Digital Commons Network^™

Dh Custom, Joey Newton

Program of Industrial Design Capstones

DH Custom is a modular, mountain bike shoe that gives Downhill Racers the ability to balance walk-ability and performance for practicing the race course.

Light Play, Richard Stone

Program of Industrial Design Capstones

An interactive playground experience

Embrace, Matthew Selnick

Program of Industrial Design Capstones

A conceptual modular skate shoe system, for personalized protection and style

Guardlock, Michael Grosso, Joe Mooney

Program of Industrial Design Capstones

An analog pistol lock that stays attached to the pistol at all times, for in-home defense and unwanted user firearm discharge

Savecase, Matthew Napoli

Program of Industrial Design Capstones

Concept for Reducing Harmful Smartphone Use & Enhancing Productivity

Drift, Nate Miles

Program of Industrial Design Capstones

DRIFT uses active circadian lighting to help establish a sleep routine with children from their first night in the crib until they are sleeping through the night.

Galaetics, Curran Smith

Program of Industrial Design Capstones

A juggling prop designed for a enhance user and viewer experience.

Ray, Angela Banner

Program of Industrial Design Capstones

This capstone documents the design process of developing a lighting solution to the complex system that is public pedestrian spaces.

Atlas, Ryan Langeveld, Jordan Kissinger

Program of Industrial Design Capstones

Rucking, a form of weight training centered around the use of a bag, is a new, niche market whose demographic is under-served with gear that does not provide features necessary for the best rucking experience. Atlas embodies human-centered design, incorporating features and performance ruckers need for an uncompromising experience.

Switchback 1.2, Dan Alderfer, Max Munao

Program of Industrial Design Capstones

Adventure photography is about going out and getting that shot that you can show people and blow them away. Currently, there are no bags that address the needs of an adventure photographer in the rigorous setting that they encounter. The Wanderer focuses on accessibility, protection and weight distribution, and is designed so you can retrieve your camera, grab the quick shot, and stow the camera away, all without the hassle of digging through your bag.

Cuoco Cart, Sarah Nellis

Program of Industrial Design Capstones

Cuoco Cart is a food preparation system for children that provides a safe, contained environment for collaborative cooking and early childhood independence between the ages of 5-8 years.

Flux Bag, Gabrielle Karlis

Program of Industrial Design Capstones

The Flux Bag improves the urban commuting experience by seamlessly converting from backpack to shoulder bag on the fly

Predicting Risk Of Hospitalisation: A Retrospective Population-Based Analysis In A Paediatric Population In Emilia-Romagna, Italy., Daniel Z. Louis, Clara A. Callahan, Mary Robeson, Mengdan Liu, Jacquelyn Mcrae, Joseph S. Gonnella, Marco Lombardi, Vittorio Maio

College of Population Health Faculty Papers

OBJECTIVES: Develop predictive models for a paediatric population that provide information for paediatricians and health authorities to identify children at risk of hospitalisation for conditions that may be impacted through improved patient care.

DESIGN: Retrospective healthcare utilisation analysis with multivariable logistic regression models.

DATA: Demographic information linked with utilisation of health services in the years 2006-2014 was used to predict risk of hospitalisation or death in 2015 using a longitudinal administrative database of 527 458 children aged 1-13 years residing in the Regione Emilia-Romagna (RER), Italy, in 2014.

OUTCOME MEASURES: Models designed to predict risk of hospitalisation or death in …

Analysis Of Clinical Data To Determine The Minimum Number Of Sensors Required For Adequate Skin Temperature Monitoring Of Superficial Hyperthermia Treatments., Akke Bakker, Rebecca Holman, Dario B. Rodrigues, Hana Dobšíček Trefná, Paul R. Stauffer, Geertjan Van Tienhoven, Coen R.N. Rasch, Hans Crezee

Department of Radiation Oncology Faculty Papers

PURPOSE: Tumor response and treatment toxicity are related to minimum and maximum tissue temperatures during hyperthermia, respectively. Using a large set of clinical data, we analyzed the number of sensors required to adequately monitor skin temperature during superficial hyperthermia treatment of breast cancer patients.

