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Prevalence And General Characteristics Of Dementia: A Nationwide Population-Based Study Of Electronic Health Records In Türkiye, Merve Güner, Meltem Koca, Serdar Ceylan, Arzu Okyar Baş, Ayşe Di̇kmeer, Mert Eşme, Osman Çeli̇k, Mustafa Okan Ayvali, Murat Çağlayan, Mustafa Mahi̇r Ülgü, Gülni̇hal Gökçe Ünal, Cafer Balci, Nai̇m Ata, Mustafa Cankurtaran, Burcu Balam Doğu, Şuayi̇p Bi̇ri̇nci̇
Prevalence And General Characteristics Of Dementia: A Nationwide Population-Based Study Of Electronic Health Records In Türkiye, Merve Güner, Meltem Koca, Serdar Ceylan, Arzu Okyar Baş, Ayşe Di̇kmeer, Mert Eşme, Osman Çeli̇k, Mustafa Okan Ayvali, Murat Çağlayan, Mustafa Mahi̇r Ülgü, Gülni̇hal Gökçe Ünal, Cafer Balci, Nai̇m Ata, Mustafa Cankurtaran, Burcu Balam Doğu, Şuayi̇p Bi̇ri̇nci̇
Turkish Journal of Medical Sciences
Background/aim: Türkiye is a country with an increasing life expectancy and an older adult population in parallel with the rest of the world. Several national small-scale studies were performed regarding the prevalence and characteristics of dementia in Türkiye, and the results of these studies differ from each other. We aimed to determine the prevalence of dementia in Türkiye to present the demographic characteristics, the frequency of use of health services, and the management of dementia.Materials and methods: Patients aged 65 years and over with a diagnosis of any type of dementia between January 1, 2019, and December 31, 2020, were …
Comparison Of The Effects Of 0.05% Topical Cyclosporine A Versus 0.1% Topical Cyclosporine A On Recurrence And Clinical Parameters Following Pterygium Surgery, Emi̇n Serbülent Güçlü, Tamer Meti̇n, Ömer Özer, Fatma Merve Bektaş
Comparison Of The Effects Of 0.05% Topical Cyclosporine A Versus 0.1% Topical Cyclosporine A On Recurrence And Clinical Parameters Following Pterygium Surgery, Emi̇n Serbülent Güçlü, Tamer Meti̇n, Ömer Özer, Fatma Merve Bektaş
Turkish Journal of Medical Sciences
Background/aim: To compare the efficacy of topical 0.05% cyclosporine A (CsA) and 0.1% topical cyclosporine A (CsA) over a 6-month period following pterygium surgery, specifically evaluating their effects on postoperative recurrence and clinical parameters.Material and methods: This clinical study enrolled 245 patients with pterygium who underwent surgery using the conjunctival autograft technique with mitomycin C (MMC) were enrolled. Participants were divided into three groups: Group 1 (0.05% CsA) (n = 80), Group 2 (0.1% CsA) (n = 80), and a control group (n = 85). They were examined at postoperative first day, first week, first month and sixth month. The …
Can Volumetric Magnetic Resonance Imaging Evaluations Be Helpful In The Follow-Up Of Cognitive Functions In Cognitively Normal Parkinson’S Disease Patients?, Hasan Armağan Uysal, Duygu Hünerli̇, Rai̇f Çakmur, Beri̇l Dönmez Çolakoğlu, Emel Ada, Görsev Yener
Can Volumetric Magnetic Resonance Imaging Evaluations Be Helpful In The Follow-Up Of Cognitive Functions In Cognitively Normal Parkinson’S Disease Patients?, Hasan Armağan Uysal, Duygu Hünerli̇, Rai̇f Çakmur, Beri̇l Dönmez Çolakoğlu, Emel Ada, Görsev Yener
Turkish Journal of Medical Sciences
Background/aim: In this study, besides the evaluation of gray and white matter changes in cognitively normal Parkinson’s disease (PD-CN) patients with volumetric magnetic resonance imaging (MRI) parameters, it was tried to show that some neuropsychological tests may be impaired in PD-CN patients.Materials and methods: Twenty-six PD-CN patients and 26 healthy elderly (HC) participants were included in the current study. Global cognitive status was assessed using the mini-mental state examination (MMSE), and the Montreal cognitive assessment scale (MoCA). Attention and executive functions were evaluated using the Wechsler memory scale-revised (WMS-R) digit span test and trail making test (TMT) part A and …
Relationships Between Stenosis Severity, Functional Limitation, Pain, And Quality Of Life In Patients With Cervical Spondylotic Radiculopathy, Aydin Si̇nan Apaydin, Musa Güneş
Relationships Between Stenosis Severity, Functional Limitation, Pain, And Quality Of Life In Patients With Cervical Spondylotic Radiculopathy, Aydin Si̇nan Apaydin, Musa Güneş
Turkish Journal of Medical Sciences
