Digital Commons Network^™

Pim Kinase Inhibition: Single Agent And Combination Approaches In B-Cell Lymphoma, Qingshan Yang

Dissertations and Theses (Open Access)

Proviral integration site for Moloney murine leukemia virus (Pim) kinases are Ser/Thr/Tyr kinases. They modulate B-cell development but become oncoproteins and promote cancer development once overexpressed. Containing three isoforms, Pim-1, -2 and -3 are known to phosphorylate various substrates that regulate transcription, translation, cell cycle, and survival pathways in both hematological and solid tumors.

Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma. Elevated Pim kinase levels are common in MCL, and it negatively correlates with patient outcome. SGI-1776 is a small molecule inhibitor selective for Pim-1/-3. We hypothesize that SGI-1776 treatment in MCL will inhibit Pim kinase function, and …

Knowledge And Expectations Of Support People In Prenatal Genetic Counseling Sessions, Michelle A. Mcdougle

Dissertations and Theses (Open Access)

Prenatal genetic counseling patients have the ability to choose from a myriad of screening and diagnostic testing options, each with intricacies and caveats regarding accuracy and timing. Decisions regarding such testing can be difficult and are often made on the same day that testing is performed. Therefore, it is reasonable to consider that the support people brought to an appointment may have a role in the decision-making process. We aimed to better define this potential role by examining the incoming knowledge and expectations of support people who attended prenatal genetic counseling appointments.

Support people were asked to complete a survey …

An Assessment Of Knowledge And Attitudes Of Genetic Counseling Services In U.S. Htcs, Brad Rolf, Deborah Brown, Miguel Escobar, Syed Hashmi M.D., Ph.D, Aroub Ayham Khleif, Sarah Noblin, Marianna Raia

Dissertations and Theses (Open Access)

Hemophilia is a hereditary bleeding disorder which requires lifelong specialized care. A network of Hemophilia Treatment Centers (HTCs) exists to meet the medical needs of patients affected by hemophilia. Genetic counseling services are an integral part of the HTC model of care; however, many HTCs do not have genetic counselors on staff. As a result, the duty to provide these services must fall to other healthcare providers within the HTC. To assess the knowledge and attitudes of these providers we developed a 49 question survey that was distributed electronically to hematologists and nurses at U.S. HTCs. The survey consisted of …

Stimulation Through Tlr4 Increases Fviii Inhibitor Formation In A Mouse Model Of Hemophilia A, Claire K. Holley

Dissertations and Theses (Open Access)

Hemophilia A is a clotting disorder caused by functional factor VIII (FVIII) deficiency. About 25% of patients treated with therapeutic recombinant FVIII develop antibodies (inhibitors) that render subsequent FVIII treatments ineffective. The immune mechanisms of inhibitor formation are not entirely understood, but circumstantial evidence indicates a role for increased inflammatory response, possibly via stimulation of Toll-like receptors (TLRs), at the time of FVIII immunization. I hypothesized that stimulation through TLR4 in conjunction with FVIII treatments would increase the formation of FVIII inhibitors. To test this hypothesis, FVIII K.O. mice were injected with recombinant human FVIII with or without concomitant doses …

Delayed Thrombus Resolution And Fibroproliferative Vascular Wound Healing From Deficiency Of Type Iii Collagen: A Paradoxical Mechanism For Tissue Fragility, Amy J. Reid

Dissertations and Theses (Open Access)

Vascular Ehlers-Danlos syndrome is a heritable disease of connective tissue caused by mutations in COL3A1, conferring a tissue deficiency of type III collagen. Cutaneous wounds heal poorly in these patients, and they are susceptible to spontaneous and catastrophic rupture of expansible hollow organs like the gut, uterus, and medium-sized to large arteries, which leads to premature death. Although the predisposition for organ rupture is often attributed to inherent tissue fragility, investigation of arteries from a haploinsufficient Col3a1 mouse model (Col3a1^+/-) demonstrates that mutant arteries withstand even supraphysiologic pressures comparably to wild-type vessels. We hypothesize that injury …

Connecting Public Libraries With Community Emergency Responders, Michelle Malizia, Karen Vargas, Rebecca Hamilton, Deborah Littrell, Cynthia Olney

Library Staff Publications

No abstract provided.

