Digital Commons Network^™

Boric Acid Enhances The Antitumor Effects Of Paclitaxel By Modulating Apoptosis, Autophagy-Related Protein Expression, And Proinflammatory Cytokine Expression In Ovcar-3 Ovarian Cancer Cells ​, Nazmi̇ye Bi̇tgen, Gözde Özge Önder, Münevver Baran, Fatma Esen Karakuş, Meli̇ke Akbulut, Arzu Yay

Turkish Journal of Medical Sciences

Background/aim: Ovarian cancer is the eighth most prevalent malignancy among women globally and ranks third among gynecological cancers in terms of incidence. The limited efficacy of standard chemotherapy, primarily due to intrinsic drug resistance and high recurrence rates, highlights the urgent need for novel therapeutic strategies that are both effective and selectively cytotoxic.

Materials and methods: This study aimed to investigate the combined effects of boric acid (BA), a biologically active boron compound with emerging antitumor potential, and paclitaxel (PTX), a conventional chemotherapeutic agent, on cell viability, cell cycle progression, apoptosis, autophagy-related protein expression, and inflammatory signaling in the chemoresistant …

Robust Soil Moisture Content Detection Based On Data Augmentation Under Different Testing Conditions, Yang Li, Chenghao Liu, Jing Nie, Jingbin Li

Turkish Journal of Agriculture and Forestry

Accurate and cost-effective monitoring of soil moisture content is essential for the development of precision agriculture and the optimization of water resource management. While low-frequency acoustic signals are used to detect soil moisture content, models trained with controlled laboratory acoustic data often exhibit significant performance degradation with field data due to their sensitivity to environmental noise, soil heterogeneity, and structural variations. This study proposes a novel framework to enhance model robustness and generalization by integrating a WGAN-GP network data augmentation strategy into the soil moisture content workflow. This framework is designed to generate high-quality and diverse data on different soil …

Estimation Of Genetic Parameters In Lemon-Scented Basil (Ocimum Basilicum L.) Lines, Erdi̇nç Günay, İsa Telci̇

Turkish Journal of Agriculture and Forestry

Selective breeding of basil (Ocimum basilicum L.) is primarily aimed at improving plant architecture and essential oil quality, which are critical factors in increasing yield. In lemon-scented basil, the citral component responsible for the intense lemony aroma has significant commercial value in the cosmetics and perfumery industries. This study aimed to evaluate the genetic variability, heritability, and genetic advance of nine agronomic and quality related traits in lemon basil lines, and to explore the interrelationships among these traits. The phenotypic coefficient of variation (PCV) was higher than the genotypic coefficient of variation (GCV) for all traits, suggesting the influence of …

In Vitro Propagation Of A New Clonal Apple Rootstock Candidate Hatay, Zeynep Nas, Ahmet Eşi̇tken, Lütfi̇ Pirlak

Turkish Journal of Agriculture and Forestry

​Some clonal apple rootstocks are traditionally propagated using the layering technique. However, traditional propagation methods are seasonal and require a lot of space and labor. In addition, the multiplication rate is low with these methods, resulting in low-profit sapling production for growers. In vitro propagation techniques provide an efficient and effective method of obtaining species-appropriate, quality saplings in less time and space. The study aims to determine the in vitro propagation protocol of the Hatay genotype and to establish an appropriate method. In the study, the highest number of shoots was observed in media containing BA and mT at concentrations …

Landscape Character Analysis And Assesment At Local Scale, Eli̇f Önal, Serkan Özer

Turkish Journal of Agriculture and Forestry

​Landscape areas are one of the most important elements of human life all over the world. Varied landscape areas are a valuable natural resource and have high cultural value. The first step to ensure the effective landscape use is to identify these areas, analyze them in detail, and determine their characteristics. The northeastern Anatolia region in Türkiye has a rich diversity of landscapes because of varied geographic, climatic, and topographic features. The aim of this study was to identify the landscape character types in the Tortum district, located in the Tortum River basin in northeastern Türkiye, and to assess the …

Daam2 Gene Variants P.(Asp165glu) And P.(Asn614thrfster2) In Pediatric Cryptorchidism: A Hypothesis-Generating Pilot Case-Control Study From The Eastern Black Sea Region Of Türkiye ​, Onur Yalçin, Çağri Doğan