Background/aimThis study aims to examine the relationship between severity of stenosis, pain, functional limitation, disability, and quality of life in patients with cervical spondylotic radiculopathy.Materials and methodsPatients (45 female, 19 male) with radiculopathy due to spondylotic changes in the cervical spine were included in the study. Stenosis severity (thecal sac cross-sectional area (CSA)), numbness, neck, and arm pain severity, functional limitation (Cervical radiculopathy impact scale), disability, and quality of life (EuroQol (EQ) five-dimensions-3-level general quality of life scale) were evaluated. ClinicalTrial number: NCT06001359ResultsAccording to CSA, 28 (43.75%) patients had severe stenosis, 36 (56.25%) had moderate stenosis, and the average CSA …
Prognostic And Diagnostic Utility Of Pancreatic Stone Protein In Pediatric Sepsis And Mortality, Mehmet Aki̇f Dündar, Emi̇n Ceran, Başak Nur Akyildiz
Prognostic And Diagnostic Utility Of Pancreatic Stone Protein In Pediatric Sepsis And Mortality, Mehmet Aki̇f Dündar, Emi̇n Ceran, Başak Nur Akyildiz
Turkish Journal of Medical Sciences
Background/aim: Early detection and prognosis of sepsis in critically ill children is crucial. The aim of this research was to investigate the prognostic ability of pancreatic stone protein (PSP) in validating sepsis and predicting mortality in a prospective observational study.Materials and methods: In a single-center study, pediatric intensive care unit patients were divided into cohorts of confirmed and suspected sepsis, as well as survivors and nonsurvivors. Patients with positive blood culture growth were considered to have confirmed sepsis, while their negative counterparts were considered to have suspected sepsis. Comparisons were made between complete blood counts, laboratory parameters, mortality indices, and …
The Sharp Edge Of Immunosuppressive Treatments: Infections, Aybegüm Özşahi̇n, Tuba İlgar, Sudem Mahmutoğlu Çolak, Kübra Akyüz, Meli̇h Gaffar Gözükara, Uğur Kostakoğlu, İlknur Esen Yildiz, Ayşe Ertürk
The Sharp Edge Of Immunosuppressive Treatments: Infections, Aybegüm Özşahi̇n, Tuba İlgar, Sudem Mahmutoğlu Çolak, Kübra Akyüz, Meli̇h Gaffar Gözükara, Uğur Kostakoğlu, İlknur Esen Yildiz, Ayşe Ertürk
Turkish Journal of Medical Sciences
Background and aim: Different side effects, including infections, are encountered in patients receiving anticytokines used for the treatment of severe coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the infections and the effects of these infections that develop in this patient group. Materials and Methods: This study included 208 patients who were followed-up with the diagnosis of severe COVID-19 in two different hospitals. Patient data were obtained retrospectively from the hospital information system. Results: Of the 208 patients included, 54 were in the anakinra group, and 154 were in the tocilizumab group. Of these patients, 73 …
Use Of Intraoperative Microvascular Doppler During Subinguinal Microsurgical Varicocelectomy In Children Reduces Complications, Cem Kaya, Si̇bel Eryilmaz, Alparslan Kapisiz, Ali̇ Atan, Ramazan Karabulut, Zafer Türkyilmaz, Kaan Sönmez
Use Of Intraoperative Microvascular Doppler During Subinguinal Microsurgical Varicocelectomy In Children Reduces Complications, Cem Kaya, Si̇bel Eryilmaz, Alparslan Kapisiz, Ali̇ Atan, Ramazan Karabulut, Zafer Türkyilmaz, Kaan Sönmez
Turkish Journal of Medical Sciences
Background /aim: to assess the impact of microvascular Doppler ultrasonography (MDU) used intraoperatively during children's microsurgical subinguinal varicocele correction.Materials and methods: Nineteen patients who received intraoperative MDU during subinguinal microsurgical varicocelectomy between 2021 and 2023 were included in this study. The patients' age, varicocele side, clinical examinations, preoperative US results, intraoperative findings, spermatic artery counts and findings regarding the use of MDU, postoperative complications, and results were evaluated.Results: All varicoceles were on the left side and the average age was 15.2 years. The indications of varococelectomy were testicular hypotrophy(n=10) and scrotal pain or fullness(n=9). Under the surgical microscope, testicular artery …
Evaluation Of Volume Measurements Of Neuroanatomical Structures Related To Speech In Multiple Sclerosis Patients, Hidir Pekmez, Anil Altiparmak, Feyza İnceoğlu, Mehmet Akçi̇çek, Asli Bolayir, Zeynep Özbay, Merve Aydin, Muhammed Furkan Arpaci
Evaluation Of Volume Measurements Of Neuroanatomical Structures Related To Speech In Multiple Sclerosis Patients, Hidir Pekmez, Anil Altiparmak, Feyza İnceoğlu, Mehmet Akçi̇çek, Asli Bolayir, Zeynep Özbay, Merve Aydin, Muhammed Furkan Arpaci
Turkish Journal of Medical Sciences
