Digital Commons Network^™

An Innovative Collective Parent Engagement Model For Families And Neighborhoods In Arrival Cities, Tania Alameda-Lawson, Michael A. Lawson, Hal A. Lawson

Journal of Family Strengths

Arrival Cities are special urban places. Amid the largest migration in human history, they provide homes for large numbers of mobile, low-income, immigrant families. These families need new human service and child welfare service models. Collective parent engagement (CPE) is one such model. CPE is designed to build on the strengths and meet the needs of immigrant families living in Arrival City neighborhoods. In contrast to interventions focused on individual parents, this CPE model mobilizes groups of parents; and with a dual agenda. CPE develops much-needed “anchoring supports” for mobile, vulnerable families, at the same time that it positions local …

Family Roots: Sustenance For Samoan And Tongan American Elders, Halaevalu F.O. Vakalahi, Emily S. Ihara, Moana P. Hafoka

Journal of Family Strengths

This article discusses the centrality of the family in supporting cultural responsibilities and in the well-being of Samoan and Tongan-American elders. Informed by the Ho’okele model, this grounded theory study was conducted in the State of Hawaii, the port of entry for most Pacific Islander-Americans migrating to the U.S. and the state in which a majority of Samoans and Tongans reside. Qualitative data was collected from 10 Samoan and 10 Tongan elders, and analysis was conducted by immersion in the data and reading for natural emergence of themes, patterns and categories. Cultural foundation of family relationships, expectations of the keepers …

Using State Wide Child And Family Services Review Data To Analyze Policies To Improve Educational Outcomes Of Children In Foster Care, Corie G. Hebert

Journal of Family Strengths

The poor educational outcomes of foster children is recognized as a national problem. The literature is reviewed to define and illustrate the magnitude of the problem. Steps have been taken to improve the problem with passage of the Fostering Connections to Success and Increasing Adoptions Act of 2008; it requires states to ensure the educational stability of foster youth. A description of utilizing state level Child and Family Service Review data to analyze a state’s ability to comply with the Fostering Connections to Success and Increasing Adoptions Act of 2008 is provided.

Commentary On "Family Roots: Sustenance For Samoan And Tongan American Elders", Meripa T. Godinet

Journal of Family Strengths

The article discusses the relevance of family as the foundation of well being for Samoan and Tongan elders. Negotiating dual identities (Samoan American or Tongan American) can be challenging, particularly when contexts of each identity are at odds with one another. This study indicated relevant findings that underscored the role and responsibility of Samoan and Tongan elders in transmitting cultural ways of knowing and doing to current and future generations. The role of families then becomes all the more important as they are key to supporting the health and wellbeing of their elders.

Artifacts Of Schooling, Frank S. Kelly

Journal of Applied Research on Children: Informing Policy for Children at Risk

The paper explores important issues in today’s education, not by analyses and statistics, but by projecting readers into the future and then asking them to look back on today’s schools and to act like archaeologists—to surmise from all sorts of things they can observe, what was really important to us, what we really valued, how we treated kids, how our schools related to the communities they serve, how we used funds and time, how we used the ideas and technology available to us. Readers may find themselves amazed, amused or angered by their own answers.

Real School Gardens Program: Learning Gardens And Teacher Training To Improve Student Engagement And Academic Performance In Low-Performing Elementary Schools, Jeanne Mccarty

Journal of Applied Research on Children: Informing Policy for Children at Risk

Children who grow up in poverty are less likely to graduate high school, enter college and find economic stability. REAL School Gardens believes the right educational opportunities – ones that engage and motive children to learn – can break this cycle. The REAL School Gardens Program builds learning gardens and offers teacher training to improve academic engagement and performance in low-income elementary schools. Since its launch, REAL School Gardens has partnered with 92 low-income schools, and preliminary findings show that 84% of students experiencing hands-on academic lessons in a REAL School Garden report high levels of engagement, specifically in math …

Sexual Violence Against Girls In Schools: Addressing The Gaps Between Policy And Practice In Awaso, Ghana, Geneviève M. Proulx, Andrea Martinez

Journal of Applied Research on Children: Informing Policy for Children at Risk

Despite the established relationship between girls' education and several social development outcomes, gender disparities in education remain particularly concerning. Among the many obstacles that still hinder girls’ access to quality education, sexual violence against girls in schools (SVAGS) is one of the most worrying but also one that has received the least attention in light of recent efforts to increase girls’ attendance in school. This article explores the interface between the seemingly solid Ghanaian legal and policy framework to protect children in educational institutions and the high incidence of SVAGS in such institutions. Its purpose is twofold: to identify the …

