Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (5932)
- Medicine and Health Sciences (2313)
- Animal Sciences (2151)
- Physical Sciences and Mathematics (1962)
- Biology (1669)
-
- Medical Sciences (1464)
- Zoology (1302)
- Chemistry (1183)
- Botany (1118)
- Plant Sciences (1118)
- Agriculture (994)
- Forest Sciences (994)
- Veterinary Medicine (849)
- Computer Engineering (461)
- Computer Sciences (461)
- Electrical and Computer Engineering (461)
- Engineering (461)
- Mathematics (146)
- Earth Sciences (107)
- Physics (65)
- Keyword
-
- Turkey (609)
- Taxonomy (221)
- Oxidative stress (132)
- New records (121)
- New species (104)
-
- Apoptosis (93)
- Morphology (93)
- New record (91)
- Antioxidant (83)
- Distribution (80)
- Phylogeny (79)
- COVID-19 (78)
- Cytotoxicity (73)
- Growth (73)
- Biodiversity (72)
- Antimicrobial activity (71)
- Iran (71)
- 1 (67)
- Inflammation (66)
- 2 (63)
- Breast cancer (62)
- Fauna (61)
- Rat (61)
- Antioxidant activity (60)
- Genetic diversity (60)
- Gene expression (59)
- Antioxidant enzymes (48)
- Endemic (48)
- Antibacterial activity (47)
- Cancer (47)
- Publication Year
Articles 6331 - 6360 of 10521
Full-Text Articles in Entire DC Network
Photosynthetic Characteristics Of Red And Green Leaves In Growing Seedlings Of Jatropha Curcas, Munna Singh, Sanjay Ranjan, Krishan Kumar Verma, Uday Vashudav Pathre, Pramod Arvind Shirke
Photosynthetic Characteristics Of Red And Green Leaves In Growing Seedlings Of Jatropha Curcas, Munna Singh, Sanjay Ranjan, Krishan Kumar Verma, Uday Vashudav Pathre, Pramod Arvind Shirke
Turkish Journal of Biology
The use of Jatropha (Jatropha curcas L.) as a source of biofuel is documented. The physiological characteristics and growth studies of Jatropha have received less attention. In the present study, we measured leaf gas exchange with an infrared gas analyzer for red (immature) and green (mature) leaves of Jatropha curcas in response to various environmental conditions including photosynthetic photon flux density (PPFD), vapor pressure difference, and temperature. The seedlings were grown in pots for 45 days in a natural environment. Jatropha is a C_3 plant based on its leaf-gas exchange characteristics. The optimal light-saturated photosynthetic CO_2 assimilation, leaf conductance, and …
Preconditioning Effect Of Cytokinins On In Vitro Multiplication Of Embryonic Node Of Grass Pea (Lathyrus Sativus L.) Cultivar Gürbüz, Surendra Barpete, Muhammad Aasim, Khalid Mahmood Khawar, Sancar Fati̇h Özcan, Sebahatti̇n Özcan
Preconditioning Effect Of Cytokinins On In Vitro Multiplication Of Embryonic Node Of Grass Pea (Lathyrus Sativus L.) Cultivar Gürbüz, Surendra Barpete, Muhammad Aasim, Khalid Mahmood Khawar, Sancar Fati̇h Özcan, Sebahatti̇n Özcan
Turkish Journal of Biology
Lathyrus sativus L. (grass pea) is an important grain legume crop grown all over the world. It is very recalcitrant and difficult to regenerate under in vitro conditions. The present study determined the effect of preconditioning of cytokinins [10 and 20 mg L^{-1} thidiazuron (TDZ) and 2-isopentenyl adenine (2iP)] and postconditioning of dissimilar levels of TDZ-indole-3-butyric acid (IBA) and 2iP-IBA on in vitro shoot multiplication using embryonic node explants. The results showed that preconditioning followed by postconditioning on Murashige and Skoog (MS) medium with 0.25, 0.50, 0.75, and 1.0 mg L^{-1} 2iP or TDZ combined with 0.10 mg L^{-1} IBA …