Turkish Journal of Medical Sciences

Background/aim: Cryptorchidism is the most common congenital anomaly of the male genitourinary system, characterized by a multifactorial etiology. The disheveled-associated activator of morphogenesis 2 (DAAM2) gene regulates androgen receptor (AR)- dependent transcription; its variants are associated with partial androgen insensitivity. Since the inguinoscrotal phase of testicular descent is androgen-dependent, we hypothesized that DAAM2 variants contribute to cryptorchidism susceptibility. This pilot study, designed to generate hypotheses rather than to establish association, investigated the frequency of two functionally characterized DAAM2 variants, p.(Asp165Glu) and p.(Asn614ThrfsTer2), in pediatric cryptorchidism.

Materials and methods: This prospective case-control study included 40 male pediatric cryptorchidism patients and 39 …

Readability Of Dermatology Patient Education Materials: A Comparative Analysis Of Turkish Dermatology Association Brochures And Texts Generated By Chatgpt And Gemini ​, Ahmet Kağan Özdemi̇r, Bengü Reyhan Botsali Özdemi̇r, Akin Aktaş

Turkish Journal of Medical Sciences

Background/aim: In modern healthcare, patient education materials (PEMs) are essential for bridging the gap between clinical knowledge and patient understanding. However, in Türkiye, where 64.6% of the adult population possesses inadequate or problematic health literacy, traditional medical brochures often exceed recommended reading levels. This study aimed to evaluate and compare the readability of Turkish dermatology PEMs prepared by the Turkish Dermatology Association (TDA) with those generated by artificial intelligence (AI) models.

Materials and methods: A total of 68 TDA PEMs were analyzed. Readability was assessed using the Ateşman Readability Index. Responses were generated by AI models to questions extracted from …

Risk Of Systemic Reactions During Pediatric Allergen-Specific Immunotherapy: Clinical Predictors And Safety Outcomes ​, Fi̇gen Çelebi̇ Çeli̇k, Alp Kazancioğlu, Soner Günder, Meli̇ke Ocak, Berna Uzunoğlu, Canan Şule Karkiner, Özlem Sancakli, Ayfer Tuncer, Özge Uysal Soyer, Bülent Eni̇s Şekerel, Demet Can, Ümi̇t Murat Şahi̇ner

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the frequency, timing, severity, and clinical predictors of systemic reactions in children receiving subcutaneous allergen-specific immunotherapy (SCIT) with house dust mite (HDM) and grass pollen extracts under real-world clinical conditions.

Materials and methods: This multicenter retrospective study included 623 children with moderate-to-severe allergic rhinitis, with or without asthma, who received SCIT between 2006 and 2023 at two tertiary pediatric allergy centers. Clinical characteristics, laboratory findings, immunotherapy protocols, and systemic reactions (SRs) were recorded and graded according to the updated 2024 World Allergy Organization (WAO) systemic reaction scale.

Results: SCIT was well tolerated. Systemic reactions …

Uniportal Vats Wedge Pulmonary Resections, Kubi̇lay İnan, Özgür Ömer Yildiz

Turkish Journal of Medical Sciences

Background/aim: Video-assisted thoracic surgery (VATS) has emerged as a common approach in surgical procedures involving the lung, mediastinum, thoracic wall, and diaphragm. Recent studies have described the performance of diagnostic and therapeutic VATS procedures via a single port, and the technique has become the preferred diagnostic modality for various intrathoracic pathologies and for patients deemed unsuitable for fine-needle biopsy.

Materials and methods: The records of 57 patients who underwent diagnostic and therapeutic uniportal VATS for wedge pulmonary resection between January 2024 and January 2025 were reviewed retrospectively, and details regarding the surgical method, length of hospital stay, complications, and diagnostic …

Thyroid Function In Children With Attention-Deficit/Hyperactivity Disorder And Specific Learning Disorder: A Retrospective Comparative Study, Gül Trabzon, Seda Aybüke Sari, Servet Yüce, Şeyma Demi̇ray Güllü

Turkish Journal of Medical Sciences

Background/aim: This study analyzes thyroid function parameters (free T₃, free T₄, TSH) in children with attention-deficit/hyperactivity disorder (ADHD), ADHD with specific learning disorder, and healthy controls, to determine whether subtle thyroid dysregulation contributes to the phenotypic heterogeneity of ADHD.

