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Evaluation Of Muc1, Ck20, And Htert Expression In Peripheral Blood Of Gastrointestinal Cancer Patients In Search Of Diagnostic Criteria, Si̇bel Küçükyildirim Çeli̇k, Beri̇l Erdem, Emel Sağlar, Zülfi̇kar Polat, Hati̇ce Mergen
Evaluation Of Muc1, Ck20, And Htert Expression In Peripheral Blood Of Gastrointestinal Cancer Patients In Search Of Diagnostic Criteria, Si̇bel Küçükyildirim Çeli̇k, Beri̇l Erdem, Emel Sağlar, Zülfi̇kar Polat, Hati̇ce Mergen
Turkish Journal of Biology
The goal of this study was to identify the optimal marker or marker combinations for detection of gastrointestinal malignancies using reverse-transcriptase polymerase chain (RT-PCR) reaction. To detect the presence of tumors, we analyzed mucin 1 (MUC1), cytokeratin 19 (CK19), cytokeratin 20 (CK20), and human telomerase reverse transcriptase (hTERT) mRNA in the peripheral blood of 31 patients with gastrointestinal (esophagus, stomach, and colorectal) cancer and 30 healthy individuals. In RT-PCR analysis of the peripheral blood, 77.4% (24/31), 61.29% (19/31), and 45.16% (14/31) of cancer patients were positive for MUC1, CK20, and hTERT mRNA, respectively. According to our results, any one of …
The Effect Of Survivin Gene Promoter Polymorphism On Breast Cancer, Mehmet Deni̇z Altiparmak, Celal İsmai̇l Bi̇lgi̇ç, Nüzhet Cenap Dener, Esra Gündüz, Si̇bel Yeni̇dünya, Muradi̇ye Acar, Meral Şen, Mehmet Gündüz
The Effect Of Survivin Gene Promoter Polymorphism On Breast Cancer, Mehmet Deni̇z Altiparmak, Celal İsmai̇l Bi̇lgi̇ç, Nüzhet Cenap Dener, Esra Gündüz, Si̇bel Yeni̇dünya, Muradi̇ye Acar, Meral Şen, Mehmet Gündüz
Turkish Journal of Biology
Breast cancer is the most common malignant tumor in women and accounts for about 25% of all cancer diagnoses. Survivin is a member of the apoptosis inhibitor protein family of antiapoptotic proteins. In our study, we investigated one of those, the survivin gene promoter 31G/C polymorphism. Included in this study were 111 breast cancer patients who were operated on in our hospital and 101 healthy female subjects. Blood samples from the healthy subjects and paraffin-embedded tissue samples from the patients were used for DNA extraction and subsequent genetic analysis. PCR-RFLP was used for genotype analysis. We established the clinicopathologic characteristics …
Downregulation Of C-Myc Mediated Odc Expression After Purvalanol Treatment Is Under Control Of Upstream Mapk Signaling Axis In Mcf-7 Breast Cancer Cells, Pinar Obakan, Gi̇zem Alkurt, Betsi̇ Köse, Ajda Çoker Gürkan, Eli̇f Damla Arisan, Deni̇z Coşkun, Zeynep Narçi̇n Ünsal
Downregulation Of C-Myc Mediated Odc Expression After Purvalanol Treatment Is Under Control Of Upstream Mapk Signaling Axis In Mcf-7 Breast Cancer Cells, Pinar Obakan, Gi̇zem Alkurt, Betsi̇ Köse, Ajda Çoker Gürkan, Eli̇f Damla Arisan, Deni̇z Coşkun, Zeynep Narçi̇n Ünsal
Turkish Journal of Biology
Roscovitine and purvalanol are specific cyclin-dependent kinase (CDK) inhibitors, which induce apoptosis by triggering cell cycle arrest in various cancer cells such as colon, prostate, and breast cancer cells. Although the apoptotic action of roscovitine was clarified at the molecular level, the exact mechanism of purvalanol-induced apoptosis is still under investigation. The mitogen-activated protein kinase (MAPK) signaling cascade is activated by different inducers related to growth, proliferation, differentiation processes, or environmental stress factors. Recent reports showed that modulation of MAPKs might lead to regulation of c-Myc, which is a transcription factor for the polyamine (PA) biosynthesis enzyme, ornithine decarboxylase (ODC). …
Antioxidant And Radical Scavenging Activities In Fruits Of 6 Sea Buckthorn (Hippophae Rhamnoides L.) Cultivars, Otakar Rop, Sezai̇ Erci̇şli̇, Jiri Mlcek, Tunde Jurikova, Ignac Hoza
Antioxidant And Radical Scavenging Activities In Fruits Of 6 Sea Buckthorn (Hippophae Rhamnoides L.) Cultivars, Otakar Rop, Sezai̇ Erci̇şli̇, Jiri Mlcek, Tunde Jurikova, Ignac Hoza
