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Are Cinnamon Derivatives Effective And Safe For Diabetes?, Methi̇ye Mancak, Ufuk Koca Çalişkan

Turkish Journal of Medical Sciences

Background/aimCinnamon spice is obtained by drying the tree bark of the Cinnamomum Schaeff genus. Cinnamomum genus belongs to the Lauraceae family and there are approximately 250 different species around the world. The most common species in the market are Cinnamomum verum J. S. Presl, C. cassia (L.) J. Presl, C. burmannii (Nees & T. Nees) Blume and C. loureiroi Nees. Cinnamon and its by-products are used for many years for their antidiabetic effect. In this research, the major chemical content and in vitro antidiabetic activities of different commercially available cinnamon samples were evaluated to conclude whether they are safe to …

Association Of Certain Biochemical Parameters Related To Bone Cycle With Genotype In Mps Iii-B Patients, Seda Gökkurt, İrem Peker Eyüboğlu, Banu Nur Güzel, Ercan Mihçi, Ayşe Özer, Mustafa Akki̇pri̇k

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to investigate the genotype-phenotype correlation in Sanfilippo type B patients in terms of bone formation/resorption parameters, and to determine the release/inhibition of biomarkers accompanying osteoporosis.Materials and Methods: Plasma levels of Osteoprotegerin, Matrix metalloproteinases (MMP2, MMP9), TIMP-1, TIMP-2, BALP, Cathepsin K, and TRACP-5b were examined by ELISA method in MPS IIIB patients. At the same time, mutations in the NAGLU gene causing this disease were detected by whole exome sequencing, and their correlation with biochemical parameters was investigated.Results: Based on the enzyme analysis results, MMP-9, TIMP1, TIMP-2, and MMP-2 were significantly high, while Cathepsin-K …

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Turkish Journal of Medical Sciences

No abstract provided.

Thoracic Disc Herniations: Diagnosis, Surgical Techniques, And Complication Insights, Mehmet Deni̇zhan Yurtluk, Aydin Si̇nan Apaydin, Hakan Kina, Khoi Than

Turkish Journal of Medical Sciences

Abstract: Thoracic disc herniations (TDHs) are rare conditions, comprising 0.1% to 5% of all reported herniation cases, and affecting up to 1 in 1,000,000 individuals. The mid to lower thoracic spine, particularly between the T11 and T12 vertebrae, is most frequently affected and often associated with trauma. Conditions like Scheuermann’s disease can predispose patients to TDHs. This study explores the clinical manifestations, diagnostic methods, surgical techniques, and complications associated with TDHs. Diagnosis relies on magnetic resonance imaging and computed tomography myelography to identify the level and nature of the herniation. Various surgical approaches, including posterolateral, lateral, and anterior, have been …

A Comparison Study Of Sensory Processing In Older Adults With And Without Dementia, Medi̇ne Nur Özata Değerli̇, Di̇dem Karaduman, Burcu Balam Doğu, Onur Altuntaş

Turkish Journal of Medical Sciences

Background/aim: Sensory processing is affected by aging, and dementia may lead to changes in sensory processing. This study aimed to examine the differences in sensory processing and sensory modulation between older adults with and without dementia.Materials and methods: This study was designed as a comparative study of community-dwelling older adults aged 65 years and older with and without dementia. Participants and their caregivers were recruited at the occupational therapy clinic of a public hospital. They completed a sociodemographic information form and the Adolescent/Adult Sensory Profile to assess sensory processing and sensory modulation.Results: The study included 120 older adults (60 with …

Novel Nonmagnetic Abutment Designs For Facial Prostheses: An Experimental Study, İrem Sozen Yani̇k, Ufuk Adali̇, Jamila Yassine, Fransizka Schmidt, Wolfgang Hannak, Bahadir Ersu