Study Of Exogenous Oxidative Stress Response In Escherichia Coli, Pseudomonas Spp., Bacillus Spp., And Salmonella Spp., Ifratun Nur, Mohammad Sakil Munna, Rashed Noor
Study Of Exogenous Oxidative Stress Response In Escherichia Coli, Pseudomonas Spp., Bacillus Spp., And Salmonella Spp., Ifratun Nur, Mohammad Sakil Munna, Rashed Noor
Turkish Journal of Biology
With a previous observation of Escherichia coli growth cessation with the supplementation of 3 mM hydrogen peroxide (H_{2}O_{2}) at the late log phase, the current study further demonstrated the consequences of the addition of an increased concentration (6 mM) of H_{2}O_{2} and further extended the investigation on such an oxidant's impact on the growth of Salmonella spp., Pseudomonas spp., and Bacillus spp. Cell culturability was measured through the enumeration of colony-forming units (CFUs) on agar plates for up to 72 h. Subsequent changes in cell morphology and arrangements were monitored, and the cell viability was simultaneously retraced by spot tests. …
Melatonin Is Effective In Reducing Stress-Induced Organ Damage In Wistar Albino Rats, Mukaddes Eşrefoğlu, Ayşi̇n Akinci Bak, Hülya Elbe, Eli̇f Taşlidere, Asli Çeti̇n, Burhan Ateş
Melatonin Is Effective In Reducing Stress-Induced Organ Damage In Wistar Albino Rats, Mukaddes Eşrefoğlu, Ayşi̇n Akinci Bak, Hülya Elbe, Eli̇f Taşlidere, Asli Çeti̇n, Burhan Ateş
Turkish Journal of Biology
In the present study, we tried to investigate the effects of melatonin, a novel antioxidant and a potent free radical scavenger, in stress-induced cerebral, cerebellar, cardiac, and hepatic oxidative damage using microscopic and biochemical analysis. A total of 32 male Wistar albino rats were divided into control, stress, stress + saline, and stress + melatonin groups. The rats from the stress groups were exposed to high stress conditions of starvation, immobilization, and cold exposure. The rats from the stress + melatonin group received melatonin daily at 20 mg/kg body weight intraperitoneally for 7 days. At the end of the experiment, …
Polyploidy And Apomixis In Accessions Of Senna Rugosa (G.Don) H.S.Irwin & Barneby, Katia Resende, Clara Prado, Lisete Davide, Giovana Torres
Polyploidy And Apomixis In Accessions Of Senna Rugosa (G.Don) H.S.Irwin & Barneby, Katia Resende, Clara Prado, Lisete Davide, Giovana Torres
Turkish Journal of Biology
Senna rugosa (G.Don) H.S.Irwin & Barneby (Leguminosae) is a species from the Brazilian Cerrado commonly used for medicinal purposes. Chromosome variability (n = 14 and 28) described for this species indicates the occurrence of chromosome races and recent polyploidization in its evolution history. The aim of this study was to verify the relationship between ploidy level and occurrence of polyembryony in 5 accessions of S. rugosa. Cytogenetic analysis revealed the type of interphasic nuclei, chromosome number and morphology, and nuclear DNA content. Frequency of polyembryony was estimated by germination test. Pollen grain viability was estimated by different techniques. There was …
Styrian Oil Pumpkin Pollen Germinability At Higher Irradiation Doses: Optimization Of The In Vitro Germination Protocol And Irradiation Procedure, Kristina Kosmrlj, Damijana Kastelec, Borut Bohanec
Styrian Oil Pumpkin Pollen Germinability At Higher Irradiation Doses: Optimization Of The In Vitro Germination Protocol And Irradiation Procedure, Kristina Kosmrlj, Damijana Kastelec, Borut Bohanec
Turkish Journal of Biology
