Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Physical Sciences and Mathematics (7711)
- Life Sciences (5833)
- Medicine and Health Sciences (4678)
- Medical Sciences (3344)
- Computer Engineering (2852)
-
- Computer Sciences (2852)
- Electrical and Computer Engineering (2852)
- Engineering (2852)
- Animal Sciences (2532)
- Mathematics (1969)
- Chemistry (1528)
- Veterinary Medicine (1334)
- Agriculture (1249)
- Forest Sciences (1249)
- Zoology (1198)
- Botany (1048)
- Plant Sciences (1048)
- Biology (1004)
- Earth Sciences (763)
- Physics (599)
- Keyword
-
- Turkey (586)
- Taxonomy (199)
- COVID-19 (155)
- Oxidative stress (136)
- New species (125)
-
- New records (105)
- Apoptosis (96)
- Morphology (88)
- Inflammation (86)
- Children (85)
- Classification (85)
- Deep learning (85)
- Iran (85)
- Antioxidant (81)
- Machine learning (80)
- Breast cancer (79)
- New record (78)
- Phylogeny (75)
- Biodiversity (72)
- Rat (71)
- Optimization (68)
- Genetic diversity (66)
- Distribution (64)
- Mortality (64)
- Cytotoxicity (63)
- Fauna (60)
- Genetic algorithm (60)
- Cancer (58)
- Gene expression (58)
- SARS-CoV-2 (55)
- Publication Year
Articles 601 - 630 of 18793
Full-Text Articles in Entire DC Network
G-Topological Groupoids, Osman Mucuk
G-Topological Groupoids, Osman Mucuk
Turkish Journal of Mathematics
In the groupoid theory, it is unclear that a topological groupoid's quotient groupoid with the quotient topology is topological. In this paper, we approach this problem considering G-methods and G-convergence. We define G-topological groupoid, which agrees with the sequential version of a topological groupoid in the particular case G=lim, and give some counterexamples. Then, we extend the usual properties of topological groupoids to the G-topological groupoids. We also prove that a G-topological groupoid's quotient groupoid is G-topological groupoid when a normal subgroupoid is suitably chosen. This result enables us to obtain examples of topological quotient groupoids in a particular case.
The Variation Of Eigenvalues Of The Two-Dimensional Magnetic Schrödinger Operator With Respect To The Angle Of A Flat Sector, Araz R. Aliev, Elshad H. Eyvazov
The Variation Of Eigenvalues Of The Two-Dimensional Magnetic Schrödinger Operator With Respect To The Angle Of A Flat Sector, Araz R. Aliev, Elshad H. Eyvazov
Turkish Journal of Mathematics
A two-dimensional Schrödinger operator with a spherically symmetric electric potential and an Aharonov Bohm magnetic field in a circular sector under Neumann boundary conditions is considered. The intervals of the angular variation of the flat region are found, where the eigenvalues of the Neumann problem for the Schrödinger operator with a spherically symmetric electric potential strictly decrease monotonically in the Aharonov-Bohm magnetic field.
Further Geometric Properties Of The Generalized K-Bessel Functions, Merve Görgülü, İbrahi̇m Aktaş
Further Geometric Properties Of The Generalized K-Bessel Functions, Merve Görgülü, İbrahi̇m Aktaş
Turkish Journal of Mathematics
This study investigates certain geometric properties of the normalized k-Bessel function, which is a natural generalization of classical and modified Bessel functions of the first kind. These geometric properties include η-starlikeness, η-uniform convexity, starlikeness associated with exponential function and Bernoulli’s lemniscate, and convexity associated with exponential function and Bernoulli’s lemniscate. Moreover, certain corollaries related to classical and modified Bessel functions are presented by specialising parameters. In addition, some examples and their graphical representations are provided to support the findings of this study.
