Digital Commons Network^™

​Functional Characterization Of Stmtpsl Terpene Synthase-Like Genes And Their Role In Pathogen Resistance In Selaginella Tamariscina, Zhijie He, Bo Bi

Turkish Journal of Agriculture and Forestry

The biological activity and function of microbial terpene synthase-like genes from Selaginella tamariscina (StMTPSL) were investigated using molecular and biochemical approaches. After isolating and amplifying StMTPSL genes (StMTPSL1-StMTPSL6), both native and site-directed mutant forms were expressed in tobacco via Agrobacterium-mediated transformation. The resulting transgenic plants had increased expression of StMTPSL genes, enhanced monoterpene production (as confirmed by GC-MS), and significantly improved resistance to Pseudomonas syringae infection compared to nontransgenic controls. These results show that StMTPSL genes are functionally active in plants and contribute to pathogen resistance through elevated terpene biosynthesis. This study provides new insights into the role of MTPSL …

Effect Of Some Organic Fertilizers On Yield And Quality Of Olive Oil In Semiarid Conditions, İshak Bayyi̇ği̇t, Ebru Sakar

Turkish Journal of Agriculture and Forestry

This two-year field experiment evaluated the effects of different organic fertilizers on olive oil quality of the Gemlik cultivar grown under semiarid conditions in Mardin, Türkiye. Treatments of olive pomace (P1: 4, P2: 8, P3: 12 kg tree⁻¹), leonardite (L1: 1.5, L2: 3.0, L3: 4.5 kg tree⁻¹), and vermicompost (SG1: 3, SG2: 6, SG3: 9 kg tree⁻¹) were applied in a randomized complete block design with three replicates. Oils were analyzed for free acidity (FA), peroxide value, and phenolic profile using high-pressure liquid chromatography. FA ranged from 0.27% to 0.42% (as oleic acid), remaining well below the International Olive Council …

Comparative Evaluation Of Curd Enriched With Essential Oils Derived From Dill, Caraway, And Cumin, Hafize Fidan, Toncho Kolev, Denis Dervish, Ivayla Dincheva, Ira Taneva, Serkan Yilmaz, Yusuf Şavşatli, Albena Stoyanova

Turkish Journal of Agriculture and Forestry

Curd cheese is a traditional dairy product that, in recent years, has increasingly been supplemented with various functional additives aimed at enhancing its aroma and flavor profile, improving overall quality, and extending shelf-life. The objective of the present study was to conduct a comparative evaluation of changes in selected physicochemical, microbiological, and sensory parameters of curd cheese enriched with 0.01% essential oils derived from dill (Anethum graveolens L.), cumin (Cuminum cyminum L.), and caraway (Carum carvi L.) fruits. Fatty acid profiling revealed a reduction in saturated fatty acids and an increase in oleic and linoleic acids in essential oil-enriched curds …

Deep Learning Technology In Multimodal Remote Sensing Data Fusion To Analyze Crop Growth And Economic Forecast, Tianlong Jiang, Ziyang Liu, Li Sun

Turkish Journal of Agriculture and Forestry

This paper integrated multimodal remote sensing (RS) data with deep learning to develop a maize growth analysis and income prediction model based on CNN (Convolutional Neural Network)-Attention and Bi-LSTM (Bidirectional Long Short-Term Memory). Utilsing Landsat 8, Sentinel-2, and Sentinel-1 satellite data, the CNN-Attention network extracts vegetation features such as NDVI (Normalised Difference Vegetation Index), EVI (Enhanced Vegetation Index), and canopy density for corn growth stage identification and prediction. The study combined these features with meteorological, soil, and market data and fed them into a Bi-LSTM model for time series analysis to forecast corn income. The method achieved 98.3% accuracy in …

Long-Term Tillage And Straw Returning Practices Enhance Soil Humus Composition, Carbon Sequestration, And Ecological–Economic Benefits, Kai Wang

Turkish Journal of Agriculture and Forestry

While straw return is widely promoted, its specific effects on soil humus composition, structure, and ecological functions are not fully understood. This study investigates the long-term impacts of different straw types and farming practices on humus composition, carbon sequestration, and ecological–economic benefits. In Hunan Province’s paddy fields, six soils with 5–30-year farming histories were selected. Treatments included a blank control, corn straw return, and rice straw return, each replicated three times. Humus structure was analyzed via infrared spectroscopy, component contents were determined by alkali extraction, and a carbon footprint model assessed emissions. Ecological economic analysis integrated soil carbon pool dynamics, …