METHODS: Hyperthermia treatments monitored with >60 stationary temperature sensors were selected from a database of patients with recurrent breast cancer treated with re-irradiation (23 × 2 Gy) and hyperthermia using single 434 MHz applicators (effective field size 351-396 cm²). Reduced temperature monitoring schemes involved randomly selected subsets of stationary skin sensors, and another subset …

A Novel Approach To Debriefing Medical Simulations: The Six Thinking Hats., Xiao Chi Zhang, Hyunjoo Lee, Carlos Rodriguez, Joshua Rudner, Dimitrios Papanagnou

Department of Emergency Medicine Faculty Papers

Simulation has become a standard training method in emergency medicine (EM). Specifically, post-simulation debriefings offer participants the opportunity for reflection while exposing their knowledge and practice gaps. The educational yield of these debriefings, however, is contingent on the debriefer's skills. Without professional development, faculty and educators may not be equipped with supportive debriefing strategies. We propose the Six Thinking Hats (6TH), originally developed by Edward de Bono (1970) as a debriefing framework to support effective, high-yield debriefing conversations. The six colored hats represent six unique approaches to critical thinking. The white hat represents the facts; the green hat, creativity and …

Cd8+ T-Cell Responses In Vaccination: Reconsidering Targets And Function In The Context Of Chronic Antigen Stimulation, Gabriela L. Cosma, Laurence Eisenlohr

Department of Microbiology and Immunology Faculty Papers

Cytotoxic CD8 T cells play important roles in eliminating infected and transformed cells. Owing to their potential for therapeutic applications, significant efforts are dedicated toward developing CD8 T cell-based vaccines. Thus far, CD8 T-cell vaccination strategies have had limited success therapeutically in contrast to those targeting antibody-based immunity. However, if the current challenges and gaps in the understanding of T-cell biology are overcome, the full potential of rational CD8 T-cell vaccine design might be realized. Here, we review recent progress in this direction, focusing on target selection and maintenance of function in the settings of chronic infections and cancers.

Associations Between Feeding Practices And Growth And Neurodevelopmental Outcomes, Barbara T. Do, Nellie I. Hansen, Carla Bann, Rebecca L. Lander, Shivaprasad S. Goudar, Omrana Pasha, Elwyn Chomba, Sangappa M. Dhaded, Vanessa R. Thorsten, Jan L. Wallander, Fred J. Biasini, Richard Derman, Robert L. Goldenberg, Waldemar A. Carlo

Global Health Articles

Background

Feeding practices over the first several years of a child’s life can critically influence development. The purpose of this study was to examine associations between feeding practices and growth and neurodevelopmental outcomes at 36 months of age among children from low- and low-middle-income countries (LMIC).

Methods

We conducted a secondary analysis using data collected from children in India, Pakistan, and Zambia who were enrolled in a randomized controlled trial of a home-based early development intervention program called Brain Research to Ameliorate Impaired Neurodevelopment Home-based Intervention Trial. Qualitative dietary data collected at 36 months was used to assess the modified …

A 6-Week Hip Muscle Strengthening And Lumbopelvic-Hip Core Stabilization Program To Improve Pain, Function, And Quality Of Life In Persons With Patellofemoral Osteoarthritis: A Feasibility Pilot Study., Lisa T. Hoglund, Laura Pontiggia, John D. Kelly

Department of Physical Therapy Faculty Papers

Background: Patellofemoral joint (PFJ) osteoarthritis (OA) is prevalent in middle-aged and older adults. Despite this, there are minimal studies which have examined conservative interventions for PFJ OA. Weakness of proximal lower extremity muscles is associated with PFJ OA. It is unknown if a hip muscle strengthening and lumbopelvic-hip core stabilization program will improve symptoms and function in persons with PFJ OA. This study examined the feasibility and impact of a 6-week hip muscle strengthening and core stabilization program on pain, symptoms, physical performance, peak muscle torques, and quality of life in persons with PFJ OA.

Methods: Ten females with PFJ …

Epigenetic Regulation Of Tumor Suppressors By Helicobacter Pylori Enhances Ebv-Induced Proliferation Of Gastric Epithelial Cells, Saurabh Pandey, Hem Chandra Jha, Sanket Kumar Shukla, Meghan K. Shirley, Erle S. Robertson

Department of Medicine Faculty Papers

Helicobacter pylori and Epstein-Barr virus (EBV) are two well-known contributors to cancer and can establish lifelong persistent infection in the host. This leads to chronic inflammation, which also contributes to development of cancer. Association with H. pylori increases the risk of gastric carcinoma, and coexistence with EBV enhances proliferation of infected cells. Further, H. pylori-EBV coinfection causes chronic inflammation in pediatric patients. We have established an H. pylori-EBV coinfection model system using human gastric epithelial cells. We showed that H. pylori infection can increase the oncogenic phenotype of EBV-infected cells and that the cytotoxin-associated gene (CagA) protein encoded by H. …

