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Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Evaluation Of Blood-To-Fluid Gradient Of Glucose And Lactate As Biomarkers In The Early Diagnosis Of Septic Peritonitis In Dogs, Silpa Sn, Sujata Turkar, Neetu Saini, Sushma Chhabra, Kuldip Gupta, Gursimran Filia

Turkish Journal of Veterinary & Animal Sciences

Septic peritonitis is a serious, life-threatening condition with a high mortality rate. Accurate diagnosis is crucial for the survival of the affected animal. The present study analyzed the use of a blood-to-fluid gradient of glucose and lactate as a biomarker in the diagnosis of septic peritonitis. Thirteen dogs with septic peritonitis and nine dogs with aseptic peritonitis were included in this study. Blood-to-fluid glucose gradient was significantly high, and blood-to-fluid lactate gradient was significantly low in septic peritonitis compared with the aseptic peritonitis. A blood-to-fluid glucose gradient of ≥12 mg/dL showed 100% sensitivity and 55.6% specificity, whereas a blood-to-fluid lactate …

Determination Of The Cecal Microbiota Profile Of Anadolu-T Broiler Breeder Chickens Using 16s Metagenomic Sequencing, Kürşat Teti̇k, İsmai̇l Özkan, Serpi̇l Kahya Demi̇rbi̇lek

Turkish Journal of Veterinary & Animal Sciences

The gut microbiota has significant effects on the performance, health status, and immune systems of chickens. The complex microbial community structure begins to form after chicks hatch with the intake of feed, water, and air into the digestive system. Disrupting the balance of this system can lead to the proliferation of pathogenic microorganisms. Until recently, studies on microbiota relied on traditional microbiological techniques that cultured only a small fraction of the microbial diversity. However, significant advancements in DNA sequencing and bioinformatics have enabled the identification of diverse bacterial populations in environmental samples. In this study, a total of 2000 broiler …

Differences In Lactation Curve Parameters And Milk Yield Responses Between Artificially Induced And Naturally Calved Cows Milked In An Automatic Milking System, Marcos Busanello

Turkish Journal of Veterinary & Animal Sciences

Despite advances in artificial induction of lactation (AIL) protocols, they do not perfectly mimic the hormonal patterns of natural pregnancy. Recent studies show improved milk yield (MY) responses; however, comparisons of lactation curve parameters between AIL and naturally calved (NC) cows often do not extend beyond 305 days in milk (DIM). Thus, this study aimed to compare MY responses and lactation curve parameters between AIL and NC cows milked in an automated milking system (AMS). Data from 38 Holstein cows (19 AIL and 19 NC) were analyzed, focusing on the 305 DIM period. Wood’s lactation curve model was used to …

Antimicrobial Sensitivity Of Bacterial Isolates And Molecular Detection Of Staphylococcus Aureus And Staphylococcus Pseudintermedius Isolated From Urinary Tract Infections Of Canines, Mankaran Kaur, Gursimran Filia, Ashok Kumar

Turkish Journal of Veterinary & Animal Sciences

Urinary tract infections (UTIs) are commonly encountered in canine clinical cases and can result in significant health complications if not properly treated. This study isolated and identified bacterial pathogens from dogs with clinical signs of UTI. Antimicrobial susceptibility profiling was performed on the bacterial isolates and further molecular detection of Staphylococcus aureus and Staphylococcus pseudintermedius was also performed. A total of 104 urine samples were collected via cystocentesis and catheterization. Bacterial identification was conducted using standard bacteriological procedures, and antimicrobial susceptibility was assessed using the disc diffusion method with 21 different antimicrobial discs. Polymerase chain reaction (PCR) was used for …

Parameter Optimization For Runs Of Homozygosity (Roh) Detection In The Pig Genome, Timofey Romanets, Anna Korobeynikova, Lyubov Getmantseva, Maria Kolosova, Elena Romanets, Ilona Bakoeva, Varvara Shevtsova, Anatoly Kolosov, Alexander Maksimov, Siroj Bakoev

Turkish Journal of Veterinary & Animal Sciences

The present study analyses the influence of various parameters on the accuracy and reliability of ROH identification procedures, as well as their relationship with inbreeding and genetic diversity in Duroc pig populations. The genotyping data of 70 Duroc pigs obtained using PorcineSNP80v1 chips were used, and the effects of LD pruning and ROH calling parameters were evaluated. It was found that the use of strict basic filters during the execution of the --homozyg command reduces the likelihood of false positives and contributes to the more accurate identification of ROH. The results show that LD pruning reduces the detection of random …