Turkish Journal of Medical Sciences

Background/aim: This in vitro study aimed to evaluate and compare the retentive forces of novel nonmagnetic abutment designs developed as an alternative to conventional magnetic abutments for facial prostheses.Materials and methods: A plexiglass model was constructed and two extraoral implants were placed in these blocks in a parallel position. Nonmagnetic abutments made of titanium were fabricated and screwed onto the implants. The nonmagnetic systems represent a novel design and include two different abutment designs (Type 1 and Type 2) with silicone attachments. Retentive force values for three abutment types: Conventional Magnetic System (CMS), Nonmagnetic abutment Type 1 System (NMS1), and …

Duple-Mondnet: Duple Deep Learning-Based Mobile Net For Motor Neuron Disease Identification, Sony Helen, Joseph Jawhar

Turkish Journal of Medical Sciences

Background/aim: Motor neuron disease (MND) is a devastating neuron ailment that affects the motor neurons that regulate muscular voluntary actions. It is a rare disorder that gradually destroys aspects of neurological function. In general, MND arises as a result of a combination of natural, behavioral, and genetic influences. However, early detection of MND is a challenging task and manual identification is time-consuming. To overcome this, a novel deep learning-based duple feature extraction framework is proposed for the early detection of MND.Materials and methods: Diffusion tensor imaging tractography (DTI) images were initially analyzed for color and textural features using dual feature …

Relationship Between Uncoupling Protein 1 (Ucp1) Levels And Psoriasis, Fi̇kret Akyurek, Fatma Tuncez Akyurek, Fatma Sengul

Turkish Journal of Medical Sciences

Background/aim: Psoriasis is an autoimmune, chronic and common skin disease. Comorbidities also increase the mortality risk of the disease. The aim of this study is to investigate the changes in UCP1 levels in psoriasis patients and to evaluate their possible role in the pathogenesis of the disease, focusing on disease severity (Psoriasis Area and Severity Index), dyslipidemia, inflammation and cardiovascular risk.Materials and methods: This study included 30 psoriasis patients and 30 healthy individuals as a control group. Serum UCP1 was measured using an ELISA test kit. The laboratory results of psoriasis patients and healthy controls were compared.Results: UCP1 level was …

Ascorbic Acid Exhibits More Of A Protective Effect Than Estradiol Against Nephrotoxicity Induced By Malathion In Rats: A Histopathological And Molecular Docking Study, Mohammad Alhilal, Mahmoud Salem, Ahmed Albakoush, Suzan Alhilal, Basant Farag, Sobhi M. Gomha

Turkish Journal of Medical Sciences

Background/Aim: Despite the known harmful effects associated with malathion toxicity in various organs, it continues to be widely used for plant protection and insect control. This study is the first to compare the protective effects of estradiol and ascorbic acid against malathion-induced nephrotoxicity through histopathological assessment and molecular docking analyses.

Materials and Methods: This study was conducted using 20 female albino rats that were distributed into sham, malathion, malathion + estradiol, and malathion + ascorbic acid groups. Nephrotoxicity was induced by daily treatment with malathion, and the effects of estradiol and ascorbic acid on nephrotoxicity were evaluated. After 4 weeks …

Erratum To “ Telemedicine In Pediatric Rheumatology: The Video Pediatric Gait, Arms, Legs, And Spine (V-Pgals) Examination” [Turkish Journal Of Medical Sciences 54 (5) 2024 963-969 ], Zeynep Balik, Seher Şener, Yağmur Bayindir, Müşerref Kasap Cüceoğlu, Emi̇l Ali̇yev, Özge Başaran, Yelda Bi̇lgi̇ner, Seza Özen, Ezgi̇ Deni̇z Batu

Turkish Journal of Medical Sciences

This erratum is written to correct an error in our previous publication. Supplement Figure 2 was published incorrectly as one page instead of six.
DOI of original article: https://doi.org/10.55730/1300-0144.5874

A New Formula For Predicting The Actual Volume Of Parathyroid Adenoma In Patients With Primary Hyperparathyroidism, İbrahi̇m Kilinç, Mustafa Oruç, Serap Ulusoy, Ali̇ Coşkun, Mehmet Kiliç