Turkish Journal of Agriculture and Forestry
Sea buckthorn (Hippophae rhamnoides L.) is a minor fruit crop. The most important breeding activities focused on the production of sea buckthorn fruits as a top-quality food product have been performed in Russia, Germany, and the Czech Republic. Over the past several decades, plant breeders have selected a number of cultivars that show excellent physical and nutritional properties. The aim of this study was to monitor and determine the total contents of phenols and flavonoids as well as antioxidant capacity and scavenging activity of methanolic extracts on reactive oxygen species and lipid peroxidation in some cultivars of sea buckthorn suitable …
Cytotoxic And Apoptotic Effects Of Ceranib-2 Offering Potential For A New Antineoplastic Agent In The Treatment Of Cancer Cells, Djanan Vejselova, Hati̇ce Mehtap Kutlu, Gökhan Kuş, Selda Kabadere, Ruhi̇ Uyar
Cytotoxic And Apoptotic Effects Of Ceranib-2 Offering Potential For A New Antineoplastic Agent In The Treatment Of Cancer Cells, Djanan Vejselova, Hati̇ce Mehtap Kutlu, Gökhan Kuş, Selda Kabadere, Ruhi̇ Uyar
Turkish Journal of Biology
Fibrocarcinomas are malignant tumours that originate in mesenchymal cells. The tumours typically form in the presence of connective tissue and are of key consideration when assessing research priorities for future healthcare management. Ceramidase inhibitors, such as ceranib-2, have demonstrated capacity to interfere with cellular DNA functionality, initiating apoptosis in many cancer cell lines. The enzyme ceramidase can regulate cellular levels of sphingosine and sphingosine-1-phosphate by controlling hydrolysis of ceramide. The present study investigates the antigrowth effects of ceranib-2 on mouse embryonic fibroblast cells (NIH/3T3 normal cell line) and rat embryonic fibroblast cells (5RP7 cancer cell line). Research was conducted using …
The Choice Of Auxin Analogue For In Vitro Root Induction Influences Post-Induction Root Development In Eucalyptus Grandis, Muhammad Nakhooda, Maria Paula Watt, David Mycock
The Choice Of Auxin Analogue For In Vitro Root Induction Influences Post-Induction Root Development In Eucalyptus Grandis, Muhammad Nakhooda, Maria Paula Watt, David Mycock
Turkish Journal of Agriculture and Forestry
Previous studies on in vitro rooting for improved micropropagation of eucalypts indicated that root graviperception and post-acclimatisation architecture are determined by the relative exogenous auxin analogue and its stability, supplied during the pre-rooting culture stages. The specific roles of indole-3-acetic acid (IAA) and indole-3-butyric acid (IBA) in the rooting medium on the in vitro root morphological processes were explored using a good-rooting clone. In vitro rooting percentage was significantly reduced when either of the auxin inhibitors 2,3,5-triiodobenzoic acid (TIBA) and ρ-chlorophenoxyisobutyric acid (PCIB) or the auxin antagonist kinetin was supplied at rooting, with or without exogenous auxin. For all treatments, …
Genetic Comparison Between Natural And Planted Populations Of Pinus Brutia And Cupressus Sempervirens In Syria, Batoul N. Al-Hawija, Viktoria Wagner, Isabell Hensen
Genetic Comparison Between Natural And Planted Populations Of Pinus Brutia And Cupressus Sempervirens In Syria, Batoul N. Al-Hawija, Viktoria Wagner, Isabell Hensen
Turkish Journal of Agriculture and Forestry
There is wide consensus that ongoing deforestation contributes to global warming and poses a threat to species diversity. Less understood is whether the practice of creating plantations might also erode genetic diversity and undermine the genetic structure of tree populations. We tested these hypotheses in natural and planted populations of Pinus brutia Ten. subsp. brutia and Cupressus sempervirens L. var. horizontalis (Mill.), 2 important forestry species in the Mediterranean region. We used plant material from 3 different bioclimatic regions in Syria. Using RAPD markers, we evaluated the genetic diversity and structure of 12 populations of P. brutia (6 natural, 6 …