Background/aim: Individuals with multiple sclerosis (MS) may experience various speech-related issues, including decreased speech rate, increased pauses, and changes in speech rhythms. The purpose of this study was to compare the volumes of speech-related neuroanatomical structures in MS patients with those in a control group.Materials and methods: The research was conducted in the Neurology and Radiology Departments of Malatya Training and Research Hospital. The records of patients who presented to the Neurology Department between 2019 and 2022 were examined. The study included the magnetic resonance imaging (MRI) findings of 100 individuals, with 50 in the control group and 50 patients …
The Effect Of Wet Cupping Therapy On The Clinical Symptoms Of Adult-Onset Asthma: A Randomized Clinical Trial, Abbas Joushan, Hamid Reza Hatami, Khosrow Agin, Hoorieh Mohammadi Kenari, Sajjad Sadeghi, Rasool Choopani
The Effect Of Wet Cupping Therapy On The Clinical Symptoms Of Adult-Onset Asthma: A Randomized Clinical Trial, Abbas Joushan, Hamid Reza Hatami, Khosrow Agin, Hoorieh Mohammadi Kenari, Sajjad Sadeghi, Rasool Choopani
Turkish Journal of Medical Sciences
Background/aim: Asthma is an inflammatory disease of the lungs. Cupping therapy is a traditional method used in Persian medicine for treating various ailments. This study aimed to evaluate the anti-asthmatic effects of wet cupping therapy (WCT) in patients with mild to moderate asthma. Materials and methods: This is a randomized clinical trial conducted on 103 asthma patients who were referred to Loghman Hakim Hospital, Tehran, Iran. The diagnosis of the disease was confirmed by a pulmonologist based on the patient’s history and clinical examinations. The patients who were treated with common asthma medications were assigned to intervention and control groups. …
The Histological And Biochemical Analysis Of The Effects Of Radiofrequency Radiation On Testis Tissue Of Rats And The Protective Effect Of Melatonin, Armağan Yardim, Bahri̇ye Sirav Aral, Arin Tomruk, Si̇nem Oruç, Kevser Delen, Di̇lek Kuzay Aksoy, Cemi̇le Merve Seymen, Gülnür Take Kaplanoğlu
The Histological And Biochemical Analysis Of The Effects Of Radiofrequency Radiation On Testis Tissue Of Rats And The Protective Effect Of Melatonin, Armağan Yardim, Bahri̇ye Sirav Aral, Arin Tomruk, Si̇nem Oruç, Kevser Delen, Di̇lek Kuzay Aksoy, Cemi̇le Merve Seymen, Gülnür Take Kaplanoğlu
Turkish Journal of Medical Sciences
Background/aim: Primarily due to wireless communication devices, especially mobile phones, there has been a steady rise in the intensity of nonionizing radiofrequency radiation (RFR). In recent years, increased human health problems raised concerns about whether there is a positive relationship between intense exposure to RFR and public health. The present study aims to investigate the effects of GSM-like RFR exposure on the male reproductive system and the impact of melatonin treatment (synergistic, antagonist, or additive).Materials and methods: Thirty-six male Wistar Albino rats were used and separated into six groups: i. Control; ii. Sham; iii. RFR exposure; iv. Control-melatonin; v. Sham-melatonin; …
Examination Of The Transport Characteristics Of Pediatric Trauma Patients, Rami̇z Yazici, Muhammed Güner, Efe Demi̇r Bala, Ayşe Fethi̇ye Basa Kalafat, Eyüp Sari, Sali̇h Fettahoğlu, Rabi̇a Bi̇rsen Tapkan, Utku Murat Kalafat, Azi̇z Ahmet Sürel, Serkan Doğan
Examination Of The Transport Characteristics Of Pediatric Trauma Patients, Rami̇z Yazici, Muhammed Güner, Efe Demi̇r Bala, Ayşe Fethi̇ye Basa Kalafat, Eyüp Sari, Sali̇h Fettahoğlu, Rabi̇a Bi̇rsen Tapkan, Utku Murat Kalafat, Azi̇z Ahmet Sürel, Serkan Doğan
Turkish Journal of Medical Sciences
Background/aim: Injury is an important public health problem in the pediatric age group, which is one of the leading causes of morbidity and mortality internationally. The fact that pediatric trauma has a great impact on individuals, families, and countries has revealed the need for a better understanding of this phenomenon.Materials and methods: This study was designed as a retrospective observational study and includes all patients under the age of 18 who received emergency healthcare due to trauma and were registered in the Emergency Health Automation System after being called to the call center between 1/1/2018 and 31/12/2022. Information such as …
Are There Any Concerns About Usage Of Biological Agents In Psoriasis?, Burhan Engi̇n, Eylül Kasapoğlu
Are There Any Concerns About Usage Of Biological Agents In Psoriasis?, Burhan Engi̇n, Eylül Kasapoğlu
Turkish Journal of Medical Sciences
No abstract provided.