Turkish Journal of Medical Sciences

Backround/AimKnowing the adenoma volume in patients with primary hyperparathyroidism (PHPT) is useful for surgeons during parathyroidectomy. The primary aim of our study was to determine how to calculate adenoma volume with the greatest accuracy. Our secondary aim was to determine the relationship between adenoma volume and preoperative biochemical parameters (parathyroid hormone [PTH] and calcium levels).Material and MethodsWe prospectively collected the medical history of 75 patients who underwent surgery for a single parathyroid adenoma. After excision, the adenomas were placed in water-filled syringes and the actual volume was determined according to the amount of water displaced. The radiological volume of the …

Effects Of Vitamin D Replacement Combined With Graves’ Disease Therapy: A Retrospective Cohort Study, Beyza Taşkent Sezgi̇n, Muhammed Kizilgül, Özgür Özçeli̇k, Taner Demi̇rci̇, Hayri̇ Bostan, Ümran Gül, Beki̇r Uçan

Turkish Journal of Medical Sciences

Background/aim: In Graves’ disease (GD), an autoimmune disease, antibodies targeting the TSH receptor cause the production of excessive amounts of thyroid hormone. A significant association has been reported between low 25(OH) Vitamin D3 (VitD) levels and various autoimmune disorders. Therefore, this study aimed to investigate the effects of VitD deficiency and replacement therapy on laboratory and clinical parameters in GD patients.Methods:Fourty GD and 37 healthy control patients were included in this study. Patients with GD were divided into two groups, and the first group was given only antithyroid treatment (n:18), and the second group was given antithyroid treatment plus VitD …

Could Eras Protocols Be Integrated Into The National Standards For Quality In Healthcare In Türkiye?, Mi̇ne Gürsaç Çeli̇k, Adem Az, Mehmet Çeti̇n, Nesli̇han Alkiş

Turkish Journal of Medical Sciences

No abstract provided.

Assessing Knowledge Levels Of Intensive Care Unit Nurses And Doctors Regarding Drug Administration Via Enteral Feeding Tubes: A Survey Study, Ayşe Gül Koçoğlu Kinal, Yunus Emre Ayhan, Aslinur Albayrak

Turkish Journal of Medical Sciences

Background/aimKnowledge deficiency regarding appropriate drug administration through enteral feeding tubes (EFTs). is common in intensive care units (ICUs). The aim of this study is to evaluate the knowledge levels of nurses and doctors in ICUs about drug administration via EFTs.Materials and methodsThis study was conducted as a cross-sectional online survey. Survey questions were created using Google Forms and distributed to nurses and doctors in various ICUs across hospitals in Istanbul, Türkiye. The researchers designed the survey questions based on literature reviews and existing examples. The survey consisted of three sections and a total of 25 questions: the first section included …

Navigating Pregnancy With Cardiovascular Disease: Pathophysiology, Risk Stratification, And Maternal–Fetal Outcomes, Osman Türkmen, Serra Akar İnan

Turkish Journal of Medical Sciences

Pregnancy induces significant cardiovascular changes, including increases in heart rate, blood volume, and cardiac output, which may exacerbate existing heart conditions or unmask previously undiagnosed heart diseases.. This review outlines the types of cardiovascular diseases that affect pregnant women, organized by the modified World Health Organization risk classification. It covers key areas, including how pregnancy impacts the heart, common maternal and fetal complications, and effective management strategies. The review emphasizes the importance of preconception counseling, risk assessment, and continuous monitoring to ensure the best maternal and fetal outcomes. It also highlights practical guidelines for healthcare providers and discusses the latest …

The Use Of Antiepileptic Drugs And Their Effects In Pregnancy, Pinar Öztürk, Ali̇ Turhan Çağlar

Turkish Journal of Medical Sciences

Background/Aim: Epilepsy is one of the most common chronic neurological diseases. Epilepsy can affect the entire life, including childbearing age. It is estimated that epileptic women give three to five births per thousand births. Although the use of antiepileptic drugs (AEDs) during pregnancy has been associated with major congenital malformations in the fetus, many patients cannot discontinue the drugs before pregnancy due to the risk of seizures that may harm the mother as well as the children. In this study, our aim is to examine the follow-up findings of pregnant women who are epileptic and use AEDs during pregnancy and …

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Turkish Journal of Chemistry

No abstract provided.