Genotoxic, Cytotoxic, And Apoptotic Effects Of Crude Extract Of Usnea Filipendula Stirt. In Vitro, Serap Çeli̇kler Kasimoğullari, Seyhan Oran, Ferda Ari, Engi̇n Ulukaya, Nazlihan Aztopal, Mehmet Sarimahmut, Şule Öztürk
Genotoxic, Cytotoxic, And Apoptotic Effects Of Crude Extract Of Usnea Filipendula Stirt. In Vitro, Serap Çeli̇kler Kasimoğullari, Seyhan Oran, Ferda Ari, Engi̇n Ulukaya, Nazlihan Aztopal, Mehmet Sarimahmut, Şule Öztürk
Turkish Journal of Biology
Lichens are recently receiving great attention because they have potential anticancer activity. Therefore, in this study, genotoxic and antigrowth properties of lichen species Usnea filipendula Stirt. were tested against human breast cancer cell lines (MCF-7 and MDA-MB-231). Antigrowth effect was assayed by the MTT and ATP viability assays. Cell death modes (apoptosis/necrosis) were evaluated morphologically (fluorescence staining) and biochemically (caspase-cleaved cytokeratin 18, caspase-3 activity, and poly-(ADP-ribose) polymerase (PARP) cleavage). Genotoxic activity of U. filipendula was determined by using micronucleus, chromosomal aberration, and comet assays in human lymphocyte culture. U. filipendula inhibited growth in a dose-dependent manner and induced apoptosis by …
Plzf Overexpression In T-All Cell Line Cem-C7h2-2c8 Downregulates Glucocorticoid Receptor (Gr) And Its Target Genes, Muhammad Wasim, Muhammad Mansha, Muhammad Tayyab, Ali Raza Awan, Sehrish Firyal, Christine Mantinger, Tahir Yaqub
Plzf Overexpression In T-All Cell Line Cem-C7h2-2c8 Downregulates Glucocorticoid Receptor (Gr) And Its Target Genes, Muhammad Wasim, Muhammad Mansha, Muhammad Tayyab, Ali Raza Awan, Sehrish Firyal, Christine Mantinger, Tahir Yaqub
Turkish Journal of Biology
Glucocorticoids (GCs) induce cell cycle arrest and apoptosis in lymphoid cells and constitute a central component in the treatment of lymphoid malignancies. The molecular basis of this clinically important phenomenon remains, however, poorly understood. Using whole genome expression profiling we have previously identified glucocorticoid response genes in children with acute lymphoblastic leukemia (ALL). The promyelocytic leukemia zinc finger (PLZF) appeared as one of the most promising candidate genes, which has been implicated in the pathogenesis of several leukemia types. We have already established that transgenic PLZF reduced the sensitivity to GC-induced apoptosis in the CEM-C7H2-2C8 leukemic cell line and knockdown …
Effectiveness Of Nitrogen Fertilization And Application Of Microbial Preparations In Potato Cultivation, Marek Kolodziejczyk
Effectiveness Of Nitrogen Fertilization And Application Of Microbial Preparations In Potato Cultivation, Marek Kolodziejczyk
Turkish Journal of Agriculture and Forestry
This study examined the effectiveness of nitrogen fertilization and application of microbiological preparations in potato cultivation. The experiment factors were doses of nitrogen of 0, 60, 120, and 180 kg N ha^{-1} and microbial preparations of BactoFil B10, Effective Microorganisms EM, and UGmax. The amount of inorganic N in the 0-0.9 m soil layer before potato planting fluctuated from 63.5 to 80.4 kg N ha^{-1}, while after harvest it ranged from 44.4 to 119.7 kg N ha^{-1}. Nitrogen supply from mineralization during potato vegetation ranged from 36.1 to 46.3 kg N ha^{-1}. Each of the applied nitrogen doses caused a …
Concentration And Detection Of Tobacco Etch Virus From Irrigation Water Using Real-Time Pcr, Wei Chen, Jin Dai, Huawei Zhang, Honghong Jiao, Julong Cheng, Yunfeng Wu
Concentration And Detection Of Tobacco Etch Virus From Irrigation Water Using Real-Time Pcr, Wei Chen, Jin Dai, Huawei Zhang, Honghong Jiao, Julong Cheng, Yunfeng Wu
Turkish Journal of Agriculture and Forestry