Some Methods For Finding The Number Of Partitions Of N With M−Parts, P(N, M), Yusuf Soyvural, Ali̇ Bülent Eki̇n
Some Methods For Finding The Number Of Partitions Of N With M−Parts, P(N, M), Yusuf Soyvural, Ali̇ Bülent Eki̇n
Turkish Journal of Mathematics
P(n, m) denotes the number of partitions of n with m parts, while Pm(n) denotes the number of partitions of n with parts at most m. It is a well-known result that the number of partitions of n ≥ 0 into m or fewer parts is equal to Pm(n). In the literature, there are some results for P(n, m) and Pm(n) for some values of m. In this work, we give more compact results for P(n …
On Almost Kenmotsu Manifolds Admitting Nearly Vacuum Static Equations With Applications, Uday Chand De, Krishnendu De, Sudhakar Kumar Chaubey
On Almost Kenmotsu Manifolds Admitting Nearly Vacuum Static Equations With Applications, Uday Chand De, Krishnendu De, Sudhakar Kumar Chaubey
Turkish Journal of Mathematics
In this article, we study certain characteristics of nearly vacuum static equations on almost Kenmotsu manifolds. It is established that an η-Einstein almost Kenmotsu manifold allowing nearly vacuum static equations is of constant scalar curvature and either the solution is trivial or, the manifold reduces to an Einstein manifold. Next, nearly vacuum static equations on (κ,μ)-almost Kenmotsu manifolds and generalized (κ,μ)'-nullity distribution are considered and we obtain several interesting results. Moreover, we illustrate that if a 3-dimensional Kenmotsu manifold allows nearly vacuum static equations, then the manifold is locally isometric to the hyperbolic space Η3(-1). After that, we investigate a …
Fubini Collocation Method For Numerical Solutions Of Differential Equations With Quadratic And Cubic Nonlinearities, Kübra Erdem Bi̇çer, Havva Türkhan
Fubini Collocation Method For Numerical Solutions Of Differential Equations With Quadratic And Cubic Nonlinearities, Kübra Erdem Bi̇çer, Havva Türkhan
Turkish Journal of Mathematics
In this study, the Fubini collocation method is proposed for the approximate solution of nonlinear differential equations. The method utilizes fundamental relations involving Fubini polynomials and their derivatives, employing collocation points to enhance solution accuracy. Within this framework, the given differential equation is transformed into a system of nonlinear algebraic equations involving the unknown coefficients of the approximate solution. This resulting system is then solved using appropriate numerical techniques to obtain the approximate solution. The effectiveness of the proposed method is demonstrated through several test problems, with accuracy evaluated using absolute error functions. Furthermore, illustrative examples and residual-based error analysis …
The Derivative Of Spectral Function Of The Problem With The Boundary Condition Dependent On Spectral Parameter, Eli̇f Başkaya, Haskiz Coşkun
The Derivative Of Spectral Function Of The Problem With The Boundary Condition Dependent On Spectral Parameter, Eli̇f Başkaya, Haskiz Coşkun
Turkish Journal of Mathematics
In this study, the computation of the derivative of the spectral function for Sturm-Liouville problem with eigenvalue dependent boundary condition at the finite left end is considered.
Representation Of Inverse Ordered Semigroups By Means Of Symmetric Inverse Semigroups On A Set, Michael Tsingelis
Representation Of Inverse Ordered Semigroups By Means Of Symmetric Inverse Semigroups On A Set, Michael Tsingelis
Turkish Journal of Mathematics
A partial one-to-one mapping on a set X is a mapping whose domain is a subset of X. The set of partial one-one mappings on a set X is an inverse semigroup (the symmetric inverse semigroup on X). An element x of an ordered semigroup (S, ·, ≤) is called an inverse element of α ∈ S if α ≤ xαx and x ≤ xαx. An inverse ordered semigroup is an ordered semigroup S for which every element of S possesses an inverse element and the inverse elements of any element of S are in …
Cospectrality Results For Signed Graphs With Two Eigenvalues Unequal To ±1, Willem H. Haemers, Hati̇ce Topcu
Cospectrality Results For Signed Graphs With Two Eigenvalues Unequal To ±1, Willem H. Haemers, Hati̇ce Topcu
Turkish Journal of Mathematics
Recently the collection G of all signed graphs for which the adjacency matrix has all but at most two eigenvalues equal to ±1 has been determined. Here we investigate G for cospectral pairs, and for signed graphs determined by their spectrum (up to switching). If the order is at most 20, the outcome is presented in a clear table. If the spectrum is symmetric we find all signed graphs in G determined by their spectrum, and we obtain all signed graphs cospectral with the bipartite double of the complete graph. In addition we determine all signed graphs cospectral with the …
Codazzi Normalized Null Hypersurfaces, Théophile Kemajou Mbiakop, Cyriaque Atindogbe, Ferdinand Ngakeu
Codazzi Normalized Null Hypersurfaces, Théophile Kemajou Mbiakop, Cyriaque Atindogbe, Ferdinand Ngakeu
Turkish Journal of Mathematics
We introduce a class of null hypersurfaces of Lorentzian manifolds, namely Codazzi normalized null hyper surfaces, whose (screen) shape operator associated with the rigged vector field is a Codazzi tensor. Several examples are given to support our study. Moreover, we investigate conditions implying that the induced Riemannian screen structure on a Codazzi-type normalized null hypersurface of a Lorentzian space is locally a nontrivial warped product.