Ms 015 Guide To Joseph Melnick, Phd Papers (1943-1989), Joseph Melnick (1914-2001)

Manuscript Finding Aids

Joseph Melnick, PhD papers contains correspondence and reprints that document the career of Dr. Melnick, who was a leading epidemiologist, best known for his research on polio. See more at MS 015.

Ms 160 Guide To The D. H. Rankin Medical Artifacts Collection (1800-2000), Douglas H. Rankin

Manuscript Finding Aids

The D.H. Rankin Medical Artifacts Collection was donated by Dr. Rankin, a family physician in Austin, Texas. Dr. Rankin had a personal interest in hearing related devices and early twentieth century quack medical devices. Dr. Rankin acquired artifacts from online auction sites, auction houses, and catalogs. Receipts and sale information for some items are included in the control folder. See more at MS 160.

Journeying Beyond The Balcony To The Block Party And Up To 50,000 Feet: Disparities In Children’S Health And Healthcare, Yolande M. Pengetnze, Glenn Flores

Journal of Applied Research on Children: Informing Policy for Children at Risk

Invited Commentary on “Observations from the Balcony: Directions for Pediatric Health Disparities Research and Policy".

Nothing About Us Without Us! The Failure Of The Modern Juvenile Justice System And A Call For Community-Based Justice, Charisa Smith Esq.

Journal of Applied Research on Children: Informing Policy for Children at Risk

The modern juvenile justice system is failing our society. A literature review reveals resounding criticism of the system at all points—arrest, court processing, and incarceration. The current system does not effectively reduce recidivism, is wrought with racial disparities, operates with a minimal degree of cultural competence, violates human rights norms, and fails to empower and reform individuals who are directly affected. The current system shatters social bonds and does not hold governmental agencies accountable for wrongdoing or ineffectiveness. Community-based approaches more effectively reduce crime, cost less, are more empowering and culturally competent, help ameliorative civic fragmentation, and are more socially …

Observations From The Balcony: Directions For Pediatric Health Disparities Research And Policy, Jean L. Raphael

Journal of Applied Research on Children: Informing Policy for Children at Risk

In 2002, the Institute of Medicine released Unequal Treatment: Confronting Racial and Ethnic Disparities in Healthcare, a landmark monograph documenting health disparities in the U.S. health care system. Since the publication of Unequal Treatment, the field of pediatric health disparities research has advanced significantly with a proliferation of studies examining a wide array of topics concerning inequities in child health. Advances in health care policy and legislation have also added to a heightened discourse on pediatric health disparities. While there has been substantial activity in efforts to address pediatric health disparities, questions remain regarding whether these efforts have changed …

Family Structure And Obesity Among U.S. Children, Jennifer M. Augustine Ph.D., Rachel T. Kimbro

Journal of Applied Research on Children: Informing Policy for Children at Risk

Child obesity in the U.S. is a significant public health issue, particularly among children from disadvantaged backgrounds. Thus, the roles of parents’ human and financial capital and racial and ethnic background have become important topics of social science and public health research on child obesity. Less often discussed, however, is the role of family structure, which is an important predictor of child well-being and indicator of family socioeconomic status. The goal of this study, therefore, is to investigate how preschool aged children’s risk of obesity varies across a diverse set of family structures and whether these differences in obesity are …

A University System’S Approach To Enhancing The Educational Mission Of Health Science Schools And Institutions: The University Of Texas Academy Of Health Science Education, L. Maximilian Buja, Susan M. Cox, Steven A. Lieberman, Jonathan Macclements, Janet F. Williams, Robert M. Esterl Jr., Kenneth I. Shine

Library Staff Publications

Background: The academy movement developed in the United States as an important approach to enhance the educational mission and facilitate the recognition and work of educators at medical schools and health science institutions. Objectives: Academies initially formed at individual medical schools. Educators and leaders in The University of Texas System (the UT System, UTS) recognized the academy movement as a means both to address special challenges and pursue opportunities for advancing the educational mission of academic health sciences institutions. Methods: The UTS academy process was started by the appointment of a Chancellor’s Health Fellow for Education in 2004. Subsequently, the …

Ms171: Interview With Dorothy Otto, Dorothy Otto M.S.N., Ed.D., Anef, Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

Interview with Dorothy Otto, Associate Professor at the School of Nursing, University of Texas Houston Health Science Center. See more at Texas Medical Center-Women's History Project and its finding aid.