Attitudes Surrounding Contraceptive Responsibility: Do Latino Youth Differ From Other Groups?, Kari White, Kristine Hopkins, Emily Schiefelbein

Journal of Applied Research on Children: Informing Policy for Children at Risk

Latina teens have lower rates of contraceptive use and higher rates of pregnancy compared to other racial/ethnic groups. Differences in attitudes about contraceptive responsibility have been suggested as reasons for these disparities. We conducted 36 gender- and race/ethnicity-specific focus groups with young women aged 15 to 21 years and young men aged 18 to 24 in four large Texas cities. To explore youths’ attitudes about contraceptive responsibility, we analyzed transcripts using thematic analysis and compared themes across race/ethnicity and gender. Across all groups, youth often reported that young women were primarily responsible for contraception because of the physical implications of …

Socioeconomic And Cultural County-Level Factors Associated With Race/Ethnic Differences In Body Mass Index In 4th Grade Students In Texas, Jennifer J. Salinas, Manasi S. Shah, Jennifer L. Gay, Ken Sexton, Eileen Nehme, Dorothy Mandell, Deanna M. Hoelscher

Journal of Applied Research on Children: Informing Policy for Children at Risk

Purpose: To evaluate the relationship between county-level socioeconomic environment and the propensity to be overweight or obese by race/ethnic group in a sample of fourth grade children the Texas public school system.

Methods: The data used come from the School Physical Activity and Nutrition (SPAN) surveillance study – a surveillance study of school-aged children in Texas. The outcome variable used was Body Mass Index (BMI) categorized as underweight/normal/healthy, overweight, and obese. Exposure variables were derived from county-level Hispanic and Black concentration and socioeconomic data using the Human Security Index (HSI) as a framework. We made comparisons between Non-Hispanic White, Black …

Memory Functioning For Personally Experienced And Witnessed Events In Children With Autism And The Implications For Educators, Mental Health Professionals, And The Law, Kelly A. Cornett, Deborah S. Miora, Tracy Fass, Dennis Dixon

Journal of Applied Research on Children: Informing Policy for Children at Risk

Several researchers have hypothesized a deficit in memory processing to exist in children with a diagnosis of autism spectrum disorder (ASD). This hypothesis has been supported by findings of deficient recall and recognition ability in children with ASD. Specifically, research has pointed to greater deficits in their ability to recall events related to the self as opposed to others. However, such research has not explored how memory functioning would be impacted when an event with an emotional tenor was used and when a forced choice yes/no paradigm was used to extricate what was remembered from the event. The current study …

Trends In Child Health Insurance Coverage: A Local Perspective, Jean L. Raphael, Richard R. Batsell, Marc A. Kowalkowski, Aileen Beltran, Angelo P. Giardino, Charles G. Macias

Journal of Applied Research on Children: Informing Policy for Children at Risk

Background: Over the past decade, the percentage of Americans with access to employer-sponsored insurance (ESI) has declined. Dependents, specifically children, are the most likely to bear the burden of lost coverage.

Objectives: The objectives of this study were to 1) describe trends in children’s health insurance taking into account the heterogeneity across different sub-populations and 2) assess the associations between individual, local (offers of ESI), and supply side (proximity to safety net hospitals) characteristics and children’s health insurance.

Methods: We analyzed locally collected survey data for children living in the 12 counties of greater Houston, Texas (years 2003, 2006, 2008, …

Symptoms In Early And Long-Term Breast Cancer Survivors Who Have Completed Primary Therapy, Faith Strunk

Dissertations and Theses (Open Access)

Background

Many breast cancer survivors continue to have single or multiple symptoms after they have completed primary cancer therapy. The quantifiable, subjective experience of multiple symptoms and their impact is defined as symptom burden. Previous research has focused on symptoms during primary therapy or shortly after completion of treatment.

Objectives

Our study objectives were to determine whether symptom burden differed according to survivor status (early as opposed to long-term survival) and/or use of endocrine or hormonal adjuvant therapy. We hypothesized that there would be no difference in the symptoms expressed among early- and long-term survivors.