Utilization Of Phytogenic Silver Nanoparticles And Bacterial Agents For The Management Of Citrus Canker Disease, Zainab Jamil, Tariq Mukhtar, Muhammad Usman Raja, Muhammad Shahbaz, Jaya Seelan S. Seelan, Muhammed Tatar, Amjad Ali, Noor Fatima, Rahma Bejaoui, Ayşe Usanmaz Bozhüyük
Utilization Of Phytogenic Silver Nanoparticles And Bacterial Agents For The Management Of Citrus Canker Disease, Zainab Jamil, Tariq Mukhtar, Muhammad Usman Raja, Muhammad Shahbaz, Jaya Seelan S. Seelan, Muhammed Tatar, Amjad Ali, Noor Fatima, Rahma Bejaoui, Ayşe Usanmaz Bozhüyük
Turkish Journal of Agriculture and Forestry
Citrus is one of the most important and widely cultivated fruit crops globally. However, its productivity is increasingly threatened by various diseases, with bacterial infections being particularly the most destructive. Among these, citrus canker, caused by Xanthomonas axonopodis pv. citri (Xac), poses a significant challenge, requiring effective management strategies. Traditional approaches have shown limited success, but nanotechnology has emerged as a promising alternative for disease control. In this study, Xanthomonas spp. was isolated from two locations: Koont Farm and the National Agricultural Research Centre (NARC) citrus orchards in Islamabad, Pakistan. The isolates were identified through morpho-biochemical methods. Moreover, three Bacillus …
Optimizing Cultivated Land Productivity Through Integrated Fertilization Strategies And Uav-Assisted Management, Kejun Wang
Turkish Journal of Agriculture and Forestry
This study investigates the impact of long-term fertilization modes on crop health and productivity using unmanned aerial vehicle (UAV)-assisted monitoring and a Q-learning-based approach for optimized fertilization strategies. An approximate state-matching Q-learning algorithm was developed to improve the efficiency of agricultural UAVs in fertilization tasks. The spatiotemporal patterns of cultivated land productivity under different fertilization regimes were analyzed in a long-term experiment. An evaluation system for cultivated land health productivity was established. The results indicated that the Q-learning algorithm enabled UAVs to achieve efficient task completion. QLASM outperformed traditional methods on all metrics. QLASM achieved a 92% task completion rate …
Jujubenet: A Dual-Stage Spectral Reconstruction Network For Rapid Jujube Moisture Content Estimation, Yalei Xu, Yang Li, Jing Nie, Jingbin Li
Jujubenet: A Dual-Stage Spectral Reconstruction Network For Rapid Jujube Moisture Content Estimation, Yalei Xu, Yang Li, Jing Nie, Jingbin Li
Turkish Journal of Agriculture and Forestry
Spectral analysis methods can nondestructively assess the quality of agricultural products but are limited by imaging speed and equipment costs. Therefore, they have not yet been fully integrated into engineering practices. This paper presents JujubeNet, a two-stage hyperspectral reconstruction model for detecting moisture content in jujubes. The first stage utilizes a generative pretrained Pix2Pix generative adversarial network (GAN) to generate RGB images of jujubes that mimic real camera styles and are pixel-to-pixel aligned with hyperspectral images. The second stage uses a transformer-based spectral reconstruction model to achieve hyperspectral reconstruction. Additionally, we developed a moisture content detection model based on hyperspectral …
Effect Of Nettle (Urtica Dioica L.) Seed Powder Supplementation On Some Important Quality Characteristics Of Cakes, Esra İrem Can, Kadi̇r Çebi̇
Effect Of Nettle (Urtica Dioica L.) Seed Powder Supplementation On Some Important Quality Characteristics Of Cakes, Esra İrem Can, Kadi̇r Çebi̇
Turkish Journal of Agriculture and Forestry