Protocols for haploid induction in cucurbits are based on pollination with irradiated pollen, but the induction frequency is low and the majority of obtained embryos are zygotic. The longevity of Cucurbita pepo L. pollen is short even under natural conditions; following irradiation, germinability is decreased even further. This study was initiated to develop an optimal in vitro germination medium for styrian oil pumpkin (Cucurbita pepo L. subsp. pepo var. styriaca Greb.) pollen, which would enable accurate germination testing. Different pH values and the addition of sucrose, mannitol, and polyethylene glycol to the Brewbaker and Kwack germination medium were tested. The …
Characterization Of The Human Sialidase Neu4 Gene Promoter, Volkan Seyrantepe, Murat Delman
Characterization Of The Human Sialidase Neu4 Gene Promoter, Volkan Seyrantepe, Murat Delman
Turkish Journal of Biology
There are 4 different sialidases that have been described in humans: lysosomal (Neu1), cytoplasmic (Neu2), plasma membrane (Neu3), and lysosomal/mitochondrial (Neu4). Previously, we have shown that Neu4 has a broad substrate specificity and is active against glyco-conjugates, including G_{M2} ganglioside, at the acidic pH of 3.2. An overexpression of Neu4 in transfected neuroglia cells from a Tay-Sachs patient shows a clearance of accumulated G_{M2}, indicating the biological importance of Neu4. In this paper, we aimed to characterize a minimal promoter region of the human Neu4 gene in order to understand the molecular mechanism regulating its expression. We cloned 7 different …
Reproductive Biology Study Of Dynamics Of Female Sexual Hormones: A 12-Month Exposure To Lead Acetate Rat Model, Eugenia Dumitrescu, Romeo Teodor Cristina, Florin Muselin
Reproductive Biology Study Of Dynamics Of Female Sexual Hormones: A 12-Month Exposure To Lead Acetate Rat Model, Eugenia Dumitrescu, Romeo Teodor Cristina, Florin Muselin
Turkish Journal of Biology
In human and animal organisms, lead can cause reproductive problems beginning with pregnant females. The reproductive axis is particularly sensitive to lead, its influence resulting in a delayed sexual maturity due to biosynthesis suppression of the sexual steroids. An animal model study was carried out on 28 white Wistar adult female rats, divided into 3 experimental (E) groups that were exposed for 12 months to lead acetate in drinking water as follows: 50 ppb Pb (E_1), 100 ppb Pb (E_2), and 150 ppb Pb (E_3), with a control group (M) that received unleaded tap water. Levels of FSH, LH, estradiol, …
Characterization Of A Novel Xylose Isomerase From Anoxybacillus Gonensis G2^T, Derya Yanmiş, Hakan Karaoğlu, Di̇lşat Ni̇gar Çolak, Fulya Ay Şal, Sabri̇ye Çanakçi, Ali̇ Osman Beldüz
Characterization Of A Novel Xylose Isomerase From Anoxybacillus Gonensis G2^T, Derya Yanmiş, Hakan Karaoğlu, Di̇lşat Ni̇gar Çolak, Fulya Ay Şal, Sabri̇ye Çanakçi, Ali̇ Osman Beldüz
Turkish Journal of Biology
The xylA gene encoding xylose isomerase from Anoxybacillus gonensis G2^T has been cloned and successfully expressed in E. coli. Xylose isomerase was purified 10.98-fold by heat-shock and sequential column chromatography techniques to homogeneity, and the biochemical properties of the enzyme were characterized. The optimum temperature of the enzyme was 85 °C and maximum activity was observed at a pH of 6.5. Its Km and Vmax values were calculated as 25 ± 2 mM and 0.12958 ± 0.002 mumol/min/mg protein, respectively. The effects of various metal ions on the xylose isomerase were examined. Divalent cations Co^{2+}, Mg^{2+}, and Mn^{2+} were essential …