Contrast-Enhanced Ultrasound Identifies Early Extrahepatic Collateral Contributing To Residual Hepatocellular Tumor Viability After Transarterial Chemoembolization., Sriharsha Gummadi, Maria Stanczak, Andrej Lyshchik, Flemming Forsberg, Colette M. Shaw, John R. Eisenbrey

Department of Radiology Faculty Papers

The mainstay of treatment for unresectable hepatocellular carcinoma is locoregional therapy including percutaneous ablation and transarterial chemo- and radioembolization. While monitoring for tumor response after transarterial chemoembolization is crucial, current imaging strategies are suboptimal. The standard of care is contrast-enhanced magnetic resonance imaging or computed tomography imaging performed at least 4 to 6 weeks after therapy. We present a case in which contrast-enhanced ultrasound identified a specific extra-hepatic collateral from the gastroduodenal artery supplying residual viable tumor and assisting with directed transarterial management.

Partnering For Success! Occupational Therapy, Industrial Design, & Medicine: Creating Innovative Solutions, Brenna Jacko, Ots, Megan Vesey, Ots, Nuriya Neumann, Ots, Mikael Avery, Ms, Otr/L, M. Arch, Kim Mollo, Otd, Otr/L

Department of Occupational Therapy Posters and Presentations

No abstract provided.

Reflecting The Communities That We Serve: Embracing Diversity And Inclusion Initiatives In Occupational Therapy Education, Jonette Ishmael, Ots, Nuriya Neumann, Ots, Tracey Vause-Earland, Otr/L, Phd

Department of Occupational Therapy Posters and Presentations

Background

• There is a current lack of diversity seen in OT classrooms across the country.
• It is paramount we create a diverse occupational therapy student body in order to meet the needs of the diverse communities we serve.
• Students, educators, and therapists, need to develop cultural reflexivity, humility and safety when serving patients of various background (Taff & Blash, 2017).
• Through establishing diversity and inclusion initiatives within OT education we can increase awareness and provide education that will radically shape the OT workforce in coming years.
• Efforts to diversify OT programs is key to progressing as a profession, and reflecting …

Multi-Institution Analysis Of Racial Disparity Among African- American Men Eligible For Prostate Cancer Active Surveillance, Michael Dinizo, Weichung Shih, Young Suk Kwon, Daniel Eun, Adam Reese, Laura Giusto, Edouard J. Trabulsi, Bertram Yuh, Nora Ruel, Daniel Marchalik, Jonathan Hwang, Shilajit D. Kundu, Scott Eggener, Isaac Yi Kim

Department of Urology Faculty Papers

There is a significant controversy on whether race should be a factor in considering active surveillance for low-risk prostate cancer. To address this question, we analyzed a multi-institution database to assess racial disparity between African-American and White-American men with low risk prostate cancer who were eligible for active surveillance but underwent radical prostatectomy. A retrospective analysis of prospectively collected clinical, pathologic and oncologic outcomes of men with low-risk prostate cancer from seven tertiary care institutions that underwent radical prostatectomy from 2003–2014 were used to assess potential racial disparity. Of the 333 (14.8%) African-American and 1923 (85.2%) White-American men meeting active …

Rehabilitation: The Health Strategy Of The 21st Century., Gerold Stucki, Jerome Bickenbach, Christoph Gutenbrunner, John L. Melvin

Department of Rehabilitation Medicine Faculty Papers

There is strong evidence that population ageing and the epidemiological transition to a higher incidence of chronic, non-communicable diseases will continue to profoundly impact societies worldwide, putting more pressure on healthcare systems to respond to the needs of the people they serve. These trends argue for the need to address what matters to people about their health: limitations in their functioning that affect their day-to-day actions and goals in life. From its inception, rehabilitation, 1 of the 4 health strategies identified in the Declaration of Alma Ata in 1978, has had functioning as its outcome of interest. Its practitioners are …

Strengthening Health-Related Rehabilitation Services At National Levels., Christoph Gutenbrunner, Jerome Bickenbach, John L. Melvin, Jorge Lains, Boya Nugraha

Department of Rehabilitation Medicine Faculty Papers

OBJECTIVE: One of the aims of the World Health Organization's Global Disability Action Plan is to strengthen rehabilitation services. Some countries have requested support to develop (scale-up) rehabilitation services. This paper describes the measures required and how (advisory) missions can support this purpose, with the aim of developing National Disability, Health and Rehabilitation Plans.