Expressions Of The Satellite Repeat Hsat5 And Transposable Elements Are Implicated In Disease Progression And Survival In Glioma, Sila Naz Köse, Tutku Yaraş, Ahmet Bursali, Yavuz Oktay, Ci̇hangi̇r Yandim, Gökhan Karakülah
Expressions Of The Satellite Repeat Hsat5 And Transposable Elements Are Implicated In Disease Progression And Survival In Glioma, Sila Naz Köse, Tutku Yaraş, Ahmet Bursali, Yavuz Oktay, Ci̇hangi̇r Yandim, Gökhan Karakülah
Turkish Journal of Biology
The glioma genome encompasses a complex array of dysregulatory events, presenting a formidable challenge in managing this devastating disease. Despite the widespread distribution of repeat and transposable elements across the human genome, their involvement in glioma's molecular pathology and patient survival remains largely unexplored. In this study, we analysed the expression levels of satellite repeats and transposons along with genes in low-grade glioma (LGG) and high-grade glioma (HGG). Endogenous transposable elements LTR5 and HERV_a-int exhibited higher expression in HGG patients, along with immune response-related genes. Altogether, 16 transposable elements were associated with slower progression of disease in LGG patients. Conversely, …
Exploring The Impact Of Diabetes On Aging: Insights From Tert And Col1a1 Methylation, Jessica Nathania Liamry, Farizky Martriano Humardani, Giovani Chandra, Lisa Thalia Mulyanata, Tjie Kok, Fenny Irawati, Hikmawan Wahyu Sulistomo, Christoph Reichetzeder, Sulistyo Emantoko Dwi Putra
Exploring The Impact Of Diabetes On Aging: Insights From Tert And Col1a1 Methylation, Jessica Nathania Liamry, Farizky Martriano Humardani, Giovani Chandra, Lisa Thalia Mulyanata, Tjie Kok, Fenny Irawati, Hikmawan Wahyu Sulistomo, Christoph Reichetzeder, Sulistyo Emantoko Dwi Putra
Turkish Journal of Biology
Background/aim: Aging, a multifaceted biological process, leading to diminished physical performance, especially in older adults with diabetes, where a mismatch between biological and chronological age is noticeable. Numerous studies have demonstrated that diabetes accelerates aging at both cellular and organ levels. Notable aging markers are TERT, related to telomere length, and COL1A1, a key component of skin collagen. Additionally, age-related methylation increases, as revealed through methylation analysis, illuminate aspects of aging. However, the detailed interplay between aging and diabetes, particularly regarding methylation, remains underexplored and warrants further study to elucidate their biological links.Materials and methods: In this research, we elucidate …
Bud14 Function Is Crucial For Spindle Pole Body Size Maintenance, Sevi̇lay Müni̇re Gi̇rgi̇n, Ayşe Koca Çaydaşi
Bud14 Function Is Crucial For Spindle Pole Body Size Maintenance, Sevi̇lay Müni̇re Gi̇rgi̇n, Ayşe Koca Çaydaşi
Turkish Journal of Biology
Background/aimSpindle Pole Bodies (SPB), functional equivalent of centrosomes in yeast, duplicate through generation of a new SPB next to the old one. Yet, SPBs are dynamic structures that can grow and exchange, and mechanisms that regulate SPB size remain largely unknown. This study aims to elucidate the role of Bud14 in SPB size maintenance in Saccharomyces cerevisiae.Materials and methodsWe employed quantitative fluorescence microscopy to assess the relative and absolute amounts of SPB structural proteins at SPBs of wildtype cells and in cells lacking BUD14 (bud14∆). Quantifications were performed using asynchronous cell cultures as well as cultures synchronously progressing through the …
Distal Interphalangeal Joint Involvement In Patients With Rheumatoid Arthritis: Where Are We?, Mete Pekdi̇ker, Sertaç Ketenci̇, Gökhan Sargin
Distal Interphalangeal Joint Involvement In Patients With Rheumatoid Arthritis: Where Are We?, Mete Pekdi̇ker, Sertaç Ketenci̇, Gökhan Sargin
Turkish Journal of Medical Sciences