Determination Of Serum Cortisol Levels As A Stress Marker In Hospitalized Dogs, Emre Tüfekçi̇, Gencay Eki̇nci̇, İlknur Karaca Bekdi̇k, Ali̇ Cesur Onmaz, Öznur Aslan, Vehbi̇ Güneş, İhsan Keleş, Mehmet Çi̇ti̇l

Turkish Journal of Veterinary & Animal Sciences

In veterinary medicine, various diseases and surgical procedures may require the isolation and hospitalization of dogs, allowing for more effective individual patient monitoring and increasing the chance of successful treatment by preventing unnecessary drug use. However, this process can be stressful. Our study aimed to determine the changes in cortisol levels, one of the primary stress hormones responsible for stress responses, in individually hospitalized dogs. In addition, epinephrine (EPN) levels, another stress marker, as well as hematological and some biochemical values were measured and vital signs were recorded. The dogs included in the study were divided into 3 groups: healthy, …

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Turkish Journal of Medical Sciences

No abstract provided.

In Recent Research: Exosomal And Molecular Regulators Of Browning And Thermogenesis In Adipose Tissues, Merve İnel, Bahadir Öztürk

Turkish Journal of Medical Sciences

This review synthesizes current knowledge on the molecular mechanisms regulating brown, white, and beige adipose tissues, with particular emphasis on the browning process of white adipose tissue. Rather than considering adipose tissue as a passive energy reservoir, this review underscores its active role as a dynamic endocrine and metabolic organ. Brown and beige adipose tissues, recognized for their thermogenic capacity and contribution to energy expenditure, have emerged as promising therapeutic targets for the treatment of obesity, type 2 diabetes, and related metabolic disorders. The review draws upon recent findings on adrenergic signaling, transcription factors, exosomal microRNAs, and other novel regulatory …

Telemedicine Versus Conventional Care For Nonspecific Neck Pain: A Randomized Controlled Study, Selki̇n Yilmaz Muluk, Sevtap Badil Güloğlu, Begüm Ünlütaşkiran

Turkish Journal of Medical Sciences

Background/aim: Telemedicine (TM) can overcome travel barriers in nonspecific neck pain (NNP), yet a comprehensive, physiatrist-supervised TM model has not been directly compared to standard in-clinic care. The aim of this study was to determine whether a video-based exercise and remote follow-up program is as effective as conventional follow-up in reducing pain and disability in NNP.

Materials and methods: This parallel-group randomized controlled trial (registered in ClinicalTrials.gov) included 68 adults (mean age = 40.52 years) with NNP who were randomly allocated 1:1 to the TM group (TG, n = 34) or control group (CG, n = 34). Both received identical …

The Impact Of Hypophosphatemia On Biochemical Profile And Renal Outcomes In Primary Hyperparathyroidism: A Nationwide Retrospective Study, Nai̇m Ata, Beki̇r Uçan, Hali̇l Durantaş, Oğulcan Boz, Mustafa Şahi̇n, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Muhammed Kizilgül

Turkish Journal of Medical Sciences

Background/aim: Although low phosphorus (P) concentrations are a recognized feature of primary hyperparathyroidism (PHPT), they are not among the diagnostic or surgical criteria. The present study evaluates the association between serum phosphorus levels and clinical outcomes in PHPT patients.

Materials and methods: A search of the Turkish Ministry of Health’s National Electronic Database was conducted using ICD-10 diagnostic codes and laboratory data to identify PHPT cases within the Turkish population from 2017 to 2022.

Results: The records of a total of 113,330 PHPT patients (77.5% female; mean age 58.9 ± 15.6 years) were analyzed, revealing a mean serum phosphorus level …

Relcovaptan: A Promising Therapeutic Agent In Traumatic Spinal Cord Injury That Acts By Modulating Newly Identified Transcriptional Regulators Of Aquaporins Compared To Tolvaptan, Şeyma İş, Duygu Ceman, Meri̇h İş, Neşe Keser, Şaban Teki̇n