Materials and methods: This retrospective, cross-sectional study included 135 children aged 6–18 years: 62 diagnosed with ADHD (38 isolated ADHD and 24 ADHD+SLD) and 73 healthy controls. Demographic, anthropometric, and thyroid function data (free T₃, free T₄, TSH) were extracted from medical records. Group comparisons were conducted using independent samples t-tests, ANOVA, and ANCOVA adjusted for age, sex, and treatment status. …

Sarcopenia Risk In Women With Postmenopausal Osteoporosis: A Sarc-F-Based Assessment ​, Burak Kami̇l Turan, Ayşe Adi̇le Küçükdeveci̇, Zafer Günendi̇, Ayşegül Yaman, Oya Özdemi̇r, Jale Meray, Fatma Yeşi̇m Gökçe Kutsal

Turkish Journal of Medical Sciences

Background/aim: Osteoporosis and sarcopenia are diseases of bone and muscle tissue, respectively. Studies reported that these disorders were interrelated. However, this relation was explored in older adults and/or with certain comorbidities, and information about nonelderly postmenopausal women is scarce. This study’s objectives were to investigate the relationship between osteoporosis and SARC-F-defined sarcopenia risk in postmenopausal women aged ≤70 years and to examine the effect of other factors on this risk.

Materials and methods: This multicenter case-control study included postmenopausal women aged 45–70 years. Dual-energy X-ray absorptiometry was utilized to diagnose osteoporosis. Sociodemographic and clinical variables, sarcopenia risk (SARC-F), muscle strength …

Can Hydrolyzed Silk Fibroin Derived From Bombyx Hatayensis And Ozonized Gel Modulate Inflammatory And Angiogenic Responses In A Corneal Alkali Burn Model? ​​, Şule Barman Kaki̇l, Hamdullah Suphi̇ Bayraktar, Okan Soylu, İshak Gökçek, Meryem İlkay Karagül, Zehra Demi̇ray Asoğlu

Turkish Journal of Medical Sciences

Background/aim: The therapeutic effects of hydrolyzed silk fibroin derived from Bombyx hatayensis and a commercially available ozonized gel, administered individually and in combination, were evaluated in a rat model of corneal alkali burn.

Materials and methods: A standardized corneal alkali burn was induced in the right eyes of Wistar albino rats using 1 N sodium hydroxide (NaOH). Animals were randomly assigned to six groups: negative control, positive control (PC), hydrolyzed silk fibroin (SF), ozonized gel (O), combined treatment (SF + O), and antibiotic treatment. Topical treatments were administered for 21 consecutive days. Clinical evaluation included assessments of corneal opacity, neovascularization, …

Repurposing Diclofenac For Combination Therapy: Targeting The Warburg Effect To Enhance Breast Cancer Treatment ​, Gonca Tuna, Eli̇f Ertürk, Ayşen Sağnak, Ferda Ari

Turkish Journal of Medical Sciences

Background/aim: Diclofenac (Diclo), a widely used nonsteroidal antiinflammatory drug, has emerged as a potential candidate for drug repurposing in oncology, with reported anticancer effects extending beyond cyclooxygenase (COX) inhibition, including modulation of tumor metabolism. This study investigated the antiproliferative and glycolysis-associated effects of Diclo in MCF-7 breast cancer cells, alone and in combination with docetaxel (Doc) or 5-fluorouracil (5-FU).

Materials and methods: Cell viability was assessed using the sulforhodamine B (SRB) assay. To evaluate metabolic alterations, glucose uptake and lactate release were quantified following treatment. In addition, Triosephosphate Isomerase (TPI) protein levels and Lactate Dehydrogenase (LDH) activity were measured to …

Antiobesity, Antidiabetic, And Antioxidant Activities Of Selected Rubia Species (Rubiaceae) And Lc–Ms/Ms-Based Chemical Profiling ​, Semi̇h Bulut, Ahmet Kahraman, Ayşenur Işik, Mustafa Abdullah Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Rubia species (Rubiaceae) are recognized as medicinal and industrial plants exhibiting diverse biological activities. This study was conducted to evaluate the antioxidant, antidiabetic, and antiobesity potential of extracts prepared from Rubia davisiana Ehrend. (an endemic species), R. peregrina L., and R. rotundifolia Banks & Sol., which grow naturally in Türkiye.