Ultrasound-Assisted Enzymatic Extraction Improves The Antiinflammatory Activity Of Red Dragon Fruit Peel Pectin, Bao Le, Seung Hwan Yang, Hoang Dang Khoa Ta

Turkish Journal of Biology

Background/aim: Inflammatory bowel disease is a chronic inflammatory disorder characterized by excessive immune activation, primarily mediated by nitric oxide and proinflammatory cytokines. This condition encompasses ulcerative colitis and Crohn’s disease, both of which significantly impair patients’ quality of life and pose persistent challenges in clinical management. Pectin, a complex carbohydrate found in plant cell walls, has shown promise in reducing inflammation. Materials and methods: In this study, pectin was extracted from red dragon fruit peel using two methods: ultrasound-assisted extraction and ultrasound-assisted enzymatic extraction. The structural characteristics and antiinflammatory effects of the extracted pectin were evaluated in lipopolysaccharide-stimulated RAW 264.7 …

Ankrd2 May Alleviate Denervation-Induced Skeletal Muscle Atrophy By Inhibiting Inflammation, Yalin Zhang, Lin Zhang, Li Li, Liqin Zhang, Li Zeng, Jiaying Qiu, Zhengrong Xi, Wenwen Wang

Turkish Journal of Biology

Background/aim: Sciatic nerve injury causes a loss of skeletal muscle innervation, reduced motor function, and eventual muscle atrophy. Inflammation and increased protein degradation are key factors contributing to muscle atrophy. Inflammation is activated early during muscle atrophy and can be modulated by various factors. However, the precise role of inflammation in denervation-induced muscle atrophy remains unclear. Materials and methods: Transcriptome sequencing was used to determine that the inflammatory response occurs early during denervation-induced muscle atrophy. RT-qPCR validation of several inflammatory factors showed rapid upregulation at early stages, followed by gradual downregulation. Weighted gene coexpression network analysis of differentially expressed genes …

Analysis Of Agricultural Remote Sensing Data Driven By Artificial Intelligence On Crop Growth Patterns And Economic Benefits Of Grain, Yang Wang

Turkish Journal of Agriculture and Forestry

To address the shortcomings of conventional agricultural statistical and monitoring methods on a regional scale, this paper proposes the use of artificial intelligence-driven remote sensing data for analysing crop growth patterns and the economic benefits of grain. Winter wheat data from three stations in a single province from 2011 to 2020 was used, with the leaf area index (LAI) used as the key crop growth indicator value. The simulated annealing algorithm was used to assimilate the LAI and remote sensing leaf area index (MODIS-LAI), simulated by the World Food Study (WOFOST) simulation model, to carry out simulation analysis of winter …

Nitrogen Transport Patterns And Vegetation Community Optimization In Urban Green Space Soils Using Multifactor Coupling Analysis, Shujian Yang, Baoxi Yu, Zheng He, Baochang Liu, Chang Liu

Turkish Journal of Agriculture and Forestry

As vital components of urban ecosystems, urban green spaces directly affect soil fertility and plant growth through nitrogen transport dynamics. This study addresses the existing methodological gaps in understanding nitrogen cycling within urban green spaces, particularly the unclear interaction mechanisms between vegetation structure and soil physicochemical characteristics. The study was conducted in the Green Expo Park located in Nanjing, China. Using a stratified sampling approach, physicochemical indicators of soil layers were measured and combined with community parameters—including leaf area index, vegetation coverage, and plant density—to identify key drivers through correlation and multiple regression analyses. The regulatory mechanisms of soil physicochemical …

Mitigation Of Salinity Stress In Carnation Plants Through Zinc Oxide Nanoparticles: Growth, Physiological, And Biochemical Responses, Adel A. Rezk, Ishtiaq Ahmad, Maryam, Muhammad Saleem, Othman Al-Dossary, Hossam S. El-Beltagi, Mohammed Aldaej, Bader Y. Alsubaie, Hati̇ce Gülen, Tarek Shalaby, Riaz Ahmad