Background/aim: Rheumatoid arthritis (RA) usually affects the wrist, metacarpophalangeal joint, and proximal interphalangeal joint of the hands. However, the distal interphalangeal (DIP) joints may also be involved in RA patients. In this study, we aimed to evaluate the frequency and associated factors of DIP joint erosion in patients with RA.Materials and methods: Medical records of patients with RA were reviewed retrospectively. Patients with major trauma affecting DIP joints, osteoarthritis, erosive osteoarthritis, psoriatic arthritis, systemic sclerosis, calcium pyrophosphate dihydrate disease, and gout were excluded. Anteroposterior hand X-rays were evaluated and patients were divided into groups according to autoantibody profile.Results: We reviewed …
Chlorogenic Acid Ameliorates Memory Dysfunction Via Attenuating Frontal Lobe Oxidative Stress And Apoptosis In Diabetic Rat Model, Ramedhea Laila Afifa An Nur Willya Saputri, Nur Arfian, Junaedy Yunus, Fauziyatul Munawaroh, Sagita Mega Sekar Kencana, Dwi Cayhani Ratna Sari
Chlorogenic Acid Ameliorates Memory Dysfunction Via Attenuating Frontal Lobe Oxidative Stress And Apoptosis In Diabetic Rat Model, Ramedhea Laila Afifa An Nur Willya Saputri, Nur Arfian, Junaedy Yunus, Fauziyatul Munawaroh, Sagita Mega Sekar Kencana, Dwi Cayhani Ratna Sari
Turkish Journal of Medical Sciences
Background/aim: Diabetes mellitus, characterized by hyperglycemia, causes various complications, one of which is memory dysfunction. The frontal lobe is known to be responsible for impaired memory function due to hyperglycemia and is associated with oxidative stressmediated neuronal cell apoptosis. Chlorogenic acid (CGA) is reported to have neuroprotective effects. However, its effect on the frontal lobe in diabetes mellitus (DM) rats is not widely known. This research aimed to elucidate the effect of CGA on the mRNA expressions of SOD1, SOD2, p53, and Bcl-2 in the frontal lobe of DM rats. Materials and methods: Thirty male Wistar rats (2-month-old, 150–200 gBW) …
Spinal Stabilization Exercises For Transversus Abdominis And Lumbar Multifidus Thickness Via Telerehabilitation And Face-To-Face Approaches In Patients With Nonspecific Chronic Neck Pain: A Randomized Controlled Trial, Di̇lara Onan, Erkan Demi̇rci̇, Egemen Turhan, Özlem Ülger
Spinal Stabilization Exercises For Transversus Abdominis And Lumbar Multifidus Thickness Via Telerehabilitation And Face-To-Face Approaches In Patients With Nonspecific Chronic Neck Pain: A Randomized Controlled Trial, Di̇lara Onan, Erkan Demi̇rci̇, Egemen Turhan, Özlem Ülger
Turkish Journal of Medical Sciences
Background/aim: Strengthening the muscles of the lumbar region in individuals with neck pain may be protective against future back problems. In addition, telerehabilitation applications, which gained momentum in the literature and clinical practice during the COVID-19 pandemic, are among the applications preferred by patients thanks to their various advantages. This study aimed to compare the effects of telerehabilitation and spinal stabilization exercises applied with face-to-face approaches on the thickness of the transversus abdominis (M.TrA) and lumbar multifidus (M.LM) muscles in patients with nonspecific neck pain.Materials and methods: The primary outcomes were the thickness of the M.TrA and M.LM. Neck pain …
Comparison Of Bulut Index-Beta Method And Global Health Security Index: Results From World Countries, Tevfi̇k Bulut, Mehmet Top, Murat Atan, Burkay Genç
Comparison Of Bulut Index-Beta Method And Global Health Security Index: Results From World Countries, Tevfi̇k Bulut, Mehmet Top, Murat Atan, Burkay Genç
Turkish Journal of Medical Sciences