Turkish Journal of Medical Sciences

Background/aim: Every year, hundreds of thousands of people worldwide suffer from traumatic spinal cord injury (tSCI), which causes irreversible damage, edema, and inflammation. Despite its devastating impact, no safe and effective medication is available. Edema formation is one of the earliest pathological events in tSCI, beginning within minutes after injury. Cytotoxic edema progresses to vasogenic edema, exacerbating irreversible damage. Our study aimed to investigate a therapeutic approach targeting cytotoxic edema in the acute phase of tSCI to improve treatment outcomes. Aquaporins (AQPs) are crucial in edema formation and tSCI pathogenesis. Vasopressin, also known as the antidiuretic hormone, modulates Aqp expression …

Transformation Of Juvenile Idiopathic Arthritis In Adult-Oriented Rheumatology Care, Şeri̇fe Asya Germe Dağlioğlu, Zeynep Balik, Zehra Özsoy, Yunus Emre Dalkiliç, Ezgi̇ Deni̇z Batu, Özge Başaran, Yelda Bi̇lgi̇ner, Umut Kalyoncu, Seza Özen, Şule Apraş Bi̇lgen, Levent Kiliç

Turkish Journal of Medical Sciences

Background/aim: Juvenile idiopathic arthritis (JIA) is the most prevalent form of chronic inflammatory arthritis in children, and the symptoms persist into adulthood for a considerable number of patients. This study aimed to compare the JIA subtypes using the diagnostic criteria used for adults and identify the clinical characteristics and treatment approaches for patients with JIA transitioning to adult-oriented rheumatology care.

Materials and methods: Patients diagnosed with JIA in the pediatric rheumatology clinic were retrospectively evaluated. The patients (n=107) who had at least one follow-up visit in the adult rheumatology clinic were included in the study. After transitioning from pediatric to …

Preoperative Awareness Of Nasal And Facial Aesthetic Deformities Among Rhinoplasty Candidates, Ağah Yeni̇çeri̇, Nagi̇han Gülhan Yaşar, Burak Hazir, Meli̇h Çayönü

Turkish Journal of Medical Sciences

Background/aim: This study primarily aimed to evaluate the preoperative awareness of nasal and facial anatomical deformities among patients scheduled for primary rhinoplasty. The secondary objective was to assess changes in patients’ self-perception and aesthetic expectations regarding surgical outcomes following preoperative consultation with the surgeon.

Materials and methods: In this prospective cross-sectional study, 56 adult patients seeking primary aesthetic rhinoplasty at a tertiary care center were included. Each participant completed a 10-item anatomical evaluation form. An experienced rhinoplasty surgeon independently evaluated the same parameters. Additionally, participants completed a two-item visual analogue scale (VAS) questionnaire both before and after the preoperative consultation. …

Evaluation Of Prognostic Value Of Vascular Endothelial Growth Factor And Endocan In Non-Small Cell Lung Cancer, Mesut Meli̇h Özercan, Burcu Ancin, Yi̇ği̇t Yilmaz, Ahmet Müderri̇soğlu, Serkan Uysal, Ulaş Kumbasar, Zeynep Saribaş, Erkan Di̇kmen, Riza Doğan

Turkish Journal of Medical Sciences

Background/aim: No reliable, easily measurable biomarker currently exists for the screening or prognosis of lung cancer. The present study evaluates the potential utility of vascular endothelial growth factor (VEGF) and endocan, which can be readily measured in blood samples, as biomarkers for screening and prognostic assessment in lung cancer.

Materials and methods: Included in the study were 38 patients with early-stage non-small cell lung cancer (NSCLC) and 29 controls. All patients underwent surgical intervention and were monitored for 1 month postoperatively. Serum VEGF and endocan levels were measured preoperatively and postoperatively. Clinical characteristics, laboratory data, and histopathological findings were recorded …

Chemotherapy Tolerance And Continuity Are Prognostic For Overall Survival In Patients With Localized And Advanced Biliary Tract Cancer, Erman Akkuş, Pinar Kubi̇lay Tolunay, Eli̇f Berna Köksoy, Hati̇me Arzu Yaşar

Turkish Journal of Medical Sciences

Background/aim: Biliary tract cancers (BTC) are relatively rare and have a poor prognosis in both localized and metastatic settings. Clinical trials tend to include patients who can tolerate treatments; however, chemotherapy eligibility, patterns, and survival may differ in the real world. The present study provides a 5-year overview of chemotherapy eligibility, patterns, tolerance, and survival in patients with resected and advanced BTCs.

Materials and methods: Included in the study were patients with resectable or advanced BTC (excluding ampullary cancers) diagnosed between 2019 and 2024. The demographic/clinical characteristics, chemotherapy eligibility, patterns, and survival outcomes of the patients were evaluated.