Turkish Journal of Agriculture and Forestry

Carnation (Dianthus caryophyllus L.) growth and floral yield are severely reduced when grown in soils with excessive salinity. Mitigation of adverse effects from salinity-induced stress is necessary for sustainable carnation cultivation. Although various approaches have been developed, the use of zinc oxide nanoparticles (ZnO-NPs) to ameliorate these effects remains scarcely explored. The current study explored the potential of ZnO-NPs to alleviate salinity-induced stress by examining their effects on morphophysiological and biochemical traits. A controlled pot experiment was conducted using a factorial design with three concentrations of sodium chloride (0, 50, and 100 mM) and three of ZnO-NPs (0, 50, and …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

Unusual Rna Polymerase Ii Patterns In Meiotic Prophase I In Nannospalax Xanthodon: Insights Into Chromatin, Telomeres, And Sex Chromosomes, Sergey N. Matveevsky, Ferhat Matur, Faruk Çolak, Andrei Kandaurov, Mustafa Sözen, Svetlana V. Pavlova, Oxana Kolomiets

Turkish Journal of Biology

Background: Meiotic transcription is a highly regulated process involving stage-specific chromatin remodeling and dynamic RNA polymerase II (RNAPII) activity. Nevertheless, our current understanding is largely based on classical model organisms, while many nonmodel mammals remain unexplored. This study investigates the transcriptional dynamics and chromatin features during meiotic prophase I in Nannospalax xanthodon, a subterranean blind mole rat species with extensive intraspecific karyotype variation.Materials and methods: Using immunofluorescence, we analyzed synapsis and transcriptional activity in spermatocyte nuclei of two geographically distant N. xanthodon males, detecting SYCP3, CREST, γH2AFX, and phosphorylated RNAPII (Ser5, Ser2). Telomereassociated proteins RAP1 and TERT were also examined …

Protective Effect Of Pinocembrin On Zearalenone-Induced Hepatotoxicity Via Pi3k/Akt And Nrf2 Signaling In Albino Mice, Sujatha Tejavat

Turkish Journal of Biology

Background/aim: Zearalenone (ZEA) is a Fusarium-derived mycotoxin that frequently contaminates food and feed and induces hepatotoxicity in humans and animals through oxidative stress and inflammation. Pinocembrin (PCM), a naturally occurring flavonoid, has potent antioxidant and antiinflammatory properties. This study investigated the hepatoprotective effects of PCM against ZEAinduced liver injury in albino mice, with a focus on the nuclear factor erythroid 2–related factor 2 (NRF2) and phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathways. Materials and methods: Twenty-four albino male mice were allocated into four groups: (1) control (vehicle 0.05% dimethyl sulfoxide), (2) ZEA-treated (40 mg/kg body weight), (3) PCM-treated (50 mg/kg …

Single-Walled Carbon Nanotube-Mediated Plasmid Dna Delivery In The Model Monocot Brachypodium Distachyon, Kaya İşleyen Bi̇lge, Bahar Soğutmaz Özdemi̇r

Turkish Journal of Biology

Background/aim: Plant genetic engineering is a valuable approach for improving stress tolerance, crop productivity, and quality traits. However, its progress is limited by the drawbacks of traditional transformation methods. Commonly used techniques, such as Agrobacterium-mediated transformation and biolistics, are restricted by genotype dependency, lengthy tissue culture steps, and low efficiency, particularly in monocot species. Therefore, the development of alternative gene delivery strategies remains an ongoing research focus in plant biotechnology. Nanoparticle-based delivery systems have recently gained attention due to their physiochemical properties, biocompatibility, and potential for alternative gene delivery approaches in plant systems.Materials and methods: We investigated the use of …

Modulating Microtubule Stability Via Α-Tubulin Acetylation Partially Restores Golgi Fragmentation In Spinal Muscular Atrophy, Peli̇n Zobaroğlu Özer, Memet Gözüböyük, Özge Çeti̇n, Niko Hensel, Güzi̇n Emecen, Adam Malik, Melissa Bowerman, Peter Claus, Hayat Erdem Yurter, Gamze Bora Akoğlu

Turkish Journal of Biology

Background/aim: Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of survival of motor neuron (SMN) protein. SMN deficiency leads to perturbations of the cytoskeleton, including microtubules, which are mainly involved in motilityrelated cellular processes. However, the molecular mechanisms of microtubule dysregulation in SMA remain elusive. Alpha (α)-tubulin is a structural component of microtubules, and its posttranslational modifications affect microtubule dynamics. Here, we aimed to investigate α-tubulin acetylation and related molecular mechanisms in SMA. Materials and methods: Two different SMA mouse models, the Drosophila melanogaster model and patient-derived fibroblasts, were used in the study. Western blot and …

