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Evidence-Based Elements Of Child Welfare In-Home Services, Lisa E. D'Aunno, Shamra Boel-Studt, Miriam J. Landsman

Journal of Family Strengths

In this article we discuss evidence-based elements of effective in-home child welfare services as a foundation for advancing the evidence base for family-centered child welfare practice. In 2009 the U.S. Children’s Bureau established the National Resource Center for In-Home Services to build the capacity of state and tribal child welfare agencies to ensure the safety and well-being of children and youth in their homes, prevent their initial placement or re-entry into out-of-home care, and to support families in their role as primary caregivers. Through a nationwide assessment of in-home services conducted over four years of research and technical assistance, we …

Development And Evaluation Of The Family Asset Builder: A New Child Protective Services Intervention To Address Chronic Neglect, Tyler W. Corwin, Erin J. Maher, Monica Idzelis Rothe, Maggie Skrypek, Caren Kaplan, Dan Koziolek, Brenda Mahoney

Journal of Family Strengths

Over the past 20 years, neglect has been the most pervasive form of child maltreatment in the United States, affecting more than half a million children annually. Further, neglect is more likely than other forms of maltreatment to occur repeatedly within child welfare-involved families. Children experiencing neglect, especially early in childhood and with regularity, face long-term deleterious effects on their physical, cognitive, social, and emotional development. Despite the ubiquity of neglect throughout child welfare and the potentially devastating consequences, interventions designed to target families chronically reported to Child Protective Services (CPS) for neglect are scant. The Family Asset Builder intervention …

Mdm2-Mediated Degradation Of Sirt6 Phosphorylated By Akt1 Promotes Tumorigenesis And Trastuzumab Resistance In Breast Cancer, Umadevi Thirumurthi

Dissertations and Theses (Open Access)

Sirtuin6 (SIRT6) is one of the members of the Sirtuin family and functions as a longevity assurance gene by promoting genomic stability. It also regulates various cancer-associated pathways and was recently established as a bonafide tumor suppressor in colon cancer. This suggests that SIRT6 is an attractive target for pharmacological activation in cancer treatment, and hence, identification of potential regulators of SIRT6 would be an important and critical contribution towards cancer treatment. Here, we show that AKT1 phosphorylates SIRT6 at Ser³³⁸ and induces MDM2-SIRT6 interaction, priming SIRT6 for degradation via the MDM2-dependent ubiquitin-proteasome pathway. Blocking SIRT6 Ser³³⁸ phosphorylation …

Association Of Cardiorespiratory Fitness And Adiposity With Inflammatory Biomarkers In Young Adults, Eunduck Park

Dissertations and Theses (Open Access)

Background: Low grade systemic inflammation plays a key role in atherosclerosis, and C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor- alpha (TNF -a), markers of systemic inflammation, are associated with cardiovascular events and adiposity. Cardiorespiratory fitness has shown health benefits by reducing circulating levels of inflammatory markers. However, it remains uncertain whether the negative association between cardiorespiratory fitness and inflammatory biomarkers is due to cardiorespiratory fitness itself or results from lower levels of adiposity. Moreover, the evidence examining the interaction between cardiorespiratory fitness and adiposity in inflammation in young adults is lacking.

Purpose: The aims of this study were …

Novel Serum Biomarkers For Lung Cancer Early Diagnosis And Clinical Outcome, Fanmao Zhang

Dissertations and Theses (Open Access)

The five-year survival rate for all stages of lung cancer combined is only 17%, which has changed little over the past 40 years. Despite the tremendous efforts made, serum biomarkers with clinical utility for lung cancer early detection and clinical outcome prediction are still lacking. Metabolic alterations have been recognized as an emerging hallmark of cancer. We aimed to investigate the metabolic changes associated with lung cancer and to identify novel clinically applicable serum biomarkers for lung cancer early diagnosis and clinical outcome.