Results: Of …

Predictive Impact Of Pi-Rads 3 Lesion Volume/Total Prostate Volume Ratio In Prostate Cancer Diagnosis In Biopsy-Naïve Patients, Emrah Özsoy, Musab Ali̇ Kutluhan, Emre Tokuç, Ridvan Kayar, Samet Demi̇r, Kaan Meri̇ç, Meti̇n İshak Öztürk

Turkish Journal of Medical Sciences

Background/aim: To assess the potential of the ratio between PI-RADS 3 lesion volume and total prostate volume as a predictive parameter for guiding the decision to perform a biopsy in patients presenting with PI-RADS 3 lesions on multiparametric prostate magnetic resonance imaging (mpMRI).

Materials and methods: A total of 749 patients who underwent mpMRI due to suspected prostate cancer between January 2014 and August 2023 were scanned. Based on predefined inclusion and exclusion criteria, 308 patients were included. Age, total prostate-specific antigen (PSA) value, prostate volume measured in mpMRI, mpMRI result, PI-RADS 3 lesion volume, and biopsy results were collected. …

Subjective Memory Complaints Among Older Adults In Türkiye: Prevalence And Contributing Factors, Mustafa Çeti̇n, Zehra Sarikaya Demi̇rbaş, Mehmet İlki̇n Naharci

Turkish Journal of Medical Sciences

Background/aim: Subjective memory complaints (SMCs), defined as self-perceived declines in memory performance, are common among older adults and may serve as early indicators of neurocognitive impairment. Despite their clinical relevance, no previous studies have examined the prevalence and associated factors of SMCs in Türkiye.

Materials and methods: A total of 500 community-dwelling older adults were included in this retrospective, cross-sectional, observational study; all underwent a comprehensive geriatric assessment at a tertiary-level outpatient clinic. Participants with an mini-mental state examination score ≥27, independence in instrumental activities of daily living, and no diagnosis of mild cognitive impairment were assessed for SMCs. Sociodemographic …

Diagnostic Yield Of Clinical Exome Sequencing In Patients With Suspected Hereditary Neuropathy, Can Ebru Beki̇rcan-Kurt, Doruk Arslan, Naz Güleray, Sevi̇m Erdem-Özdamar, Burcu Balci-Hayta, Ersi̇n Tan

Turkish Journal of Medical Sciences

Background/aim: Hereditary neuropathies exhibit significant genetic heterogeneities, often making molecular diagnosis challenging. Clinical Exome Sequencing (CES) allows the simultaneous evaluation of a wide range of candidate genes, and can be considered an efficient approach to identifying underlying genetic causes. The present study assesses the diagnostic utility of CES in patients with clinically suspected hereditary neuropathy.

Materials and methods: Included in the study were 21 patients with clinically suspected hereditary neuropathy who underwent CES. DNA samples were isolated from peripheral blood and subjected to CES on an Illumina NextSeq 2000 system, while a bioinformatics analysis and variant interpretation were performed using …

Serial D-Dimer Measurements Dynamically Predict Severity In Acute Biliary Pancreatitis: A Prospective Observational Study, Kemal Tekeşi̇n, Tolga Canbak, Ayli̇n Acar, Fati̇h Başak, Hasan Kumru, Olgun Erdem

Turkish Journal of Medical Sciences

Background/aim: Early risk stratification is required in cases of acute biliary pancreatitis (ABP). Traditional scoring systems such as Ranson’s criteria are complex and often delay treatment. D-dimer, a basic marker of systemic inflammation and coagulation, has shown promise as a prognostic tool. The present study investigates whether the predictive accuracy of serial serum D-dimer measurements is superior to that of the Ranson and BISAP scoring systems for moderate-to-severe ABP.

Materials and methods: Included in this single-center prospective observational study were 264 patients diagnosed with ABP between July 2022 and July 2025 whose collected data were analyzed. The participants were categorized …

Impact Of Patient Education Meetings On Disease Knowledge In Chronic Urticaria Patients, Nazan Beyhan, Hati̇ce Eylül Bozkurt Yilmaz, Asli Çi̇ftci̇, Ömür Aydin, Di̇lşad Mungan, Betül Ayşe Si̇n, Gülfem Eli̇f Çeli̇k, Murat Türk, İnsu Yilmaz, Sevi̇m Bavbek

Turkish Journal of Medical Sciences

Background/aim: Chronic urticaria (CU) is a manageable disease with symptoms of itching and visible lesions that can disrupt daily life and reduce quality of life. The severity of symptoms can vary, and the cause is often unknown. Concerns among patients as regards to treatment and prognosis highlight the need for disease education to enhance self-management and reduce anxiety. The present study examines the effect of disease education on the knowledge level of CU patients.