The nutritional adjustment of food products has gained popularity in recent years as consumer interest in healthy eating has increased. Cake is a widely consumed cereal-based product containing such key nutrients as carbohydrate, fat, protein, fiber, vitamins, and minerals. In the present study, crust and crumb color, specific volume, microstructure, antimicrobial activity, total phenolic content, antioxidant activity, and sensory analyses were evaluated in four cake groups: a control cake (IT0) and cakes supplemented with 1% (IT1), 3% (IT2), and 5% (IT3) nettle seed powder. The addition of nettle seed powder to the cakes significantly reduced the crust (L*, a* and …
Mango Leaf Disease Detection And Classification Using A Federated Learning Based Lightweight Vision Transformer Model, Vinay Gautam, Prabhjot Kaur, Anand Muni̇ Mishra, Achyut Shankar, Laxman Singh
Mango Leaf Disease Detection And Classification Using A Federated Learning Based Lightweight Vision Transformer Model, Vinay Gautam, Prabhjot Kaur, Anand Muni̇ Mishra, Achyut Shankar, Laxman Singh
Turkish Journal of Agriculture and Forestry
The detection and management of horticultural crop diseases is crucial for enhancing productivity, reducing costs, and promoting environmentally sustainable practices. Recently, various techniques have been developed for managing crop-related issues, including leaf diseases and pest control. A centralized control approach has been implemented for disease detection. This centralized system faced significant challenges, including concerns over data privacy and the costs associated with data migration. This study addressed the problems with centralized solutions through a federated learning approach enhanced by the attention mechanism of the vision transformer (ViT). We investigated the key features of the federated learning method and propose a …
Effects Of Different Perfluoroalkyl Substances On Rice Morphology, Physiology, And Biochemistry, Maryam M. Alomran, Muhammad Aqeel, Noreen Khalid, Noreen Akhter, Muhammad Kashif Irshad, Suliman Mohammed Suliman Alghanem, Fahad Mohammed Alzuaibr, Saher Nawaz, Omar Mahmoud Alzoubi, Muhammad Usman Akbar, Ali Noman
Effects Of Different Perfluoroalkyl Substances On Rice Morphology, Physiology, And Biochemistry, Maryam M. Alomran, Muhammad Aqeel, Noreen Khalid, Noreen Akhter, Muhammad Kashif Irshad, Suliman Mohammed Suliman Alghanem, Fahad Mohammed Alzuaibr, Saher Nawaz, Omar Mahmoud Alzoubi, Muhammad Usman Akbar, Ali Noman
Turkish Journal of Agriculture and Forestry
Perfluoroalkyl substances (PFASs) are synthetic organic compounds that have not been extensively studied in natural environments. The current study aimed to explore how PFASs, including perfluorooctane sulfonic acid (PFOS), perfluorobutane sulfonate (PFBS), perfluorohexanoate (PFHxA), perfluorotetradecanoate (PFTeDA), and perfluorobutanoate (PFBA), affect rice plants and influence their metabolism. These substances had a notable impact on root and shoot growth, reducing fresh and dry weights across various treatments compared to the control. These attributes were the least affected by PFOS treatment. PFBA treatment had significant adverse effects on chlorophyll a, b, and total chlorophyll levels, followed by the effects of PFHxA and PFTeDA. …
Exploring Bioactive Components Of Sugar Bean With Some Data Mining Algorithms: Relationships Between Antioxidants, Enzyme Inhibitors, And Minerals, İrem Ayran Çolak
Exploring Bioactive Components Of Sugar Bean With Some Data Mining Algorithms: Relationships Between Antioxidants, Enzyme Inhibitors, And Minerals, İrem Ayran Çolak
Turkish Journal of Agriculture and Forestry