Methods

In this cross-sectional study, …

Radiogenic Second Cancer Risk Differences In Female Hodgkin Lymphoma Patients Treated With Proton Versus Photon Radiotherapies, Kenneth L. Homann

Dissertations and Theses (Open Access)

Hodgkin Lymphoma (HL) is the most common cancer diagnosis of young adults in the United States. Advances in curative treatments for HL, including the use of photon radiation therapy (RT) techniques, have increased 10 year survival rates to approximately 90% among young patients. These RT treatments, however, contribute to an increased incidence of radiogenic second cancer (RSC) formation to the healthy tissue surrounding the tumor volume relative to the general population. These RSCs are the leading cause of death among long-term HL survivors. Proton therapy has been shown to reduce the therapeutic dose, and therefore, the risk of developing a …

Ventral Tegmental Area Neuronal Responses To Methylphenidate Correlated To Behavioral Responses Of Adolescent And Adult Rats, Zachary Jones

Dissertations and Theses (Open Access)

Methylphenidate (MPD) is a psychostimulant used in the treat treatment of attention deficit hyperactivity disorder and more recently is being used as a cognitive enhancement and recreational drug. Its therapeutic effects are not fully understood, nor are the long term effects of the drug on brain development. The ventral tegmental area (VTA) is a site of psychostimulant action thought to be involved in behavioral sensitization. The aim of the this study was to first determine if there are differences in neuronal responses between individuals, with respect to neuronal firing patterns in the ventral tegmental area (VTA), and whether these differences …

C-Jun N-Terminal Kinases Regulate Adenovirus-Mediated Autophagy And Antigen Presentation, Sarah R. Klein

Dissertations and Theses (Open Access)

Targeted immunotherapy with recombinant, oncolytic adenoviruses is under investigation for the treatment of cancer. Evidence indicates adenoviruses induce autophagy that is required for oncolysis, but the molecular regulation of autophagy in infected cells remains under investigation. Our data suggested the canonical pathway regulating starvation-induced autophagy was not implemented in adenovirus-induced autophagy; however, adenovirus infection triggered phosphorylation of c-Jun N-terminal kinases (JNK) that was essential for autophagy. Adenoviral replication within the host cell elicited JNK pathway activation leading to B cell lymphoma-2 (Bcl-2) phosphorylation. JNK-dependent Bcl-2 phosphorylation stimulated the dissociation of Bcl-2/beclin 1 heterodimers, enabling beclin 1 to initiate autophagy. Moreover, …

Basis For Targeting Met Activation Mediated Resistance To Pi3k Inhibition In Breast Cancer, Ana M. Gonzalez-Angulo

Dissertations and Theses (Open Access)

The identification of resistance mechanisms to emerging therapies, such as those targeting the PI3K pathway and the MET receptor, has the potential to benefit a significant number of patients with breast cancer. In this study we hypothesized that concurrent aberrations in PI3K and MET will render breast cancers resistant to therapies targeting each pathway, and that combination therapy targeting the PI3K and MET pathway will optimize therapy-effect by preventing the acquisition of resistance.

We analyzed cMET and phospho-cMET levels in 257 breast cancer samples and found that high levels of both the proteins were seen in all breast cancer subtypes, …

Neural Correlates Of Audiovisual Speech Perception In Aphasia And Healthy Aging, Sarah H. Baum

Dissertations and Theses (Open Access)

Understanding speech in face-to-face conversation utilizes the integration of multiple pieces of information, most importantly the auditory vocal sounds and visual lip movements. Prior studies of the neural underpinnings of audiovisual integration in the brain have provided converging evidence to suggest that neurons within the left superior temporal sulcus (STS) provide a critical neural hub for the integration of auditory and visual information in speech. While most studies of audiovisual processing focus on neural mechanisms within healthy, young adults, we currently know very little about how changes to the brain can affect audiovisual integration in speech. To examine this further, …

Early Diagnosis And Treatment Of Invasive Pulmonary Aspergillosis In A Patient With Cystic Fibrosis, Ricardo Alberto Mosquera, Lila Estrada, Roya Mohebpour Clements, Cindy K Jon

Faculty, Staff and Student Publications

Invasive pulmonary aspergillosis is a rare and fatal complication in patients with cystic fibrosis (CF) who lack concomitant risk factors. The few documented cases in children have all resulted in deaths during hospitalisation. We present the case of a 12-year-old boy with CF who was admitted for an exacerbation which was unresponsive to antibiotic therapy. The findings on imaging raised concerns about a possible fungal infection. As a result, voriconazole therapy was started prior to his respiratory deterioration. He was later found to be β-D glucan and Aspergillus Ag galactomannan positive confirming the suspicion for invasive pulmonary aspergillosis. Three months …

Development And Evaluation Of An Ontology-Based Quality Metrics Extraction System, Sina Madani

Dissertations and Theses (Open Access)

The Institute of Medicine reports a growing demand in recent years for quality improvement within the healthcare industry. In response, numerous organizations have been involved in the development and reporting of quality measurement metrics. However, disparate data models from such organizations shift the burden of accurate and reliable metrics extraction and reporting to healthcare providers. Furthermore, manual abstraction of quality metrics and diverse implementation of Electronic Health Record (EHR) systems deepens the complexity of consistent, valid, explicit, and comparable quality measurement reporting within healthcare provider organizations.