Materials and methods: The antioxidant activity of 80% ethanol extracts prepared from the aerial parts was evaluated using 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays, ferric reducing power, metal chelating capacity, and total antioxidant capacity assays. Inhibition assays for α-glucosidase and α-amylase were performed to evaluate antidiabetic activity, …

Cervical Conjoined Nerve Root Anomalies: Prevalence And Impact On Posterior Cervical Surgery, Ahmet Eren Seçen, Ayfer Aslan, Musa Onur Özbakir, Uğur Kemal Gündüz, Ali̇ Dalgiç

Turkish Journal of Medical Sciences

Background/aim: Anomalous nerve roots (ANRs) are well described in the lumbosacral spine but are rarely reported in the cervical region. The aim of this study was to evaluate the incidence, clinical characteristics, and surgical outcomes of cervical ANRs, with particular emphasis on conjoined nerve roots, in a single-center clinical series.

Materials and methods: A retrospective analysis was conducted of patients who underwent posterior cervical discectomy for cervical disc herniation at our institution between 2010 and 2025. A total of 113 posterior cervical procedures were performed, and seven patients were found to have surgically confirmed cervical ANRs. For these patients, demographic …

Preserved Inflammatory Homeostasis During Emergency Transport: A Multibiomarker Assessment Of Neonatal Rds Transfers ​, Eyüp Sari, Şeri̇fe Suna Oğuz, Mehmet Semi̇h Demi̇rtaş, Bensu Bulut, Medi̇ne Akkan Öz, Murat Genç, Ayşenur Gür, Ümi̇t Alper Özcan, Hüseyi̇n Mutlu, Rami̇z Yazici

Turkish Journal of Medical Sciences

Background/aim: The aim was to compare the pre- and posttransport levels of systemic inflammatory markers in neonatal infants transported to a tertiary intensive care unit via emergency health services with a neonatal respiratory distress syndrome (nRDS) diagnosis and to assess the quality of transport.

Materials and methods: This retrospective study was conducted between January 2019 and December 2023. A total of 117 nRDS patients’ emergency transports were included in the study. Demographic data, transfer time, intubation, cold treatment, cardiopulmonary resuscitation (CPR), and pre- and posttransport laboratory parameters were obtained retrospectively. The statistical analysis was performed using IBM SPSS Statistics (Version …

Posttraumatic Stress In Newly Diagnosed Epilepsy: Associations With Early Maladaptive Schemas, Anxiety, And Quality Of Life In A 6-Month Prospective Study ​, Mehmet Öztürk, Pinar Öztürk, Fügen Sönmez Çeti̇nkaya, İlker Özdemi̇r

Turkish Journal of Medical Sciences

Background/aim: Epilepsy is a chronic neurological disorder that significantly affects psychosocial functioning, self-perception, and quality of life. Emerging evidence suggests that posttraumatic stress (PTS) symptoms may be more prevalent in individuals with epilepsy than previously recognized, particularly following seizure-related experiences perceived as traumatic. The aim of this study was to evaluate short- and long-term PTS levels in individuals with newly diagnosed epilepsy and examine their associations with anxiety, depression, early maladaptive schemas, and quality of life.

Materials and methods: In this prospective study, 31 individuals with newly diagnosed epilepsy were enrolled. Participants completed a sociodemographic data form, the Post-Traumatic Stress …

Cover And Contents

Turkish Journal of Agriculture and Forestry

No abstract provided.