Materials and methods: Patients with CU who presented to the allergy clinics of two tertiary university hospitals were invited to inperson education sessions including slide presentations …

Evaluation Of The Efficacy Of Radiofrequency Ablation Therapy In Cases With Parathyroid Adenoma, Bahri̇ Evren, Abdulkadi̇r Bozbay, İsmai̇l Okan Yildirim, Ömercan Topaloğlu, İbrahi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Radiofrequency ablation of solitary parathyroid adenoma has been used to treat primary hyperparathyroidism (pHPT) in high-risk patients for parathyroidectomy. This study aimed to evaluate the clinical efficacy of radiofrequency ablation for treating pHPT in patients with parathyroid adenomas.

Materials and methods: The sample for this retrospective study comprised all consecutive patients with solitary parathyroid adenoma treated with radiofrequency ablation between 2013 and 2021. Patients’ baseline serum calcium and parathyroid hormone (PTH) values were obtained. The patients were followed up with serial biochemical measurements after the intervention, then at the first-week, first-month, third-month, sixth-month, and twelfth-month follow-ups. The study’s primary …

Validity And Reliability Of The Turkish Version Of The Topical Corticosteroid Phobia (Topicop) Scale, Esra Ağaoğlu, Hi̇lal Kaya Erdoğan, Hi̇lal Çavuş, Selma Meti̇ntaş

Turkish Journal of Medical Sciences

Background/aim: Concerns about the use of topical corticosteroids (TCSs), commonly referred to as corticophobia, are widespread among dermatology patients and often lead to nonadherence to TCS treatment. This study aimed to evaluate the validity and reliability of the Turkish version of the topical corticosteroid phobia (TOPICOP) scale.

Materials and methods: The TOPICOP scale comprises 12 items grouped into 2 dimensions: beliefs (6 items) and worries (6 items). For cultural adaptation, the scale was forward and backward translated. The final Turkish version was administered to 123 patients with chronic dermatoses who rated their perceptions of TCSs using a 4-point Likert scale. …

Irisin And Adropin Decrease In Preobese Or Obese Individuals With Nonalcoholic Fatty Liver Disease, Cuma Mertoğlu, Yaprak Sule Örek, Bülent Albayrak, Yusuf Kemal Arslan, Taha Abdulkadi̇r Çoban

Turkish Journal of Medical Sciences

Background/aim: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease that is commonly observed in individuals with obesity. The present study investigates the irisin and adropin levels of sera in preobese or obese adults with NAFLD.

Materials and methods: Included in the study were 89 patients who were categorized into four groups: Group 1: 25 normal-weight individuals without NAFLD (Control group); Group 2: 17 preobese or obese individuals without NAFLD; Group 3: 24 preobese or obese individuals with Grade 1 NAFLD; and Group 4: 23 preobese or obese individuals with Grade 2–3 NAFLD. The demographic details of all participants were …

Etiology And Outcomes Of Upper Extremity Venous Thrombosis: A Retrospective Cohort Study, Selçuk Coşkun, Pinar Köksal Coşkun, Ferhat İçme, Mehmet Ali̇ Ceyhan

Turkish Journal of Medical Sciences

Background/aim: Upper extremity venous thrombosis (UEVT), encompassing upper extremity deep vein thrombosis (UEDVT) and superficial vein thrombosis (UESVT), is increasingly recognized due to invasive procedures and advanced diagnostics. This study characterizes the 5-year outcomes and etiological factors of UEVT in a large cohort.

Materials and methods: We conducted a retrospective cohort study of 304 consecutive adult patients with acute UEVT (2019–2025) at a tertiary care center in Türkiye. Demographics, medical history, thrombosis characteristics, treatments, and outcomes—including thrombosis resolution, pulmonary embolism, and mortality—were analyzed. Statistical analyses were performed using chi-square tests, multivariate logistic regression, and random forest models.