RECOMMENDATIONS: It is important to clarify the involvement of governments in the mission, to define clear terms of reference, and to use a systematic pathway for situation assessment. Information must be collected regarding policies, health, disability, rehabilitation, social security systems, the need for rehabilitation, and the …

Scaling Up Rehabilitation - Towards An International Policy Agenda., Christoph Gutenbrunner, Jerome Bickenbach, Kristian Borg, Boya Nugraha, John L. Melvin, Gerold Stucki

Department of Rehabilitation Medicine Faculty Papers

No Abstract (Guest Editorial).

Spontaneous Coronary Artery Dissection: A Case Series Of 9 Patients With Literature Review., Ali Raza Ghani, Md, Faisal Inayat, Nouman Safdar Ali, Reema Anjum, Michael Viray, Arsalan Talib Hashmi, Iqra Riaz, Bruce D. Klugherz, Hafeez Ul Hassan Virk

Abington Jefferson Health Papers

Spontaneous coronary artery dissection is an increasingly recognized nonatherosclerotic cause of acute coronary syndrome. Reports regarding the prognosis and natural history of this disease are limited. In addition to the diagnostic difficulty, this condition poses a significant therapeutic challenge due to the lack of specific management guidelines. We present here a case series of 9 patients with spontaneous coronary artery dissection. Additionally, this article reviews the incidence, clinical characteristics, risk factors, diagnostic modalities, therapeutic approaches, and patterns of recurrence in patients with spontaneous coronary artery dissection.

Evaluation Of Hepatocellular Carcinoma Transarterial Chemoembolization Using Quantitative Analysis Of 2d And 3d Real-Time Contrast Enhanced Ultrasound., Kibo Nam, Maria Stanczak, Andrej Lyshchik, Priscilla Machado, Yuko Kono, Flemming Forsberg, Colette M. Shaw, John R. Eisenbrey

Department of Radiology Faculty Papers

Quantitative 2D and 3D contrast-enhanced ultrasound (CEUS) was assessed to evaluate early transarterial chemoembolization (TACE) treatment response. Seventeen patients scheduled for TACE for the treatment of hepatocellular carcinoma participated in the study. 2D and 3D CEUS were performed for each patient at three time points: Prior to TACE, 1-2 weeks post TACE, and 1 month post TACE. Peak-intensities of the tumor and surrounding liver tissue were calculated from 2D and 3D data before and after TACE and used to evaluate tumor treatment response. Residual tumor percentages were calculated from 2D and 3D CEUS acquired 1-2 weeks and 1 month post …

Primary Care-Ot For Older African Americans With Diabetes And Mild Cognitive Impairment: Intervention Approaches And Case Stories, Catherine Verrier Piersol, Phd, Otr/L, Faota, Susan Santalucia, Ms, Otr/L, Michele Rifkin, Mhsed, Otr/L, Barry Rovner, Md, Robin Casten, Phd, Neva White, Np, Crnp, Cde

Department of Occupational Therapy Posters and Presentations

Purpose:

To test the efficacy of a collaborative intervention to lower hemoglobin A1c levels (HbA1c) in older African Americans with Type 2 diabetes (DM), Mild Cognitive Impairment (MCI), and suboptimal medication adherence and glycemic control.

Aims:

1. To reduce HbA1c level by 0.5% at 6 and 12 months.
2. To increase MEMS-measured adherence to an oral DM medication at 6 and 12 months.

Hypotheses:

1. Fifty-five percent of intervention participants, compared to 25% of control participants, will have a reduction in HbA1c of 0.5% at 6 months (short term effect) and 12 months (maintenance effect).
2. The Primary Care-Occupational Therapy intervention will increase MEMS-measured …

Preclinical Comparison Of Proteasome And Ubiquitin E1 Enzyme Inhibitors In Cutaneous Squamous Cell Carcinoma: The Identification Of Mechanisms Of Differential Sensitivity, Angela Mchugh, Kenneth Fernandes, Andrew P. South, Jemima E. Mellerio, Julio C. Salas-Alanis, Charlotte M. Proby, Irene M. Leigh, Mark K. Saville

Department of Dermatology and Cutaneous Biology Faculty Papers

Proteasome inhibitors have distinct properties and the biochemical consequences of suppressing ubiquitin E1 enzymes and the proteasome differ. We compared the effects of the proteasome inhibitors bortezomib, ixazomib and carfilzomib and the ubiquitin E1 enzyme inhibitor MLN7243/TAK-243 on cell viability and cell death in normal keratinocytes and cutaneous squamous cell carcinoma (cSCC) cell lines. The effects of both a pulse of treatment and more extended incubation were investigated. This is relevant to directly-delivered therapy (topical treatment/intratumoral injection) where the time of exposure can be controlled and a short exposure may better reflect systemically-delivered inhibitor pharmacokinetics. These agents can selectively kill …