Ms171: Interview With Anna Steinberger, Anna Steinberger Ph.D., Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral interview with Dr. Anna Steinberger, who taught and conducted basic research in Reproductive Biology and served as Assistant Dean for Faculty Affairs at UT Medical School-Houston. Her research yielded over 250 scientific articles, books, and book chapters for which she received numerous awards and recognitions in the USA and abroad. See more at Texas Medical Center-Women's History Project and its finding aid.

Ms171: Interview With Dianna Milewicz, Dianna Milewicz M.D., Ph.D., Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral interview with Dianna Milewicz, M.D., Ph.D., Professor and Vice Chairman of the Department of Internal Medicine at The University of Texas Medical School at Houston and Director of the M.D./Ph.D. Program and co-Director of the Biomedical Engineering Center. Her research interests include the genetic basis of cardiovascular diseases, and understanding the effect of identified mutations on protein function. She has recently established a genetic core laboratory to provide molecular biology and genetic expertise to clinicians who want to initiate genetic studies on their patient populations. See more at Texas Medical Center-Women's History Project and its finding aid.

Ms171: Interview With Lu Ann Aday, Lu Ann Aday Ph.D., Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral Interview with Dr. Lu Ann Aday, distinguished professor emerita in public health and medicine at the University of Texas School of Medicine and Public Health. She is the inaugural holder of the Lorne D. Bain Distinguished Professorship in Public Health and Medicine at the University of Texas, School of Public Health, and has advised numerous masters' and doctoral candidates and post-doctoral fellows during her more than 30 years in the field. With training in economics and sociology, Dr. Aday has authored a number of books dealing with conceptual or empirical aspects of research on access to health and …

Ms171: Interview With Julie Knobil, Julie Knobil M.A., Ph.D., Houston Academy Of Medicine-Texas Medical Center Library

Texas Medical Center - Women's History Project

An oral interview with Juile (Hotchkiss) Knobil, research professor of physiology and then integrative biology at the Medical School, where she lectured on mammalian physiology and perinatal endocrinology. See more at Texas Medical Center-Women's History Project and its finding aid.

Website Usage And Weight Loss In A Free Commercial Online Weight Loss Program: Retrospective Cohort Study, Kevin O Hwang, Jing Ning, Amber W Trickey, Christopher N Sciamanna

Faculty, Staff and Student Publications

BACKGROUND: Online weight loss programs are increasingly popular. However, little is known about outcomes and associations with website usage among members of free online weight loss programs.

OBJECTIVE: This retrospective cohort study examined the association between website usage and weight loss among members of a free commercial online weight loss program (SparkPeople).

METHODS: We conducted a retrospective analysis of a systematic random sample of members who joined the program during February 1 to April 30, 2008, and included follow-up data through May 10, 2010. The main outcome was net weight change based on self-reported weight. Measures of website usage included …

Biomarkers Of Maternal And Fetal Exposure To Organochlorine Pesticides Measured In Pregnant Hispanic Women From Brownsville, Texas, Ken Sexton, Jennifer J Salinas, Thomas J Mcdonald, Rose M Z Gowen, Rebecca P Miller, Joseph B Mccormick, Susan P Fisher-Hoch

Faculty, Staff and Student Publications

Biomarkers of organochlorine pesticides were measured in both venous and umbilical cord blood from 35 pregnant Hispanic women living in Brownsville, Texas, USA. Gas chromatography with an electron capture detector was used to analyze specimens for 30 individual pesticides or their metabolites. Results indicate that blood concentrations were relatively low for most individual compounds, but that high-end (upper 10th percentile) values for total DDT were comparatively high. Although health effects associated with measured blood concentrations are uncertain, there is concern that fetal exposure to low levels of these OC compounds, either individually or in combination, might contribute to subsequent health …

Annual Report 2012-2013, Houston Academy Of Medicine-Texas Medical Center Library

Annual Reports: 1943 - Present

This file contains the Annual Report for the library from 2012-2013.

Ms 102 Guide To Robert Hickey, Md Papers (1909-1992), Robert Hickey (1915-2006)

Manuscript Finding Aids

The Robert Hickey, MD papers contains various papers and reprints relating to Dr. Robert Hickey and his research on railroad medicine.

Ms225: 2013 Faculty Meeting Minutes, Thomas R. Cole

Thomas R. Cole, PhD Papers

Original Filename: Faculty Meeting Minutes 010213.docx. Format Details: fmt/412; Microsoft Word for Windows; 2007 onwards. See more at Thomas R. Cole, PhD Papers and its finding aid.