Irrigation water can be polluted by the tobacco etch virus (TEV), which causes serious economic loss in tobacco. However, it is difficult to monitor the sanitary status of irrigation water because TEV presents at extremely low concentrations. This study designed a procedure for concentrating TEV from a standard water sample using polyethylene glycol and detecting it using SYBR Green-based quantitative real-time polymerase chain reaction (qRT-PCR). The concentration factors were optimized through orthogonal tests and the highest recovery efficiency of the TEV genome from a standard water sample was 92.05%. The sensitivity was evaluated using nine 10-fold dilution series of TEV …
Dry Matter Yield, Feeding Value, And Antioxidant Activity In Mediterranean Chicory (Cichorium Intybus L.) Germplasm, Giovanna Piluzza, Leonardo Sulas, Simonetta Bullitta
Dry Matter Yield, Feeding Value, And Antioxidant Activity In Mediterranean Chicory (Cichorium Intybus L.) Germplasm, Giovanna Piluzza, Leonardo Sulas, Simonetta Bullitta
Turkish Journal of Agriculture and Forestry
Knowledge about the forage yield potential and bioactive compound contents of Mediterranean natural populations of chicory is still scarce, even though it could be very helpful in view of the exploitation of the feeding value of local chicory germplasm for ruminants. Dry matter yield, chemical composition, antioxidant capacity, total polyphenols, flavonoids, and condensed tannins content were determined in 7 natural populations of Mediterranean wild chicory and, as a comparison, in the chicory commercial variety Spadona. Original seed was collected in different pastureland areas of Sardinia (Italy) and plants were grown in North Sardinia. Statistically significant differences were found in the …
Chloroplast Dna Variation And Pollen Contamination In A Pinus Brutia Ten. Clonal Seed Orchard: Implication For Progeny Performance In Plantations, Behi̇ye Banu Bi̇lgen, Nuray Kaya
Chloroplast Dna Variation And Pollen Contamination In A Pinus Brutia Ten. Clonal Seed Orchard: Implication For Progeny Performance In Plantations, Behi̇ye Banu Bi̇lgen, Nuray Kaya
Turkish Journal of Agriculture and Forestry
Pollen contamination is one of the important factors affecting the yield, adaptability, and genetic quality of the seed produced from seed orchards in forest tree breeding programs. Incoming pollen from the forests surrounding the seed orchard is a major concern in tree breeding because it contributes to losses in the expected genetic gains from seed orchard crops. The genetic variation and the level of pollen contamination in a 16-year-old Pinus brutia Ten. first-generation clonal seed orchard was studied using chloroplast microsatellite markers (cpSSRs). In total, 23 alleles and 36 unique allelic combinations (haplotypes) were detected based on the 6 cpSSR …
Nutrient Uptakes And Their Contributions To Yield In Peanut Genotypes With Different Levels Of Terminal Drought Resistance, Wunna Htoon, Sanun Jogloy, Nimitr Vorasoot, Banyong Toomsan, Wanwipa Kaewpradit, Naveen Puppala, Aran Patanothai
Nutrient Uptakes And Their Contributions To Yield In Peanut Genotypes With Different Levels Of Terminal Drought Resistance, Wunna Htoon, Sanun Jogloy, Nimitr Vorasoot, Banyong Toomsan, Wanwipa Kaewpradit, Naveen Puppala, Aran Patanothai
Turkish Journal of Agriculture and Forestry
Different peanut yields under terminal drought might be due to the different nutrient uptakes among peanut genotypes. Nutrient uptake was presumed to be a drought-resistant trait and might involve drought tolerance mechanisms. The aims of this study, therefore, were to characterize the effect of terminal drought on peanut nutrient uptake and to investigate the genotypic variability of nutrient uptake and its interactions with terminal drought. Field experiments were conducted at the Field Crop Research Station of Khon Kaen University, Khon Kaen, Thailand, from October 2010 to January 2011 and October 2011 to January 2012. Six peanut genotypes were tested under …