Crispr-Cas9: An Emerging And Precise Genome Editing System For Crops To Combat Food Insecurity, Muhammad Faran Tahi̇r, Muhammad Hamzah Saleem, Sidra Aslam, Emi̇ne Orhan, Hayat Topçu, Tauqeer Ahmed Qadri, Khalid Ali Khan, Muhammad Anas

Turkish Journal of Agriculture and Forestry

Genome editing has emerged as a transformative tool to improve crop productivity, resilience, and nutritional quality, helping address global food insecurity. Among gene-editing platforms, clustered regularly interspaced short palindromic repeats (CRISPR)/ Cas systems (notably CRISPR-Cas9) offer simple, efficient, and scalable methods for targeted modifications, including knockouts, base edits, and precise “search-and-replace” prime edits. In plants, recent advances such as improved base editors, optimized prime-editing platforms, and DNA-free delivery methods have expanded the scope of edits achievable while reducing off-target effects and regulatory concerns. This review summarizes CRISPR principles, highlights technical breakthroughs and crop applications that mitigate biotic and abiotic stresses, …

Cultivar, Canopy Architecture, And Harvest Stage Shape The Chemical Profile Of Plum (Prunus Domestica) Fruit, Jelisaveta Seka Cvijanović, Milica Sredojević, Dragana Dabić Zagorac, Maja Natić, Geza Bujdoso, Miljan Cvetković

Turkish Journal of Agriculture and Forestry

Plum (Prunus domestica L.) is a nutritionally valuable fruit with significant commercial importance, yet consumer acceptance is often constrained by inconsistent fruit quality. This study investigated the effects of cultivar, training system, and harvest stage on the chemical composition of plum fruit, focusing on polyphenols, organic acids, sugars, and sugar alcohols. Three cultivars (Čačanska lepotica, Stanley, and Empress) were evaluated under different canopy architectures, including plum spindle as a control and novel 2-dimensional systems (Bi axe and upright fruiting offshoot), across multiple ripening stages. The results showed that genotype and canopy structure significantly influenced the accumulation of primary and secondary …

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Trace Elements In Complete Feeds Used In Intensive Rearing Of Cattle, Poultry, And Pigs: Occurrence And Predicted Transferred Concentrations In Animal-Derived Food, Elizabeta Dimitrieska Stojkovikj, Vangelica Enimiteva, Aleksandra Angjeleska, Risto Uzunov

Turkish Journal of Veterinary & Animal Sciences

This study investigated the concentrations of essential (Zn, Cu, Mn, Co, and Mo) and toxic (Pb, Cd, As, and Hg) trace elements in complete feeds used for the intensive rearing of cattle, poultry, and pigs in North Macedonia and predicted their transfer into animal-derived foods. A total of 107 feed samples were collected from 40 farms between May 2023 and April 2024 and analyzed using inductively coupled plasma mass spectrometry. The results revealed that while most essential elements were within the regulatory limits, Co exceeded the maximum level in two cattle feed samples. Zn, Cu, and Mn levels were generally …

Molecular Characterization Of Pasteurella Multocida Capsular Type A Strains Isolated From Different Regions Of Anatolia, Türkiye​, Adam Bashir Tawor, Osman Ergani̇ş, Asli Balevi̇, Suliman Mohamed Yousof Sadam

Turkish Journal of Veterinary & Animal Sciences

Pasteurella multocida serotype A is an important pathogen that causes respiratory illness in both farm animals and poultry, leading to severe economic losses worldwide. This study aimed to isolate P. multocida capsular type A (capA) as well as investigate the virulence-associated genes (VAGs) within the isolates. Samples (n = 250) were collected in the Anatolia region from cattle (n = 130), sheep (n = 70), goats (n = 45), and pet birds (n = 5) with clinical respiratory signs. Polymerase chain reaction (PCR) assays were conducted using kmt1 and capA primers for P. multocida species identification and capsular serogroup A …

Effect Of Rangeland Quality On Rumen Development Of Angora (Mohair) Goat Kids And Bucks, Betül Zehra Sariçi̇çek

Turkish Journal of Veterinary & Animal Sciences

This study was conducted to determine the effect of rangeland quality on the rumen development of Angora goat kids and bucks. Twenty male singleton Angora goat kids with similar birth dates and birth weights were selected from each farm in an area with three different rangeland quality levels (good, medium, or poor) in Ankara Province. The kids were weaned at 60 days of age and then grazed completely on rangeland until slaughter. Rumen volumetric and papillary development of animals slaughtered at 4 and 7 months of age were determined. Empty rumen length, width, and weight were affected by rangeland quality …