Sugar bean (Phaseolus vulgaris L.) is a legume of notable nutritional and functional value, and its genotypes have substantial variation in bioactive compounds, antioxidant activity, mineral composition, and enzyme inhibition properties. This study aimed to comprehensively evaluate the biochemical and functional diversity of 10 sugar bean genotypes using data mining algorithms to identify superior candidates for functional food and nutraceutical development. Associations between the phytochemical profiles of sugar bean genotypes and their bioactivity, antioxidant capacity, and enzyme inhibition were modeled with classification and regression trees (CART), random forests (RF), and multivariate adaptive regression splines (MARS), while one-way ANOVA quantified varietal …
A New Longidoridae Member, Xiphinema Brevicolle, From Citrus Orchards In Türkiye, Adem Özarslandan, Ayşenur Aslan, Lerzan Öztürk
A New Longidoridae Member, Xiphinema Brevicolle, From Citrus Orchards In Türkiye, Adem Özarslandan, Ayşenur Aslan, Lerzan Öztürk
Turkish Journal of Agriculture and Forestry
Individuals of the genus Xiphinema were recovered from soil samples collected during citrus surveys in south-eastern Türkiye. Morphological examination using light microscopy identified the species as X. brevicolle. The female individuals measured 2000–2050 μm in length, and displayed a slightly flattened lip region, an amphidelphic reproductive system with two well-developed branches, and a short conoid tail ending in a rounded tip. These morphometric and morphological features were consistent with those of previously described X. brevicolle specimens. For molecular confirmation, the D2–D3 segment of the 28S rDNA was amplified using the D2AD3B primer pair, and sequenced; the resulting sequence has been …
Effects Of Different Mixing Ratios Of Common Vetch And Oats On Forage Yield And Quality, Meli̇h Okcu, Sedat Severoğlu, İbrahi̇m Kavuncu
Effects Of Different Mixing Ratios Of Common Vetch And Oats On Forage Yield And Quality, Meli̇h Okcu, Sedat Severoğlu, İbrahi̇m Kavuncu
Turkish Journal of Agriculture and Forestry
This study investigates the optimal mixing ratios of common vetch (Vicia sativa L., CV) and oats (Avena sativa L., O) for enhanced forage yield and quality in the ecological conditions of Erzurum Province. The research was conducted over two growing seasons with three replications in a randomized complete block design (RCBD). Specifically, three common vetch cultivars (Gülhan, Albayrak, Kubilay) and one oat cultivar (Kupa) were evaluated by sowing as sole crops and in different ratios (25% vetch + 75% oat, 50% vetch + 50% oat, 75% vetch + 25% oat). The analyzed parameters included hay forage yield (HFY), dry matter …
Gamma Secretase Inhibitors, Dapt And Mk0752, Exhibit Synergistic Anticancer Effects With Cisplatin And Docetaxel In 2d And 3d Models Of Breast Cancer, Kübra Telli̇, Johannes Gubat, Padraig D'Arcy, Özden Yalçin Özuysal
Gamma Secretase Inhibitors, Dapt And Mk0752, Exhibit Synergistic Anticancer Effects With Cisplatin And Docetaxel In 2d And 3d Models Of Breast Cancer, Kübra Telli̇, Johannes Gubat, Padraig D'Arcy, Özden Yalçin Özuysal
Turkish Journal of Biology
Background/aim: Breast cancer remains a major malignancy among women, and severe side effects and the development of acquired drug resistance frequently hinder current therapeutic strategies. The Notch signaling pathway, a key regulator of cell fate, is commonly dysregulated in breast cancer and associated with poor prognosis. Gamma-secretase inhibitors (GSIs) block Notch receptor activation and have shown potential anticancer efficacy. This study aimed to investigate the synergistic activity of two commonly used GSIs, DAPT and MK0752, combined with docetaxel or cisplatin in both 2D and 3D breast cancer models.Materials and methods: Triple-negative, highly metastatic MDA-MB-231 and ER+/PR+ MCF-7 breast cancer cell …
Study On The Role Of Shenfu Injection In Mediating Ferroptosis Through The Akt/Gsk-3Β/Nrf2 Pathway In Yang-Deficient Chronic Heart Failure, Xiaojie Chen, Jiayun Guo, Bing Lin, Huamin Wang, Ziyu Lu, Bayi Liu