Effect Of Cereal Cyst Nematode Heterodera Avenae (Tylenchida: Heteroderidae) On Yield Of Some Spring Wheat Varieties In Adana Province, Turkey, Mustafa İmren, İbrahi̇m Hali̇l Elekci̇oğlu
Effect Of Cereal Cyst Nematode Heterodera Avenae (Tylenchida: Heteroderidae) On Yield Of Some Spring Wheat Varieties In Adana Province, Turkey, Mustafa İmren, İbrahi̇m Hali̇l Elekci̇oğlu
Turkish Journal of Agriculture and Forestry
Cereal cyst nematode Heterodera avenae is found predominantly in the spring wheat-growing areas in Adana Province in the eastern Mediterranean region of Turkey. The impact of H. avenae on wheat yield has been observed but not quantified. This study was conducted to determine the effect of H. avenae on the yield of 6 wheat varieties in the 2011/2012 and 2012/2013 growing seasons in the naturally infested fields of Adana. According to our results, H. avenae significantly suppressed grain yield of the wheat varieties, ranging from 4.3% to 25.7%. Negative or positive linear regressions between the reproduction factor of H. avenae …
Germination And Electrical Conductivity Tests On Artificially Aged Seed Lots Of 2 Wall-Rocket Species, Simona-Laura Lazar, Sara Mira, Doru Pamfil, Juan Bautista Martinez-Laborde
Germination And Electrical Conductivity Tests On Artificially Aged Seed Lots Of 2 Wall-Rocket Species, Simona-Laura Lazar, Sara Mira, Doru Pamfil, Juan Bautista Martinez-Laborde
Turkish Journal of Agriculture and Forestry
The aim of this study was to determine whether the loss of germinability and vigour in wall-rocket seed lots was related to electrolyte leakage. Ten seed lots of 2 wall-rocket species (9 of Diplotaxis tenuifolia and one of D. erucoides (Brassicaceae)) were stored at 45 °C and 70% relative humidity and electrolyte leakage was measured using the conductivity test. Small differences in longevity were found among species or seed lots, suggesting that a similar relative longevity might be expected within the genus Diplotaxis after artificial ageing, and that it will be above the average of that found in other species …
L-Arginine Impact On Cherry Rootstock Rooting And Biochemical Characteristics In Tissue Culture, Virginia Sarropoulou, Kortessa Dimassi-Theriou, Ioannis Therios
L-Arginine Impact On Cherry Rootstock Rooting And Biochemical Characteristics In Tissue Culture, Virginia Sarropoulou, Kortessa Dimassi-Theriou, Ioannis Therios
Turkish Journal of Agriculture and Forestry
In the present study, the effects of indole-3-butyric acid (IBA) separately and simultaneously with L-arginine on the morphogenic and biochemical responses in the cherry rootstocks CAB-6P (Prunus cerasus L.) and Gisela 6 (Prunus cerasus × Prunus canescens) were investigated. In the CAB-6P rootstock, the best root number and root length results were obtained with 2 mg L^{1} IBA plus 0.5 mg L^{1} L-arginine and 1 mg L^{1} IBA plus 1 mg L^{1} L-arginine, respectively. The rooting percentage was highest (100%) with 2 mg L^{1} IBA alone or combined with 1 mg L^{1} L-arginine. In the Gisela 6 explants, 2 mg …
Application Of A Multicriteria Decision-Making Approach For Rice Land Suitability Analysis In Turkey, İsmai̇l Sezer, Orhan Dengi̇z
Application Of A Multicriteria Decision-Making Approach For Rice Land Suitability Analysis In Turkey, İsmai̇l Sezer, Orhan Dengi̇z
Turkish Journal of Agriculture and Forestry
The main objective of this study was to implement a spatial model with a multicriteria assessment approach for rice (Oryza sativa L.) land suitability by using geographic information system (GIS) techniques. The land mapping units resulting from the overlay of the selected theme layers had unique land quality information on which land suitability was based. The selected theme layers of rice include topographic factor (slope), soil physical factors (soil depth, soil texture, drainage, stoniness, hydraulic conductivity), and soil chemical factors (pH, electrical conductivity, CaCO_3, soil fertility). These theme layers were collected from existing information. Spatial information of soil physical and …