Background/aimThe Global Health Security Index (GHSI), which is used to assess global health security preparedness level of countries, and Bulut Index-Beta (BI-β) method, developed as a multi-criteria decision-making method, were compared in terms of global health security in the context of world countries. Thus, it is aimed to demonstrate feasibility of BI-β method by testing it on GHSI datasets and then to contribute to methodological development of GHSI.Materials and methodsData set of the study consists of the publicly available GHSI data set, which allows for comparative evaluation of countries. BI-β method and GHSI were used to compare countries in terms …
Relationship Between Functional Status And Fatigue After Covid-19 Infection: A Multicenter Study From Türkiye, İpek Candemi̇r, Pinar Ergün, Di̇cle Kaymaz, Mustafa Engi̇n Şahi̇n, İpek Özmen, Eli̇f Yildirim, Asli Görek Di̇lektaşli, Büşra Yi̇ği̇tli̇ler, Ayten Odabaş, Deni̇z Kizilirmak, Seçi̇l Sari, Celaletti̇n Korkmaz, Cantürk Taşçi, Yakup Arslan, Sema Savci, Buse Kahraman, Ayli̇n Tanriverdi̇, Can Sevi̇nç, Melda Sağlam, Deni̇z İnal İnce, Naci̇ye Vardar Yağli, Ebru Kütükçü, Di̇lber Durmaz, Nesli̇han Durutürk, Gaye Ulubay, Lütfi̇ye Kiliç, Benan Çağlayan, Ayli̇n Moray, Sabri̇ Serhan Olcay, Güven Özkaya
Relationship Between Functional Status And Fatigue After Covid-19 Infection: A Multicenter Study From Türkiye, İpek Candemi̇r, Pinar Ergün, Di̇cle Kaymaz, Mustafa Engi̇n Şahi̇n, İpek Özmen, Eli̇f Yildirim, Asli Görek Di̇lektaşli, Büşra Yi̇ği̇tli̇ler, Ayten Odabaş, Deni̇z Kizilirmak, Seçi̇l Sari, Celaletti̇n Korkmaz, Cantürk Taşçi, Yakup Arslan, Sema Savci, Buse Kahraman, Ayli̇n Tanriverdi̇, Can Sevi̇nç, Melda Sağlam, Deni̇z İnal İnce, Naci̇ye Vardar Yağli, Ebru Kütükçü, Di̇lber Durmaz, Nesli̇han Durutürk, Gaye Ulubay, Lütfi̇ye Kiliç, Benan Çağlayan, Ayli̇n Moray, Sabri̇ Serhan Olcay, Güven Özkaya
Turkish Journal of Medical Sciences
Background/aim: Symptoms of COVID-19 may persist for months. One of the persistent symptoms of COVID-19 is fatigue, which reduces functional status. The relationship between fatigue, functional status, and various other factors has received little attention, which this study aims to address.. Materials and methods: Patients with COVID-19 infection were included in this multicenter cross-sectional study. Age, sex, body mass index (BMI), marital status, smoking status, presence and duration of chronic disease, comorbidity index, regular exercise habits, time since COVID-19 diagnosis, hospitalization status, length of hospital stay, intubation status, home oxygen therapy after discharge, participation in a pulmonary rehabilitation program, presence …
Turkish Adaptation Of The Neonatal Eating Assessment Tool–Bottle-Feeding In Preterm Infants Discharged To Home, Burcu Aykanat Gi̇rgi̇n, Duygu Gözen, Sabi̇ha Çağlayan, Bri̇tt Pados
Turkish Adaptation Of The Neonatal Eating Assessment Tool–Bottle-Feeding In Preterm Infants Discharged To Home, Burcu Aykanat Gi̇rgi̇n, Duygu Gözen, Sabi̇ha Çağlayan, Bri̇tt Pados
Turkish Journal of Medical Sciences
Background/aim: Preterm infants often continue to have feeding difficulties after hospital discharge. Parental use of assessment tools and collaboration with health professionals are important for the early diagnosis of post-discharge feeding difficulties. This methodological study examined the validity and reliability of the Turkish version of the Neonatal Eating Assessment Tool (NeoEAT)–Bottle-feeding in post-discharge preterm infants in Turkey.Materials and methods: A Turkish version of the NeoEAT–Bottle-feeding was developed and applied to 321 mothers of preterm infants younger than seven months of corrected age between August 2021 and December 2022. Cronbach’s α, exploratory factor, confirmatory factor, item-total correlation, test-retest, and known-groups validity …
Correlation Between Plasma Ccfdna, Mtdna Changes, Ctcs, And Epithelial-Mesenchymal Transition In Breast Cancer Patients Undergoing Nact, Betül Çeli̇k, İrem Peker Eyüboğlu, Si̇nan Koca, Mustafa Ümi̇t Uğurlu, Özkan Alan, Gökçe Güllü Amuran, Tuğba Akin Telli̇, Fulden Yumuk, Mustafa Akki̇pri̇k