Ham-Tmc Library Strategic Plan - Fy 2013-16, Houston Academy Of Medicine-Texas Medical Center Library

Strategic Plans

No abstract provided.

Willingness To Undergo A Repeat Liver Biopsy Among Hiv/Hepatitis C Virus-Coinfected And Hepatitis C Virus-Monoinfected Patients, Valerianna K Amorosa, Omowunmi Aibana, Norah J Shire, Zachariah Dorey-Stein, Thomas Ferrara, Joanne Gilmore, Jay R Kostman, Vincent Lo Re

Faculty, Staff and Student Publications

BACKGROUND: Guidelines for chronic hepatitis C virus (HCV) management have recommended that a liver biopsy be repeated at 3-year intervals for HIV/HCV-coinfected patients and 5-year intervals for those with HCV monoinfection to assess fibrosis progression. However, it is unclear if patients are willing to repeat this procedure.

OBJECTIVE: To determine the prevalence and factors, particularly HIV coinfection, associated with willingness to repeat a liver biopsy.

METHODS: A questionnaire was administered to 235 HCV-infected patients (113 with HIV coinfection) between January 2008 and June 2011 who previously underwent liver biopsy. The main outcome was self-reported willingness to repeat the biopsy. The …

Ms 127 Guide To Bernard M. Barrett Papers (1951-1982), Bernard M. Barrett (1944-)

Manuscript Finding Aids

Dr. Bernard M. Barrett studied at the University of Miami for his medical degree. His collection documents his involvement in editing and coauthoring different research, books, and articles. The collection includes several edited drafts by Dr. Barrett and his colleagues' drafts he would edit. The most prominent collection of documents surrounding the publication of the book and its editions, "Patient Care in Plastic Surgery," is well documented in the collection. The collection also includes: pamphlets; reports; reprints; correspondence; letters; memos; research; advertisements; and financial records.

Can The Bicuspid Aortic Valve Be Spared? The Con Position, With Caveats And Nuances, Joseph E Bavaria, Caroline M Komlo, Tyler Rhode, Prashanth Vallabhajosyula

The Texas Heart Institute Journal

No abstract provided.

Mitochondrial Cardiomyopathy: Pathophysiology, Diagnosis, And Management, Deborah E Meyers, Haseeb Ilias Basha, Mary Kay Koenig

The Texas Heart Institute Journal

Mitochondrial disease is a heterogeneous group of multisystemic diseases that develop consequent to mutations in nuclear or mitochondrial DNA. The prevalence of inherited mitochondrial disease has been estimated to be greater than 1 in 5,000 births; however, the diagnosis and treatment of this disease are not taught in most adult-cardiology curricula. Because mitochondrial diseases often occur as a syndrome with resultant multiorgan dysfunction, they might not immediately appear to be specific to the cardiovascular system. Mitochondrial cardiomyopathy can be described as a myocardial condition characterized by abnormal heart-muscle structure, function, or both, secondary to genetic defects involving the mitochondrial respiratory …

Feasibility Of Temporary Biventricular Pacing After Off-Pump Coronary Artery Bypass Grafting In Patients With Reduced Left Ventricular Function, Daniel Y Wang, Lauren A Kelly, Marc E Richmond, T Alexander Quinn, Bin Cheng, Michelle D Spotnitz, Santos E Cabreriza, Yoshifumi Naka, Allan S Stewart, Craig R Smith, Henry M Spotnitz

The Texas Heart Institute Journal

In selected patients undergoing cardiac surgery, our research group previously showed that optimized temporary biventricular pacing can increase cardiac output one hour after weaning from cardiopulmonary bypass. Whether pacing is effective after beating-heart surgery is unknown. Accordingly, in this study we examined the feasibility of temporary biventricular pacing after off-pump coronary artery bypass grafting.

The effects of optimized pacing on cardiac output were measured with an electromagnetic aortic flow probe at the conclusion of surgery in 5 patients with a preoperative mean left ventricular ejection fraction of 0.26 (range, 0.15–0.35). Atrioventricular (7) and interventricular (9) delay settings were optimized in …

Some Thoughts About The Historic Events That Led To The First Clinical Implantation Of A Total Artificial Heart, Denton A Cooley

The Texas Heart Institute Journal

No abstract provided.