Large-Scale Purification Of A Bacteriocin Produced By Leuconostoc Mesenteroides Subsp. Cremoris Using Diatomite Calcium Silicate, Hali̇l Dündar, Ömür Çeli̇kbiçak, Beki̇r Sali̇h, Tahsi̇n Faruk Bozoğlu
Large-Scale Purification Of A Bacteriocin Produced By Leuconostoc Mesenteroides Subsp. Cremoris Using Diatomite Calcium Silicate, Hali̇l Dündar, Ömür Çeli̇kbiçak, Beki̇r Sali̇h, Tahsi̇n Faruk Bozoğlu
Turkish Journal of Biology
Leuconostoc mesenteroides subsp. cremoris strain W3, isolated from wine, was previously found to produce a bacteriocin with inhibitory activity towards malolactic bacteria and hence inhibit malolactic fermentation in model wine medium. The bacteriocin, which we termed mesentericin W3, was purified by multistep chromatography and found in a previous study to be similar to mesentericin Y105, albeit with a low recovery (3.2%). In this study, we aimed to achieve large-scale isolation of mesentericin W3 by adsorption of the bacteriocin from culture supernatant onto Micro-Cel (diatomite calcium silicate) and then by subsequent desorption. Water-soluble surfactants including Tween 80, Triton X-100, sodium deoxycholate, …
Comprehensive Evaluation Of Phytoestrogen Accumulation In Plants And In Vitro Cultures Of Medicago Sativa L. 'Elçi' And Natural Tetraploid Trifolium Pratense L., Hati̇ce Çölgeçen, Ufuk Koca Çalişkan, Murat Kartal, Hati̇ce Nurhan Büyükkartal
Comprehensive Evaluation Of Phytoestrogen Accumulation In Plants And In Vitro Cultures Of Medicago Sativa L. 'Elçi' And Natural Tetraploid Trifolium Pratense L., Hati̇ce Çölgeçen, Ufuk Koca Çalişkan, Murat Kartal, Hati̇ce Nurhan Büyükkartal
Turkish Journal of Biology
The main goal of this study was to establish callus cell suspension cultures of Medicago sativa L. 'Elçi' and natural tetraploid Trifolium pratense L. and to compare the isoflavone production of the cultures to the original plants. The callus culture was transferred to liquid Murashige and Skoog media (MS3 and MS5) in order to establish the cell suspension cultures. The extracts were then analyzed by liquid chromatography-mass spectroscopy (LC-MS) for their isoflavones (phytoestrogen), mainly formononetin, biochanin A, daidzein, and genistein. The production of daidzein and formononetin was higher in cell suspension culture than in callus and herba of M. sativa …
Identification Of Hla-A*0201-Restricted Ctl Epitopes From The Receptor-Binding Domain Of Mers-Cov Spike Protein Using A Combinatorial In Silico Approach, Naghmeh Poorinmohammad, Hassan Mohabatkar
Identification Of Hla-A*0201-Restricted Ctl Epitopes From The Receptor-Binding Domain Of Mers-Cov Spike Protein Using A Combinatorial In Silico Approach, Naghmeh Poorinmohammad, Hassan Mohabatkar
Turkish Journal of Biology
A novel SARS-like illness called Middle East respiratory syndrome coronavirus (MERS-CoV), caused by an emerging coronavirus, has been a recent cause for concern due to its fatality and pandemic potential. Developing a peptide-based vaccine could be helpful in fighting against the virus. Since the experimental procedure is time-consuming and expensive, computational analysis can play an important role in accelerating the process. Therefore, the aim of this study was to computationally identify cytotoxic T-lymphocyte epitopes presented by the human leukocyte antigen (HLA)-A*0201, as this is the most frequent HLA class I allele among Middle Eastern populations. The receptor-binding domain of the …