The main objective of this research is to evaluate an ontology-based information extraction framework …

Cholera Vaccination Campaign Contributes To Improved Knowledge Regarding Cholera And Improved Practice Relevant To Waterborne Disease In Rural Haiti, Omowunmi Aibana, Molly F Franke, Jessica E Teng, Johanne Hilaire, Max Raymond, Louise C Ivers

Faculty, Staff and Student Publications

BACKGROUND: Haiti's cholera epidemic has been devastating partly due to underlying weak infrastructure and limited clean water and sanitation. A comprehensive approach to cholera control is crucial, yet some have argued that oral cholera vaccination (OCV) might result in reduced hygiene practice among recipients. We evaluated the impact of an OCV campaign on knowledge and health practice in rural Haiti.

METHODOLOGY/PRINCIPAL FINDINGS: We administered baseline surveys on knowledge and practice relevant to cholera and waterborne disease to every 10th household during a census in rural Haiti in February 2012 (N = 811). An OCV campaign occurred from May-June 2012 after …

Spatial Warping By Oriented Line Detectors Can Counteract Neural Delays, Don A. Vaughn, David M. Eagleman

Faculty, Staff and Students Publications

The slow speed of neural transmission necessitates that cortical visual information from dynamic scenes will lag reality. The "perceiving the present" (PTP) hypothesis suggests that the visual system can mitigate the effect of such delays by spatially warping scenes to look as they will in ~100 ms from now (Changizi, 2001). We here show that the Hering illusion, in which straight lines appear bowed, can be induced by a background of optic flow, consistent with the PTP hypothesis. However, importantly, the bowing direction is the same whether the flow is inward or outward. This suggests that if the warping is …

Library Partnerships: Oh, The Possibilities!, Joanne Romano

Library Staff Publications

A presentation given at the annual meeting of the South Central Chapter of Medical Library Association (SCC/MLA).

Project Description

OBJECTIVE: To determine if new, strategic partnerships can be initiated between The Texas Medical Center Library (The TMC Library), Baylor College of Medicine (BCM) and University of Texas Health Science Center-Houston (UTHSC-H).

METHODS: Cohort study

The TMC Library joined a 22-member cohort of academic and research libraries to participate in the DuraSpace/ARL/DLF 2012 E-Science Institute, to discover new methods of supporting computational scientific research. From September to December 2012, library teams completed coursework that included interviews with key stakeholders at …

Network Dynamics Of Visual Naming, Christopher R. Conner

Dissertations and Theses (Open Access)

Recognition and naming of objects and actions are fundamental components of language. They involve several different systems working in coordination to accomplish a complex behavior. During visual naming, sensory and semantic processing are carried out by dedicated cortical substrates in the temporal and occipital lobes, while response selection and articulatory planning are handled by prefrontal cortex. Despite decades of research using lesion analysis, functional MRI and electro-encephalography, the precise dynamics involved remain unknown due to the inadequate spatio-temporal resolution of these methodologies. Of particular interest is the organization of semantic knowledge and the degree of serial and parallel organization of …

Characterization Of Jak, Stat, And Src Interactions In Head And Neck Squamous Cell Carcinoma, Reshma Jaseja, Reshma Jaseja

Dissertations and Theses (Open Access)

Recurrence of Head and Neck Squamous Cell Carcinoma (HNSCC) is common; thus, it is essential to improve the effectiveness and reduce toxicity of current treatments. Proteins in the Src/Jak/STAT pathway represent potential therapeutic targets, as this pathway is hyperactive in HNSCC and it has roles in cell migration, metastasis, proliferation, survival, and angiogenesis. During short-term Src inhibition, Janus kinase (Jak) 2, and signal transducer and activator of transcription (STAT) 3 and STAT5 are dephosphorylated and inactivated. Following sustained Src inhibition, STAT5 remains inactive, but Jak2 and STAT3 are reactivated following their early inhibition. To further characterize the mechanism of this …

Prevalence And Patterns Of Sexting Among Ethnic Minority Urban High School Students, Melissa Fleschler Peskin, Christine M Markham, Robert C Addy, Ross Shegog, Melanie Thiel, Susan R Tortolero