Effect Of Ginkgo Biloba On Brain Volume After Carotid Artery Occlusion In Rats: A Stereological And Histopathological Study, Zeynep Aktürk, Ersan Odaci, Ayşe İki̇nci̇, Orhan Baş, Si̇nan Canpolat, Serdar Çolakoğlu, Osman Fi̇kret Sönmez
Effect Of Ginkgo Biloba On Brain Volume After Carotid Artery Occlusion In Rats: A Stereological And Histopathological Study, Zeynep Aktürk, Ersan Odaci, Ayşe İki̇nci̇, Orhan Baş, Si̇nan Canpolat, Serdar Çolakoğlu, Osman Fi̇kret Sönmez
Turkish Journal of Medical Sciences
This study investigated the effect of Ginkgo biloba (GB) on brain volume in cerebral ischemia induced by stopping carotid artery blood flow. Materials and methods: Twenty-four adult male rats were divided into 4 groups of 6 rats each. No procedure was performed on the control group. Ischemia was applied to the rats in the ischemia and ischemia + GB groups by clamping the arteria carotis communis for 30 min. The rats in the ischemia + GB group were given 100 mg/kg drops (Tebokan Fort Drop, Abdi İbrahim İlaç Sanayi A.Ş., Turkey) containing dry GB leaf extract orally, every day for …
Comparison Of Hippocampal Interleukin-6 Immunoreactivity After Exhaustive Exercise In Both Exercise-Trained And Untrained Rats, Lati̇fe Arzu Aral, Lamia Pinar, Güleser Göktaş, Elçi̇n Yaşar Deveden, Deni̇z Erdoğan
Comparison Of Hippocampal Interleukin-6 Immunoreactivity After Exhaustive Exercise In Both Exercise-Trained And Untrained Rats, Lati̇fe Arzu Aral, Lamia Pinar, Güleser Göktaş, Elçi̇n Yaşar Deveden, Deni̇z Erdoğan
Turkish Journal of Medical Sciences
Exhaustive exercise is a strong stress factor and can impact cytokine production in the brain. Interleukin-6 (IL-6) is produced in greater amounts than any other cytokine in response to exercise, and its effects are closely related to both exercise duration and intensity. In this study, we measured the differences between the amount of IL-6 reactivity of the hippocampus after an exhaustive session of running in long-term exercise-trained and untrained rats. Materials and methods: The exercise-trained group ran on a treadmill for 12 weeks. Both groups were forced to run until exhaustion. Each group of rats was sacrificed immediately, 1 day, …
The Role Of Hepcidin And Its Related Genes (Bmp6, Gdf-15, And Hjv) In Rats Exposed To Ischemia And Reperfusion, Recep Dokuyucu, Tuncer Demi̇r, Önder Yumrutaş, Ayşe Bi̇nnur Erbağci, Mustafa Örkmez, Abdulkadi̇r Yasi̇r Bahar, Recep Bayraktar, İbrahi̇m Bozgeyi̇k, Davut Si̇nan Kaplan, Beyhan Cengi̇z, Cahi̇t Bağci
The Role Of Hepcidin And Its Related Genes (Bmp6, Gdf-15, And Hjv) In Rats Exposed To Ischemia And Reperfusion, Recep Dokuyucu, Tuncer Demi̇r, Önder Yumrutaş, Ayşe Bi̇nnur Erbağci, Mustafa Örkmez, Abdulkadi̇r Yasi̇r Bahar, Recep Bayraktar, İbrahi̇m Bozgeyi̇k, Davut Si̇nan Kaplan, Beyhan Cengi̇z, Cahi̇t Bağci
Turkish Journal of Medical Sciences
To determine the roles of hepcidin and its related genes in a renal ischemia/reperfusion model. Materials and methods: A total of 20 Wistar albino rats were equally divided into 2 groups: Group I was the control group and Group II was the ischemia and reperfusion (I/R) group (60 min of ischemia + 48 h of reperfusion). I/R was performed on the left kidneys of these rats and then the I/R-treated kidneys were removed. The levels of serum biochemical markers were evaluated after renal I/R. The expression levels of hepcidin-linked genes [growth differentiation factor 15 (GDF-15), bone morphogenetic protein 6 (BMP6), …
Asymmetric Dimethyl Arginine Levels In Chronic Hemodialysis Patients, Aydin Çi̇fci̇, Sali̇h İnal, Coşkun Kaya
Asymmetric Dimethyl Arginine Levels In Chronic Hemodialysis Patients, Aydin Çi̇fci̇, Sali̇h İnal, Coşkun Kaya
Turkish Journal of Medical Sciences