Study On The Role Of Shenfu Injection In Mediating Ferroptosis Through The Akt/Gsk-3Β/Nrf2 Pathway In Yang-Deficient Chronic Heart Failure, Xiaojie Chen, Jiayun Guo, Bing Lin, Huamin Wang, Ziyu Lu, Bayi Liu
Turkish Journal of Biology
Background/aim: The present study investigates the role of Shenfu injection in the treatment of yang-deficient chronic heart failure (CHF). Materials and methods: Sprague-Dawley (SD) rats were modeled for yang-deficient CHF by abdominal aortic coarctation. Echocardiography was performed to detect changes in cardiac function, and serum N-terminal B-type natriuretic peptide proteins (NT-proBNP), cardiac troponin I (cTnI), and ferroptosis-related factors were measured using ELISA kits. Pathological changes in cardiac tissues were observed through hematoxylin-eosin (HE) and Masson’ trichrome staining, cardiomyocyte apoptosis was measured by TUNEL staining, and reactive oxygen species (ROS) production was determined through dihydroethidium (DHE) staining. The expression of nuclear …
Identification Of Epigenetic Monotherapy Candidates In Taxane-Resistant Crpc, Buse Cevatemre, İpek Bulut, Ezgi̇ Karyemez, Ceyda Açilan
Identification Of Epigenetic Monotherapy Candidates In Taxane-Resistant Crpc, Buse Cevatemre, İpek Bulut, Ezgi̇ Karyemez, Ceyda Açilan
Turkish Journal of Biology
Background/aim: Taxane resistance remains a significant challenge in the effective treatment of castration-resistant prostate cancer (CRPC). Given the association of epigenetic regulation with chemotherapy resistance and cancer progression, this study aims to identify epigenetic vulnerabilities in two CRPC cell lines (DU145 and 22Rv1) established as resistant to two different taxanes, docetaxel (Dtx) and cabazitaxel (Cbz), using a small-molecule screening approach. Materials and methods: A small-molecule library targeting epigenetic regulators, including histone deacetylases (HDAC), histone methyltransferases, histone demethylases, bromodomain proteins, deoxyribonucleic acid methyltransferases, protein arginine deiminase, and histone acetyltransferase was utilized. Drug screening was performed on parental and taxane-resistant CRPC cell …
In Vitro Antibiofilm Activity Of Tyrosol Against Single And Dual-Species Biofilms Of Candida Tropicalis And Streptococcus Mutans, Zarifeh Adampour, Betül Yilmaz Öztürk, Bükay Yeni̇ce Gürsu, İlknur Dağ
In Vitro Antibiofilm Activity Of Tyrosol Against Single And Dual-Species Biofilms Of Candida Tropicalis And Streptococcus Mutans, Zarifeh Adampour, Betül Yilmaz Öztürk, Bükay Yeni̇ce Gürsu, İlknur Dağ
Turkish Journal of Biology
Background/aim: The cross-kingdom biofilm structure formed by Candida tropicalis and Streptococcus mutans may increase caries formation. The aim of this study was to evaluate the in vitro effect of the exogenous tyrosol on single- and dual-species biofilms as well as planktonic cultures formed by C. tropicalis and S. mutans. Materials and methods: The antimicrobial efficacy of tyrosol was evaluated through broth microdilution, colony-forming unit (CFU) enumeration, and XTT reduction tests to assess cell viability and metabolic activity. Transmission electron microscopy (TEM) was used to examine ultrastructural changes in planktonic cells. Biofilm dynamics were visualized via scanning electron microscopy (SEM) and …
Eucommia Ulmoides Extract Attenuates Oxidative Stress And Promotes Melanogenesis Via Wnt/Β-Catenin Signaling In B16 Cells And Mice, Xiaojin Liu, Yaqian Qiu, Xiaobing Lv, Lei Chang, Tiancheng Ji, Yefan Gu, Shuyue Chen
Eucommia Ulmoides Extract Attenuates Oxidative Stress And Promotes Melanogenesis Via Wnt/Β-Catenin Signaling In B16 Cells And Mice, Xiaojin Liu, Yaqian Qiu, Xiaobing Lv, Lei Chang, Tiancheng Ji, Yefan Gu, Shuyue Chen
Turkish Journal of Biology