Arterial Architecture Of The Goat Spleen (Capra Hircus) Revealed By Corrosion Casting And Scanning Electron Microscopy, Baran Erdem, Sevi̇nç Ateş, Meryem Karan

Turkish Journal of Veterinary & Animal Sciences

The spleen is an essential organ involved in hematopoietic and immune functions. A comprehensive understanding of its anatomy, including vascular topography and segmentation, is essential for the accurate diagnosis and treatment of splenic diseases, and the minimization of complications during surgical procedures. Detailed knowledge of the vascular architecture also supports the accurate prediction and management of hemorrhage severity in cases of splenic rupture. The spleen’s microvascular system has a unique and complex organization that is distinct from other organs, and its elucidation is critical for understanding splenic function. In the present study, the spleens of 20 hair goats were examined. …

Hard Palate Morphology In The Anatolian Water Buffalo (Bubalus Bubalis), Mehmet Can, Şükrü Hakan Atalgin, Mehmet Faruk Aydin, Soner Bekmezci̇

Turkish Journal of Veterinary & Animal Sciences

This study aimed to examine the morphological and histological features of the hard palate in the Anatolian water buffalo through light and scanning electron microscopy, complemented by gross and morphometric evaluations. Eight hard palates were used in the study. A total of eight Anatolian water buffalo heads from healthy adult female water buffaloes were collected immediately after slaughter from various slaughterhouses in Balıkesir, Türkiye. After analyzing and identifying the obtained hard palate samples, measurements were taken and documented through photography. The papilla incisiva, located in the middle of the caudal concave edge on the ventral surface of the pulvinus dentalis, …

Toroidal Plasmonic Nanodimers For Enhanced Near-Infrared Emission In Heterostructured Inp Quantum Dots, Arda Gülücü, Emre Ozan Polat

Turkish Journal of Physics

Near-infrared (NIR) emitters operating in the 650--900 nm spectral range are highly attractive for imaging and sensing in turbid media. However, cadmium-free InP-based quantum dots (QDs) often exhibit limited brightness owing to nonradiative recombination pathways and inefficient photon outcoupling. In particular, heterostructured InP QDs may possess band alignments that induce partial spatial separation of charge carriers, thereby reducing the electron-hole wavefunction overlap. This characteristic modifies the intrinsic recombination dynamics and increases the sensitivity of their emission to the surrounding photonic environment. Here, we investigate silver toroidal plasmonic nanoantenna dimers (Ag TPNDs) using finite-difference time-domain (FDTD) simulations as a geometry-tunable platform …

Cover And Contents

Turkish Journal of Physics

No abstract provided.

The Effect Of Spin Polarization On Ion-Acoustic Solitary Waves In Quantum Plasmas, Amirhosein Rezvani, Sedigheh Miraboutalebi, Leila Rajaei, Mahmoodreza Sharifian

Turkish Journal of Physics

The exchange interaction, a fundamentally quantum-mechanical phenomenon, can significantly modify the classical description of cold, overdense plasmas. These quantum effects can be systematically analyzed within the framework of quantum magnetohydrodynamic (QMHD) theory, which enables the use of separate momentum equations for spin-up and spin-down electron populations. In this study, we adopt this approach to incorporate exchange interactions for both spin species and investigate the excitation of ion-acoustic wave (IAW) solitons in the plasma system. Using a perturbative expansion method, the governing equations are reduced to a nonlinear Schrödinger equation (NLSE), which admits solitonic wave solutions. The stability of these solitons …

Radiation Pressure And Membrane Dynamics In Cavity Optomechanics: Interaction Hamiltonian And Quantization, Mahmut Can Özuygur

Turkish Journal of Physics

Cavity optomechanics explores the interaction between light confined in optical cavities and mechanical oscillators, primarily driven by radiation pressure forces. These interactions enable significant advances in precision measurements, quantum information processing, and tests of fundamental quantum mechanics. This paper presents a detailed analysis of membrane vibration and radiation pressure force within a cavity optomechanical system. The membrane's equation of motion is derived, the radiation pressure force is evaluated within the Lorentz force formalism, and the corresponding interaction Hamiltonian is formulated. Quantization of the resulting Hamiltonian enables the investigation of quantum phenomena, including entanglement generation and quantum state transfer, and provides …