Correlation Between Plasma Ccfdna, Mtdna Changes, Ctcs, And Epithelial-Mesenchymal Transition In Breast Cancer Patients Undergoing Nact, Betül Çeli̇k, İrem Peker Eyüboğlu, Si̇nan Koca, Mustafa Ümi̇t Uğurlu, Özkan Alan, Gökçe Güllü Amuran, Tuğba Akin Telli̇, Fulden Yumuk, Mustafa Akki̇pri̇k
Turkish Journal of Medical Sciences
Background/aim: Breast cancer is the most prevalent cancer in women, emphasizing need for noninvasive blood biomarkers to aid in treatment selection. Previous studies have demonstrated elevated levels of plasma circulating cell-free DNA (ccfDNA) in breast cancer patients. Both ccfDNA and mitochondrial DNA (mtDNA) are fragments released into the bloodstream. In this study, we investigated effectiveness of ccfDNA and mtDNA as indicators of treatment response and explored their potential as monitoring biomarkers. Additionally, we compared these markers with circulating tumor cell (CTC) data and assessed their relationship with epithelial-mesenchymal transition (EMT).Materials and methods: Thirty-six female breast cancer patients and 21 healthy …
Prediction Of Inherited Metabolic Disorders Using Tandem Mass Spectrometry Data With The Help Of Artificial Neural Networks, Pembe Soylu Üstkoyunciu, Nuretti̇n Üstkoyuncu
Prediction Of Inherited Metabolic Disorders Using Tandem Mass Spectrometry Data With The Help Of Artificial Neural Networks, Pembe Soylu Üstkoyunciu, Nuretti̇n Üstkoyuncu
Turkish Journal of Medical Sciences
Background/aim: Tandem mass spectrometry is helpful in diagnosing amino acid metabolism disorders, organic acidemias, and fatty acid oxidation disorders and can provide rapid and accurate diagnosis for inborn errors of metabolism. The aim of this study was to predict inborn errors of metabolism in children with the help of artificial neural networks using tandem mass spectrometry data.Materials and methods: Forty-seven and 13 parameters of tandem mass spectrometry datasets obtained from 2938 different patients were respectively taken into account to train and test the artificial neural networks. Different artificial neural network models were established to obtain better prediction performances. The obtained …
Serum Vascular Endothelial Growth Factor Has Diagnostic And Prognostic Significiances In Ulcerative Colitis, Musa Salmanoğlu, İrfan Küçük, Başak Çakir Güney, Betül Doğanteki̇n, Nurgül Tükel, Zeli̇ha Seri̇ndağ, Habi̇p Yilmaz, Mustafa Kaplan
Serum Vascular Endothelial Growth Factor Has Diagnostic And Prognostic Significiances In Ulcerative Colitis, Musa Salmanoğlu, İrfan Küçük, Başak Çakir Güney, Betül Doğanteki̇n, Nurgül Tükel, Zeli̇ha Seri̇ndağ, Habi̇p Yilmaz, Mustafa Kaplan
Turkish Journal of Medical Sciences
Background/aim: In ulcerative colitis (UC), serum vascular endothelial growth factor (sVEGF) concentrations are elevated and there are conflicting results about serum calprotectin (SCP) and sVEGF as biomarkers. We aimed to evaluate the relationship between sVEGF and SCP levels in UC patients, and the associations of these molecules and the phenotypes of UC. Materials and methods: This prospective case-control study included 60 UC patients and 30 healthy controls. The Mayo Clinical Scoring System (MCS) was used for patients' clinical and endoscopic features (MES). Truelove and Richard's method was applied to the histology activity index (HAI). The human VEGF (Cat.E0080Hu) and the …
Preparation Of A Chiral Hyperbranched Polymer Based On Cinchona Alkaloids And Investigation Of Its Catalytic Activity In Asymmetric Reactions, Rafiqul Islam, Mohammad Shahid Ullah, Abdus Salam, Shinichi Itsuno
Preparation Of A Chiral Hyperbranched Polymer Based On Cinchona Alkaloids And Investigation Of Its Catalytic Activity In Asymmetric Reactions, Rafiqul Islam, Mohammad Shahid Ullah, Abdus Salam, Shinichi Itsuno
Turkish Journal of Chemistry