To investigate serum asymmetric dimethyl arginine (ADMA) levels in maintenance hemodialysis (HD) patients and to assess their potential correlations with C-reactive protein (CRP), albumin, and cholesterol levels as the established cardiovascular and nutritional parameters. Materials and methods: Forty-nine patients on maintenance HD treatment and 22 healthy volunteers with similar age and sex characteristics were recruited into the study. Serum albumin, CRP, creatinine, calcium, phosphate, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, hemoglobin, white blood cell counts, and serum ADMA levels were measured. Results: HD patients had significantly higher ADMA levels compared with healthy controls (0.51 ± 0.25 …
Genotype Distribution Of Hepatitis C Virus In Khorasan Razavi Province, Iran, Reza Afshari, Hosein Nomani, Fatemeh Riyahi Zaniani, Maryam Sadat Nabavinia, Zohreh Mirbagheri, Mojtaba Meshkat, Sina Gerayli, Sina Rostami, Zahra Meshkat
Genotype Distribution Of Hepatitis C Virus In Khorasan Razavi Province, Iran, Reza Afshari, Hosein Nomani, Fatemeh Riyahi Zaniani, Maryam Sadat Nabavinia, Zohreh Mirbagheri, Mojtaba Meshkat, Sina Gerayli, Sina Rostami, Zahra Meshkat
Turkish Journal of Medical Sciences
Several types of the hepatitis C virus (HCV), with variations in different parts of the genome, have been isolated from different regions of the world. Based on heterogenic sequences in the isolated genome, HCV is classified into different genotypes and subtypes. Data on distribution of HCV genotypes in a certain region could be important to patient management. Therefore, this study was conducted to determine the distribution of HCV in Mashhad, Northeast Iran. Materials and methods: This cross-sectional study was conducted on 103 patients with HCV infections in Mashhad. Among the participants, at least 22 (21.4%) were intravenous drug users. HCV …
Hormone Replacement Therapy-Related Changes In The Early Postmenopausal Period (Critical Window): An In Vivo Brain Proton Magnetic Resonance Spectroscopy Study, Kamran Mahmutyazicioğlu, Fahri̇ Hali̇t Beşi̇r, Mustafa Bardakçi, Hami̇t Alper Tanriverdi̇, Handan Ankarali
Hormone Replacement Therapy-Related Changes In The Early Postmenopausal Period (Critical Window): An In Vivo Brain Proton Magnetic Resonance Spectroscopy Study, Kamran Mahmutyazicioğlu, Fahri̇ Hali̇t Beşi̇r, Mustafa Bardakçi, Hami̇t Alper Tanriverdi̇, Handan Ankarali
Turkish Journal of Medical Sciences
Findings from clinical studies in postmenopausal women with late initiation of hormone replacement therapy (HRT) that test whether HRT protects cognitive functions in women are inconsistent. The aim of this study was to investigate the effects of HRT on brain metabolite ratios when initiated in the early postmenopausal period (critical window). Materials and methods: Proton magnetic resonance spectrometry (1H MRS) was performed in 4 brain regions of 47 healthy postmenopausal women (21 received HRT, 26 did not). The subjects were aged between 45 and 65 years. The duration of HRT ranged from 1 to 12 years (mean: 6.3 years). The …
Behavioural And Neurobiological Consequences Of 2 Different Chronic Stressors In Rats, Refi̇a Aslihan Dönmez, Fatma Duygu Kaya, Okşan Deri̇nöz, Ömer Hakan Emmez, Selçuk Candansayar, Hayrunni̇sa Bolay Belen
Behavioural And Neurobiological Consequences Of 2 Different Chronic Stressors In Rats, Refi̇a Aslihan Dönmez, Fatma Duygu Kaya, Okşan Deri̇nöz, Ömer Hakan Emmez, Selçuk Candansayar, Hayrunni̇sa Bolay Belen
Turkish Journal of Medical Sciences
To compare the behavioural and neurobiological consequences of chronic headache and chronic mild stress (CMS) in rats. Materials and methods: Forty-eight male Wistar rats were divided into 4 groups: 1) control group, 2) chronic headache group, 3) CMS group, and 4) sham group. Their behaviour prior to (D0) and after (D14) chronic stress was analysed. Afterwards, they were exposed to the Elevated Plus Maze (EPM) in order to evaluate anxiety-like behaviour and the Forced Swim Test (FST) for observation of depressive-like behaviour. Ultrasonic vocalisations (USVs) were recorded by a USV detector system at D0 and D14 and during the FST. …