Serum metabolites are potential biomarkers for lung cancer early detection. We first performed global metabolomic profiling followed …

Genetic Predictors Of Metabolic Side Effects Of Diuretic Therapy, Jorge L. Del Aguila

Dissertations and Theses (Open Access)

Thiazide diuretics are a recommended first-line monotherapy for hypertension (i.e.SBP>140 mmHg or DBP>90 mmHg). Even so, diuretics are associated with adverse metabolic side effects, such as hyperlipidemia, hyperglycemia and hypokalemia which increase the risk of developing type II diabetes. This thesis used three analytical strategies to identify and quantify genetic factors that contribute to the development of adverse metabolic effects due to thiazide diuretic treatment. I performed a genome-wide association study (GWAS) and meta-analysis of the change in fasting plasma glucose and triglycerides in response to HCTZ from two different clinical trials: the Pharmacogenomic Evaluation of Antihypertensive Responses …

Dissecting The Roles Of Trim24 In Regulation Of Hepatic Lipid Metabolism And Inflammation, Lindsey C. Minter

Dissertations and Theses (Open Access)

DISSECTING THE ROLES OF TRIM24 IN REGULATION OF HEPATIC LIPID

METABOLISM AND INFLAMMATION

Lindsey Cauthen Minter, B.S., B.A.

Advisory Professor: Michelle C. Barton, Ph.D.

In this dissertation, I report the characterization of a new mouse model that recapitulates development of hepatocellular carcinoma (HCC) following spontaneous hepatic lipid accumulation, inflammation, and damage of liver tissue, due to complete loss of Trim24 expression. In human HCC and other cancers, TRIM24 expression is aberrantly high, while deletion of TRIM24 in the mouse has been shown to act as a liver specific tumor suppressor. The hypothesis tested here was that TRIM24, the E3 ubiquitin …

Angiomotin Is A Novel Cadherin-11 Interacting Protein That Mediates Migration In Prostate Cancer Cells, Angelica Ortiz

Dissertations and Theses (Open Access)

Prostate cancer (PCa), the second leading cause of cancer-related deaths among men in the United States, has the proclivity to metastasize to bone resulting in sclerotic lesions. These cancer induced bone growths cause bone pain and fractures. Therefore, understanding the molecular mechanisms contributing to PCa bone metastasis is required in order to find better prognostic tools and suitable targets for metastasis treatment and/ or prevention. Previous work in our laboratory showed increased expression of cadherin-11 (Cad11), a mesenchymal cadherin, during PCa progression. Furthermore, Cad11 expression endows PCa cells with increased migratory potential and metastasis to bone. Deletion of the Cad11 …

Energy Stress Causes Chaperones To Assemble Into Cytoplasmic Complexes, Kimberly J. Cope

Dissertations and Theses (Open Access)

The majority of proteins require molecular chaperones to assist their folding into tertiary and quaternary structures. Certain stresses can compromise the weak hydrophobic forces responsible for these structures and lead to protein unfolding, misfolding, and aggregation. Aggregates of proteins are hallmarks of devastating diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Fortunately, bacteria, plants, and fungi have a potent disaggregase, named Hsp104 in Saccharomyces cerevisiae. Recently, heat-induced aggregates, termed Q-bodies, were found to contain three molecular chaperones: Hsp70, Hsp104, and Hsp42. Their coalescence from small puncta into larger inclusions required Hsp104. During glucose deprivation, a stress that isn’t known to …

A National Survey Of Parent Support Legislation And Regulations, Nancy P. Correa, Bethanie Van Horne, Bracewell & Giuliani Llp, Christopher Greeley, Angelo P. Giardino

Journal of Applied Research on Children: Informing Policy for Children at Risk

Introduction: Parent education has a positive impact on children, parents, families, and the community. CHILDREN AT RISK and Bracewell & Giuliani LLP conducted a policy scan of state statutes regarding parent education.

Methodology: To identify state statutes that address parent education, we conducted a search of statutes in all 50 states using keywords and the online legal research systems. After all state-level policies were ascertained, we selected the most relevant statutes to parent education and identified major themes.

Results: The policy scan identified statutes regarding non-mandated parent education in 40 out of the 50 states. Common themes include: home visitation …

Is It Time To Do More Homework On The Impact Of Childhood Obesity On Academic Achievement?, Shreela V. Sharma

Journal of Applied Research on Children: Informing Policy for Children at Risk

Purpose: To provide commentary on the research article “Impact of Pediatric Obesity on Grades in Elementary School,” by Craig A. Johnston, Jennette P. Moreno, Sandra A. Stansberry, and Deborah Woehler .