Faculty, Staff and Student Publications

Although sexting among U.S. youth has received much popular media attention, there are only limited data on its prevalence among ethnic minority youth. This study, therefore, specifically examined the prevalence and patterns of sexting (sending and/or receiving a nude or semi-nude picture/video or a sexual text-only message) among a sample of black and Hispanic youth. Data from 1,034 tenth graders from a large, urban school district in southeast Texas were used to calculate the prevalence of sexting by gender-race/ethnicity. Overlap among sexting behaviors was also examined. Electronic surveys were administered via an audio-computer-assisted self-interview on laptop computers. Prevalence estimates were …

Ms 094 Guide To Lysle H. Peterson, Md Papers (1967-1974), Lysle H. Peterson (1919-1994)

Manuscript Finding Aids

The Lysle Peterson papers contains U.S Airforce scientific Advisory Board information and reports, Scientific Board of the International Cardiology Society, Titres et Travaux Scientifiques de J. Baillet, commentary, Southwest Foundation for Research and Education, liaison committee on medical education, University of Pennsylvania School of Medicine planning committee, investment information, resident evaluations, various correspondence, transparencies, newspaper clippings, manuscript drafts and notes, various symposium booklets, miscellaneous meetings, various articles, diagrams, reprints, photos, air force documents, U.S naval report, health mark documents and information, herbicide orange, grants, gifts, donations, space science board, abstracts, and other prints and papers related to the work and …

Behavioral Responses To Methylphenidate: Correlations With Neuronal Activity In The Caudate Nucleus, Catherine M. Claussen

Dissertations and Theses (Open Access)

Methylphenidate is currently a drug of abuse and readily prescribed to both adolescents and adults. Chronic methylphenidate (MPH) exposure results in an increase in DA in the motive circuit, including the caudate nucleus (CN), similar to other drugs of abuse. This study focuses on research aimed to elucidate if there are intrinsic underlying differences in the CN electrophysiological activity of animals exhibiting different chronic responses to the same dose of MPH. Behavioral and caudate nucleus (CN) neuronal activity following acute and chronic doses of MPH was assessed by simultaneously recording the behavioral and neuronal activity. The experimental protocol lasted for …

The P63 Isoform ∆Np63Α Inhibits Epithelial – Mesenchymal Transition By Promoting The Expression Of Mir-205 In Human Bladder Cancer Cells, Mai Tran

Dissertations and Theses (Open Access)

p63, a p53 family member, is a transcription factor that has complex roles in cancer. This study focuses on the role of the ∆Np63α isoform in bladder cancer (BC). Epithelial – mesenchymal transition (EMT) is a physiological process that plays an important part in metastasis and drug resistance. At the molecular level, EMT is characterized by the loss of the epithelial marker E-cadherin, and the acquisition of the transcriptional repressors of E-cadherin (ZEB1, ZEB2, TWIST, SNAI1 and SNAI2). Recent publications highlight the role of microRNAs belonging to the miR-200 family and miR-205 in preventing EMT through suppression of ZEB1 and …

Genome-Wide Profiling Unveils Criticial Functions Of P53 In Human Embryonic Stem Cells, Kadir C. Akdemir

Dissertations and Theses (Open Access)

Embryonic stem cells (ESCs) possess two unique characteristics: infinite self-renewal and the potential to differentiate into almost every cell type (pluripotency). Recently, global expression analyses of metastatic breast and lung cancers revealed an ESC-like expression program or signature, specifically for cancers that are mutant for p53 function. Surprisingly, although p53 is widely recognized as the guardian of the genome, due to its roles in cell cycle checkpoints, programmed cell death or senescence, relatively little is known about p53 functions in normal cells, especially in ESCs. My hypothesis is that p53 has specific transcription regulatory functions in human ESCs (hESCs) that …

Galectin-3 Enhances The Malignant Melanoma Phenotype By Regulating Autotaxin, Russell R. Braeuer

Dissertations and Theses (Open Access)

In melanoma patient specimens and cell lines, the over expression of galectin-3 is associated with disease progression and metastatic potential. Herein, we have sought out to determine whether galectin-3 affects the malignant melanoma phenotype by regulating downstream target genes. To that end, galectin-3 was stably silenced by utilizing the lentivirus-incorporated small hairpin RNA in two metastatic melanoma cell lines, WM2664 and A375SM, and subjected to gene expression microarray analysis. We identified and validated the lysophospholipase D enzyme, autotaxin, a promoter of migration, invasion, and tumorigenesis, to be down regulated after silencing galectin-3. Silencing galectin-3 significantly reduced the promoter activity of …