate emerging principles in healthcare for elders.

Advancing Interprofessional Education: Changing A Cultural Paradigm In Health And Education, Ivy F. Oandasan, Md, Mhsc, Ccfp, Fcfp

InterProfessional Care for the 21st Century: Redefining Education 2008

Keynote address.

Objectives:

1. Describe what interprofessional education entails.

2. Discuss the rationale for interprofessional education experiences.

3. List the elements of successful interprofessional programs.

Jefferson Review - Fall 2008

Jefferson Review

Contents

Features

• 3 - Margaret Fetsko Herbut Nursing Scholarship
• 4 - Mentorship Has Mutual Benefits
• 8 - Reflections on Practicum
• 10 - The Jefferson-AOTA Connection
• 12 - What's New in Interprofessional Education
• 14 - Profiles: Carrie Kimball and Marlene Weiner
• 23 - Commencement '08
• 24 - Alumni Board Membership Initiative
• 25 - Alumni Family and Friends Day

On Campus

• 16 - Bioscience Technologies
• 16 - CARAH
• 17 - Nursing
• 19 - Occupational Therapy
• 20 - Pharmacy
• 21 - Physical Therapy
• 21 - Radiologic Sciences
• 24 - Class Notes

Immune Evasion By Rabies Viruses Through The Maintenance Of Blood-Brain Barrier Integrity., Anirban Roy, Douglas C. Hooper

Department of Cancer Biology Faculty Papers

The attenuated rabies virus (RV) strain Challenge Virus Standard (CVS)-F3 and a highly pathogenic strain associated with the silver-haired bats (SHBRV) can both be cleared from the central nervous system (CNS) tissues by appropriate antiviral immune mechanisms if the effectors are provided access across the blood-brain barrier (BBB). In the case of SHBRV infection, antiviral immunity develops normally in the periphery but fails to open the BBB, generally resulting in a lethal outcome. To determine whether or not an absence in the CNS targeted immune response is associated with the infection with other pathogenic RV strains, we have assessed the …

Nurses Alumni Association Bulletin, Fall 2008, Paula Levine, Elizabeth K. Prisnock, Sally H. Wagner, John J. Wagner

Nursing Alumni Bulletins

Meetings and Annual Luncheon

Table of Contents

Officers for 2008-2009

President's Message

Treasurer's Financial Report

Alumni Scholarship Funds and Endowment Fund

Resume of Minutes

Alumni Office News

Committee Reports

Annual Giving Contributors

Janet C. Hindson Award

Award Qualifications

Janet C. Hindson Recipient and Nominees

Recipient's Acceptance Speech

Ode to Sally

Sally's Appreciation

News About and From Our Graduates

Happy Birthday

Interview with a Nurse

Memories

Fiftieth Anniversary Class

2008 Luncheon Attendees

Luncheon Photos

In Memoriam

Class News~ 2008

Additional Information

Application For Nurses Scholarship Fund Application

Application For Certification

Application For Relief Fund Benefits

Hotels

Campus Map

Notes

Analysis And Lessons Learned Instituting An Instant Messaging Reference Service At An Academic Health Sciences Library: The First Year, Daniel G. Kipnis

The Selected Works of Dan Kipnis

In February 2006, Thomas Jefferson University went live with a new instant messaging (IM) service. This paper reviews the first 102 transcripts to examine question types and usage patterns. In addition, the paper highlights lessons learned in instituting the service. IM reference represents a small proportion of reference questions, but based on user feedback and technological improvements, the library has decided to continue the service.

Download Full Pdf Issue Of Thomas Jefferson University Mph Public Health Link Newsletter, Vol. 4, Iss.3, Fall 2008

Public Health Link

This issue includes a faculty spotlight on Dr. Yuen, an article by Dr. Golab "MPH Program to Move to New Jefferson School of Health Policy and Population Health (JSHPPH)" and a recap of fall orientation.

Increasing Appropriateness Of Hospital Admissions In The Emilia-Romagna Region Of Italy., Daniel Louis, Francesco Taroni, Rita Melotti, Carol Rabinowitz, Maria Vizioli, Monica Fiorini, Joseph Gonnella

Department of Family & Community Medicine Faculty Papers

OBJECTIVES: The Emilia-Romagna region of Italy has reduced the number of available hospital beds and introduced financial incentives to curb hospital use. The goal of this study was to assess the impact of these policies on changes over time in the number of acute hospital admissions classified in diagnosis related groups (DRGs) that could be treated safely and effectively in alternative, less costly settings.

METHODS: The assessment of the appropriate site of care was based on analysis of hospital discharge data for all hospitals for the selected diagnosis related groups in the Emilia-Romagna region for 2001 to 2005. The necessity …

Molecular Processes That Handle — And Mishandle — Dietary Lipids, Kevin Jon Williams

Department of Medicine Faculty Papers

Overconsumption of lipid-rich diets, in conjunction with physical inactivity, disables and kills staggering numbers of people worldwide. Recent advances in our molecular understanding of cholesterol and triglyceride transport from the small intestine to the rest of the body provide a detailed picture of the fed/fasted and active/sedentary states. Key surprises include the unexpected nature of many pivotal molecular mediators, as well as their dysregulation — but possible reversibility — in obesity, diabetes, inactivity, and related conditions. These mechanistic insights provide new opportunities to correct dyslipoproteinemia, accelerated atherosclerosis, insulin resistance, and other deadly sequelae of overnutrition and underexertion.

Sensitivity Of The Human Circadian System To Short Wavelength (420 Nm) Light, George C. Brainard, David Silney, John P. Hanifin, Gena Glickman, Brenda Byrne, Jeffrey M. Greeson, Samar Jasser, Edward Gerner, Mark D. Rollag

Department of Neurology Faculty Papers

The circadian and neurobehavioral effects of light are primarily mediated by a retinal ganglion cell photoreceptor in the mammalian eye containing the photopigment, melanopsin. Nine action spectrum studies using rodents, monkeys, and human for these responses indicate peak sensitivities in the blue region of the visible spectrum ranging from 459 nm to 484 nm, with some disagreement in short wavelength sensitivity of the spectrum. The aim of this work was to quantify the sensitivity of human volunteers to monochromatic 420 nm light for plasma melatonin suppression. Adult female (N=14) and male (N=12) subjects participated in two studies, each employing a …