Combinatorial Effect Of Epirubicin And 5-Fluorouracil In The Treatment Of Temozolomide-Resistant Glioblastoma Cells, Mehrsa Bayat, Muhli̇s Akman, Türker Kiliç, Ti̇muçi̇n Avşar

Turkish Journal of Biology

Background: Glioblastoma (GBM) is a highly aggressive form of brain tumor characterized by rapid proliferation and invasiveness. It is associated with a poor prognosis due to acquired resistance to temozolomide (TMZ). In this study, we investigated whether a combination of epirubicin, 5-fluorouracil (5-FU), and TMZ could improve TMZ sensitivity in resistant GBM cells and help overcome resistance.Materials and methods: TMZ resistance was established in the U87MG cell line. The MTT assay was used to measure cell viability. Reactive oxygen species (ROS) and apoptosis were measured using flow cytometry. RNA-seq was used to evaluate genomic changes based on treatment with drugs …

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Effects Of Gnrh And Hcg Administration On Conception Rate And The Subsequent Estrous Cycle On Day 12 Following Artificial Insemination In Holstein Cows, Mustafa Hi̇lmi̇ Yaranoğlu, Hüseyi̇n Erdem

Turkish Journal of Veterinary & Animal Sciences

The present study investigates the effects of gonadotropin-releasing hormone (GnRH) and human chorionic gonadotropin administration on the conception rate of cows 12 days after artificial insemination (AI). Included in the study were 150 high milkyielding Holstein cows housed under the same husbandry and feeding conditions. All had calved at least once between the ages of 2.5 and 6 years, and were between 90 and 220 days in milk. In accordance with the farm’s reproductive management approach, a controlled internal drug release (CIDR) device was inserted into the vagina concurrent with a GnRH injection (day 0), and the device was removed …

Age-Related Estimates Of Genetic Parameters For Growth And Ultrasonic M. Longissimus Thoracis Et Lumborum Muscle Traits In Eşme Lambs, İbrahi̇m Cemal, Orhan Karaca, Onur Yilmaz, Nezi̇h Ata

Turkish Journal of Veterinary & Animal Sciences

The growth performance and ultrasonic M. longissimus thoracis et lumborum (LTL) muscle traits of 2397 Eşme lambs raised in the Eşme district of Uşak province, an important lamb production area in Western Anatolia, were evaluated at 3 months (n = 1690) and 5 months (n = 707) of age. The average age of the lambs at the time of the first measurement (at weaning) was 100.15 days, and 152.37 days at the second. At 3 months of age, the average live weight (LW) was 29.34 kg and the average daily gain (ADG) was 248.35 g/day. By month 5, the LW …

Housing System And Gender Effect On Carcass And Meat Quality Characteristics In Turkish Pekin Ducks, Hasan Önder, Uğur Şen, Mi̇ne Yilmaz, Si̇bel Bozkurt, Eli̇f Ci̇lavdaroğlu, Di̇lek Gökçek, Ahmet Uçar, Kadi̇r Erensoy, Burcu Kurnaz

Turkish Journal of Veterinary & Animal Sciences

Improving meat quality is one of the most important aims for scientists and breeders. This study aimed to evaluate the effects of housing system (indoor vs. free-range) and gender on carcass and meat quality traits in Pekin ducks. The animal material consisted of 20 male and 20 female birds in each housing system. Our results show cold carcass weights of 3174.10 ± 80.65 g and 2672.60 ± 59.63 g for male and female birds in the indoor housing system and 2821.10 ± 50.53 g and 2306.90 ± 43.32 g for male and female birds in the free-range housing system. The …

Effects Of Preslaughter Fasting On Ph And Bacterial Contamination In Akkaraman And Anatolian Merino Sheep, Sai̇m Boztepe, Özcan Şahi̇n, Talha Demi̇rci̇, Gi̇zem Coşkun, İbrahi̇m Ayteki̇n, İsmai̇l Keski̇n