Bacterial Toxin Colicin N-T Domain Structure Changes To Ordered State Upon Binding C-Terminal Domain Of Tola, Yakup Ulusu, Sema Bi̇lgi̇n Şentürk, Fatma Gedi̇kli̇, Jeremy H. Lakey, İsa Gökçe
Bacterial Toxin Colicin N-T Domain Structure Changes To Ordered State Upon Binding C-Terminal Domain Of Tola, Yakup Ulusu, Sema Bi̇lgi̇n Şentürk, Fatma Gedi̇kli̇, Jeremy H. Lakey, İsa Gökçe
Turkish Journal of Biology
Colicin N is a bacterial toxin that kills Escherichia coli and related cells. Its mode of action is of interest in protein import and toxicology. Colicin N translocates across the E. coli outer membrane and periplasm by interacting with several receptors. The translocation process involves the interaction of the colicin N with the outer membrane porin OmpF and subsequently with the integral membrane protein TolA. The N-terminal domain of colicin N is involved in the import process. TolA consists of 3 domains. The N-terminal domain of colicin N interacts with the C-terminal domain of TolA at later stages of the …
Computational Regulatory Model For Detoxification Of Ammonia From Urea Cycle In Liver, Rashith Muhammad Mubarak Ali, Poornima Devi Gurusamy, Selvakumar Ramachandran
Computational Regulatory Model For Detoxification Of Ammonia From Urea Cycle In Liver, Rashith Muhammad Mubarak Ali, Poornima Devi Gurusamy, Selvakumar Ramachandran
Turkish Journal of Biology
A nondeterministic finite automaton was designed to monitor enzymatic regulation and detoxification of excess ammonia in the urea cycle and its disorders. The designed machine is used for the diagnosis of deficiency and for regulating the expression of any of the enzymes involved with acceptance and rejection states in the urea cycle. The urea cycle is the metabolism of excess nitrogen produced by the breakdown of protein and other nitrogen-containing molecules in liver. Disorder in the urea cycle may lead to the accumulation of toxic ammonia in the blood, which leads to hyperammonemia. The elevation of plasma ammonia concentration may …
Biodegradation Of The Synthetic Pyrethroid Insecticide Α-Cypermethrin By Stenotrophomonas Maltophilia Og2, Özlem Gür, Murat Özdal, Ömer Faruk Algur
Biodegradation Of The Synthetic Pyrethroid Insecticide Α-Cypermethrin By Stenotrophomonas Maltophilia Og2, Özlem Gür, Murat Özdal, Ömer Faruk Algur
Turkish Journal of Biology
A novel gram-negative bacterium, OG2, was isolated from the body microflora of cockroaches (Blatta orientalis). Based on morphological, biochemical, and 16S ribosomal DNA sequence analysis, the isolated strain OG2 was identified as Stenotrophomonas maltophilia. This bacterial strain was screened for its alpha-cypermethrin-degrading potential with minimal salt medium (MSM). The alpha-cypermethrin degradation and utilization ability of the isolated organism was verified. Bacterial growth was measured by optical density in the presence of the pesticide at different concentrations (50-200 mg/L). S. maltophilia OG2 utilized alpha-cypermethrin as the sole carbon source for growth, and alpha-cypermethrin degradation increased when MSM was supplemented with glucose. …
Nitrate And Iron Nutrition Effects On Some Nitrate Assimilation Enzymes And Metabolites In Spirulina Platensis, Merve Esen, Razi̇ye Öztürk Ürek
Nitrate And Iron Nutrition Effects On Some Nitrate Assimilation Enzymes And Metabolites In Spirulina Platensis, Merve Esen, Razi̇ye Öztürk Ürek
Turkish Journal of Biology