Findings: In this cross-sectional study the authors examine the association between weight status and math, science and reading grades among 798 2^nd grade children in Texas. The authors show that academic performance, specifically math grades are lower in obese students compared to normal weight students. Finally, the authors propose several physiological and psychological mechanisms including the potential for teacher bias and lower expectations from children who are obese. …

Informing Parent Targeted Interventions To Promote Increased Physical Activity Among Youth, Teresia O'Connor

Journal of Applied Research on Children: Informing Policy for Children at Risk

Invited Commentary on "Examining the Disconnect Between Parents' Perceptions and Reality Regarding the Physical Activity Levels of Their Children."

Impact Of Pediatric Obesity On Grades In Elementary School, Craig A. Johnston, Jennette P. Moreno, Tzu-An Chen, Sandra A. Stansberry, Deborah Woehler

Journal of Applied Research on Children: Informing Policy for Children at Risk

Objective: The current study examines the relationship between obesity and academic performance among second grade students. We hypothesized that students who were overweight or obese would have poorer grades than students who were normal weight.

Design: Cross-sectional.

Setting: Seven elementary schools from a southeast Texas Independent School District.

Participants: The sample was composed of 798 ethnically and racially diverse elementary school children. Students were classified as normal weight, overweight, and obese.

Main Outcome Measures: Differences in cumulative grades (math, science, and reading) across weight classifications were examined using sex, race/ethnicity, and school socioeconomic level as covariates. Additionally, all subject areas …

Project Passport: An Integrated Group-Centered Approach Targeting Pregnant Teens And Their Partners, Ruth S. Buzi, Peggy B. Smith, Constance M. Wiemann, Melissa F. Peskin, Mariam R. Chacko, Claudia Kozinetz A.

Journal of Applied Research on Children: Informing Policy for Children at Risk

Objective: To describes the development of Project Passport, a perinatal intervention designed to reduce negative outcomes among pregnant teens. Methods: A logic model guided the planning, development and evaluation plan for the intervention. It included the selection of health goals, behaviors to be targeted, determinants of the selected behaviors, and activities to impact each selected determinant. Results: The process resulted in the formulation of an intervention that incorporates CenteringPregnancy, a group model of prenatal care, Positive Youth Development components, and male involvement. The evaluation examines the effectiveness of the intervention in enhancing health, educational and psychosocial outcomes among …

Factors Associated With Physical Activity In Kindergarten Children, Carol Hammonds

Dissertations and Theses (Open Access)

Background: Reversing obesity is an urgent public health need for children: worldwide, in 2011 more than 40 million children under the age of five were either overweight or obese. Increasing intensity and duration of physical activity is a strategy to aid in preventing and reducing obesity. A minimum of 60 minutes per day of moderate to vigorous physical activity is recommended for children. School settings, such as full-day kindergarten, where 74% of children in the United States are enrolled, provide opportunities for population-based interventions to increase physical activity, yet little objective data exist on current levels of physical activity in …

How Do Black Nulliparous Women Cognitively Construct Birth?, Marianne F. Moore

Dissertations and Theses (Open Access)

A focused ethnography was conducted to determine the cognitive constructions about birth described by nulliparous Black women in an urban area of the Southwestern US; also, during postpartum, how do these women reconcile expectations with the actual birth? Semi-structured interviews were conducted before birth and after birth.

Women, 16 or older, 17 - 33 weeks carrying a singleton fetus and without anomalies or problems like pre-gestational diabetes, NYHA Cardiac Class III/IV, cancer, renal failure, or sickle cell anemia that eliminated vaginal birth were sequentially recruited and sampled in an affiliated ultrasound clinic. Women scheduled for an anatomy scan were approached. …

Imbalance Between Neutrophil Elastase And Elafin Promotes Breast Cancer Growth And Progression, Joseph Anthony Caruso

Dissertations and Theses (Open Access)

Elafin, an endogenous serine protease inhibitor, is a critical component of the epithelial barrier against neutrophil elastase (NE) activity. The central hypothesis examined in this dissertation was that elafin has tumor suppressive properties in breast cancer. In support of this hypothesis, immunohistochemical (IHC) analysis revealed that elafin was downregulated in the majority of invasive breast tumors and a subset of pre-invasive ductal carcinoma in situ (DCIS) compared to elafin expression in the normal mammary epithelium. To understand the role of elafin in the mammary epithelium and the impetus for its downregulation during breast tumorigenesis, primary and immortalized human mammary epithelial …

Anti-Gd2 Etoposide-Loaded Immunoliposomes For The Treatment Of Gd2 Positive Tumors, Brandon S. Brown