Turkish Journal of Veterinary & Animal Sciences

The present study investigates the effects of the preslaughter fasting on pH and bacterial contamination in Akkaraman and Anatolian Merino sheep. Included in the study were 10 Akkaraman and 10 Anatolian Merino sheep (n = 20) that were fasted for 24 h prior to slaughter, and a further 10 Akkaraman and 10 Anatolian Merino sheep (n = 20) that continued to be fed until slaughter as a control group. The total mesophilic aerobic bacteria (TMAB) measured at 0 and 24 h in the fasting Akkaraman and Anatolian Merino sheep were 4.87/4.79 and 4.75/5.57 log CFU/g, respectively, and the corresponding Enterobacteriaceae …

The Effects Of Sodium Perborate Tetrahydrate On Digestibility And Nutrient Transporters In Rats, Büşra Özmen, Emre Şahi̇n, Muhammed Tokmak, Veysi̇ Kayri̇, Ramazan Özmen, Kazi̇m Şahi̇n

Turkish Journal of Veterinary & Animal Sciences

Boron (B) is an essential micronutrient involved in hormone activity, energy metabolism, antioxidant defense, bone development, wound healing, and immune function. The present study explores the effects of sodium perborate tetrahydrate (SPT) on nutrient digestibility and the modulation of specific nutrient transporters in the jejunum and ileum of rats. A total of 40 rats were divided into four equal groups: 1) control, 2) SPT 0.5 (0.5 mg B/kg body weight [BW]), 3) SPT 1 (1 mg B/kg BW), and 4) SPT 2 (2 mg B/kg BW), and were fed the respective diets for a period of 4 weeks. The digestibility …

Morphology And Histology Of The Developing Ovary In Malaysian Village Chicken (Gallus Gallus Domesticus) Chicks, Nur Athirah Lope Abdul Rashid, Mazlina Mazlan, Intan Shameha Abdul Razak, Rozaini Mohd Zohdi, Awang Hazmi Awang Junaidi

Turkish Journal of Veterinary & Animal Sciences

The Malaysian village chicken (MVC; Gallus gallus domesticus) is an indigenous breed derived from the red junglefowl (Gallus gallus), exhibiting slower growth and reproductive rates. The MVC plays an important ecological role in local farming systems and represents a valuable genetic resource. However, detailed information on ovarian development in this breed remains limited. This study provides the first comprehensive morphological and histological characterization of the developing ovary in MVC chicks. A total of 20 chicks aged 1, 2, 4, and 8 weeks (n = 5 per age group) were examined. These MVC chicks possessed a single functional left ovary positioned …

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

Tremor Modulation: A Systematic Review Of Resetting By Single-Pulse Transcranial Magnetic Stimulation ​, Handan Uzunçakmak Uyanik, Çağri Mesut Temuçi̇n

Turkish Journal of Medical Sciences

Background/aim: Tremor arises from mechanical, reflex, or central oscillatory mechanisms. Transcranial magnetic stimulation (TMS) can transiently perturb ongoing tremor and enables the quantitative assessment of phase resetting, offering circuit-level insight into tremor types. Although numerous studies have applied TMS-induced resetting, the findings have not been systematically reviewed. This study systematically reviews human studies evaluating TMS-induced tremor resetting across tremor types.

Materials and methods: A systematic search of PubMed and Google Scholar identified human studies using TMS to perturb tremor or rhythmic movement. Search terms included “tremor resetting,” “resetting of tremor,” “tremor phase shift,” “tremor phase reset,” “transcranial magnetic stimulation,” and …

Comparative Efficacy Of Repetitive Peripheral Magnetic Stimulation And Transcutaneous Electrical Nerve Stimulation In Upper Trapezius Myofascial Pain Syndrome ​, Shahri̇yar Kalbi̇yev, Şehi̇m Kutlay, Ati̇lla Hali̇l Elhan, Yeşi̇m Kurtai̇ş Aytür, Aysun Genç

Turkish Journal of Medical Sciences

Background/aim: In this prospective, randomized, single-blind study, the effects of repetitive peripheral magnetic stimulation (rPMS) and transcutaneous electrical nerve stimulation (TENS) on pain intensity, functional status, and tissue elasticity were evaluated in patients with upper trapezius myofascial pain syndrome (MPS).