An Overview Of Sodium-Ion Batteries As Next-Generation Sustainable Electrochemicaldevices Beyond The Traditional Lithium-Ion Framework, Gamzenur Özsi̇n

Turkish Journal of Chemistry

The rise in the popularity of electric vehicles and portable devices has boosted the demand for rechargeable batteries, withlithium-ion (Li-ion) batteries favored for their superior energy and power density. However, supply strains and sustainability issues aredriving the search for alternatives. Postlithium technologies, particularly sodium-ion (Na-ion) batteries, are gaining attention for theirpromising potential and similarity to Li-ion technology. While efforts are still needed to enhance the energy and power density as wellas the cycle life of Na-ion batteries to replace Li-ion batteries, these energy storage devices present significant advantages in terms ofsustainability, theoretical capacity, and intrinsic safety features. Through this paper, …

A Hindered Phenol Containing Pvc/Cuo Nanocomposites; Study On The Mechanical And Thermooxidative Properties, Mohsen Hajibeygi, Alireza Ghasemi

Turkish Journal of Chemistry

The effect of synthesized 5-((4-hydroxy-3,5-di-tert-butylphenyl)diazenyl)isophthalic acid (HBA) containing a hinderedphenol derivative on the thermooxidation, hydrochloric acid release time, and mechanical strength of PVC/CuO nanocompositeswas studied. Moreover, 5-((4-hydroxy-2,5-dimethylphenyl)diazenyl)isophthalic acid (HMA) was synthesized for comparison ofcorresponding PVC nanocomposite properties. PVC nanocomposite thin films were prepared through in situ surface modificationof CuO nanoparticles with HBA and HMA, individually, in the PVC solution. The XRD and FE-SEM results clarified the desirabledispersion of CuO nanoparticles. The PVC sample with loading of 5 wt% from each HBA and CuO was found to be the most thermallystable, which was confirmed by thermogravimetric analysis in inert conditions. The …

Platinum Group Metal (Pgm) Free Multi Metallic Nanomaterial: A Potential Electrocatalyst For Ethanol Oxidation, Susmita Singh, Prodipta Pal, Soumik Roy, Shalini Basak, Prantica Saha, Anushna Dutta, Sinthia Saha, Mainak Bose

Turkish Journal of Chemistry

Comprehensive studies of the ethanol oxidation reaction (EOR) have shown high interest in fuel cell technologies. As anodecatalysts, introducing platinum group metal (PGM) free catalyst is promising for higher catalytic activity towards the EOR, as these arecost-effective, pollution-tolerant, and suitable for sustainable energy conversion. In this investigation, multi walled carbon nanotube(MWCNT) supported PGM-free electrocatalysts are synthesized by the impregnation reduction method. The atomic structure,composition, and morphology of nanoalloy catalysts are discovered through X-ray diffraction (XRD), Raman spectroscopy and fourier-transform infrared (FTIR) spectroscopy techniques. Electrochemical behaviours have been analysed by cyclic voltammetry (CV), linearsweep voltammetry (LSV), Chronoamperometry (CA), and electrochemical impedance …

Nonadhesive Membranes: Preparation And Characterization Of Modified Phbhx Membranes, Funda Alkan, Murat Demi̇rbi̇lek, Oktay Aydin, Berrak Gümüşkaya Öcal, Neli̇sa Laçi̇n Türkoğlu, Mustafa Türk, Mehmet Ali̇ Onur