Dissertations and Theses (Open Access)

Systemic chemotherapeutics remain the standard of care for most malignancies even though they frequently suffer from narrow therapeutic index, poor serum solubility, and off-target effects. Monoclonal antibodies that specifically bind antigens overexpressed on many tumors such as the ganglioside, GD2, can be conjugated to drug-loaded liposomes to create a targeted drug delivery system. In this study, we have encapsulated etoposide, a topoisomerase inhibitor effective against a wide range of cancers, in surface modified liposomes decorated with anti-GD2 antibodies. We characterized the properties of the liposomes using a variety of methods including dynamic light scattering, electron microscopy, and Fourier transformed infrared …

Regulation Of The Candida Albicans Arginine Biosynthetic Pathway, Claudia Jimenez Lopez

Dissertations and Theses (Open Access)

Candida albicans is the most importan thuman-associatedfungus.It is a commensal microorganism but also an opportunistic pathogen able to cause superficial infections aswellaslife-threateninginfectionswhich are associated with a highmortalityrateof 50%. The interactions between C. albicans and the cells of the mammalian innate immune system, which confer the most important protecting mechanisms against disseminated infections, are very dynamic and determine the success of C. albicans as a pathogen. Transcriptional profiling has shown that phagocytosis of C. albicans by macrophages results primarily in the activation of alternative carbon metabolism pathways suggesting that the pathogen is exposed to a glucose poor environment. Changes in …

Related Resources

Journal of Applied Research on Children: Informing Policy for Children at Risk

Related Resources for Accountable Communities.

Solvitur Ambulando: It Is Solved By Walking, Megan Dickerson

Journal of Applied Research on Children: Informing Policy for Children at Risk

Though a significant portion of the conversation around “play provision” focuses on the quality and availability of community playgrounds, the majority of children’s play occurs in transitional spaces: sidewalks and other spaces not designed for children but used by children daily. This Perspective from the Field briefly reviews the late 19^th century roots of the American playground and argues that though a focus on playground provision may draw attention to the importance of safe play spaces, a focus on playgrounds alone is limiting. Given playgrounds’ historical rootings, the omnipresent KFC (Kit, Fence and Carpet) playground begins to seem a …

Real School Gardens Program: Learning Gardens And Teacher Training To Improve Student Engagement And Academic Performance In Low-Performing Elementary Schools, Jeanne Mccarty

Journal of Applied Research on Children: Informing Policy for Children at Risk

Children who grow up in poverty are less likely to graduate high school, enter college and find economic stability. REAL School Gardens believes the right educational opportunities – ones that engage and motive children to learn – can break this cycle. The REAL School Gardens Program builds learning gardens and offers teacher training to improve academic engagement and performance in low-income elementary schools. Since its launch, REAL School Gardens has partnered with 92 low-income schools, and preliminary findings show that 84% of students experiencing hands-on academic lessons in a REAL School Garden report high levels of engagement, specifically in math …

Socioeconomic And Cultural County-Level Factors Associated With Race/Ethnic Differences In Body Mass Index In 4th Grade Students In Texas, Jennifer J. Salinas, Manasi S. Shah, Jennifer L. Gay, Ken Sexton, Eileen Nehme, Dorothy Mandell, Deanna M. Hoelscher

Journal of Applied Research on Children: Informing Policy for Children at Risk

Purpose: To evaluate the relationship between county-level socioeconomic environment and the propensity to be overweight or obese by race/ethnic group in a sample of fourth grade children the Texas public school system.

Methods: The data used come from the School Physical Activity and Nutrition (SPAN) surveillance study – a surveillance study of school-aged children in Texas. The outcome variable used was Body Mass Index (BMI) categorized as underweight/normal/healthy, overweight, and obese. Exposure variables were derived from county-level Hispanic and Black concentration and socioeconomic data using the Human Security Index (HSI) as a framework. We made comparisons between Non-Hispanic White, Black …

Accountable Communities: A Concept Broader Than Health Care, Angelo P. Giardino, Robert D. Sanborn

Journal of Applied Research on Children: Informing Policy for Children at Risk

Angelo Giardino and Robert Sanborn's introduction for Volume 4, Issue 2: Accountable Communities: Healthier Neighborhoods, Healthier Children.