Materials and methods: A total of 75 female patients were randomly allocated to three groups: rPMS, TENS, and sham rPMS. All participants were provided with an exercise program consisting of cervical range-of-motion (ROM), stretching, and strengthening exercises. Outcome measures included pain intensity assessed using the visual analog scale, pressure pain threshold (PPT), the Neck Disability Index, cervical ROM, SF-36 subscale …

Res-Mnd: Motor Neuron Disease Detection Using Res4net–Convolutional Block Attention Module ​, Shuriya Balusamy, Rakesh Sivalingam, Shobana Rooben, Sony Helen

Turkish Journal of Medical Sciences

Background/aim: Motor neuron diseases (MNDs) are progressive neurological disorders that cause muscle weakness and wasting as a result of ongoing neurodegeneration. MNDs require comprehensive diagnostic approaches that integrate clinical symptoms, laboratory findings, and multimodal imaging data.

Materials and methods: In this study, a novel residual network for motor neuron disease detection (RES-MND) framework is proposed for detecting MNDs using multimodal imaging data. Initially, the input multimodal images, including MRI, CT, PET, and DTI, are preprocessed using adaptive dynamic histogram equalization and the total variation bilateral filter. The preprocessed multimodal images are processed through Res4Net-CBAM for feature extraction to enhance image …

Role Of Novel Renal Biomarkers In Prognosticating Patients With Chronic Kidney Disease: A Prospective Cohort Study, Raghavan Padmanabhan, Kaviya Manoharan, Melina Sahay, Pooja Bhujangarao, Luxitaa Goenka, Solai Priya, Kumaraswamy Subramaniyan, Damal Kandadai Sriram, Melvin George

Turkish Journal of Medical Sciences

Background/aim: Several biomarkers have been assessed for the diagnosis of chronic kidney disease (CKD). However, limited data are available regarding their ability to predict mortality in CKD. The aim of this study was to assess the ability of lipocalin-2, receptor for advanced glycation end products (RAGE), tissue inhibitor of metalloproteinase 1 (TIMP-1), osteopontin, and trefoil factor 3 (TFF-3) in predicting the prognosis of patients with CKD.

Materials and methods: We included patients with CKD as defined by an estimated glomerular filtration rate of <60 mL/min/1.73 m2 of either sex who were above the age of 18 years. Patients with a history of acute-on-chronic kidney disease were excluded. The novel markers of interest were estimated from patients’ plasma samples using the multiplex enzyme-linked immunosorbent assay. These patients were followed for 1 year to assess mortality.

Results: The median (with interquartile range) plasma concentrations of lipocalin-2, RAGE, TIMP-1, osteopontin, and TFF-3 were 56.9 …

The Importance Of Early Intraoperative Ultrasonography And The Relationship Between Surgical Technique And Allograft Function In Patients With Compartment Syndrome Following Renal Transplantation Surgery ​, Burak Yağdiran, Emre Karakaya, Ravana Ahmadli̇, Adem Şafak, Yağmur Kurtuluş, Nedi̇m Çekmen, Meri̇ç Yavuz Çolak, Mehmet Haberal

Turkish Journal of Medical Sciences

Background/aim: In rare cases, patients undergoing renal transplantation (RT) may develop renal allograft compartment syndrome (RACS) if the renal volume is larger than the retroperitoneal space prepared in the iliac fossa. In such cases, the optimal treatment is early decompression surgery. The primary aim of the present descriptive and comparative study is not to identify the optimal surgical technique, but rather to evaluate the role of early Doppler ultrasonography (DUSG) in the recognition of renal allograft compartment syndrome and to assess outcomes following timely decompressive interventions.

Materials and methods: A total of 275 patients were examined retrospectively for the study, …

Retinal Microvascular And Neuroretinal Structural Changes In Pulmonary Arterial Hypertension Assessed By Octa: A Comparative Study ​, Murat Erdağ, Tunahan Çalişkan, Hakan Yildirim, Tarik Kivrak, Mehmet Canleblebi̇ci̇, Ali̇ Dal, Mehmet Balbaba

Turkish Journal of Medical Sciences

Background/aim: Pulmonary arterial hypertension (PAH) is a progressive disorder with systemic vasculopathy, and noninvasive assessment remains challenging. The retina, sharing anatomical similarities with the cerebral microcirculation, is an accessible site for visualizing systemic vascular compromise. This study quantitatively evaluated retinal microvascular and neuroretinal structural changes in PAH patients compared to healthy controls using optical coherence tomography angiography (OCTA).

Materials and methods: In this single-center, cross-sectional case-control study, 40 patients with group 1 PAH and 38 healthy controls were enrolled. For statistical independence, only the right eye of each participant was analyzed (total: 78 eyes). All participants underwent high-resolution OCTA imaging. …