Turkish Journal of Chemistry

After abdominal surgery, there is a possibility of adhesions between the abdominal organs and the abdominal wall. Theadhesions can lead to problems such as chronic pain, intestinal blockage, and infertility. To prevent adhesion, antiadhesion patchescan be used. In this study, poly hydroxybutyrate-co-hexanoate membranes were fabricated as antiadhesion patches and modified witheither fatty acids or polyethylene glycol. The homogeneity and protein absorption of the membranes were assessed. The effects onblood coagulation factors were determined and the adhesion-proliferation properties of human fibroblast cells on the membranes weredetermined. The results show that myristic acid slightly increases surface free energy (40.7 ± 4.2 mN/m), …

Preparation And Characterization Of Rhfe/G-C3n4 Nanoparticles For Efficient Hydrolysis Of Sodium Borohydride, Merve Uçar Kaya, Mehmet Yurderi̇, Mehmet Zahmakiran

Turkish Journal of Chemistry

Highly effective graphitic carbon nitride-supported RhFe Nanoparticles (denoted as RhFe/g-C3N4) were prepared using a simple wet impregnation-reduction method for the hydrolysis of sodium borohydride (NaBH4). The obtained RhFe/g-C3N4 catalyst was characterized using advanced analytical/spectroscopic techniques such as inductively coupled plasma-optical emission spectroscopy (ICP-OES), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Powder X-ray diffraction (P-XRD), X-ray spectroscopy (XPS), and fourier transform infrared spectroscopy (FT-IR). The catalytic activities of RhFe/g-C3N4 catalysts with varying Rh/Fe molar ratios were investigated, demonstrating superior catalytic activity compared to monometallic Rh and Fe. The initial turnover frequency (TOF) value of the Rh0.48Fe0.52/g-C3N4 catalyst was calculated as …

The Magnetic Beads-Based Sandwich-Shaped Immune Complexes For Rapid And Sensitiveamperometric Detection Of Sox2 Protein, Göksu Özçeli̇kay Akyildiz, Mehmet Altay Ünal, Seçi̇l Gülden, Si̇bel Ayşil Özkan

Turkish Journal of Chemistry

Sex-Determining Region Y-box 2 (SOX2) is a transcription factor protein. SOX2 expression is related to lymph nodemetastasis and distant metastasis in colorectal carcinomas. SOX2 was determined with the first magnetic disposable immunoplatform.The designed sandwich-shaped immune complexes were formed by a capture antibody, SOX2 protein, and biotinylated secondaryantibodies (dAb/HRP). The sandwich-shaped immune complex was linked to carboxylic acid functionalized magnetic beads (HOOC-MBs). This magnetic bioconjugate was dropped on the surface of the screen-printed carbon electrode (SPCE). The amperometricmeasurement was performed at –0.20 V in the presence of hydroquinone (HQ) and H2O2 against a silver pseudo-reference electrode.The optimization parameters affecting the immunoassay …

Masking Of Iron And Other Interferences During The Spectrophotometric Analysis Of Aluminum From Soil Samples Using Alizarin Red S, Hafiz Zain Ul Aabidin, Muhammad Inam Ul Hassan, Tariq Yasin, Muhammad Zubair Rahim, Ahsan Amin Bhatti, Hamayun Imtiaz, Asif Raza

Turkish Journal of Chemistry

In whole-rock geochemical analysis, the quantification of aluminum in geological samples is performed using differentanalytical techniques including UV-Vis spectrophotometry. During the spectrophotometric analysis of aluminum utilizing AlizarinRed S, iron causes significant interference, leading to inaccurate measurements of the amount of aluminum in the sample. In caseswhere leached or processed samples contain titanium, interference is also observed. However, appropriate masking agents can removethese interferences. In this study, various masking agents including Tiron, oxalic acid, ascorbic acid, and thioglycolic acid were utilizedfor the masking of iron. Among these masking agents, ascorbic acid proved to be the best candidate for masking iron. A …

Simultaneous Determination Of Sunset Yellow And Tartrazine In Real Samples On An N-Butylamine-Graphite/Polyaminophenol Composite Electrode, Mürşi̇de Ceren Afşar, Zekerya Dursun