Results: Among the …

Comparison Of Spatiotemporal And Arm Swing Characteristics Of Gait Between Patients With Copd And Healthy Controls, Hi̇daye Yamikan, Ni̇hat Özgören, Serdar Aritan, Oğuz Karcioğlu, Aynur Demi̇rel

Turkish Journal of Medical Sciences

Background/aim: Impairments in spatiotemporal gait characteristics have been observed in patients with chronic obstructive pulmonary disease (COPD). However, arm swing characteristics—a fundamental component of gait that play a key role in maintaining gait stability and energy efficiency—have been largely overlooked. This study aimed to investigate the spatiotemporal characteristics of gait, together with arm swing patterns, in patients with COPD.

Materials and methods: A total of 20 patients with COPD (aged 40–65 years) and 20 age- and sex-matched healthy controls (HC) participated in this cross-sectional study. Spatiotemporal gait characteristics and arm swing data were recorded using a motion capture system equipped …

Exploring Gender Differences In The Impact Of Sleep And Fatigue On Disease Severity In Rheumatoid Arthritis: A Moderated Mediation Model, Musa Salmanoğlu, Habi̇p Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Rheumatoid arthritis (RA) is often accompanied by fatigue and sleep disturbances, which aggravate disease severity. Gender differences in these interrelationships remain insufficiently understood. This study aimed to examine whether fatigue mediates the association between sleep quality and disease severity in RA, and whether these pathways differ by gender.

Materials and methods: A single-center study was conducted with 68 RA patients (55.9% female). Disease severity was assessed using the Routine Assessment of Patient Index Data-3, fatigue using the Bristol Rheumatology Fatigue Multidimensional Questionnaire, and sleep quality using the Pittsburgh Sleep Quality Index (PSQI).

Results: Fatigue significantly mediated the relationship between …

Outcomes Of The First Adolescent-Focused Smoking Cessation Clinic In Türkiye On Tobacco Control, Demet Taş, Furkan Kalayci, Alkim Öden Akman

Turkish Journal of Medical Sciences

Background/aim: Adolescent smoking remains common, highlighting the need to control tobacco use and identify influencing factors. This study aims to evaluate the outcomes of an adolescent-focused smoking cessation clinic and the factors influencing them.

Materials and methods: The study was conducted with 262 adolescents, who, along with their parents, had direct access to the clinic. Data were drawn from patient records containing structured registration and follow-up documentation. The study investigated the effects of baseline cigarette consumption, sociodemographic characteristics, and nicotine patch use on smoking cessation rates at three months, six months, and one year.

Results: The three-month, six-month, and one-year …

The Impact Of Tizanidine, Thiocolchicoside, And Cyclobenzaprine On Vascular Function In Ovariectomized Rats, Sümeyye Nur Gürsoy, Tolga Esmerli̇gi̇l, Uğur Berkay İnce, Turhan Dost, Buket Demi̇rci̇

Turkish Journal of Medical Sciences

Background/aim: Menopause is associated with increased vascular risk. This study investigated the effects of 3 centrally acting muscle relaxants—tizanidine (TZ), thiocolchicoside (TCC), and cyclobenzaprine (CBZ)—on vascular reactivity in ovariectomized (OVX) rats as a model of menopause.

Materials and methods: Body weight, blood glucose, blood pressure, and heart rate were recorded, and the rats underwent oophorectomy surgery. Eight weeks after the operation, the rats were divided into 5 groups: sham operated rats, OVX rats, OVX rats treated with TZ (OVX + TZ), OVX rats treated with TCC (OVX + TCC), and OVX rats treated with CBZ (OVX + CBZ). All drug …

Natural Progression Of Meningeal Lymphatic Dysfunction In App/Ps1 Mice Creates A Critical Window For Alzheimer’S Disease Intervention, Zilong Shen, Xibin Zhou, Chunxiang Zhou

Turkish Journal of Medical Sciences

Background/aim: Meningeal lymphatic vessels (mLVs) facilitate the clearance of toxic metabolites like amyloid-beta (Aβ) from the central nervous system. Dysfunction in MLVs is implicated in Alzheimer’s disease (AD). However, current knowledge relies on exogenous intervention models that fail to capture spontaneous mLV decline during AD progression. In this study, we investigated the age-dependent correlation between mLV/deep cervical lymph node (dCLN) dysfunction and Aβ pathology in APP/PS1 mice under noninterventional conditions.

Materials and methods: APP/PS1 and wild-type (WT) mice at 3, 6, and 9 months of age were evaluated. Cognitive function was tested using the Morris water maze. mLV/dCLN drainage was …