Effects of different sodium nitrate and iron concentrations on the production of some metabolites and pigments and the activities of some nitrate assimilation enzymes [nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS), and glutamate synthase (GOGAT)] were investigated in the growth medium of Spirulina platensis (Gamont) Geitler. For this purpose, S. platensis was cultivated on Zarrouk's medium containing different sodium nitrate concentrations (10-180 mM). A 100 mM sodium nitrate concentration stimulated growth of this organism as well as the production of pigments and other metabolites and enzyme activities. In the presence of 100 mM sodium nitrate, different concentrations of …
Variation In Soil C And Microbial Functions Across Tree Canopy Projection And Open Grassland Microenvironments, Roberto Lai, Alessandra Lagomarsino, Luigi Ledda, Pier Paolo Roggero
Variation In Soil C And Microbial Functions Across Tree Canopy Projection And Open Grassland Microenvironments, Roberto Lai, Alessandra Lagomarsino, Luigi Ledda, Pier Paolo Roggero
Turkish Journal of Agriculture and Forestry
Mixtures of grasslands and perennial woody crops or vineyards represent a major source of potential carbon storage or release. Understanding the spatial variability of soil properties in these ecosystems is important in determining soil constraints related to the management of soil resources. The aims of the study were 1) to explore the spatial variability associated to the trees for soil C storage and its components and reactivity; and 2) to assess the similarities between microenvironments in terms of microbial functional diversity. Eight microenvironments characterized by different long-term soil management practices and different positions with respect to woody plant canopy soil …
Long-Term Water Balance Of A Bare Soil With Slope In Chuncheon, South Korea, Mehmet Aydin, Yeong-Sang Jung, Jae E. Yang, Hyun-Il Lee
Long-Term Water Balance Of A Bare Soil With Slope In Chuncheon, South Korea, Mehmet Aydin, Yeong-Sang Jung, Jae E. Yang, Hyun-Il Lee
Turkish Journal of Agriculture and Forestry
Water balance components of a bare soil with slope varying from 5% to 30% in Chuncheon, South Korea, were simulated using the E-DiGOR model, which proposed an interactive way to quantify runoff, drainage, soil water storage, and evaporation. Daily computations were carried out during the period of 1980 to 2009 for the identified soil-topography-climate combination. A strong correlation between measured pan evaporation and calculated potential soil evaporation was observed (R^2 = 63.8%, P < 0.01) based on the monthly data of the past 30 years (hereafter 'long-term'). When examining long-term dynamics of simulated soil evaporation, monthly mean potential and actual soil evaporations ranged from 9.1 and 9.0 mm in December to 110.5 and 75.2 mm in June and July, respectively. The ratio of actual to potential soil evaporation (E_a/E_p) had a close linkage with soil water content. The higher the soil water amount, the greater the E_a/E_p ratio was. A nonlinear relationship between rainfall and surface runoff was obtained at a given slope. Excess surface runoff and subsurface flow (percolation + interflow) occurred throughout the rainy months from July to September, with peaks in July. The ratio of direct surface runoff to rainfall increased with the natural logarithm of slope. The long-term mean annual direct surface runoff and subsurface flow at the maximum slope were 408.1 and 437.6 mm, respectively. Furthermore, mean annual surface runoff from the slope of 30% was approximately 2 times higher than that from the slope of 5%.