Turkish Journal of Chemistry

A composite electrode was fabricated for simultaneous determination of sunset yellow (SY) and tartrazine (Tz) in foods andsyrup. It is based on n-butylamine intercalation into graphite and then dropped on a poly (4-aminophenol)/glassy carbon electrode(GCE). The electrode surface morphologies, chemistry, and electrical properties were identified by scanning electron microscopy(SEM), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy (RS), and electrochemical impedance spectroscopy (EIS). Thenew composite electrode significantly increased the electrochemical response of SY and Tz relative to a bare GCE. The peak currentof SY and Tz increased linearly depending on their concentrations from 0.006 μmol L–1 to 1.0 μmol L–1 (r = …

A New Water-Soluble Silicon Phthalocyanine That Catalyzes The Photodegradation Of Pollutant Dyes, Damla Nur Kaya, Behi̇ce Sebnem Sesalan

Turkish Journal of Chemistry

The removal of color arising from water-soluble dyes in wastewaters is necessary to counter the threat to health. Because of thedifficulty in elimination of these dyes by conventional methods, their photodegradation using photosensitizers such as phthalocyanines(Pcs) has been employed recently. When compared to peripherally substituted derivatives, silicon Pcs are reported to be morebiocompatible with low toxicity. Thus a new silicon Pc substituted with two quaternized dimethylamino phenoxy units (compound 1)and its quaternized derivative (compound 2) were synthesized to test its photocatalytic ability employing the dyes methylene blue (MB),eosin B (EB), erythrosine (ERB), sulforhodamine B (SRB), and brilliant blue FCF (BRB), …

Pharmacokinetics Of Liposomal Levamisole After Oral, Intramuscular, And Subcutaneousadministration In Sheep, Hasan Susar, İzzet Karahan

Turkish Journal of Veterinary & Animal Sciences

This study aimed to determine the pharmacokinetics of free and liposomal levamisole in sheep following single oral (O),intramuscular (IM), and subcutaneous (SC) administrations at a dose of 7.5 mg/kg. The study developed a levamisole liposome andinvestigated relevant parameters: particle size, zeta potential, polydispersity index, encapsulation efficiency, pH, and morphology. TheBangham method, a thin-film hydration technique, was employed to prepare the liposomal levamisole. Blood samples were collectedby jugular venipuncture in heparinized tubes immediately before each free and liposomal levamisole treatment and at 2.5, 5, 10, 15,30, 60, 90, 120, 240, 360, and 480 min and 12, 16, and 24 h after …

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Impact Of Particle Size On Physical And Functional Characteristics Of Baby Corn Powder, Ubaida Akbar, Prasad Rasane, Md Sabir Ahmed Mondol, Jyoti Singh, Vikas Nanda, Hasan Kiliçgün, Sawinder Kaur

Turkish Journal of Agriculture and Forestry

This study’s objective is to explore the influence of particle size on the characteristics and functionalities of baby corn powder. In food product development and application, particle properties are crucial. Sieve analysis using a series of standardized sieves determined the particle size distribution, ranging from >500 µm to 53 µm. The particles exhibited stability, with an average size of 208.8 nm, a polydispersity index of 0.133, and a zeta potential of –20 mV. Bulk density (BD) and true density (TD) showed an inverse relationship with particle size, with BD ranging from 0.552 to 0.238 gcm–3 for particle sizes >500 to …

Mapping Of Qtls Associated With Frost Tolerance In Olive (Olea Europaea L.), Öznur Çeti̇n, Nurengi̇n Mete, Handan Ölmez, Hati̇ce Gülen

Turkish Journal of Agriculture and Forestry

The olive (Olea europaea L.) is widely distributed due to its high adaptability to different environmental conditions. However,in recent years, sudden extreme temperature decreases and frost damage have caused significant yield and quality losses in some regions.This situation has led to the development of varieties with high frost tolerance, suitable for regions where cold damage may occur.It takes many years to develop varieties using classical breeding methods in olives. Therefore, early selection should be made usingbiotechnological methods. Markers about any trait provide a great advantage, especially in plant species with a very long juvenile sterilityperiod, as they allow for a …