Background/aim: Oxidative stress is a major contributor to melanocyte dysfunction and hair graying by impairing key signaling pathways. Eucommia ulmoides bark extract (EUE), rich in antioxidant phytochemicals, has shown potential in combating oxidative damage. This study investigated the protective and promelanogenic effects of EUE under hydrogen peroxide (H₂O₂)-induced oxidative stress, with a focus on the Wnt/β-catenin signaling pathway. Materials and methods: An oxidative stress model was established using B16 cells and a C57BL/6 mouse hair follicle model. Results: EUE significantly improved melanocyte survival and reduced intracellular reactive oxygen species (ROS). Mechanistically, EUE activated the Wnt/β-catenin pathway, leading to upregulation of …
Mir-22 Inhibits The Proliferation, Migration, And Invasion Of Human Cd133-Positive Glioblastoma Stem Cells, Sevi̇l Köse, Özlenen Özkan, Ömer Özkan
Mir-22 Inhibits The Proliferation, Migration, And Invasion Of Human Cd133-Positive Glioblastoma Stem Cells, Sevi̇l Köse, Özlenen Özkan, Ömer Özkan
Turkish Journal of Biology
Background/aim: Glioblastoma multiforme (GBM) is one of the most aggressive and fatal malignancies of the central nervous system. Despite advancements in treatment strategies, effective therapies for GBM remain insufficient, necessitating further improvements. Notably, miR-22 has been found to be significantly downregulated in both glioblastoma tissues and cell lines. In this study, we aim to evaluate miR-22 expression levels in GBM (U87) and CD133-positive (CD133+) GBM stem cells (GSCs) and to investigate its effects on proliferation, colony formation, migration, invasion, and wound-healing in U87 and CD133+ U87 cells in vitro.Materials and methods: We isolated CD133+ U87 cells using magnetic-activated cell sorting …
Exploring Shootin1’S Oncogenic Role Within Fgfr2 Gene Fusions, Volkan Ergi̇n, Mutlu Erdoğan, Ekrem Yaşar, Sika Zheng
Exploring Shootin1’S Oncogenic Role Within Fgfr2 Gene Fusions, Volkan Ergi̇n, Mutlu Erdoğan, Ekrem Yaşar, Sika Zheng
Turkish Journal of Biology
Background/aim: Fibroblast Growth Factor Receptor (FGFR) gene fusions are recognized as pivotal oncogenic drivers, contributing to cancer initiation and progression across diverse malignancies. These fusions often represent significant therapeutic targets, particularly in challenging malignancies like cholangiocarcinoma. This study aimed to characterize the novel FGFR2::SHTN1 fusion, identify it as a de novo chimeric protein, and elucidate its precise oncogenic mechanism. Materials and methods: FGFR2::SHTN1 fusions were identified via cancer genomics databases and modeled using AlphaFold and HADDOCK. SHTN1 variants were expressed in Neuro-2a cells for coimmunoprecipitation, purification, and native polyacrylamide gel electrophoresis to assess oligomerization. Structural modeling included membrane embedding with …
Efflux Pump-Associated Antimicrobial Resistance Genes In Staphylococcus Spp. From Dairy And Meat Samples, M.Burcu Külahci, Sumru Çitak
Efflux Pump-Associated Antimicrobial Resistance Genes In Staphylococcus Spp. From Dairy And Meat Samples, M.Burcu Külahci, Sumru Çitak
Turkish Journal of Biology
Background/aim: This study aimed to investigate the phenotypic resistance and distribution of efflux pump-associated antimicrobial resistance genes in Staphylococcus spp. isolated from dairy and meat samples. Antimicrobial resistance in foodborne bacteria increases with antibiotic exposure and biocides, particularly through efflux mechanisms. Thus, monitoring potential genetic reservoirs in the food chain is very important. Materials and methods: A total of 132 dairy and meat samples were collected for the study, and Staphylococcus spp. were isolated using Mannitol salt phenol red agar. Antimicrobial susceptibility was evaluated using the Clinical and Laboratory Standards Institute’s microdilution method. Twenty-six resistant isolates were identified by 16S …