Using Plant Extracts To Reduce Asexual Reproduction Of Apple Scab (Venturia Inaequalis), János Bálint, Szilveszter Nagy, Rezso Thiesz, Imre-István Nyárádi, Adalbert Balog
Using Plant Extracts To Reduce Asexual Reproduction Of Apple Scab (Venturia Inaequalis), János Bálint, Szilveszter Nagy, Rezso Thiesz, Imre-István Nyárádi, Adalbert Balog
Turkish Journal of Agriculture and Forestry
The aim our research was to develop effective methods for organic apple farming, based on the use of plant extracts to control the asexual reproduction of Venturia inaequalis. Plant extracts of artemisinin, chelidonine, thymol, and populin tested in vitro under laboratory conditions significantly slowed down the germination of V. inaequalis conidia. During a 2-year study under field conditions, the effect of 1% populin, an extract from black poplar buds, on apple scab was tested in parallel with synthetic fungicides and a no-pesticide regime on Golden Delicious and Jonathan apples. Populin significantly reduced the number of scabbed leaves and fruits on …
Dynamic Base-Age Invariant Site Index Models Based On Generalized Algebraic Difference Approach For Mixed Scots Pine (Pinus Sylvestris L.) And Oriental Beech (Fagus Orientalis Lipsky) Stands, İlker Ercanli, Aydin Kahri̇man, Hakki Yavuz
Dynamic Base-Age Invariant Site Index Models Based On Generalized Algebraic Difference Approach For Mixed Scots Pine (Pinus Sylvestris L.) And Oriental Beech (Fagus Orientalis Lipsky) Stands, İlker Ercanli, Aydin Kahri̇man, Hakki Yavuz
Turkish Journal of Agriculture and Forestry
Data from stem analysis of 397 dominant trees (198 Scots pine and 199 Oriental beech) were used to evaluate dynamic base-age invariant site index models derived from Bertalanffy-Richards, Hossfeld, and Lundqvist-Korf functions with the generalized algebraic difference approach (GADA) for mixed Scots pine (Pinus sylvestris L.) and Oriental beech (Fagus orientalis Lipsky) stands. These functions were compared with respect to residuals of these models; specifically, the evaluation criteria were bias (E), root mean square error (RMSE), absolute mean error (AME), adjusted coefficient of determination (R^2_{adj}), and Akaike information criterion. The best results were obtained with generalized algebraic difference equations derived …
Aging And Cancer: Molecular Facts And Awareness For Turkey, Gülgün Gündüz, Kayahan Fişkin
Aging And Cancer: Molecular Facts And Awareness For Turkey, Gülgün Gündüz, Kayahan Fişkin
Turkish Journal of Biology
Two important subjects concerning extension of the human life-span are biological aging processes and their relationship to diseases, and especially to the formation of cancer. It is clear that an aging population poses some challenges for developing countries. We set out to show the demographic structure of Turkey and to discuss the feasibility of decreasing the prevalence of cancer. We overviewed the literature on the relationship between biological aging and cancer formation, the environmental causes of cancer, and age-related characteristics of cancer in the elderly. In addition, some statistical data on the changing demography of Turkey were reviewed. It is …
Autophagy And Cancer, Hacer Ezgi̇ Karakaş, Devri̇m Gözüaçik
Autophagy And Cancer, Hacer Ezgi̇ Karakaş, Devri̇m Gözüaçik
Turkish Journal of Biology
Autophagy is an evolutionary conserved intracellular degradation and stress response mechanism that is mainly responsible for the breakdown and recycling of cytoplasmic materials, including long-lived proteins, protein aggregates, and damaged organelles. In this way, autophagy provides the cell with building blocks and allows the maintenance of homeostasis under stress conditions such as growth factor deficiency, nutrient deprivation, hypoxia, and toxins. Consequently, abnormalities of autophagy contribute to a number of pathologies ranging from neurodegenerative diseases to cancer. Autophagy was reported to have a dual role in cancer. Depending on cancer stage, autophagy seems to act as tumor suppressor or as a …
Invadopodia: Proteolytic Feet Of Cancer Cells, Gi̇zem Bati, Devri̇m Pesen Okvur
Invadopodia: Proteolytic Feet Of Cancer Cells, Gi̇zem Bati, Devri̇m Pesen Okvur
Turkish Journal of Biology
The leading cause of death in cancer patients is metastasis. Invasion is an integral part of metastasis and is carried out by proteolytic structures called invadopodia at the cellular level. In this introductory review, we start by evaluating the definition of invadopodia. While presenting the upstream signaling events involved, we integrate current models on invadopodia. In addition, we discuss the significance of invadopodia in 2D and 3D and in vivo. We finally point out technical challenges and conclude with open questions in the field.