Cinchona alkaloid-derived sulfonamides and ester dimers containing chiral hyperbranched polymers have been successfully synthesized and applied as catalysts in asymmetric reactions. Several hyperbranched polymers derived from cinchona alkaloids, incorporating sulfonamides and esters, were synthesized through Mizoroki–Heck coupling polymerization. These polymers were subsequently applied in enantioselective Michael addition reactions. As the prepared polymers are not soluble in frequently used organic solvents, they act as efficient catalysts in the enantioselective reaction of β-ketoesters to nitroolefins, achieving up to 99% enantioselectivity with good yields. The insoluble property allows them to better satisfy “green chemistry” requirements and be used several times without losing the …
Synthesis, Characterization, And Physico-Chemical Aspects Of A New Pvc-Based Quaternary Triethanol Ammonium Chloride Anionite For Tungsten Recovery, Bahig Atia
Turkish Journal of Chemistry
The usability of polyvinyl chloride-based quaternary triethanol ammonium chloride anionite (PVC-TEAC) as a potential extractant for tungstate was investigated to recover tungstate from Gabal Qash Amir, Egypt, assaying 70.91% WO3. Structure elucidation for PVC-TEAC anionite was successfully carried out using several techniques. Experimental measurements, such as pH, agitation time, initial tungsten concentration, anionite dose, co-ions, temperature, and eluting agents, have been optimized. It was found that PVC-TEAC anionite has a maximum capacity of 63 mg per gram. From the distribution isotherm modeling, Langmuir’s model fits the experimental results better than Freundlich’s, with a theoretical value of 61.728 mg g–1. According …
Exploring The Efficiency Of Nitrogenated Carbon Quantum Dots/Tio2 S-Scheme Heterojunction In Photodegradation Of Ciprofloxacin In Aqueous Environments, Yilmaz Ateş, Zafer Eroğlu, Özkan Açişli, Önder Meti̇n, Semra Karaca
Exploring The Efficiency Of Nitrogenated Carbon Quantum Dots/Tio2 S-Scheme Heterojunction In Photodegradation Of Ciprofloxacin In Aqueous Environments, Yilmaz Ateş, Zafer Eroğlu, Özkan Açişli, Önder Meti̇n, Semra Karaca
Turkish Journal of Chemistry
The usability of polyvinyl chloride-based quaternary triethanol ammonium chloride anionite (PVC-TEAC) as a potential extractant for tungstate was investigated to recover tungstate from Gabal Qash Amir, Egypt, assaying 70.91% WO3. Structure elucidation for PVC-TEAC anionite was successfully carried out using several techniques. Experimental measurements, such as pH, agitation time, initial tungsten concentration, anionite dose, co-ions, temperature, and eluting agents, have been optimized. It was found that PVC-TEAC anionite has a maximum capacity of 63 mg per gram. From the distribution isotherm modeling, Langmuir’s model fits the experimental results better than Freundlich’s, with a theoretical value of 61.728 mg g–1. According …
Liquefaction Optimization Of Grape Pulp Using Response Surface Methodology For Biopolyol Production And Bio-Based Polyurethane Foam Synthesis, Furkan Çolakoğlu, Emre Akdoğan, Murat Erdem
Liquefaction Optimization Of Grape Pulp Using Response Surface Methodology For Biopolyol Production And Bio-Based Polyurethane Foam Synthesis, Furkan Çolakoğlu, Emre Akdoğan, Murat Erdem
Turkish Journal of Chemistry
Both environmental and economic disadvantages of using petroleum-based products have been forcing researchers to work on environmentally friendly, sustainable, and economical alternatives. The purpose of this study is to optimize the solvothermal liquefaction process of grape pomace using response surface methodology coupled with a central composite design. After investigating the physicochemical properties of the liquified products (biopolyol) in detail, a bio-based rigid polyurethane foam (RPUF) was synthesized and characterized. The hydroxyl and acid numbers and viscosity values of all the biopolyols were analyzed. According to variance analysis results (%95 confidence range), both the reaction temperature and catalyst loading were determined …