Serum Fetuin-A Levels In Postmenopausal Women With Osteoporosis, Esi̇n Özkan, Hüseyi̇n Özkan, Serkan Bi̇lgi̇ç, Ersi̇n Odabaşi, Nuray Can, Emi̇n Özgür Akgül, İbrahi̇m Yanmiş, Yüksel Yurttaş, Mustafa Kürklü, Mustafa Başbozkurt, Mehmet Kemal Erbi̇l
Serum Fetuin-A Levels In Postmenopausal Women With Osteoporosis, Esi̇n Özkan, Hüseyi̇n Özkan, Serkan Bi̇lgi̇ç, Ersi̇n Odabaşi, Nuray Can, Emi̇n Özgür Akgül, İbrahi̇m Yanmiş, Yüksel Yurttaş, Mustafa Kürklü, Mustafa Başbozkurt, Mehmet Kemal Erbi̇l
Turkish Journal of Medical Sciences
One of the functions of fetuin-A is the restriction of formation and expansion of extraosseous hydroxyapatite crystals. The exact correlation of fetuin-A with bone mineral density (BMD) has not been clearly elucidated yet. In this study, we aimed to assess the relationship between BMD and fetuin-A in postmenopausal women. Materials and methods: Fifty postmenopausal women (25 with osteoporosis, 25 healthy controls) were included in the study. All participants were comparable for age and body mass index. None of the osteoporotic patients had received any medical treatment for osteoporosis. Serum fetuin-A levels were measured by ELISA method. Results: BMD scores of …
Possible Metabolic Impact Of Ramadan Fasting In Healthy Men, Mustafa Cumhur Vardarli, Hans-Peter Hammes, İrfan Vardarli
Possible Metabolic Impact Of Ramadan Fasting In Healthy Men, Mustafa Cumhur Vardarli, Hans-Peter Hammes, İrfan Vardarli
Turkish Journal of Medical Sciences
Insulin sensitivity and \beta-cell function during Ramadan fasting in healthy male subjects have not been investigated so far. We assessed the changes of these and other metabolic parameters to judge the potential metabolic benefits of Ramadan fasting. Materials and methods: Twenty-four healthy males of Turkish origin living in Germany, with normal glucose tolerance, participated in this study during Ramadan of 2009; 19 who completed fasting were analyzed. Blood was drawn at sunset after a period of fasting lasting approximately 15 h on days 0, 16, and 30 of Ramadan, as well as 7 and 28 days later. Insulin sensitivity (Homeostasis …
Prohepcidin In Maternal Circulation: Is It Related To Spontaneous Preterm Labor?, Yüksel Onaran, Esra Aktepe Keski̇n, Zehra Candan İltemi̇r Duvan, Serap Aynur Si̇mavli, Cemi̇le Koca, Hasan Kafali, Ni̇lgün Turhan
Prohepcidin In Maternal Circulation: Is It Related To Spontaneous Preterm Labor?, Yüksel Onaran, Esra Aktepe Keski̇n, Zehra Candan İltemi̇r Duvan, Serap Aynur Si̇mavli, Cemi̇le Koca, Hasan Kafali, Ni̇lgün Turhan
Turkish Journal of Medical Sciences
To investigate whether spontaneous preterm labor (PTL) with intact membranes is associated with changes in maternal serum prohepcidin concentrations. Materials and methods: The study consisted of patients with spontaneous PTL with intact membranes (n = 25), a control group of healthy pregnant women between the 24th and 37th gestational weeks (n = 22), and uncomplicated term pregnancies in spontaneous labor (n = 19). Blood samples were collected from patients at the time of clinical diagnosis. Levels of prohepcidin, hemoglobin, serum ferritin, serum iron, unsaturated iron binding capacity, total iron binding capacity, transferrin and transferrin saturation, C reactive protein, and interleukin-6 …
Evidence That Photons Have Extension In Space, Randy Wayne
Evidence That Photons Have Extension In Space, Randy Wayne
Turkish Journal of Physics
Satyendra Nath Bose realized that there was a logical inconsistency in the derivation of Planck's radiation law since the derivation used to obtain the temperature-independent prefactor in the blackbody radiation law had been based in part on classical wave hypotheses, such as the number of degrees of freedom of the ether. Bose worked out a strictly quantum derivation by combining the quantum hypothesis with statistical mechanics to determine the number of states of each mode that would occupy a 6-dimensional phase space. Here I use the model of an extended photon to show that the temperature-independent prefactor of Planck's radiation …