It Takes 2 Antioxidants To Tango: The Interaction Between Manganese Superoxide Dismutase And Glutathione Peroxidase-1, Dede N. Ekoue, Alan M. Diamond
It Takes 2 Antioxidants To Tango: The Interaction Between Manganese Superoxide Dismutase And Glutathione Peroxidase-1, Dede N. Ekoue, Alan M. Diamond
Turkish Journal of Biology
Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism. Accumulation of ROS without an effective antioxidant response can lead to oxidative stress, resulting in macromolecular damage that is implicated in the etiology of various diseases including cancer. ROS detoxification is regulated by various antioxidant proteins, specifically manganese superoxide dismutase (MnSOD), which catalyzes the conversion of superoxide into H_{2}O_{2}, and the subsequent conversion of H_{2}O_{2} into water is catalyzed by glutathione peroxidase 1 (GPx-1). In vitro and in vivo evidence supports a conflicting role of MnSOD in tumor biology and indicates that an interaction between MnSOD and GPx-1 can modulate …
Failure Of Immunological Cells To Eradicate Tumor And Cancer Cells: An Overview, Rohit Sharma, Daizee Talukdar, Parth Malik, Tapan K. Mukherjee
Failure Of Immunological Cells To Eradicate Tumor And Cancer Cells: An Overview, Rohit Sharma, Daizee Talukdar, Parth Malik, Tapan K. Mukherjee
Turkish Journal of Biology
Inflammation can be broadly understood as a successive immune response of an organism's immune system towards nonnative or foreign antigens. This is a protective mechanism of the immune system, mediated by diverse immunological cells, to ensure homeostasis of an individual. Once activated, these immunological cells release a number of cytokines, chemokines, reactive oxygen species, reactive nitrogen species, histamines, prostaglandins, and other materials leading to inflammation. Tumor cells express altered proteins due to mutations of their genes, DNA modifications such as histone modification, DNA methylation, or other mechanisms of altered protein expression. The body's immunological cells actively recognize these altered proteins, …
Current Paradigms Of Cancer Chemoprevention, Rajendra G. Mehta
Current Paradigms Of Cancer Chemoprevention, Rajendra G. Mehta
Turkish Journal of Biology
Cancer chemoprevention has been continually evolving ever since the term was coined in the 70s. From the original approaches of identifying chemopreventive agents from the dietary constituents based on the epidemiological data to the current status of adapting them from the molecular targets, significant understanding of cancer as a disease and its possible prevention has been achieved. The identification of the chemopreventive agent from a complex mixture of natural product extracts involves numerous steps including bioassay guided fractionation; evaluation of the extracts, fractions and isolated new chemicals selectively using in vitro and in vivo experimental models; and understanding the mechanism …
Assessment Of Density-Dependent Feeding Damage By The Cotton Dusky Bug, Oxycarenus Laetus Kirby (Hemiptera: Lygaeidae), In Cotton, Muhammad Ahsan Khan, Muhammad Dildar Gogi, Muhammad Hamid Bashir, Mubasher Hussain, Zain-Ul Abdin, Muhammad Aamir Rashid
Assessment Of Density-Dependent Feeding Damage By The Cotton Dusky Bug, Oxycarenus Laetus Kirby (Hemiptera: Lygaeidae), In Cotton, Muhammad Ahsan Khan, Muhammad Dildar Gogi, Muhammad Hamid Bashir, Mubasher Hussain, Zain-Ul Abdin, Muhammad Aamir Rashid
Turkish Journal of Agriculture and Forestry
The dusky cotton bug, Oxycarenus laetus Kirby (Hemiptera: Lygaeidae), is a serious threat to cotton due to early cultivation of Bt cotton. These studies were carried out under laboratory and field conditions to estimate the feeding damage caused by O. laetus to seed weight, seed germination, and lint quality of cotton cultivar Bt-121 at 6 bug densities (0, 5, 10, 15, 20, and 25 adult pairs). The results revealed that seed germination and seed weight decreased, whereas percent reduction in seed germination and seed weight over control increased with increasing bug density. Bug density in the range of 5-25 pairs …