Attributing Meaning To Online Social Network Analysis For Tailored Socio-Behavioral Support Systems, Sahiti Myneni

Dissertations and Theses (Open Access)

Ubiquitous online social networks provide us with a unique opportunity to deliver scalable interventions for the support of lifestyle modifications in order to change behaviors that predispose toward cancer and other diseases. At the same time these networks act as rich data sources to inform our understanding of end-user needs. Traditionally, social network analysis is based on communication frequency among members. In this work, I introduce communication content as a complementary frame for studying these networks.

QuitNet, an online social network developed to provide smoking cessation support is considered for analysis. Qualitative coding, automated content analysis, and network analysis were …

Mtorc1 Signaling In Memory Formation And Dysfunction, Natalia S. Rozas De O'Laughlin

Dissertations and Theses (Open Access)

The mechanistic Target of Rapamycin Complex 1 (mTORC1) pathway integrates cellular availability of growth factors, energy and amino acids to regulate protein synthesis and autophagy. The mTORC1 pathway has also been shown to be required for memory consolidation, and its dysregulation is associated with many neurological disorders. MTORC1 is negatively regulated by the tuberous sclerosis complex (TSC1/2). When ATP and growth factors are available, TSC1/2 is inhibited and mTORC1 activity can be restored. In a complementary regulatory pathway, amino acids signal to mTORC1 through the Rag GTPases and Ragulator complex, which modulate the translocation of mTORC1 from the cytoplasm to …

Altered Ovarian Cancer Metabolism Increases Neuronal N-Acetylaspartate To Promote Tumor Growth, Behrouz Zand

Dissertations and Theses (Open Access)

Background: Altered metabolism is a well-established trait in many cancers, and is an emerging hallmark of cancer. Recent resurgence of cancer metabolism studies has identified dysregulated metabolic pathways that produce novel oncometabolites in various cancers. However, large scale studies of dysregualted high grade serous epithelial ovarian cancers (HGSOC) are unknown.

Materials and Methods: Following IRB approval, metabolic profiling of 101 HGSOC patients and 15 normal ovaries were obtained using GC/LC mass spectrometry from 2 U.S. academic centers to identify highly up-regulated metabolites. Samples from a cohort of 135 and 208 patients from a single institution were evaluated for gene expression …

T-Cell Treatments For Solid And Hematological Tumors, Drew C. Deniger

Dissertations and Theses (Open Access)

Cell-based therapies have demonstrated potency and efficacy as cancer treatment modalities. T cells can be dichotomized by their T cell receptor (TCR) complexes where alpha/beta T cells (95% of T cells) and gamma/delta T cells (+T cells proliferated to clinically significant numbers and ROR1⁺ tumor cells were effectively targeted and killed by both ROR1-specific CAR⁺ T cell populations, although ROR1RCD137 were superior to ROR1RCD28 in clearance of leukemia xenografts in vivo. The second specific aim focused on generating bi-specific CD19-specific CAR⁺ gamma/delta T cells with polyclonal TCRgamma/delta repertoire on CD19⁺ artificial antigen presenting cells (aAPC). …

Novel Inducers Of Gliotoxin Production In Aspergillus Fumigatus, Taylor J. Schoberle

Dissertations and Theses (Open Access)

Secondary metabolites are produced by numerous organisms and can either be benign to humans or harmful. Genes involved in the synthesis and transport of these secondary metabolites are frequently found in gene clusters, which are often located in subtelomeric regions of the chromosome. These clusters are often coordinately regulated, being almost exclusively dependent on transcription factors that are located within the clusters themselves. Secondary metabolites are also regulated by a variety of factors, including nutritional factors, environmental factors and developmental processes. Gliotoxin, which is produced by a variety of Aspergillus species, Trichoderma species, and Penicillium species, exhibits immunosuppressive properties and …

Development And Characterization Of An In Vitro Four-Species Anaerobic Dental Biofilm Model, Fernando Andrade

Dissertations and Theses (Open Access)

Dental caries is the most common chronic disease worldwide. It is characterized by the demineralization of tooth enamel caused by acid produced by cariogenic dental bacteria growing on tooth surfaces, termed bacterial biofilms. Cariogenesis is a complex biological process that is influence by multiple factors and is not attributed to a sole causative agent. Instead, caries is associated with multispecies microbial biofilm communities composed of some bacterial species that directly influence the development of a caries lesion and other species that are seemingly benign but must contribute to the community in an uncharacterized way. Clinical analysis of dental caries and …